A highly sensitive growth hormone (GH) enzyme-linked immunosorbent assay uncovers increased contribution of a tonic mode of GH secretion in adults with organic GH deficiency

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 4, 1996, Pages 1591-1597

  Reutens, Anne T ^a   Veldhuis, Johannes D ^b   Hoffman, David M ^a   Leung, Kin Chuen ^a   Ho, Ken K Y ^a  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HUMAN; PRIORITY JOURNAL; PULSATILE FLOW; STATISTICAL ANALYSIS;

ADULT; AGED; BODY MASS INDEX; CIRCADIAN RHYTHM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GROWTH HORMONE; HUMANS; MALE; MIDDLE AGED; PITUITARY DISEASES; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0029981793     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.4.1591     Document Type: Article

References (22)

1. Ho KY, Evans WS, Blizzard RM, et al. 1987 Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab. 64:51-58.
2. Hartman ML, Faria ACS, Vance ML, Johnson ML, Thorner MO, Veldhuis JD. 1991 Temporal structure of in-vivo growth hormone secretory events in humans. Am J Physiol. 260:E101-E110.
3. Whitehead HM, Aiken B, Lewis S, Sheridan B, Hadden DR. 1991 Physiological growth hormone secretion in adult growth hormone deficiency: comparison with normal controls. Clin Endocrinol (Oxf). 34:371-376.
4. Reutens AT, Hoffman DM, Leung K-C, Ho KKY. 1995 Evaluation and application of a highly sensitive assay for serum growth hormone (GH) in the study of adult GH deficiency. J Clin Endocrinol Metab. 80:480-484.
5. Hoffman DM, O'Sullivan AJ, Baxter RC, Ho KKY. 1994 Diagnosis of growth hormone deficiency in adults. Lancet. 343:1064-1068.
6. Hoffman DM, O'Sullivan AJ, Freund J, Ho KKY. 1995 Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism. J Clin Endocrinol Metab. 80:72-77.
7. Ho KY, Weissberger AJ, Stuart MC, Day RO, Lazarus L. 1989 The pharmacokinetic, safety and endocrine effects of authentic biosynthetic human growth hormone in normal subjects. Clin Endocrinol (Oxf). 30:335-345.
8. Veldhuis JD, Carlson ML, Johnson ML. 1987 The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA. 84:7686-7690.
9. Iranmanesh A, Grisso B, Veldhuis JD. 1994 Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminesence assay. J Clin Endocrinol Metab. 78:526-535.
10. Straume M, Veldhuis J, Johnson M. 1995 Realistic emulation of highly irregular temporal patterns of hormone release: a computer-based pulse simulator. Methods in Neurosciences. 28:220-243.
11. Veldhuis J, Liem A, South S, et al. 1995 Differential impact of age, sex-steroid hormones, and obesity on basal versus pulsatile GH secretion in men assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab. 80: 3209-3222.
12. Pincus SM, Keefe DL. 1992 Quantification of hormone pulsatility via an approximate entropy algorithm. Am J Physiol. 262:E741-E754.
13. Hartman MLS, Pincus SM, Johnson ML, et al. 1994 Enhanced basal and disorderly growth hormone (GH) secretion distinguish acromegalic from normal pulsatile GH release. J Clin Invest. 94:1277-1288.
14. Chapman IM, Hartman ML, Straume M, Johnson ML, Veldhuis JD, Thorner MO. 1994 Enhanced sensitivity growth hormone (GH) chemiluminescence assay reveals lower postglucose nadir GH concentrations in men than women. J Clin Endocrinol Metab. 78:1312-1319.
15. Van den Berg G, Frolich M, Veldhuis J, Roelfsma F. 1994 Growth hormone secretion in recently operated acromegalic patients. J Clin Endocrinol Metab. 79:1706-1715.
16. Stewart J, Clifton D, Koerker D, Rogol A, Jafe T, Goodner C. 1985 Pulsatile release of growth hormone and prolactin from the primate pituitary in vitro. Endocrinology. 116:1-5.
17. Fletcher T, Thomas G, Willoughby J, Clarke I. 1994 Constitutive growth hormone secretion in sheep after hypothalamopituitary disconnection and the direct in vivo pituitary effect of growth hormone releasing peptide 6. Neuroendocrinology. 60:76-86.
18. Weigent DA, Baxter JB, Wear WE, Smith LR, Bost KL, Blalock JE. 1988 Production of immunoreactive growth hormone by mononuclear leukocytes. FASEB J. 2:2812-2818.
19. Weigent DA, Blalock JE. 1991 The production of growth hormone by subpopulations of rat mononuclear leukocytes. Cell Immunol. 135:55-65.
20. Varma S, Sabharwal P, Sheridan JF, Malarkey WB. 1993 Growth hormone secretion by human peripheral blood mononuclear cells detected by an enzyme-linked immunoplaque assay. J Clin Endocrinol Metab. 76:49-53.
21. Hartman ML, Veldhuis JD, Vance ML, Faria ACS, Furlanetto RW, Thorner MO. 1990 Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy. J Clin Endocrinol Metab. 70:1375-1384.
22. Ho KKY, Weissberger AJ. 1994 Characterisation of 24 hour growth hormone secretion in acromegaly: implications for diagnosis and therapy. Clin Endocrinol (Oxf). 41:75-83.