메뉴 건너뛰기




Volumn 17, Issue 4, 1999, Pages 311-325

Age-related changes in growth hormone secretion: Should the somatopause be treated?

Author keywords

Aging; GH deficiency; GH releasing hormone (GHRH); Growth hormone (GH, somatotropin); Pituitary

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; SEX HORMONE;

EID: 0033508314     PISSN: 07348630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1016241     Document Type: Article
Times cited : (35)

References (74)
  • 1
    • 73849180538 scopus 로고
    • Clinical use of human growth hormone
    • Raben MS. Clinical use of human growth hormone. N Engl J Med 1962;266:82-86
    • (1962) N Engl J Med , vol.266 , pp. 82-86
    • Raben, M.S.1
  • 2
    • 0023098492 scopus 로고
    • Effects of sex and age on the 24-hour profile of GH secretion in man: Importance of endogenous estradiol Metab concentrations
    • Ho KY, Evans WS, Blizzard RM, et al. Effects of sex and age on the 24-hour profile of GH secretion in man: Importance of endogenous estradiol Metab concentrations. J Clin Endocrinol 1987;64:51-58
    • (1987) J Clin Endocrinol , vol.64 , pp. 51-58
    • Ho, K.Y.1    Evans, W.S.2    Blizzard, R.M.3
  • 3
    • 0024451386 scopus 로고
    • Alterations in the pulsatile properties of circulating GH concentrations during puberty in boys
    • Martha PM Jr, Rogol AD, Veldhuis JD. Alterations in the pulsatile properties of circulating GH concentrations during puberty in boys. J Clin Endocrinol Metab 1989;69:563-570
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 563-570
    • Martha Jr., P.M.1    Rogol, A.D.2    Veldhuis, J.D.3
  • 5
    • 0002228321 scopus 로고    scopus 로고
    • Growth hormone and growth hormone secretagogues in adults
    • Meikle AW, ed. Totowa, NJ: Humana Press
    • Cummings D, Merriam GR. Growth hormone and growth hormone secretagogues in adults. In: Meikle AW, ed. Contemporary Endocrinology: Hormone Replacement Therapy. Totowa, NJ: Humana Press; 1999:61-88
    • (1999) Contemporary Endocrinology: Hormone Replacement Therapy , pp. 61-88
    • Cummings, D.1    Merriam, G.R.2
  • 6
    • 0025368959 scopus 로고
    • Effect of human GH in men over 60 years old
    • Rudman D, Feller AG, Nagraj HS, et al. Effect of human GH in men over 60 years old. N Engl J Med 1990;323:1-6
    • (1990) N Engl J Med , vol.323 , pp. 1-6
    • Rudman, D.1    Feller, A.G.2    Nagraj, H.S.3
  • 8
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulation of GH secretion in experimental animals and the human
    • Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of GH secretion in experimental animals and the human. Endocr Rev 1998;19:717-797
    • (1998) Endocr Rev , vol.19 , pp. 717-797
    • Giustina, A.1    Veldhuis, J.D.2
  • 10
    • 0029129652 scopus 로고
    • Design and biological activities of L-163,191 (MK-0677), a potent, orally active GH secretagogue
    • Patchett AA, Nargund RP, Tata JR, et al. Design and biological activities of L-163,191 (MK-0677), a potent, orally active GH secretagogue. Proc Natl Acad Sci U S A 1995;92:7001-7005
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 7001-7005
    • Patchett, A.A.1    Nargund, R.P.2    Tata, J.R.3
  • 11
    • 0029016015 scopus 로고
    • Growth hormone (GH) responses to GH-releasing peptide and to GH-releasing hormone in GH-deficient children
    • Mericq V, Cassorla F, Garcia H, et al. Growth hormone (GH) responses to GH-releasing peptide and to GH-releasing hormone in GH-deficient children. J Clin Endocrinol Metab 1995;80:1681-1684
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1681-1684
    • Mericq, V.1    Cassorla, F.2    Garcia, H.3
  • 12
    • 0031759899 scopus 로고    scopus 로고
    • Effects of eight months' treatment with graded doses of growth hormone-releasing peptide in growth hormone-deficient children
