IL-2-mediated cell cycle progression and inhibition of apoptosis does not require NF-κB or activating protein-1 activation in primary human T cells

Journal of Immunology

Volumn 162, Issue 6, 1999, Pages 3308-3315

  Iacobelli, Milena ^a   Rohwer, Forest ^a,b   Shanahan, Paul ^a   Quiroz, Jose A ^a   McGuire, Kathleen L ^a,c  

^a SAN DIEGO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; PHORBOL 13 ACETATE 12 MYRISTATE; STAT3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR AP 1;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL SURVIVAL; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PRIORITY JOURNAL; T LYMPHOCYTE; WESTERN BLOTTING;

APOPTOSIS; CELL CYCLE; CELL SURVIVAL; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; INTERLEUKIN-2; MILK PROTEINS; NF-KAPPA B; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; THYMUS GLAND; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1;

EID: 0033559123     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Smith, K. A. 1980. T-cell growth factor. Immunol. Rev. 51:337.
2. Robb, R. J. 1984. Interleukin 2: the molecule and its function. Immunol. Today 5:203.
3. Karnitz, L. M., and R. T. Abraham. 1996. Interleukin-2 receptor signaling mechanisms. Adv. Immunol. 61:147.
4. Crabtree, G. R., and N. A. Clipstone. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045.
5. Beg, A. A., and D. Baltimore. 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274:782.
6. Liu, Z.-G., H. Hsu, D. Goeddel, and M. Karin. 1996. Dissection of TNF receptor effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565.
7. Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma. 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274:787.
8. Wang, J., and K. Walsh. 1996. Resistance to apoptosis conferred by cdk inhibitors during myocyte differentiation. Science 273:359.
9. Wu, M., H. Lee, R. E. Bellas, S. L. Schauer, M. Arsura, D. Katz, M. J. FitzGerald, T. L. Rothstein, D. H. Sherr, and G. E. Sonenshein. 1996. Inhibition of NF-κB/ Rel induces apoptosis of murine B cells. EMBO J. 15:4682.
10. Baichwal, V. R., and P. A. Baeuerle. 1997. Apoptosis: activate NF-κB or die? Curr. Biol. 7:R94.
11. Sonenshein, G. E. 1997. Rel/NF-κB transcription factors and the control of apoptosis. Semin. Cancer Biol. 8:113.
12. Duke, R. C., and J. J. Cohen. 1986. IL-2 addition: withdrawal of growth factor activates a suicide program in dependent T cells. Lymphokine Res. 5:289.
13. Arima, N., W. A. Kuziel, T. A. Grdina, and W. C. Greene. 1992. IL-2-induced signal transduction involves the activation of nuclear NF-κB expression. J. Immunol. 149:83.
14. Xie, H., R. J. Seward, and B. T. Huber. 1997. Cytokine rescue from glucocorticoid induced apoptosis in T cells is mediated through inhibition of IκBα. Mol. Immunol. 34:987.
15. Schreiber, M., B. Baumann, M. Cotton, P. Angel, and E. F. Wanger. 1995. Fos is an essential component of the mammalian UV response. EMBO J. 14:5338.
16. + thymocytes. J. Biol. Chem. 272:8558.
17. Colotta, F., N. Polentarutti, M. Sironi, and A. Mantovani. 1992. Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J. Biol. Chem. 267:18278.
18. Smeyne, R. J., M. Vendrell, M. Hayward, S. J. Baker, G. G. Miao, K. Schilling, L. Robertson M., T. Curran, and J. Morgan. 1993. Continuous c-fos expression precedes programmed cell death. Nature 363:166.
19. Ham, J., C. Babij, J. Whitfield, C. M. Pfarr, D. Lallemand, M. Yaniv, and L. L. Rubin. 1995. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14:927.
20. Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and G. M. E. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326.
21. Verheij, M., R. Bose, X. H. Lin, B. Yao, W. D. Jarvis, S. Grant, M. J. Birrer, E. Szabo, L. I. Zon, J. M. Kyriakis, et al. 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75.
22. Karin, M., L. Zheng-gang, and E. Zandi. 1997. AP-1 function and regulation. Curr. Opin. Cell Biol. 9:240.
23. Foletta, V. C., D. H. Segal, and D. R. Cohen. 1998. Transcriptional regulation in the immune system: all roads lead to AP-1. J. Leukocyte Biol. 63:139.
24. Guizani, L., M. Perrin-Wolff, J. Breard, B. Binetruy, and J. Bertoglio. 1996. Mechanisms of interleukin-2 protection against glucocorticoid-induced apoptosis: regulation of AP-1 and glucocorticoid receptor transcriptional activities. J. Interferon Cytokine Res. 16:601.
25. Xu, X., O. Heidenreich, I. Kitajima, K. McGuire, Q. Li, B. Su, and M. Nerenberg. 1996. Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis. Oncogene 12:135.
26. Crawley, J. B., L. Rawlinson, F. V. Lali, T. H. Page, J. Saklatvala, and B. M. J. Foxwell. 1997. T cell proliferation in response to interleukins 2 and 7 requires p38 MAP kinase activation. J. Biol. Chem. 272:15023.
27. Nielsen, M., A. Svejgaard, S. Skov, and N. Odum. 1994. Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of Stat3 in human T lymphocytes. Eur. J. Immunol. 24:3082.
28. Rothman, P., B. Kreider, M. Azam, D. Levy, U. Wegenka, A. Eilers, T. Decker, F. Horn, H. Kashleva, J. Ihle, et al. 1994. Cytokines and growth factors signal through tyrosines phosphorylation of a family of related transcription factors. Immunity 1:457.
