The IκB kinase: A master regulator of NF-κB, innate immunity, and epidermal differentiation

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 64, Issue , 1999, Pages 491-503

  Delhase, M ^a   Karin, M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE; HELIX LOOP HELIX PROTEIN; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; INTERLEUKIN 1; LEUCINE ZIPPER PROTEIN; LYMPHOTOXIN BETA RECEPTOR; PHOSPHOSERINE; RNA POLYMERASE II; TAX PROTEIN; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR; UBIQUITIN PROTEIN LIGASE E3;

AMINO ACID SEQUENCE; CONFERENCE PAPER; DROSOPHILA; IMMUNOGLOBULIN GENE; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ARTICLE; AUTOPHOSPHORYLATION; BACULOVIRUS EXPRESSION SYSTEM; CELL DIFFERENTIATION; CELL STIMULATION; DIMERIZATION; EPIDERMIS CELL; FRACTIONATION; GEL FILTRATION CHROMATOGRAPHY; GENETIC TRANSCRIPTION; HUMAN; INNATE IMMUNITY; NUCLEAR LOCALIZATION SIGNAL; PROTEIN DEGRADATION;

EID: 0033513188     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1999.64.491     Document Type: Conference Paper

References (36)

1. Alessi D.R., Saito Y., Campbell D.G., Cohen P., Sithanandam G., Rapp U., Ashworth A., Marshall C.J., and Cowley S. 1994. Identification of the sites in MAP kinase kinase-I phosphorylation by p74raf-1. EMBO J. 13: 1610.
2. Aliprantis A.O., Yang R-B., Mark M.R., Suggett S., Devaux B., Radolf J.D., and Kumpel G.R., Godowski P., Zychlinsky A. 1999. Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. Science 285: 736.
3. Alkalay I., Yaron A., Hatzubai A., Jung S., Avraham A., Gerlitz O., Pashut-Lavon L, and Ben-Neriah Y. 1995. In vivo stimulation of IκB phosphorylation is not sufficient to activate NFκB. Mol. Cell. Biol. 15: 1294.
4. Baeuerle P.A. and Baltimore D. 1996. NF-κB: Ten years after. Cell 87: 13.
5. Baldwin A.S.J. 1996. The NF-κB and IκB proteins: New discoveries and insights. Annu. Rev. Imnumol. 14: 649.
6. Baranger A.M., Palmer C.R., Hamm M.K., Giebler H.A., Brauweiler A., Nyborg J.K., and Schepartz A. 1995. Mechanism of DNA-binding enhancement by the human T-cell leukemia virus transactivator Tax. Nature 376: 606.
7. Baud V., Liu Z.-G., Bennett B., Suzuki N., Xia Y., and Karin M. 1999. Signaling by proinflammatory cytokines: Oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an N-terminal effector domain. Genes Dev. 13: 1297.
8. Beg A.A. and Baltimore D. 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274: 782.
9. Beg A.A., Sha W.C., Bronson R.T., and Baltimore D. 1995a. Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice. Genes Dev. 9: 2736.
10. Beg A.A., Sha W.C., Bronson R.T., Ghosh S., and Baltimore D. 1995b. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376: 167.
11. Belvin M.P. and Anderson K.V. 1996. A conserve signaling pathway: The Drosophila toll-dorsal pathway. Annu. Rev. Cell Dev. Biol. 12: 393.
12. Belvin M.P., Jin Y., and Anderson K.V. 1995. Cactus protein degradation mediates Drosophila dorsal-ventral signaling. Genes Dev. 9: 783.
13. Brightbill H.D., Libraty D.H., Krutzik S.R., Yang R.-B., Belisle J.T., Bleharski J.R., Maitland M., Norgard M.V., Plevy S.E., Smale ST., Brennan P.J., Bloom B.R., Godowski P.J., and Modlin R.L. 1999. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science 285: 732.
14. Brown K., Gerstberger S., Carlson L., Franzoso G., and Siebenlist U. 1995. Control of IκBα proteolysis by site-specific, signal-induced phosphorylation. Science 267: 1485.
