Regulation of the hypothalamo-pituitary-adrenal axis by cytokines

Bailliere's Best Practice and Research in Clinical Endocrinology and Metabolism

Volumn 13, Issue 4, 1999, Pages 503-521

  Mulla, Abeda ^b   Buckingham, Julia C ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b NONE

Author keywords

Cytokines; Eicosanoids; Glucocorticoids; Hypothalamo pituitary adrenocortical axis; Interleukins 1 and 6; Neuroendocrine immune communication; Stress; Tumour necrosis factor

Indexed keywords

CHLORISONDAMINE; CYTOKINE; CYTOKINE RECEPTOR; DEXAMETHASONE; GLUCOCORTICOID; IBUPROFEN; INDOMETACIN; INTERLEUKIN 1; INTERLEUKIN 6; MACROPHAGE MIGRATION INHIBITION FACTOR; MEPACRINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHOSPHOLIPASE A2 INHIBITOR; PROSTAGLANDIN E RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CYTOKINE RELEASE; HORMONAL REGULATION; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOREGULATION; INFLAMMATION; MOUSE; NEUROENDOCRINE SYSTEM; NONHUMAN; RAT; REVIEW;

EID: 0033504081     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1053/beem.1999.0041     Document Type: Article

References (95)

1. Buckingham J C, Loxley H D, Christian H C, Philip J G. Activation of the HPA axis by immune insults: roles and interactions of cytokines, eicosanoids and glucocorticoids. Pharmacology Biochemistry and Behaviour. 54:1996;285-298.
2. Turnbull A, Rivier C. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiological Reviews. 79:1999;1-71.
3. Besedovsky H C, Sorkin E, Keller M, Miller S L. Changes in blood hormone levels during the immune response. Proceedings of the Society for Experimental Biology and Medicine. 150:1975;466-470.
4. Besedovsky H O, del Ray A. Immune-neuroendocrine circuits: integrative role of cytokines. Frontiers in Neuroendocrinology. 13:1992;61-94.
5. Imura H, Fukata J, Mori T. Cytokines and endocrine function - an interaction between the immune and neuroendocrine system - review. Clinical Endocrinology. 35:1991;107-115.
6. Shurin G, Shanks N, Nelson L. Hypothalamic-pituitary-adrenal activation by bacterial superantigen staphylococcal enterotoxin B: role of macrophages and T-cells. Neuroendocrinology. 65:1997;18-28.
7. Fantuzzi G, Zheng H, Faggioni R. The effect of endotoxin in IL-1β deficient mice. Journal of Immunology. 157:1996;291-296.
8. Fatorri E, Cappalletti M, Coasta P. Defective inflammatory response to interleukin-6 deficient mice. Journal of Experimental Medicine. 180:1994;1243-1250.
9. Alheim K, Chai Z, Fantuzzi G. Hyperresponsive febrile reactions to interleukin (IL) 1α and IL-1β, and altered brain cytokine mRNA and serum cytokine levels in UL-1β-deficient mice. Proceedings of the National Academy of Sciences of the USA. 94:1997;2681-2686.
10. Dunn A J, Chuluyan H E. Endotoxin elicits normal tryptophan and indolamine responses but impaired catecholamine and pituitary-adrenal responses in endotoxin-resistant mice. Life Sciences. 54:1994;847-853.
11. Sapolsky R, Rivier C, Yamomoto G. Interleukin 1 stimulates the secretion of hypothalamic corticotropin releasing factor. Science. 238:1984;522-524.
12. Buckingham J C. Stress and the neuroendocrine-immune axis: the pivotal role of glucocorticoids and lipocortin 1. British Journal of Pharmacology. 118:1996;1-19.
13. Navarra P, Tsagarakis S, Faria M S. Interleukins-1 and -6 stimulate the release of corticotropin releasing hormone-41 from the rat hypothalamus in vitro via the eicosanoid cyclo-oxygenase pathway. Endocrinology. 128:1991;37-47.
14. Spangelo B L, Gorospe W C. Role of the cytokines in the neuroendocrine-immune system axis. Frontiers in Neuroendocrinology. 16:1995;1-22.
15. Bengini F, Faggioni R, Sironi M. TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF. Journal of Immunology. 157:1996;5563-5568.