29. Brunn, G. J., E. L. Falls, A. E. Nilson, and R. T. Abraham. 1995. Protein-tyrosine kinase-dependent activation of STAT transcription factors in interleukin-2-or interleukin-4-stimulated T lymphocytes. J. Biol. Chem. 270:11628.
30. Fujii, H., Y. Nakagawa, U. Schindler, A. Kawahara, H. Mori, F. Gouilleux, B. Groner, J. N. Ihle, Y. Minami, T. Miyazaki, et al. 1995. Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor β chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. USA 92:5482.
31. Hou, J., U. Schindler, W. J. Henzel, S. C. Wong, and S. L. McKnight. 1995. Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2:321.
32. Lin, J.-X., T.-S. Migone, M. Tsang, M. Friedmann, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, et al. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331.
33. Rohwer, F., S. Todd, and K. L. McGuire. 1996. The effect of IL-2 treatment on transcriptional attenuation in proto-oncogenes pim-1 and c-myb in human thymic blast cells. J. Immunol. 157:643.
34. McGuire, K. L., and M. Iacobelli. 1997. Involvement of Rel, Fos and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells. J. Immunol. 159:1319.
35. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
36. Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
37. Gilmore, T. D., M. Koedood, K. A. Piffat, and D. W. White. 1996. Rel/NF-κB/ IκB proteins and cancer. Oncogene 13:1367.
38. Imbert, V., R. A. Rupec, A. Livolsi, H. L. Pahl, E. B.-M. Traenckner, C. Mueller-Dieckmann, D. Farahifar, B. Rossi, P. Auberger, P. A. Baeuerle, et al. 1996. Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB. Cell 86:787.
39. Bours, V., G. Franzoso, V. Azarenko, S. Park, T. Kanno, K. Brown, and U. Siebenlist. 1993. The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers. Cell 72:729.
40. Fujita, T., G. P. Nolan, H. C. Liou, M. L. Scott, and D. Baltimore. 1993. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers. Genes Dev. 7:1354.
41. Watanabe, N., T. Iwamura, T. Shinoda, and T. Fujita. 1997. Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-κB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation. EMBO J. 16:3609.
42. Lecine, P., M. Algarte, P. Rameil, C. Beadling, P. Bucher, M. Nabholz, and J. Imbert. 1996. Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene. Mol. Cell. Biol. 16:6829.
43. Nakajima, H., X.-W. Liu, A. Wynshaw-Boris, L. A. Rosenthal, K. Imada, D. S. Finbloom, L. Hennighausen, and W. J. Leonard. 1997. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity 7:691.
44. Korner, M., N. Tarantino, and P. Debre. 1991. Constitutive activation of NF-κB in human thymocytes. Biochem. Biophys. Res Commun. 181:80.
45. Feuillard, J., C. Cargemont, V. Ferreira, N. Tarantino, P. Debre, M. Raphael, and M. Korner. 1997. Nuclear Rel-A and c-Rel protein complexes are differentially distributed within human thymocytes. J. Immunol. 158:2585.
46. Rincon, M., and R. A. Flavell. 1994. AP-1 transcription activity requires both T-cell receptor-mediated and costimulatory signals in primary T-lymphocytes. EMBO J. 13:4370.
47. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T-lymphocytes. Cell 77:727.
48. Werlen, G., E. Jacinto, Y. Xia, and M. Karin. 1998. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17:3101.
49. Brennan, P., J. W. Babbage, B. M. T. Burgering, B. Groner, K. Reif, and D. A. Cantrell. 1997. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7:679.
50. Kamitz, L. M., L. A. Burns, S. L. Sutor, J. Blenis, and R. T. Abraham. 1995. Interleukin-2 triggers a novel Phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol. Cell. Biol. 15:3049.
51. Alessi, D. R., and P. Cohen. 1998. Mechanism of activation and function of protein kinase B. Curr Opin. Gen. Dev. 8:55.
52. Downward, J. 1998. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Biol. 10:262.
53. Ahmed, N. H., H. L. Grimes, A. Bellacosa, T. O. Chan, and P. N. Tsichlis. 1997. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA 94:3627.
54. Miyazaki, T., A. Kawahara, H. Fujii, Y. Nakagawa, Y. Minami, Z.-J. Liu, I. Oishi, O. Silvennoinen, B. A. Witthuhn, J. N. Ihle, et al. 1994. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045.
55. c chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042.
56. Witthuhn, B. A., O. Silvennoinen, O. Miura, K. S. Lai, C. Cwik, E. T. Liu, and J. N. Ihle. 1994. Involvement of the Jak-3 Janus kinase in signaling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153.
57. Kawahara, A., Y. Minami, T. Miyazaki, J. N. Ihle, and T. Taniguchi. 1995. Critical role of the interleukin 2 (IL-2) receptor γ-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction. Proc. Natl. Acad. Sci. USA 92:8724.
58. Zamorano, J., H. Y. Wang, R. Wang, Y. Shi, G. D. Longmore, and A. D. Keegan. 1998. Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression. J. Immunol. 160:3502.
59. c chain. J. Biol. Chem. 270: 21729.
60. Liu, K. D., S. L. Gaffen, and M. A. Goldsmith. 1998. JAK/STAT signaling by cytokine receptors. Curr. Opin. Immunol. 10:271.