Mechanisms in interleukin-2 protection against glucocorticoid-induced apoptosis: Regulation of AP-1 and glucocorticoid receptor transcriptional activities

Journal of Interferon and Cytokine Research

Volumn 16, Issue 8, 1996, Pages 601-609

  Guizani, Lamia ^a   Perrin Wolff, Mallory ^a   Breard, Jacqueline ^a   Binetruy, Bernard ^b   Bertoglio, Jacques ^a  

^a INSERM   (France)

^b Institut de Recherches Scientifiques sur le Cancer   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; DNA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4 RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; APE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DNA BINDING; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ALOCASIA MACRORRHIZOS; ANIMALIA; HYLOBATES SP.; MOUSE MAMMARY TUMOR VIRUS;

EID: 0029839929     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1996.16.601     Document Type: Article

References (44)

1. WALLNER, B.P., MATTALIANO, R.J., HERSION, C., CATE, R.L., TIZARD, R., SINCLAIR, L.K., FOELLER, C., CHOW, E.P., BROWNING, J.L., RAMACHANDRAN, K.L., and PEPINSKY, R.B. (1986). Cloning and expression of human lipocortin, a phospholipase inhibitor with potential anti-inflammatory activity. Nature 320, 77-80.
2. WEINER, F.R., CZAJA, M.J., JEFFERSON, E.D.M., GIAMBRONE, M.-A., TUR-KASPA, R., REID, L.M., and ZERN, M.A. (1987). The effects of dexamethasone on in vitro collagen gene expression. J. Biol. Chem. 262, 6955-6958.
3. CULPEPPER, J.A., and LEE, F. (1985). Regulation of IL-3 expression by glucocorticoids in cloned murine T lymphocytes. J. Immunol. 135, 3191-3196.
4. KNUDSEN, P.J., DINARELLO, C.A., and STROM, T.B. (1987). Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J. Immunol. 139, 4134-4139.
5. VACCA, A., FELLI, M.P., FARINA, A.R., MARTINOTTI, S., MARODER, M., SCREPANTI, I., MECO, D., PETRANGELI, E., FRATI, L., and GULINO, A. (1990). Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones. J. Biol. Chem. 265, 8075-8380.
6. HOWARD, K.J., and DISTELHORST, C.W. (1988). Evidence for intracellular association of the glucocorticoid receptor with the 90-kDa heat shock protein. J. Biol. Chem. 263, 3474-3481.
7. PICARD, D., and YAMAMOTO, K.R. (1987). Two signals mediate hormone-dependent nuclear localisation of the glucocorticoid receptor. EMBO J. 6, 3333-3340.
8. SCHEIDEREIT, C., GEISSE, S., WESTPHAL, H.M., and BEATO, M. (1983). The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus. Nature 304, 749-752.
9. BEATO, M. (1989). Gene regulation by steroid hormones. Cell 56, 335-344.
10. CATO, A.C.B., MIKSICEK, R., SCHÜTZ, G., ARNEMANN, J., and BEATO, M. (1986). The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction. EMBO J. 5, 2237-2240.
11. AKERBLOM, I.E., SLATER, E.P., BEATO, M., BAXTER, J.D., and MELLON, P.L. (1988). Negative regulation by glucocorticoids through interference with cAMP responsive enhancer. Science 241, 350-353.
12. JONAT, C., RAHMSDORF, H.J., PARK, K.K., CATO, A.C.B., GEBEL, S.B., PONTA, H., and HERRLICH, P. (1990). Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62; 1189-1204.
13. SCHÜLE, R., RANGARAJAN, P., KLIEWER, S., RANSONE, L.J., BOLADO, J., YANG, N., VERMA, I.M., and EVANS, R.M. (1990). Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62, 1217-1226.
14. YANG-YEN, H.-F., CHAMBARD, J.C., SUN, Y.L., SMEAL, T., SCHMIDT, T.J., DROUIN, J., and KARIN, M. (1990). Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62, 1205-1215.
15. CHIU, R., BOYLE, W.J., MEEK, J., SMEAL, T., HUNTER, T., and KARIN, M. (1988). The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54, 541-552.
16. NAKABEPPU, Y., and NATHANS, D. (1988). DNA binding activities of three murine jun proteins: stimulation by c-fos. Cell 55, 907-915.
17. ANGEL, P., IMAGAWA, M., CHIU, R., STEIN, B., IMBRA, R.J., RAHMSDORF, H.J., JONAT, C., HERRLICH, P., and KARIN, M. (1987). Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49, 729-739.
18. ANGEL, P., BAUMANN, I., STEIN, B., DELIUS, H., RAHMSDORF, H.J., and HERRLICH, P. (1987). 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′-flanking region. Mol. Cell. Biol. 7, 2256-2266.
19. VACCA, A., MARTINOTTI, S., SCREPANTI, I., MARODER, M., FELLI, M.P., FARINA, A.R., GISMONDI, A., SANTONI, A., FRATI, L., and GULINO, A. (1992). Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements. J. Exp. Med. 175, 637-645.
