Potent inhibitors of protein farnesyltransferase: Heteroarenes as cysteine replacements

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 5, 1999, Pages 703-708

  Shen, Wang ^a   Fakhoury, Stephen ^a   Donner, Greg ^a   Henry, Kenneth ^a   Lee, Jang ^a   Zhang, Haichao ^a   Cohen, Jerry ^a   Warner, Robert ^a   Saeed, Badr ^a   Cherian, Sajeev ^a   Tahir, Stephen ^a   Kovar, Peter ^a   Bauch, Joy ^a   Ng, Shi Chung ^a   Marsh, Kennan ^a   Sham, Hing ^a   Rosenberg, Saul ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; CYTOTOXIC AGENT; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PACLITAXEL; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P21;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL PROLIFERATION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; ENZYME INHIBITION; NONHUMAN; PROTEIN MODIFICATION; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

3T3 CELLS; ALKYL AND ARYL TRANSFERASES; ANIMALS; ENZYME INHIBITORS; EPOXY COMPOUNDS; GENES, RAS; MICE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0033535420     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00080-3     Document Type: Article

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