    • Mericq VG, Salazar T, Avila A, et al. Effects of eight months' treatment with graded doses of growth hormone-releasing peptide in growth hormone-deficient children. J Clin Endocrinol Metab 1998;83:2355-2360
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2355-2360
    • Mericq, V.G.1    Salazar, T.2    Avila, A.3
  • 13
    • 0031732737 scopus 로고    scopus 로고
    • Growth hormone-releasing peptide-6 requires endogenous hypothalamic GHRH for maximal GH stimulation
    • Pandya N, DeMott-Friberg R, Bowers CY, et al. Growth hormone-releasing peptide-6 requires endogenous hypothalamic GHRH for maximal GH stimulation. J Clin Endocrinol Metab 1998;83:1186-1189
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1186-1189
    • Pandya, N.1    DeMott-Friberg, R.2    Bowers, C.Y.3
  • 14
    • 0022618113 scopus 로고
    • Growth hormone (GH) responses to GHRH during pubertal development in normal boys and girls: Comparison to idiopathic short stature and GH deficiency
    • Gelato MC, Malozowski S, Caruso-Nicoletti M, et al. Growth hormone (GH) responses to GHRH during pubertal development in normal boys and girls: Comparison to idiopathic short stature and GH deficiency. J Clin Endocrinol Metab 1986;63:174-179
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 174-179
    • Gelato, M.C.1    Malozowski, S.2    Caruso-Nicoletti, M.3
  • 15
    • 0022652273 scopus 로고
    • Responses of growth hormone (GH) and somatomedin-C to GH-releasing hormone in healthy aging men
    • Pavlov EP, Harman SM, Merriam GR, et al. Responses of growth hormone (GH) and somatomedin-C to GH-releasing hormone in healthy aging men. J Clin Endocrinol Metab 1986;62:595-600
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 595-600
    • Pavlov, E.P.1    Harman, S.M.2    Merriam, G.R.3
  • 16
    • 0030953395 scopus 로고    scopus 로고
    • Effect of aging on the sensitivity of GH secretion to insulin-like growth factor-I negative feedback
    • Chapman IM, Hartman ML, Pezzoli SS, et al. Effect of aging on the sensitivity of GH secretion to insulin-like growth factor-I negative feedback. J Clin Endocrinol Metab 1997;82:2996-3004
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2996-3004
    • Chapman, I.M.1    Hartman, M.L.2    Pezzoli, S.S.3
  • 17
    • 0025644397 scopus 로고
    • Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man
    • Ghigo E, Goffi S, Nicolosi M, et al. Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. J Clin Endocrinol Metab 1990;71:1481-1485
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1481-1485
    • Ghigo, E.1    Goffi, S.2    Nicolosi, M.3
  • 18
    • 0028076027 scopus 로고
    • Arginine and growth hormone-releasing hormone restore the blunted GH-releasing activity of hexarelin in elderly subjects
    • Arvat E, Giannoti L, Grottoli S, et al. Arginine and growth hormone-releasing hormone restore the blunted GH-releasing activity of hexarelin in elderly subjects. J Clin Endocrinol Metab 1994;79:1440-1443
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1440-1443
    • Arvat, E.1    Giannoti, L.2    Grottoli, S.3
  • 19
    • 0023850369 scopus 로고
    • Enhanced growth hormone (GH) responsiveness to GHRH after dietary manipulation in obese and non-obese subjects
    • Kelijman M, Frohman LA. Enhanced growth hormone (GH) responsiveness to GHRH after dietary manipulation in obese and non-obese subjects. J Clin Endocrinol Metab 1988;66:489-494
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 489-494
    • Kelijman, M.1    Frohman, L.A.2
  • 20
    • 0024241459 scopus 로고
    • Sex steroids increase spontaneous GH secretion in short children
    • Rose SR, Kibarian M, Gelato MC, et al. Sex steroids increase spontaneous GH secretion in short children. J Pediatr Endocrinol 1988;3:1-5
    • (1988) J Pediatr Endocrinol , vol.3 , pp. 1-5
    • Rose, S.R.1    Kibarian, M.2    Gelato, M.C.3
  • 21
    • 0023146199 scopus 로고