16. Dunn A J. The role of interleukin-1 and tumor necrosis factor-α in the neurochemical and neuroendocrine responses to endotoxin. Brain Research Bulletin. 29:1992;807-812.
17. Berkenbosch F, van Oers J, del Rey A. Corticotropin-releasing factor-producing neurones in the rat are activated by interleukin 1. Science. 238:1987;524-526.
18. Watanobe H, Takebe K. Intrahypothalamic perfusion with interleukin-1β stimulates the local release of corticotropin-releasing hormone and arginine vasopressin and plasma corticotropin in freely moving rats: a comparative perfusion of the paraventricular nucleus and the median eminence. Neuroendocrinology. 57:1993;593-599.
19. Cowell A-M, Buckingham J C. Eicosanoids and the hypothalamo-pituitary axis. Prostaglandins, Leukotrienes and Essential Fatty Acids. 36:1989;235-250.
20. Katsuura G, Arimura A, Koves K, Gottschall P E. Involvement of organum vasculosum of lamina terminalis and pre-optic area in interleukin-1β-induced ACTH release. American Journal of Physiology. 258:1990;E163-E171.
21. Lacroix S, Vallieres L, Rivest S. c- Fos mRNA pattern and CRF neuronal activity throughout the brain of rats injected centrally with prostaglandin of the E2 type. Journal of Neuroimmunology. 70:1996;163-179.
22. Chisari A, Spinedi E, Voirol M-J. A phospholipase A2 snake venom (from Crotalus durissus terrificus) stimulates neuroendocrine and immune functions: determination of different sites of action. Endocrinology. 139:1998;617-625.
23. Navarra P, Pozzoli G, Brunetti L. Interleukin 1β and interleukin 6 specifically increase the release of prostaglandin E2 from rat hypothalamic explants in vitro. Neuroendocrinology. 56:1992;61-68.
24. Cover P O, Slater D, Buckingham J C. Endotoxin-induced cyclo-oxygenase expression in the hypothalamo-pituitary-adrenal axis. British Journal of Pharmacology. 122:1997;80P.
25. Watanobe H S, Sasaki S, Takebe K. Role of prostaglandins E1, E2 and F2α in the brain in interleukin-1β-induced adrenocorticotropin secretion in the rat. Cytokine. 7:1995;710-712.
26. Cowell A-M, Flower R J, Buckingham J C. Studies on the role of phospholipase A2 and eicosanoids in the regulation of corticotrophin secretion by rat pituitary cells in vitro. Journal of Endocrinology. 130:1991;21-32.
27. Lacroix S, Rivest S. Functional circuitry in the brain of immune-challenged rats: partial involvement of prostaglandins. Journal of Comparative Neurology. 387:1997;307-324.
28. Niimi M, Sar M, Wada Y. Effect of central and continuous intravenous injection of interleukin-1β on brain c- fos expression in the rat: involvement of prostaglandins. Neuroimmunomodulation. 3:1996;87-92.
29. Niimi M, Wada Y, Sar M. Effect of continuous intravenous injection of interleukin-6 and pretreatment with cyclooxygenase inhibitor on brain c-fos expression in the rat. Neuroendocrinology. 66:1997;47-53.
30. Lacroix S, Rivest S. Effect of acute inflammatory response and cytokines on the transcription of the genes encoding cyclo-oxygenase enzymes (COX-1 and COX-2) in the rat brain. Journal of Neurochemistry. 70:1998;452-466.
31. Takao T, De Souza E B. Interleukin-1 receptors in the brain-endocrine-immune axis: role of stress response and infection. Buckingham J C, Cowell A-M, Gillies G E. Stress, Stress Hormones and the Immune System. 1997;265-282 John Wiley, Chichester.
32. Van Damme A-M, de Vries H E, Kuiper J. Interleukin-1 receptors on rat brain endothelial cells: a role in neuroimmune interactions? FASEB Journal. 10:1996;351-356.
33. Dunn A J, Wang J. Cytokine effects on biogenic amimes. Neuroimmunomodulation. 2:1995;319-328.
34. Wohlman A, Gaillily R, Yirmiya R, Weidenfeld J. Characterisation of the effect of Mycoplasma fermantes on the hypothalamo-pituitary-adrenal axis. Neuroendocrinology. 66:1997;221-228.
