Nuclear factor κB transactivation is increased but is not involved in the proliferative effects of thioredoxin overexpression in MCF-7 breast cancer cells

Cancer Research

Volumn 59, Issue 16, 1999, Pages 4090-4094

  Freemerman, Alex J ^a   Gallegos, Alfred ^a   Powis, Garth ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; THIOREDOXIN; TRANSCRIPTION FACTOR AP 1;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSACTIVATION; WESTERN BLOTTING; APOPTOSIS; BIOSYNTHESIS; BREAST TUMOR; CELL CULTURE; CELL DIVISION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY;

APOPTOSIS; BREAST NEOPLASMS; CELL DIVISION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NF-KAPPA B; THIOREDOXIN; TUMOR CELLS, CULTURED;

EID: 0033566376     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Gilmore, T. D., Koedood, M., Piffat, K. A., and White, D. W. Rel/NF-κB/IκB proteins and cancer. Oncogene, 11: 1367-1378, 1997.
2. Bours, V., Dejardin, E., Goujon-Letawe, F., Merville, M., and Castronovo, V. The NF-κB transcription factor and cancer: high expression of NF-κ B- and IκB-related proteins in tumor cell lines. Biochem. Pharmacol., 47: 145-149, 1994.
3. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., and Karin, M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature (Lond.), 388: 548-554, 1997.
4. Matthews, J. R., Wakasugi, N., Virelizier, J-L., Yodoi, J., and Hay, R. T. Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res., 20: 3821-3830, 1992.
5. Moore, B. E., and Bose, H. R. J. Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts. Virology, 162: 377-387, 1988.
6. Narayanan, R., Klement, J. F., Ruben, S. M., Higgins, K. A., and Rosen, C. A. Identification of a naturally occurring transforming variant of the p65 subunit of NF-κB. Science (Washington DC), 256: 367-370, 1992.
7. Kitajima, I., Shinohara, T., Bilakovics, J. D. A. B., Xu, X., and Nerenberg, M. Ablation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-κB. Science (Washington DC), 258: 1792-1795, 1992.
8. Beg, A. A., and Baltimore, D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science (Washington DC), 274: 782-784, 1996.
9. Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R., and Verma, I. M. Suppression of TNF-α-induced apoptosis by NF-κB. Science (Washington DC), 274: 787-791, 1996.
10. Holmgren, A. Thioredoxin and glutaredoxin systems. J. Biol. Chem. 264: 13963-13966, 1989.
11. Luthman, M., and Holmgren, A. Rat liver thioredoxin and thioredoxin reductase: purification and characterization. Biochemistry, 21: 6628-6633, 1982.
12. Gasdaska, J. R., Berggren, M., and Powis, G. Cell growth stimulation by the redox protein thioredoxin occurs by a novel helper mechanism. Cell Growth Differ., 6: 1643-1650, 1995.
13. Kang, S. W., Chae, H. Z., Seo, M. S., Kim, K., Baines, I. C., and Rhee, S. G. Mammalian peroxidoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-α. J. Biol. Chem., 273: 6297-6302, 1998.
14. Grippo, J. F., Tienrungroj, W., Dahmer, M. K., Housley, P. R., and Pratt, W. B. Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin. J. Biol. Chem., 258: 13658-13664, 1983.
15. Qin, J., Clore, G. M., Kennedy, W. P., Hutch, J. R., and Gronenborn, A. M. Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF-κB. Structure, 3: 289-297, 1994.
16. Abate, C., Patel, L., Rauscher, F. J., III, and Curran, T. Redox regulation of fos and jun DNA-binding activity in vitro. Science (Washington DC), 249: 1157-1161, 1990.
