An antisense oligodeoxynucleotide to lipocortin 1 reverses the inhibitory actions of dexamethasone on the release of adrenocorticotropin from rat pituitary tissue in vitro

Endocrinology

Volumn 138, Issue 7, 1997, Pages 2909-2918

  Taylor, A D ^a   Christian, H C ^b   Morris, J F ^c   Flower, R J ^d   Buckingham, J C ^a,d  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b Department of Human Anatomy ^*

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ANNEXIN; ANTISENSE OLIGODEOXYNUCLEOTIDE; CORTICOTROPIN; DEXAMETHASONE; LIPOCORTIN 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONCENTRATION RESPONSE; CORTICOTROPIN RELEASE; DNA SEQUENCE; DNA STRUCTURE; HYPOPHYSIS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

EID: 0030946799     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.7.5260     Document Type: Article

References (35)

1. Flower RJ 1988 Lipocortin 1 and the mechanisms of action of the glucocorticoids. Br J Pharmacol 94:937-1015
2. Fenetti M, Croxtall JD, Wheller S, Colliding NJ, Hannon R, Flower RJ 1996 Mobilising lipocortin 1 in adherent leukocytes downregulates their transmigration. Nature Med 2:1259-1262
3. Rothwell NJ, Flower RJ 1994 Lipocortin-1: cellular mechanisms and clinical relevance. Trends Physiol Sci 15:71-76
4. Loxley HD, Cowell AM, Flower RJ, Buckingham JC1993 Effects of lipocortin 1 and dexamethasone on the secretion of corticotrophin-releasing factors in the rat: in vitro and in two studies. J Neuroendocrinol 5:51-61
5. Loxley HD, Taylor AD, Flower RJ, Buckingham JC 1993 Modulation of the hypothalamo-pituitary-adrenocortical responses to cytokines in the rat by lipocortin 1 and glucocorticoids: a role for lipocortin 1 in the feedback inhibition of CRF-41 release? Neuroendocrinology 57:801-814
6. Taylor AD, Cowell AM, Flower RJ, Buckingham JC 1993 Lipocortin 1 mediates an early inhibitory action of glucocorticoids on the secretion of ACTH by the rat anterior pituitary gland in rifro. Neuroendocrinology 58:430-439
7. Taylor AD, Loxley HD, Flower RJ, Buckingham JC 1995 Immunoneutralization of lipocortin 1 reverses the acute inhibitory effects of dexamethasone on the hypothalamo-pituitary-adrenocortical responses to cytokines in the rat in vitro and in vivo. Neuroendocrinology 62:19-31
8. Buckingham JC 1996 Stress and the neuroendocrine-immune axis: the pivotal role of glucocorticoids and lipocortin 1. Br J Pharmacol 118:1-19
9. Taylor AD, Cowell AM, Flower RJ, Buckingham JC 1995 Dexamethasone suppresses the release of prolactin from the rat anterior pituitary gland by lipocortin 1 dependent and independent mechanisms. Neuroendocrinology 62:530-542
10. Taylor AD, Flower RJ, Buckingham JC 1995 Dexamethasone inhibits the release of thyrotrophin from the anterior pituitary gland in vitro by mechanisms dependent on de novo protein synthesis and lipocortin 1. J Endocrinol 147:533-544
11. Taylor AD, Flower RJ, Buckingham JC 1996 Antisense and immunoneutralisation studies reveal a role for lipocortin 1 in the control of growth hormone in vivo and in vitro. Br J Pharmacol, in press
12. Smith T, Flower RJ, Buckingham JC 1993 Lipocortins 1,2 and 5 in the central nervous system and pituitary gland of the rat: selective induction by dexamethasone of lipocortin 1 in the anterior pituitary gland. Mol Neuropharmacol 3:45-55
13. Christian HC, Goulding NJ, Kahan M, Wang H, Morris JF, Flower RJ, Buckingham JC 1996 Detection of lipocortin l (LC1) binding sites in the rat anterior pituitary gland by fluorescent activated cell analysis/sorting (FACS). BrJ Pharmacol 119:61P