35. Kaur D, Creuss D F, Potter W Z. Effect of IL-1α on the release of norepinephrine in the rat hypothalamus. Journal of Neuroimmunology. 90:1998;122-127.
36. MonhanKumar S M, MonhanKumar P S, Quadri S K. Lipopolysaccharide-induced changes in monoamines in specific areas of the brain: blockade by interleukin-1 receptor antagonist. Brain Research. 824:1999;232-237.
37. Elenkov I J, Kovacs K, Duda E. Presynaptic inhibitory effect of TNFα on the release of noradrenaline in isolated median eminence. Journal of Neuroimmunology. 43:1992;117-120.
38. Givalois L, Gaillet S, Mekaouche M. Deletion of the ventral noradrenergic bundle obliterates the early ACTH response after systemic LPS, independently from the plasma IL-1β surge. Endocrine. 3:1995;481-485.
39. Day H EW, Akil H. Differential pattern of c- fos mRNA in the rat brain following central and peripheral administration of interleukin-1β: implications for mechanisms of action. Neuroendocrinology. 63:1996;207-218.
40. Li H-Y, Ericsson A, Sawchenko P E. Distinct mechanisms underlie activation of hypothalamic neurosecretory neurons and their medullary catecholaminergic afferents in categorically different stress paradigms. Proceedings of the National Academy of Sciences of the USA. 93:1996;2359-2364.
41. Ericsson A, Arias C, Sawchenko P E. Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1. Journal of Neuroscience. 17:1997;7166-7179.
42. Buller K M, Xu Y, Day T A. Indomethacin attenuates oxytocin and hypothalamic-pituitary-adrenal axis responses to systemic interleukin-1β Journal of Neuroendocrinology. 10:1998;519-528.
43. Givalois L, Becq H, Siaud P. Serotonergic and suprachiasmatic nucleus involvement in the corticotrophic response to systemic endotoxin challenge in rats. Journal of Neuroendocrinology. 11:1999;629-636.
44. Wang J, Dunn A J. Mouse interleukin-6 stimulates the HPA axis and increases brain tryptophan and serotonin metabolism. Neurochem-Int. 33:1998;143-154.
45. Feleder C, Refojo D, Nacht S, Moguilevsky J A. Interleukin-1 stimulates hypothalamic inhibitory amino acid transmitter release. Neuroimmunomodulation. 5:1998;1-4.
46. Pitossi F J, Del Ray A, Kabiersch A, Besedovsky H. Induction of cytokine transcripts in the CNS and pituitary following peripheral administration of endotoxin to mice. Journal of Neuroscience Research. 48:1997;287-298.
47. Hansen M K, Taishi P, Chen Z, Kreuger J M. Vagotomy block of the induction of interleukin-1β (IL-1β) mRNA in the brain of rats in response to systemic IL-1β Journal of Neuroscience. 18:1998;2247-2253.
48. Ben Hur T, Rosenthal J, Itzik A, Weidenfeld J. Adrenocortical activation by herpes virus: involvement of IL-1β and central noradrenergic system. NeuroReport. 7:1996;927-931.
49. Kakucska I, Qu Y, Clark B D, Lechan R M. Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin 1. Endocrinology. 133:1993;815-821.
50. Zumwalt J W, Thunstrom B J, Spangelo B L. Interleukin-1β and catecholamines synergistically stimulate interleukin-6 release from rat C6 glioma cells in vitro: a potential role for lysophosphatidylcholine. Endocrinology. 140:1999;888-896.
51. Gaykema R PA, Dijkstra I, Tilders F JH. Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of hypothalamic corticotropin-release hormone neurons and ACTH secretion. Endocrinology. 136:1995;4717-4720.
52. Fleischer M, Slibert L, Goehler L E. TNFα-induced corticosterone elevation but not serum protein or corticosterone binding globulin reduction is vagally mediated. Brain Research Bulletin. 44:1997;701-716.
53. Bret-Dibat J L, Creminon C, Couraud J Y. Systemic capsaicin pretreatment fails to block the decrease in food-motivated behaviour induced by lipopolysaccharide and interleukin-1β Brain Research Bulletin. 42:1997;443-449.
