Activation of the HPA axis by immune insults: Roles and interactions of cytokines, eicosanoids, and glucocorticoids

Pharmacology Biochemistry and Behavior

Volumn 54, Issue 1, 1996, Pages 285-298

  Buckingham, Julia C ^a   Loxley, Helen D ^a   Christian, Helen C ^a   Philip, James G ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

cytokines; eicosanoids; glucocorticoids; HPA axis; neuroimmunology; stress

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ARGIPRESSIN; BACTERIUM LIPOPOLYSACCHARIDE; CAPSAICIN; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID; IBUPROFEN; ICOSANOID; INDOMETACIN; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; LIPOXYGENASE INHIBITOR; N [3 (3 PHENOXYPHENYL)ALLYL]ACETOHYDROXAMIC ACID; PHOSPHOLIPASE A2; PROADIFEN; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE INHIBITOR; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; THROMBOCYTE ACTIVATING FACTOR; THROMBOXANE A2; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

AGE; CONFERENCE PAPER; GENDER; HOMEOSTASIS; HORMONE RELEASE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE SYSTEM; INFECTION; INFLAMMATION; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; STRESS;

EID: 0029885979     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02127-2     Document Type: Conference Paper

References (138)

1. Ahluwalia, A.; Buckingham, J. C.; Croxtall, J. D.; Flower, R. J.; Goulding, N. J.; Perretti, M. The biology of annexin 1. In: Seaton, B. A., ed. The annexins. Austin, TX: Landes Co.; (in press).
2. Allen, J. B.; Blatter, D.; Calandra, G. B.; Wilder, R. L. Sex hormonal effects on the severity of streptococcal cell wall-induced polyarthritis in the rat. Arthritis Rheum. 26:560-563; 1983.
3. Angioni, S; Petraglia, F.; Gallinelli, A.; Cossarizza, A.; Franceschi, C.; Muscettota, M.; Genazzani, A. D.; Surico, N.; Genazzani, A. R. Corticotropin-releasing hormone modulates cytokine release in cultured cell peripheral blood mononuclear cells. Life Sci. 53:1735-1742; 1993.
4. Audreis, P. G.; Neri, G.; Belloni, A. S.; Mazzochi, G.; Kasprzak, A.; Nussdorfer, G. G. Interleukin-1β enhances corticosterone secretion by acting directly on the rat adrenal gland. Endocrinology 129:53-57; 1991.
5. Berkenbosch, F.; van Oers, J.; del Rey, A.; Tilders, F.; Besedovsky, H. Corticotrophin-releasing factor-producing neurones in the rat activated by interleukin-1. Science 238:524-526, 1987.
6. Bernardini, B.; Calogero, A. E.; Eurlich, Y.; Brucke, T.; Chrousos, G. P.; Gold, P. W. The alkyl-ether phospholipid platelet activating factor is a stimulator of the hypothalamic-pituitary-adrenal axis in the rat. Endocrinology 125:1067-1073; 1989.
7. Bernardini, R.; Calogero, A.; Mauceri, G.; Chrousos, G. P. Rat hypothalamic corticotropin-releasing hormone secretion in vitro is stimulated by interleukin-1 in an eicosanoid-dependent manner. Life Sci. 47:1601-1607; 1990.
8. Bernardini, R.; Chiarenza, A.; Calogero, A.; Gold, P.; Chrousos, G. Arachidonic acid metabolites modulate rat hypothalamic corticotrophin releasing hormone secretion in vitro. Neuroendocrinology 50:708-715; 1989.
9. Bernardini, R.; Kamilans, T. C.; Calogero, A. E.; Johnson, E. O.; Gomez, T. M.; Gold, P. W.; Chrousos, G. P. Interaction between tumor necrosis factor-alpha, hypothalamic corticotropin secretion in the rat. Endocrinology 126:2876-2881; 1990.
10. Besedovsky, H.; Del Rey, A.; Sorkin, E.; Dinarello, C. A. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233:652-654; 1986.
11. Besedovsky, H. C.; Sorkin, E.; Keller, M.; Miller, S. L. Changes in blood hormone levels during the immune response. Proc. Soc. Exp. Biol. Med. 150:466-470; 1975.
12. Besedovsky, H. O.; del Rey, A. Immune-neuroendocrine circuits: Intergrative role of cytokines. Front. Neuroendocrinol. 13:61-94; 1992.
13. Besedovsky, H. O.; del Rey, A.; Schardt, M.; Sorkin, E.; Normann, S.; Baumann, J.; Girard, J. Changes in plasma hormone profiles after tumour transplantation into syngeneic and allogeneic rats. Int. J. Cancer 36:209-216; 1985.
14. Besedovsky, H. O.; del Rey, A.; Sorkin, E. Immune-neuroendocrine interactions. J. Immunol. 135:750s-754s; 1985.
15. Bito, L. Z.; Davson, H.; Hollingsworth, J. R. Facilitated transport of prostaglandins across the blood cerebrospinal fluid and blood barriers. J. Physiol. 256:273-285; 1976.
16. Blalock, J. E. A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol. Rev. 69:1-32; 1989.
17. Bolton, C.; Elderfield, A.-J.; Flower, R. J. The detection of lipocortins 1, 2 and 5 in central nervous tissues from Lewis rats with acute experimental allergic encephalomyelitis. J. Neuroimmunol. 29:173-181; 1990.
18. Brown, D. H.; Sheridan, J. F.; Pearl, D.; Zwillig, B. S. Regulation of mycobacterial growth by hypothalamo-pituitary-adrenal axis: Differential responses of mycobacterium bovis BCG-resistant-and susceptible mice. Infect. Immun. 61:4793-4800; 1993.