15. Burke J.R., Miller K.R., Wood M.K., and Meyers C.A. 1998. The multisubunit IκB kinase complex shows random sequential kinetics and is activated by the C-terminal domain of IκBα. J. Biol. Chem. 273: 12041.
16. Cao Z., Henzel W.J., and Gao X. 1996. IRAK: A kinase associated with the interleukin-1 receptor. Science 271: 1128.
17. Chen Z.F. and Behringer R.R. 1995. twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev. 9: 686.
18. Chen Z.J., Parent L., and Maniatis T. 1996. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84: 853.
19. Chu Z.-L., DiDonato J.A., Hawiger J., and Ballard D.W. 1998. The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IκB kinases containing IKKα and IKKβ. J. Biol. Chem. 273: 15891.
20. Chu Z.-L., Shin Y.-A., Yang J.-M., DiDonato J.A., and Ballard D.W. 1999. IKKγ mediates the interaction of cellular IκB kinases with the tax transforming protein of human T cell leukemia virus type 1. J. Biol. Chem. 274: 15297.
21. Cohen L., Henzel W.J., and Baeuerle P.A. 1998. IKAP is a scaffold protein of the IκB kinase complex. Nature 395: 292.
22. Connelly M.A. and Marcu K.B. 1995. CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. Cell. Mol. Biol. Res. 41: 537.
23. Delhase M., Hayakawa M., Chen Y., and Karin M. 1999. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284: 309.
24. DiDonato J.A., Mercuric F., and Karin M. 1995. Phosphorylation of IκBα precedes but is not sufficient for its dissociation from NF-κB. Mol. Cell. Biol. 15: 1302.
25. DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E., and Karin M. 1997. A cytokine-responsive IκB kinase that acti-vates the transcription factor NF-κB. Nature 388: 548.
26. DiDonato J., Mercurio F., Rosette C., Wu-Li J., Suyang H., Ghosh S., and Karin M. 1996. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16: 1295.
27. Doi T.S., Marino M.W., Takahashi T., Yoshida T., Sakakura T., Old L.J., and Obata Y. 1999. Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proc. Natl. Acad. Sci. 96: 2994.
28. Drier E.A. and Steward R. 1997. The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila. Semin. Cancer Biol. 8: 83.
29. Drier E.A., Huang L.H., and Steward R. 1999. Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev. 13: 556.
30. el Ghouzzi V., Le Merrer M., Perrin-Schmitt F., Lajeunie E., Benit P., Renier D., Bourgeois P., Bolcato-Bellemin A.L., Munnich A., and Bonaventure J. 1997. Mutations of the TWIST gene in the Saethre-Chotzen syndrome [comments]. Nat. Genet. 15: 42.
31. Geleziunas R., Ferrell S., Lin X., Mu Y., Cunningham E.T., Jr., Grant M., Connelly M.A., Hambor J.E., Marcu K.B., and Greene W.C. 1998. Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase alpha (IKKα) and IKKβ cellular kinases. Mol. Cell. Biol. 18: 5157.
32. Ghosh S., May M.J., and Kopp E.B. 1998. NF-κB and Rel proteins: Evolutionary conserved mediators of immune responses. Annu. Rev. Immimol. 16: 225.
33. Graff J.M. 1997. Embryonic patterning: To BMP or not to BMP, that is the question. Cell 89: 171.
34. Hashimoto C., Hudson K.L., and Anderson K.V. 1988. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52: 269.
35. Huffman J.A., Kafatos F.C., Janeway C.A., Jr., and Ezekowiz R.A.B. 1999. Phylogenetic perspectives in innate immunity. Science 284: 1313.
36. Hogan B.L. 1996. Bone morphogenetic proteins: Multifunctional regulator of vertebrate development. Genes Dev. 10: 1580.