    • Chronic sex steroid exposure increases mean plasma GH concentration and pulse amplitude in men with isolated hypogonadotropic hypogonadism
    • Liu L, Merriam GR, Sherins RJ. Chronic sex steroid exposure increases mean plasma GH concentration and pulse amplitude in men with isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1987;64:651-656
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 651-656
    • Liu, L.1    Merriam, G.R.2    Sherins, R.J.3
  • 22
    • 0030882782 scopus 로고    scopus 로고
    • Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (GH)-IGF-1 axis in the human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement
    • Veldhuis JD, Metzger DL, Martha PM, et al. Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (GH)-IGF-1 axis in the human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement. J Clin Endocrinol Metab 1997;82:3414-3420
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3414-3420
    • Veldhuis, J.D.1    Metzger, D.L.2    Martha, P.M.3
  • 23
    • 0023098492 scopus 로고
    • Effects of sex and age on the 24-hour profile of GH secretion in man: Importance of endogenous estradiol concentrations
    • Ho KY, Evans WS, Blizzard RM, et al. Effects of sex and age on the 24-hour profile of GH secretion in man: Importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 1987;64:51-58
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 51-58
    • Ho, K.Y.1    Evans, W.S.2    Blizzard, R.M.3
  • 24
    • 0028873974 scopus 로고
    • Diminished function of the somatotropic axis in older reproductive-aged women
    • Wilshire GB, Loughlin JS, Brown JR, et al. Diminished function of the somatotropic axis in older reproductive-aged women. J Clin Endocrinol Metab 1995;80:608-613
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 608-613
    • Wilshire, G.B.1    Loughlin, J.S.2    Brown, J.R.3
  • 25
    • 0030951402 scopus 로고    scopus 로고
    • Relationships between insulin-like growth factor-I and estradiol in reproductive aging
    • Blake EJ, Adel T, Santoro N. Relationships between insulin-like growth factor-I and estradiol in reproductive aging. Fertil Steril 1997;67:697-701
    • (1997) Fertil Steril , vol.67 , pp. 697-701
    • Blake, E.J.1    Adel, T.2    Santoro, N.3
  • 26
    • 0030063379 scopus 로고    scopus 로고
    • Circulating levels of GH, insulin-like growth factor-I, and GH binding protein in normal women of advanced reproductive age
    • Klein NA, Battaglia DE, Miller PB, Soules MR. Circulating levels of GH, insulin-like growth factor-I, and GH binding protein in normal women of advanced reproductive age. Clin Endocrinol (Oxf) 1996;44:285-292
    • (1996) Clin Endocrinol (Oxf) , vol.44 , pp. 285-292
    • Klein, N.A.1    Battaglia, D.E.2    Miller, P.B.3    Soules, M.R.4
  • 28
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulation of GH secretion in experimental animals and the human
    • Veldhuis JD. Pathophysiology of the neuroregulation of GH secretion in experimental animals and the human. Endocr Rev 1998;19:719-797
    • (1998) Endocr Rev , vol.19 , pp. 719-797
    • Veldhuis, J.D.1
  • 29
    • 0029811814 scopus 로고    scopus 로고
    • Effects of oral vs. transdermal estrogen on the GH-insulin-like growth factor I axis in younger and older postmenopausal women
    • Bellantoni M, Vittone J, Campfield A, et al. Effects of oral vs. transdermal estrogen on the GH-insulin-like growth factor I axis in younger and older postmenopausal women. J Clin Endocrinol Metab 1996;81:2848-2853
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2848-2853
    • Bellantoni, M.1    Vittone, J.2    Campfield, A.3
  • 30
    • 85046501049 scopus 로고    scopus 로고
    • Optimizing GH replacement therapy by dose titration in hypopituitary adults
    • Drake W, Coyte D, Camacho H, et al. Optimizing GH replacement therapy by dose titration in hypopituitary adults. J Clin Endocrinol Metab 1998;83:9313-9319