20. NORTHROP, J.P., CRABTREE, G.R., and MATTILA, P.S. (1992). Negative regulation of interleukin 2 transcription by the glucocorticoid receptor. J. Exp. Med. 175, 1235-1245.
21. PALIOGIANNI, F., RAPTIS, A., AHUJA, S.S., NAJJAR, S.M., and BOUMPAS, D.T. (1993). Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. J. Clin. Invest. 91, 1481-1489.
22. BOUMPAS, D.T., ANASTASSIOU, E.D., OLDER, S.A., TSOKOS, G.C., NELSON, D.L., and BALOW, J.E. (1991). Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J. Clin. Invest. 87, 1739-1747.
23. COHEN, J.J. (1988). Lymphocyte death induced by glucocorticoids. In: Antiinflammatory Steroid Action: Basic and Clinical Aspects. R.P.Schleimer, H.N. Claman, and A. Oronsky (eds.). San Diego, CA: Academic Press, p. 110.
24. ALNEMRI, E.S., and LITWACK, G. (1990). Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. J. Biol. Chem. 265, 17323-17333.
25. NIETO, M.A., and LOPEZ-RIVAS, A. (1989). IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death. J. Immunol. 143, 4166-4170.
26. ZUBIAGA, A.M., MUNOZ, E., and HUBER, B.T. (1992). IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis. J. Immunol. 149, 107-112.
27. PERRIN-WOLFF, M., BERTOGLIO, J., BRESSAC, B., BOHUON, C., and PALLARDY, M. (1995). Structure-activity relationships in glucocorticoid-induced apoptosis in T lymphocytes. Biochem. Pharmacol. 50, 103-110.
28. McCONKEY, D.J., HARTZELL, P., JONDAL, M., and ORRENIUS, S. (1989). Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C. J. Biol. Chem. 264, 13399-13402.
29. SMITH, K. (1988). The interleukin 2 receptor. Adv. Immunol. 42, 165-177.
30. MOSMANN, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
31. WYLLIE, A.H. (1987). Cell death. Int. Rev. Cytol 17, (Suppl.) 755-785.
32. DIGNAM, J.D., LEBOVITZ, R.M., and ROEDER, R.G. (1983). Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1480.
33. BINETRUY, B., SMEAL, T., and KARIN, M. (1991). Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351, 120-124.
34. GORMAN, C.M., MOFFAT, L.F., and HOWARD, B.H. (1982). Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2, 1044-1051.
35. TSUDO, M., KOZAK, R.W., GOLDMAN, C.K., and WALDMANN, T.A. (1987). Contribution of a p75 interleukin 2 binding peptide to a high-affinity interleukin receptor complex. Proc. Natl. Acad. Sci. USA 84, 4215-4218.
36. GUIZANI, L., LANG, P., STANCOU, R., and BERTOGLIO, J. (1993). Regulation of interleukin-2 and interleukin-4 receptor expression in human and ape lymphoid cell lines. Lymphokine Cytokine Res. 12, 25-31.
37. CHEN, S.J., HOLBROOK, N.J., MITCHELL, K.F., VALLONE, C.A., GREENGARD, J.S., CRABTREE, J.A., and LIN, Y. (1985). A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2. Proc. Natl. Acad. Sci. USA 82, 7284-7288.
38. HATAKEYAMA, M., KAWAHARA, A., MORI, H., SHIBUYA, H., and TANIGUCHI, T. (1992). c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor β chain. Proc. Natl. Acad. Sci. USA 89, 2022-2026.
39. TROUCHE, D., ROBIN, P., ROBILLARD, O., SASSONECORSI, P., and HAREL-BELLAN, A. (1991). c-fos transcriptional activation by IL-2 in mouse CTLL-2 cells is mediated through two distinct signal transduction pathways converging on the same enhancer element. J. Immunol. 147, 2398-2403.
40. BERTOGLIO, J., and LEROUX, E. (1988). Differential effects of glucocorticoids on the proliferation of a murine helper and a cytolytic T cell clone in response to IL-2 and IL-4. J. Immunol. 141, 1191-1196.
41. WALKER, P.R., KWAST-WELFELD, J., GOURDEAN, H., LEBLANC, J., NEUGEBAUER, W., and SIKORSKA, M. (1993). Relationship between apoptosis and the cell cycle in lymphocytes: roles of protein kinase C, tyrosine phosphorylation, and AP1. Exp. Cell Res. 207, 142-151.
42. TANIGUCHI, T., and MINAMI, Y. (1993). The IL-2/IL-2 receptor system: a current overview. Cell 73, 5-8.
43. HELMBERG, A., AUPHAN, N., CAELLES, C., and KARIN, M. (1995). Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 14, 452-460.
44. BEADLING, C., GUSCHIN, D., WITTHUHN, B.A., ZIEMEECKI, A., IHLE, J.N., KERR, I.M., and CANTRELL, D.A. (1994). Activation of JAK kinases and STAT proteins by interleukin-2 and interferon α, but not the T cell antigen receptor, in human T lymphocytes. EMBO J. 13, 5605-5615.