GDNF is a trophic factor for adult rat corticospinal neurons and promotes their long-term survival after axotomy in vivo

European Journal of Neuroscience

Volumn 9, Issue 11, 1997, Pages 2479-2489

  Giehl, Klaus M ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Amyotrophic lateral sclerosis; Axotomy; Corticospinal neurons; CSF; GDNF; Survival

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAPSULA INTERNA; CELL DEATH; CELL SURVIVAL; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRACISTERNAL DRUG ADMINISTRATION; MOTOR CONTROL; NERVE FIBER TRANSECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SPINAL CORD MOTONEURON;

ANIMALS; AXOTOMY; BODY WEIGHT; CELL SIZE; CELL SURVIVAL; CEREBRAL CORTEX; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; IMMUNOHISTOCHEMISTRY; MALE; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 0031452823     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1997.tb01665.x     Document Type: Article

References (3)

1. Arsenis, G. and Livingstone, J. N. (1986) Alterations in the tyrosine kinase activity of the insulin receptor produced by in vitro hyperinsulinemia. J. Biol Chem., 261, 147-153.
2. Beck, K. D., Valverde, J., Alexi, T., Poulsen, K., Moffat, B., Vandlen, R. A., Rosenthal, A. and Hefti, F. (1995) Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature, 373, 339-341.
3. Blake, A. D., Hayes, N. S., Slater, E. E. and Strader, C. D. (1987) Insulin receptor desensitization correlates with attenuation of tyrosine kinase activity, but not of receptor endocytosis. Biochem. J., 245, 357-364.