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 9313-9319
    • Drake, W.1    Coyte, D.2    Camacho, H.3
  • 31
    • 0033343113 scopus 로고    scopus 로고
    • Route of estrogen administration helps to determine GH replacement dose in GH-deficient adults
    • Cook DC, Ludlam WH, Cook MB. Route of estrogen administration helps to determine GH replacement dose in GH-deficient adults. J Clin Endocinol Metab 1999;84:3956-3960
    • (1999) J Clin Endocinol Metab , vol.84 , pp. 3956-3960
    • Cook, D.C.1    Ludlam, W.H.2    Cook, M.B.3
  • 32
    • 0031027955 scopus 로고    scopus 로고
    • Growth hormone deficient men are more responsive to GH replacement than women
    • Burman P, Johansson A, Siegbahn A, et al. Growth hormone deficient men are more responsive to GH replacement than women. J Clin Endocrinol Metab 1997;82:550-555
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 550-555
    • Burman, P.1    Johansson, A.2    Siegbahn, A.3
  • 33
    • 0033594893 scopus 로고    scopus 로고
    • Normal growth and development in the absence of hepatic insulin-like growth factor-I
    • Yakar S, Liu J-L, Stannard B, et al. Normal growth and development in the absence of hepatic insulin-like growth factor-I. Proc Natl Acad Sci U S A 1999;96:7324-7329
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7324-7329
    • Yakar, S.1    Liu, J.-L.2    Stannard, B.3
  • 36
    • 0030777287 scopus 로고    scopus 로고
    • The consequences of GH deficiency in adulthood, and the effects of GH replacement
    • Christ ER, Carroll PV, Russell JDL, Sonksen PH. The consequences of GH deficiency in adulthood, and the effects of GH replacement. Schweiz Med Wochenschr 1997;127:1440-1449
    • (1997) Schweiz Med Wochenschr , vol.127 , pp. 1440-1449
    • Christ, E.R.1    Carroll, P.V.2    Russell, J.D.L.3    Sonksen, P.H.4
  • 38
    • 0029057967 scopus 로고
    • Growth hormone deficiency in adults and its response to GH replacement
    • Labram EK, Wilkin TJ. Growth hormone deficiency in adults and its response to GH replacement. QJM 1995;88:391-399
    • (1995) QJM , vol.88 , pp. 391-399
    • Labram, E.K.1    Wilkin, T.J.2
  • 39
    • 0028830103 scopus 로고
    • Consequences of GH deficiency in adults and the benefits and risks of recombinant human GH treatment
    • Ros'en T, Johannsson G, Johansson JO, Bengtsson BA. Consequences of GH deficiency in adults and the benefits and risks of recombinant human GH treatment. Horm Res 1995;43:93-99
    • (1995) Horm Res , vol.43 , pp. 93-99
    • Ros'en, T.1    Johannsson, G.2    Johansson, J.O.3    Bengtsson, B.A.4
  • 41
    • 0029915281 scopus 로고    scopus 로고
    • Growth hormone deficiency in adults: Characteristics and response to GH replacement
    • Lieberman SA, Hoffman AR. Growth hormone deficiency in adults: Characteristics and response to GH replacement. J Pediatr 1996;128:S58-S60
    • (1996) J Pediatr , vol.128
    • Lieberman, S.A.1    Hoffman, A.R.2
  • 42
    • 0025333249 scopus 로고
    • Premature mortality due to cardiovascular disease in hypopituitarism
    • Ros'en T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990;336:285-288
    • (1990) Lancet , vol.336 , pp. 285-288
    • Ros'en, T.1    Bengtsson, B.A.2
  • 44
    • 0027210051 scopus 로고
    • The consequences of GH deficiency in adults
    • Bengtsson BA. The consequences of GH deficiency in adults. Acta Endocrinol (Copenh) 1993;2:2-5
    • (1993) Acta Endocrinol (Copenh) , vol.2 , pp. 2-5
    • Bengtsson, B.A.1
  • 45
    • 0025151831 scopus 로고
    • Epidemiology of diabetes mellitus among the elderly in the United States
    • Harris MI. Epidemiology of diabetes mellitus among the elderly in the United States. Clin Geriatr Med 1990;6:703-719
    • (1990) Clin Geriatr Med , vol.6 , pp. 703-719
    • Harris, M.I.1
  • 47
    • 0025906737 scopus 로고
    • Clinical review 18: Are patients with acromegaly at increased risk for neoplasia?