54. Goehler L E, Relton J K, Dripps D. Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication. Brain Research Bulletin. 42:1993;357-364.
55. Laye S, Bluthe R M, Kent S. Subdiaphragmatic vagotomy blocks induction of IL-1β mRNA in mouse brain in response to peripheral LPS. American Journal of Physiology. 37:1995;R1327-R1331.
56. Ray D, Melmed S. Pituitary cytokine and growth factor expression and action. Endocrine Reviews. 18:1997;206-228.
57. Kobayashi H, Fukata J, Murakami N. Tumor necrosis factor receptors in pituitary cells. Brain Research. 758:1997;45-50.
58. Akita S, Malkin J, Melmed S. Disrupted murine leukemia inhibitory factor (LIF) gene attenuates adrenocorticotropic hormone (ACTH) secretion. Endocrinology. 137:1996;3140-3143.
59. Takao T, Tojo C, Nishioka T. Stress-induced upregulation of pituitary interleukin-1 receptors is mediated by corticotropin releasing factor. Life Sciences. 59:1996;PL165-PL168.
60. French R A, Zachary J F, Dantzer R. Dual expression of p80 type I and p68 type II interleukin-I receptors on anterior pituitary cells synthesizing growth hormone. Endocrinology. 137:1996;4027-4036.
61. Wong M L, Bongiorno P B, Rettori V. Interleukin (IL), 1β, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: pathophysiological implications. Proceedings of the National Academy of Sciences of the USA. 94:1997;227-232.
62. Ferrara N, Winer J, Henzel W J. Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor. Proceedings of the National Academy of Sciences of the USA. 89:1992;698-702.
63. Auernhammer C J, Chesnokova V, Melmed S. Leukemia inhibitor factor modulates interleukin-1β-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology. 139:1998;2201-2208.
64. Chenokova V, Auernhammer C J, Melmed S. Murine leukemia inhibitory factor gene disruption attenuates the hypothalamic-pituitary-adrenal axis stress response. Endocrinology. 139:1998;2209-2216.
65. Auernhammer C J, Melmed S. Interleukin-11 stimulates pro-opiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamic-pituitary-adrenal axis. Endocrinology. 140:1999;1559-1566.
66. Katahria M, Iwasaki Y, Aoki Y. Cytokine regulation of the rat pro-opiomelanocortin gene expression in AtT-20 cells. Endocrinology. 139:1998;2414-2422.
67. Ray D W, Ren S G, Melmed S. Leukemia inhibitory factor (LIF) stimulates pro-opiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway. Journal of Clinical Investigation. 97:1996;1852-1859.
68. Bousquet C, Ray D W, Melmed S. A common pro-opiomelanocortin-binding element mediates leukemia inhibitory factor and corticotropin-releasing hormone transcriptional synergy. Journal of Biological Chemistry. 272:1997;10551-10557.
69. Kim D S, Melmed S. Stimulatory effects of leukemia inhibitory factor on ACTH secretion of dispersed rat pituitary cells. Endocrine Research. 25:1999;11-19.
70. Ehrhart-Bornstein M, Hinson J P, Bornstein S R. Intra-adrenal interactions in the regulation of adrenocortical steroidogenesis. Endocrine Reviews. 19:1998;101-143.
71. Kapcala L P, He J R, Gao Y. Subdiaphragmatic vagotomy inhibits intra-abdominal interleukin 1β stimulation of adrenocorticotropin secretion. Brain Research. 726:1996;247-254.
72. Tominaga T, Fukata J, Naito Y. Prostaglandin dependent in vitro stimulation of adrenal steroidogenesis by interleukins. Endocrinology. 128:1991;526-531.
73. Gwosdow A R, O'Connell N A, Spencer J A. Interleukin-1-induced corticosterone release occurs by an adrenergic mechanism from rat adrenal gland. American Journal of Physiology. 263:1992;E461-E466.
74. Andreiss P G, Neri G, Meneghelli V. Effect of interleukin-1β on the renin-angiotensin-aldosterone system in rats. Research in Experimental Medicine. 192:1992;1-6.
75. Costa A, Trainer P, Besser M, Grossman A. Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro. Brain Research. 44:1993;187-192.