17. Fujii, S., Nanbu, Y., Nonogaki, H., Konishi, I., Mori, T., Masutani, H., and Yodoi, J. Coexpression of adult T-cell leukemia-derived factor, a human thioredoxin homologue, and human papillomavirus DNA in neoplastic cervical squamous epithelium. Cancer (Phila.), 68: 1583-1591, 1991.
18. Kawahara, N., Tanaka, T., Yokomizo, A., Nanri, H., Ono, M., Wada, M., Kohno, K., Takenaka, K., Sugimachi, K., and Kuwano, M. Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin. Cancer Res., 56: 5330-5333, 1996.
19. Gasdaska, P. Y., Oblong, J. E., Cotgreave, I. A., and Powis, G. The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors. Biochim. Biophys. Acta, 1218: 292-296, 1994.
20. Berggren, M., Gallegos, A., Gasdaska, J. R., Gasdaska, P. Y., Warneke, J., and Powis, G. Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia. Anticancer Res., 16: 3459-3466, 1996.
21. Gallegos, A., Gasdaska, J. R., Taylor, C. W., Paine-Murrieta, G. D., Goodman, D., Gasdaska, P. Y., Berggren, M., Briehl, M. M., and Powis, G. Transfection with human thioredoxin increases cell proliferation and a dominant negative mutant thioredoxin reverses the transformed phenotype of breast cancer cells. Cancer Res., 56: 5765-5770, 1996.
22. Baker, A., Payne, C. M., Briehl, M. M., and Powis, G. Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. Cancer Res., 57: 5162-5167, 1997.
23. Li, J. J., Rhim, J. S., Schlegel, R., Vousden, K. H., and Colburn, N. H. Expression of dominant negative Jun inhibits elevated AP-1 and NF-κB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes. Oncogene, 16: 2711-2721, 1998.
24. Cai, Z., Korner, M., Tarantino, N., and Chouaib, S. IκB overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-κB activation but not tumor necrosis factor-α-induced apoptosis. J. Biol. Chem., 272: 96-101, 1997.
25. Miyamoto, S., and Verma, I. M. Rel/NF-κB/IκB story. Adv. Cancer Res., 66: 255-292, 1995.
26. Gerondakis, S., Grumont, R., Rourke, I., and Grossman, M. The regulation and roles of NF-κB transcription factors during lymphocyte activation. Curr. Opin. Immunol., 10: 353-359, 1998.
27. Janicke, R. U., Sprengart, M. L., Wati, M. R., and Porter, A. G. Caspase 3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem., 273: 9357-9360, 1998.
28. Li, F., Srinivasan, A., Wang, Y., Armstrong, R. C., Tomaselli, K. J., and Fritz, L. C. Cell specific induction of apoptosis by microinjection of cytochrome c. J. Biol. Chem., 272: 30299-30305, 1997.
29. Schenk, H., Klein, M., Erdbrügger, W., Dröge, W., and Schulze-Osthoff, K. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-κB and AP-1. Proc. Natl. Acad. Sci. USA, 91: 1672-1676, 1994.
30. Perkins, N. D., Schmid, R. M., Duckett, C. S., Leung, K., Rice, N. R., and Nabel, G. J. Distinct combinations of NF-κB subunits determine the specificity of transcriptional activation. Proc. Natl. Acad. Sci. USA, 89: 1529-1533, 1992.
31. Hirota, K., Matsui, M., Iwata, S., Nishiyama, A., Mori, K., and Yodoi, J. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc. Natl. Acad. Sci. USA, 94: 3633-3638, 1997.
32. Zhang, P., Liu, B., Kang, S. W., Seo, M. S., Rhee, S. G., and Obeid, L. M. Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2. J. Biol. Chem., 272: 30615-30618, 1997.
33. Jin, D., Zoon, H. J., Rhee, S. G., and Jeang, K. Regulatory role for a novel human thioredoxin peroxidase in NF-κB activation. J. Biol. Chem., 272: 30952-30961, 1997.
34. Gomez del Arco, P., Martinez-Martinez, S., Calvo, V., Armesilla, A. L., and Redondo, J. M. Antioxidants and AP-1 activation: a brief overview. Immunobiology, 198: 273-278, 1997.
35. Karin, M., Liu, Z., and Zandi, E. AP-1 function and regulation. Curr. Opin. Cell Biol., 9: 240-246, 1997.