    • Ezzat S, Melmed S. Clinical review 18: Are patients with acromegaly at increased risk for neoplasia? J Clin Endocrinol Metab 1991;72:245-249
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 245-249
    • Ezzat, S.1    Melmed, S.2
  • 48
    • 0025190619 scopus 로고
    • Colon cancer and polyps in acromegaly: Increased risk associated with family history of colon cancer
    • Brunner JE, Johnson CC, Zafar S, et al. Colon cancer and polyps in acromegaly: Increased risk associated with family history of colon cancer. Clin Endocrinol (Oxf) 1990;32:65-71
    • (1990) Clin Endocrinol (Oxf) , vol.32 , pp. 65-71
    • Brunner, J.E.1    Johnson, C.C.2    Zafar, S.3
  • 49
    • 0032499440 scopus 로고    scopus 로고
    • Circulating concentrations of IGF-1 and risk of breast cancer
    • Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of IGF-1 and risk of breast cancer. Lancet 1998;351:1393-1396
    • (1998) Lancet , vol.351 , pp. 1393-1396
    • Hankinson, S.E.1    Willett, W.C.2    Colditz, G.A.3
  • 50
    • 0032559272 scopus 로고    scopus 로고
    • Plasma IGF-1 and prostate cancer risk: A prospective study
    • Chan JM, Stampfer MJ, Giovanucci E, et al. Plasma IGF-1 and prostate cancer risk: A prospective study. Science 1998;279:563-566
    • (1998) Science , vol.279 , pp. 563-566
    • Chan, J.M.1    Stampfer, M.J.2    Giovanucci, E.3
  • 51
    • 0032499448 scopus 로고    scopus 로고
    • IGF-1 and new opportunities for cancer prevention
    • Holly J. IGF-1 and new opportunities for cancer prevention. Lancet 1998;351:1373-1375
    • (1998) Lancet , vol.351 , pp. 1373-1375
    • Holly, J.1
  • 52
    • 0031792510 scopus 로고    scopus 로고
    • Consensus guidelines for the diagnosis and treatment of adults with GH deficiency: Summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency
    • Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency: Summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. J Clin Endocrinol Metab 1998;83:379-381
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 379-381
  • 53
    • 0033539018 scopus 로고    scopus 로고
    • Increased mortality associated with GH treatment in critically ill adults
    • Takala J, Ruokonen E, Webster NR, et al. Increased mortality associated with GH treatment in critically ill adults. N Engl J Med 1999;341:785-792
    • (1999) N Engl J Med , vol.341 , pp. 785-792
    • Takala, J.1    Ruokonen, E.2    Webster, N.R.3
  • 54
    • 0025787687 scopus 로고
    • Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men
    • Iranmanesh A, Lizarralde G, Velduis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 1991;73:1081-1088
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1081-1088
    • Iranmanesh, A.1    Lizarralde, G.2    Velduis, J.D.3
  • 55
    • 0027249894 scopus 로고
    • Low circulating levels of insulin-like growth factors and testosterone in chronically institutionalized elderly men
    • Abbasi AA, Drinka PJ, Mattson DE, Rudman D. Low circulating levels of insulin-like growth factors and testosterone in chronically institutionalized elderly men. J Am Geriatr Soc 1993;41:975-982
    • (1993) J Am Geriatr Soc , vol.41 , pp. 975-982
    • Abbasi, A.A.1    Drinka, P.J.2    Mattson, D.E.3    Rudman, D.4
  • 56
    • 0029981793 scopus 로고    scopus 로고
    • A highly sensitive GH ELISA uncovers increased contribution of a tonic mode of GH secretion in adults with organic GH deficiency
    • Reutens AT, Veldhuis JD, Hoffman DM, et al. A highly sensitive GH ELISA uncovers increased contribution of a tonic mode of GH secretion in adults with organic GH deficiency. J Clin Endocrinol Metab 1996;81:1591-1597
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1591-1597
    • Reutens, A.T.1    Veldhuis, J.D.2    Hoffman, D.M.3
  • 57
    • 0030062657 scopus 로고    scopus 로고
    • Beyond the somatopause: GH deficiency in adults over the age of 60 years
    • Toogood AA, O'Neill PA, Shalet SM. Beyond the somatopause: GH deficiency in adults over the age of 60 years. J Clin Endocrinol Metab 1996;81:460-465
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 460-465
    • Toogood, A.A.1    O'Neill, P.A.2    Shalet, S.M.3
  • 58
    • 0030746255 scopus 로고    scopus 로고
    • Preservation of GH pulsatility despite pituitary pathology, surgery, and irradiation
    • Toogood AA, Nass RM, Pezzoli SS, et al. Preservation of GH pulsatility despite pituitary pathology, surgery, and irradiation. J Clin Endocrinol Metab 1997;82:2215-2221
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2215-2221
    • Toogood, A.A.1    Nass, R.M.2    Pezzoli, S.S.3
  • 61