76. Kostoglou-Athanassiou I, Costa A, Navarra P. Endotoxin stimulates an endogenous pathway regulating corticotropin releasing hormone and vasopressin involving the generation of nitric oxide and carbon monoxide. Journal of Neuroimmunology. 86:1998;104-109.
77. Papadopoulos A D, Wardlaw S L. Endogenous α-MSH modulates the hypothalamic-pituitary-adrenal response to the cytokine interleukin-1β Journal of Neuroendocrinology. 11:1999;315-319.
78. Raber J, Koob G F, Bloom F E. Interferon-α and transforming growth factor-β regulate corticotropin-releasing factor release from amygdala: comparison with the hypothalamic response. Neurochem-Int. 30:1997;455-463.
79. Heiman M L, Ahima R S, Craft L S. Leptin inhibition of the hypothalamic-pituitary-adrenal axis. Endocrinology. 138:1997;3859-3863.
80. Calandra T, Bernhagen J, Metz C N. MIF as a glucocorticoid-induced modulator of cytokine production. Nature. 377:1995;68-71.
81. Ahluwalia A, Buckingham J C, Croxtall J D. The Biology of Annexin 1. Seaton B A. The Annexins. 1996;161-199 : R. Landes and Co, Austin.
82. Philip J G, Flower R J, Buckingham J C. Blockade of the classical pathway of protein secretion does not affect the cellular exportation of lipocortin 1. Regulatory Peptides. 73:1998;133-139.
83. Taylor A D, Christian H C, Morris J F. An antisense oligodeoxynucleotide to lipocortin 1 reverses the inhibitory actions of dexamethasone on the release of adrenocorticotropin from rat pituitary tissue in vitro. Endocrinology. 138:1997;2909-2918.
84. Christian H C, Taylor A D, Flower R J. Characterization and localization of lipocortin 1-binding sites on rat anterior pituitary cells by fluorescence-activated cell analysis/sorting and electron microscopy. Endocrinology. 138:1997;5341-5351.
85. Traverso, V, T, Christian, H, C, Morris, J, F, Buckingham, J, C, Lipocortin 1 (annexin 1) is localised in pituitary folliculostellate cells, Endocrinology.
86. Christian H C, Flower R J, Morris J F, Buckingham J C. Localisation and semi-quantitative measurement of lipocortin 1 in rat anterior pituitary cells by fluorescence activated cell analysis/sorting and electron microscopy. Journal of Neuroendocrinology. 11:1999;707-714.
87. Wong M L, Rettori V, Al-Shekhlee A. Inducible nitric oxide synthase gene expression in the brain during systemic inflammation. Nature Medicine. 2:1996;581-584.
88. Dunn A J. Brain catecholaminergic and tryptophan responses to restraint are attenuated by nitric oxide synthase inhibition. Neurochem-Int. 33:1998;551-557.
89. Bucala R. MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response. FASEB Journal. 10:1996;1607-1613.
90. Bacher M, Meinhardt A, Lan H Y. MIF expression in the rat brain: implications for neuronal function. Molecular Medicine. 4:1998;217-230.
91. Shanks N, La Rocque S, Meaney M J. Hypothalamic-pituitary-adrenocortical responses to endotoxin challenge in neonatal rats: mediation via CRH. Journal of Neuroendocrinology. 6:1994;375-383.
92. Shizuya K, Komori T, Fujiwara R. The influence of restraint stress on the expression of mRNAs for IL-6 and the IL-6 receptor in the hypothalamus and midbrain of the rat. Life Sciences. 612:1997;135-140.
93. Zhou D, Kusnecov A W, Shurin R. Exposure to physical and psychological stressors elevate plasma interleukin-6: relationship to the activation of the hypothalamic-pituitary-adrenal axis. Endocrinology. 133:1993;2523-2530.
94. Paranicdaou D A, Petrides J S, Tsigos C. Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. American Journal of Physiology. 271:1996;E601-E625.
95. Mekaoucho M, Givalois M L, Barbanel G. Chronic restraint enhances interleukin-1β release in the basal state and after and endotoxin challenge independently of adrenocorticotropin and corticosterone release. Neuroimmunomodulation. 1:1994;292-299.