Lack of Effect of Recombinant Human Growth Hormone (GH) on Muscle Morphology and GH-Insulin-Like Growth Factor Expression in Resistance-Trained Elderly Men

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 1, 1996, Pages 421-425

  Taaffe, Dennis R ^a,c   Jin, Isabella H ^b   Vu, Thanh H ^b   Hoffman, Andrew R ^b,c   Marcus, Robert ^a,b,c  

^a Education and Clinical Center   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; MESSENGER RNA; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR;

AGED; AGING; ARTICLE; GENE EXPRESSION REGULATION; GROWTH REGULATION; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MORPHOLOGY; MUSCLE HYPERTROPHY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS REGULATION; TRAINING; VASTUS LATERALIS MUSCLE;

AGED; AGED, 80 AND OVER; BASE SEQUENCE; DOUBLE-BLIND METHOD; GENE EXPRESSION; GROWTH HORMONE; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; PHYSICAL EDUCATION AND TRAINING; RECEPTORS, SOMATOMEDIN; RECEPTORS, SOMATOTROPIN; RECOMBINANT PROTEINS; RNA, MESSENGER; SOMATOMEDINS;

EID: 0030029181     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.81.1.8550787     Document Type: Review

References (43)

1. Marcus R, Butterfield G, Holloway L, et al. 1990 Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab. 70:519-527.
2. Rudman D, Feller AG, Nagraj HS, et al. 1990 Effects of human growth hormone in men over 60 years old. N Engl J Med. 323:1-6.
3. Jørgensen JOL, Pedersen SA, Thuesen L, et al. 1989 Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet. 1:1221-1225.
4. Salomon F, Cuneo RC, Hesp R, Sönksen PH. 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med. 321:1797-1803.
5. Bengtsson B-Å, Edén S, Lönn L, et al. 1993 Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab. 76:309-317.
6. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sonksen PH. 1991 Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. J Appl Physiol. 70:688-694.
7. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sonksen PH. 1991 Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. J Appl Physiol. 70:695-700.
8. Taaffe DR, Pruitt L, Reim J, et al. 1994 Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab. 79:1361-1366.
9. Murphy LJ, Bell GI, Duckworth ML, Friesen HG. 1987 Identification, characterization, and regulation of rat complementary deoxyribonucleic acid which encodes insulin-like growth factor-I. Endocrinology. 121: 684-691.
10. Ullman M, Oldfors A. 1989 Effects of growth hormone on skeletal muscle. I. Studies on normal adult rats. Acta Physiol Scand. 135:531-536.
11. Bergström J. 1962 Muscle electrolytes in man. Scand J Clin Lab Invest. 68(Suppl):1-110.
12. Dubowitz V, Brooke MB. 1973 Muscle biopsy: a modern approach. In: Major problems in neurology. Philadelphia: Saunders; 1-33.
13. Blomstrand E, Celling F, Fridén J, Ekblom B. 1984 How to calculate human muscle fibre areas in biopsy samples-methodological considerations. Acta Physiol Scand. 122:545-551.
14. Hu JF, Vu TH, Hoffman AR. 1995 Differential biallelic activation of three insulin-like growth factor-II promoters in the mouse central nervous system. Mol Endocrinol. 9:628-636.
15. Vu TH, Hoffman AR. 1994 Promotor-specific imprinting of the human insulin-like growth factor-II gene. Nature. 371:714-717.
16. Vu TH, Yballe C, Boonyanit S, Hoffman AR. 1995 Insulin-like gowth factor-II in uterine smooth muscle tumors: maintenance of genomic imprinting in leiomyomata and loss of imprinting in leiomyosarcomata. J Clin Endocrinol Metab. 80:1670-1676.
17. MacDougall JD, Elder GCB, Sale DG, Moroz JR, Sutton JR. 1980 Effects of strength training and immobilization on human muscle fibers. Eur J Appl Physiol. 43:25-34.
18. Frontera WR, Meredith CN, O'Reilly KP, Knuttgen HG, Evans WJ. 1988 Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol. 64:1038-1044.
19. Yarasheski KE, Zachwieja JJ, Bier DM. 1993 Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly adults. Am J Physiol 265:E210-E214.
20. Yarasheski KE. 1994 Growth hormone effects on metabolism, body composition, muscle mass, and strength. In: Holloszy JO, ed. Exercise and sports science reviews. Baltimore: Williams & Wilkins; 285-312.
21. Goldberg AL. 1967 Work-induced growth of skeletal muscle in normal and hypophysectomized rats. Am J Physiol. 212:1193-1198.