14. Matteucci MD, Wagner RW 1996 In pursuit of antisense. Nature 384:20 -22
15. Stein CA, Cheng YC 1993 Antisense oligonucleotides as therapeutic agents is the bullet really magical? Science 261:1004-1012
16. Cowell AM, Flower RJ, Buckingham JC 1991 Studies on the roles of phospholipase A2 and eicosanoids in the regulation of corticotrophin secretion by rat pituitary cells in t'ilro. J Endocrinol 130:21-32
17. Rees LH, Cook DM, Kendall J W, Alien CF, Kramer RM, Ratclif f e JG, Knight RA 1971 A radioimmunoassay for plasma ACTH. Endocrinology 89:254-261
18. Bradford MM 1976 A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-254
19. Croxtall JD, Flower RJ 1992 Lipocortin-1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line. Proc Natl Acad Sci USA 89:3571-3575
20. Cornera C, Russo-Marie F1995 glucocorticoid-induced annexin l secretion by monocytes and peritoneal leukocytes. BrJ Pharmacol 115:1043-1047
21. Croxtall JD, Flower RJ 1994 Antisense oligonucleotides to human lipocortin 1 inhibit glucocorticoid induced inhibition of A549 cell growth and eicosanoid release. Biochem Pharmacol 48:1729-1734
22. Merril C, Gildman D, Sedman SA, Ebert MH 1981 Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science 211:1437-1438
23. Hanaichi T, Sato T, Iwamoto T, Malavasi-Yamashiro J, Hoshino M, Mizuno N 1986 A stable lead by modification of Satos' method. J Electron Microsc Tokyo 35:304-306
24. Nakane PK 1975 Identifiaction of anterior pituitary cells by immunoelectron microscopy. In: Tixier-Vidal A, Farquahar M (ed) The Anterior Pituitary. Academic Press, New York, pp 134-158
25. Gillies GE, Buckingham JC 1995 The application of i rifro models of pituitary function for toxicity testing. In: Hare SO, Atterwill C (eds) In Vitro Toxicity Testing Protocols. Humana Press, Inc., NJ, vol 43:81-93
26. De B, Misono K, Lukas T, Mroczkowski B, Cohen S 1986 A calcium dépendent 35 kilodalton substrate for epidermal growth factor receptor kinase isolated from normal tissue. J Biol Chem 261:13784-13792
27. Wagner RW 1995 The state of art of antisense research. Nature Medicine 1:1116-1118
28. Murray JAH (ed) 1992 Antisense RNA and DNA. Modern Cell Biology WileyLiss, Inc., New York, vol 11:1-401
29. Pepinsky R, Tizard R, Mattaliano R, Sinclair G, Miller G, Browing J, Chow E, Burne C, Huang K-S, Prall D, Hession C, Frey A, Wallner B 1988 Five distinct calcium and phospholipid binding proteins share homology with lipocortin 1. J Biol Chem 63:10799-10811
30. Stein ÇA, Cohen JS 1988 Oligonucleotides as inhibitors of gene expression a review. Cancer Res 48:2659-2668
31. Morris M, Lucian AB 1995 Antisense oligonucleotides in the study of neuroendocrine systems. J Neuroendocrinol 7:493-500
32. Wahlstedt C1995 Antisense oligonucleotide strategies in neuropharmacology. Trends Physiol Sci 15:42-46
33. Goulding NJ, Guyre PM 1993 Lipocortin 1 binding to human leucocytes correlates with its ability to inhibit IgG interactions with FC-y receptors. Biochem Biophys Res Commun 192:351-358
34. Goulding NJ, Pan LY, Jefferiss CM, Rigby W, Guyre PM 1992 Specific binding of lipocortin l (annexin l) to monocytes and neutrophils is decreased in rheumatoid arthritis. Arthritis Rheum 35:1395-1397
35. Christian HD, Goulding NJ, Kahan M, Morris JF, Flower RJ, Buckingham JC 1996 Detection and estimation of intracellular lipocortin 1 in the pituitary gland by fluorescence activated cell (FAC) analysis/sorting. J Endocrinol 151:04