    • 0025368959 scopus 로고
    • Effects of human GH in men over 60 years old
    • Rudman D, Feller AG, Nagraj HS, et al. Effects of human GH in men over 60 years old. N Engl J Med 1990;323:1-6
    • (1990) N Engl J Med , vol.323 , pp. 1-6
    • Rudman, D.1    Feller, A.G.2    Nagraj, H.S.3
  • 62
    • 0026331981 scopus 로고
    • Effects of human GH on body composition in elderly men
    • Rudman D, Feller AG, Cohn L, et al. Effects of human GH on body composition in elderly men. Horm Res 1991;36(suppl):73-81
    • (1991) Horm Res , vol.36 , Issue.SUPPL. , pp. 73-81
    • Rudman, D.1    Feller, A.G.2    Cohn, L.3
  • 63
    • 0029064540 scopus 로고
    • The effects of recombinant human insulin-like growth factor-I and GH on body composition in elderly women
    • Thompson JL, Butterfield GE, Marcus R, et al. The effects of recombinant human insulin-like growth factor-I and GH on body composition in elderly women. J Clin Endocrinol Metab 1995;80:1845-1852
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1845-1852
    • Thompson, J.L.1    Butterfield, G.E.2    Marcus, R.3
  • 64
    • 0029993686 scopus 로고    scopus 로고
    • Growth hormone replacement in healthy older men improves body composition but not functional ability
    • Papadakis MA, Grady D, Black D, et al. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 1996;124:708-716
    • (1996) Ann Intern Med , vol.124 , pp. 708-716
    • Papadakis, M.A.1    Grady, D.2    Black, D.3
  • 65
    • 0030029181 scopus 로고    scopus 로고
    • Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men
    • Taaffe DR, Jin IH, Vu TH, et al. Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men. J Clin Endocrinol Metab 1996;81:421-425
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 421-425
    • Taaffe, D.R.1    Jin, I.H.2    Vu, T.H.3
  • 66
    • 0030801116 scopus 로고    scopus 로고
    • Effect of resistance exercise and GH on bone density in older men
    • Yarasheski KE, Campbell JA, Kohrt WM. Effect of resistance exercise and GH on bone density in older men. Clin Endocrinol 1997;47:223-229
    • (1997) Clin Endocrinol , vol.47 , pp. 223-229
    • Yarasheski, K.E.1    Campbell, J.A.2    Kohrt, W.M.3
  • 67
    • 0025159241 scopus 로고
    • Effects of short term administration of recombinant human GH to elderly people
    • Marcus R, Butterfield G, Holloway L, et al. Effects of short term administration of recombinant human GH to elderly people. J Clin Endocrinol Metab 1990;70:519-527
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 519-527
    • Marcus, R.1    Butterfield, G.2    Holloway, L.3
  • 69
    • 0028146277 scopus 로고
    • Effects of recombinant human GH on metabolic indices, body composition, and bone turnover in healthy elderly women
    • Holloway L, Butterfield G, Hintz RL, et al. Effects of recombinant human GH on metabolic indices, body composition, and bone turnover in healthy elderly women. J Clin Endocrinol Metab 1994;79:470-479
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 470-479
    • Holloway, L.1    Butterfield, G.2    Hintz, R.L.3
  • 70
    • 0028822657 scopus 로고
    • Treatment of postmenopausal osteoporosis with a combination of GH and pamidronate: A placebo controlled trial
    • Erdtsieck RJ, Pols HA, Valk NK, et al. Treatment of postmenopausal osteoporosis with a combination of GH and pamidronate: A placebo controlled trial. Clin Endocrinol (Oxf) 1995;43:557-565
    • (1995) Clin Endocrinol (Oxf) , vol.43 , pp. 557-565
    • Erdtsieck, R.J.1    Pols, H.A.2    Valk, N.K.3
  • 71
    • 0031749620 scopus 로고    scopus 로고
    • Growth hormone as therapy for older men and women
    • Marcus R, Hoffman AR. Growth hormone as therapy for older men and women. Annu Rev Pharmacol Toxicol 1998;38:45-61
    • (1998) Annu Rev Pharmacol Toxicol , vol.38 , pp. 45-61
    • Marcus, R.1    Hoffman, A.R.2
  • 72
    • 0345765603 scopus 로고    scopus 로고
    • Clinical and physiological studies with growth hormone-releasing hormone
    • Smith RG, Thorner MO, eds. Totowa, NJ: Humana Press
    • Merriam GR, Cassorla F. Clinical and physiological studies with growth hormone-releasing hormone. In: Smith RG, Thorner MO, eds. Human Growth Hormone: Research and Clinical Practice. Totowa, NJ: Humana Press; 1999:297-313
    • (1999) Human Growth Hormone: Research and Clinical Practice , pp. 297-313
    • Merriam, G.R.1    Cassorla, F.2
  • 74
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakagato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakagato, M.4    Matsuo, H.5    Kangawa, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.