22. Pell JM, Bates PC. 1987 Collagen and non-collagen protein turnover in skeletal muscle of growth hormone-treated lambs. J Endocrinol 115:R1-R4.
23. Horber FF, Haymond MW. 1990 Human growth hormone prevents the protein catabolic effects of prednisone in humans. J Clin Invest, 86:265-272.
24. Sonntag WE, Hylka VW, Meites J. 1985 Growth hormone restores protein synthesis in skeletal muscle of old male rats. J Gerontol. 40:689-694.
25. Ullman M, Alameddine H, Skottner A, Oldfors A. 1989 Effects of growth hormone on skeletal muscle. II. Studies on regeneration and denervation in adult rats. Acta Physiol Scand. 135:537-543.
26. Maltin CA, Delday MI, Hay SM, Innes GM, Williams PEV. 1990 Effects of bovine pituitary growth hormone alone or in combination with the β-agonist clenbuterol on muscle growth and composition in veal calves. Br J Nutr. 63:535-545.
27. Preece MA, Round JM, Jones DA. 1987 Growth hormone deficiency in adults - an indication for therapy? Acta Paediatr Scand. 331(Suppl):76-79.
28. Rutherford OM, Jones DA, Round JM, Buchanan CR, Preece MA. 1991 Changes in skeletal muscle and body composition after discontinuation of growth hormone treatment in growth hormone deficient young adults. Clin Endocrinol (Oxf). 34:469-475.
29. Whitehead HM, Gilliland JS, Allen IV, Hadden DR. 1989 Growth hormone treatment in adults with growth hormone deficiency: effect on muscle fibre size and proportions. Acta Paediatr Scand. 356(Suppl):65-67.
30. Cuneo RC, Salomon F, Wiles CM, Jones D, Hesp R, Sönksen PH. 1992 Histology of skeletal muscle in adults with GH deficiency: comparison with normal muscle and response to GH treatment. Horm Res. 37:23-28.
31. Yarasheski KE, Campbell JA, Smith K, Rennie MJ, Holloszy JO, Bier DM. 1992 Effect of growth hormone and resistance exercise on muscle growth in young men. Am J Physiol 262:E261-E267.
32. Deyssig R, Frisch H, Blum WF, Waldhör T. 1993 Effect of growth hormone treatment on hormonal parameters, body composition, and strength in athletes. Acta Endocrinol (Copenh). 128:313-318.
33. Yarasheski KE, Zachwieja JJ, Angelopoulos TJ, Bier DM. 1993 Short-term growth hormone treatment does not increase muscle protein synthesis in experienced weight lifters. J Appl Physiol. 74:3073-3076.
34. De Vroede MA, Romanus JA, Standaert ML, Pollet RJ, Nissley SP, Rechler MM. 1984 Interaction of insulin-like growth factors with a nonfusing mouse muscle cell line: binding, action, and receptor down-regulation. Endocrinology. 114:1917-1929.
35. De Mellow JSM, Baxter RC. 1988 Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I stimulated DNA synthesis in human skin fibroblasts. Biochem Biophys Res Commun. 156:199-206.
36. Snyder DK, Clemmons DR, Underwood LE. 1988 Treatment of obese, diet-restricted subjects with growth hormone for 11 weeks: effects on anabolism, lipolysis, and body composition. J Clin Endocrinol Metab. 67:54-61.
37. Henneman PH, Forbes AP, Moldawer M, Dempsey EF, Carroll EL. 1960 Effects of human growth hormone in man. J Clin Invest. 39:1223-1238.
38. Mandel S, Moreland E, Nichols V, Hanna C, Lafranchi S. 1995 Changes in insulin-like growth factor-I (IGF-I), IGF-binding protein-3, growth hormone (GH)-binding protein, erythrocyte IGF-I receptors, and growth rate during GH treatment. J Clin Endocrinol Metab. 80:190-194.
39. Hochberg Z, Barkley RJ, Even L, Peleg I, Youdim MBH, Amit T. 1991 The effect of human growth hormone therapy on GH binding protein in GH-deficient children. Acta Endocrinol (Copenh). 125:23-27.
40. DeVol DL, Rotwein P, Sadow JL, Novakofski J, Bechtel PJ. 1990 Activation of insulin like growth factor gene expression during work-induced skeletal muscle growth. Am J Physiol 259:E89-E95.
41. Zanconato S, Moromisato DY, Moromisato MY. 1994 Effect of training and growth hormone supression on insulin-like growth factor 1 mRNA in young rats. J Appl Physiol. 76:2204-2209.
42. Czerwinski SM, Martin JM, Bechtel PJ. 1994 Modulation of IGF mRNA abundance during stretch-induced skeletal muscle hypertrophy and regression. J Appl Physiol. 76:2026-2030.
43. Daughaday WH, Rotwein P. 1989 Insulin-like growth factors I and II. Peptide messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev. 10:69-91.