19. Browning, J. L.; Ward, M. P.; Wallner, B. P.; Pepinsky, R. B. Studies on the structural properties of lipocortin 1 and the regulation of its synthesis by steroids. In: Melli, M.; Parente, L., eds. Cytokines and lipocortins in inflammation and differentiation. New York: Wiley-Liss; 1990:27-45.
20. Buckingham, J. C. Effects of adrenocortical and gonadal steroids on the secretion in vitro of corticotrophin and its hypothalamic releasing factor. J. Endocrinol. 93:123-132; 1982.
21. Buckingham, J. C.; Döhler, K.-D.; Wilson, C. A. Activity of the pituitary-adrenocortical system and thyroid gland during the oestrous cycle of the rat. J. Endocrinol. 78:359-366; 1978.
22. Buckingham, J. C.; Loxley, H. D.; Taylor, A. D.; Flower, R. J. Cytokines, glucocorticoids and neuroendocrine function. Pharmacol. Res. 30:35-42; 1994.
23. Buckingham, J. C.; Smith, T.; Loxley, H. D. The control of ACTH secretion. In: James, V. H. T., ed. The adrenal gland, 2nd ed. New York: Raven Press; 1992:131-158.
24. Cambronero, J. C.; Rivas, F. J.; Borrell, J.; Guaza, C. Interleukin-2 induces corticotropin-releasing hormone release from superfused rat hypothalami: Influence of glucocorticoids. Endocrinology 131:677-683; 1992.
25. Chikanza, I. C.; Petoru, P.; Kingsley, G.; Chrousos, G. P.; Panayi, G. S. Defective hypothalamic response to immune/inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum. 35:1281-1288; 1992.
26. Christian, H.; Goulding, N. J.; Flower, R. J.; Buckingham, J. C. Flow cytometric detection of lipocortin 1 binding sites on rat anterior pituitary cells. Pharmacol. Res. 31:81P; 1995.
27. Coceani, F.; Lees, J.; Dinarello, C. Occurrence of interleukin-1 in the cerebrospinal fluid of the conscious cat. Brain Res. 446: 245-250; 1988.
28. Cohen, P. L.; Eisenberg, R. A. Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243-269; 1991.
29. Cowell, A.-M.; Buckingham, J. C. Eicosanoids and the hypothalamo-pituitary axis. Prostaglandins Leukot. Essent. Fatty Acids 36:235-250; 1989.
30. Cowell, A.-M.; Flower, R. J.; Buckingham, J. C. Studies on the roles of phospholipase A2 and eicosanoids in the regulation of corticotrophin secretion by rat pituitary cells in vitro. J. Endocrinol. 130:21-32; 1991.
31. Cunningham, E. T.; de Souza, E. B. Interleukin-1 receptors in the brain and endocrine system. Immunol. Today 14:171-173; 1992.
32. De Simoni, M. G.; del Bo, R.; de Luigi, A.; Simard, S.; Forloni, G. Central endotoxin induces different patterns of interleukin-1 (IL)-1β and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery. Endocrinology 136:897-902; 1995.
33. de Kloet, E. R.; Rotd, N. Y.; van den Berg, D. T. W.; Oitzl, M. S. Brain mineralocorticoid receptor function. Ann. NY Acad. Sci. 746;8-21; 1994.
34. Derjik, R.; Sternberg, E. M. Corticosteroid action and neuroendocrine-immune interactions. Ann. NY Acad. Sci. 746:33-41; 1994.
35. Dobbs, C. M.; Vasquez, R.; Glaser, R.; Sheridan, J. F. Mechanisms of stress-induced modulation of viral pathogenesis and immunity. J. Neuroimmunol. 48:151-160; 1993.
36. Dunn, A. J. Nervous system-immune system interactions: An overview. J. Recept. Res. 8:589-607; 1988.
37. Dunn, A. M. Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism paralleling the increased plasma concentration. Life Sci. 43:429-435; 1988.
38. Ericsson, A. E.; Kovács, K. J.; Sawchenka, P. E. A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurones. J. Neurosci. 14:897-913; 1994.
39. Funder, J. W. Corticosteroid hormones and signal specificity. Ann. NY Acad. Sci. 746:1-7; 1994.
40. Gebicke-Haerter, P. J.; Schobert, A.; Dieter, P.; Honeggar, P.; Hertting, G. Regulation and glucocorticoid-independent induction of lipocortin 1 in culture astrocytes. J. Neurochem. 57:175-183; 1991.
41. Geelhoed, G. W.; Chernow, B., eds. Endocrine aspects of Acute Illness. New York: Churchill Livingstone; 1985:1-350.
42. 2 enzymes: Regulation and inhibition. Trends Pharmacol. Sci. 14:92-98; 1993.
43. Go, K. G.; Ter Haar, J. G.; de Ley, L.; Zuiderveen, F.; Parente, L.; Solito, E.; Molenaar, W. M. The effect of steroid treatment on lipocortin immunoreactivity of rat brain. Mediat. Inflammat. 3:177-180; 1994.
44. Goulding, N. J.; Guyre, P. M. Lipocortin 1 binding to human leukocytes correlates with its ability to inhibit IgG interactions with Fcg receptors. Biochem. Biophys. Res. Commun. 192:351-358; 1993.
45. Goulding, N. J.; Luying, P.; Guyre, P. M. Characteristics of lipocortin binding to the surface of human peripheral blood leukocytes. Biochem. Soc. Trans. 18:1237-1238; 1991.
46. Grossman, C. J.; Roselle, G. A.; Mendehall, C. L. Sex steroid regulation of autoimmunity. J. Steroid Biochem. Mol. Biol. 40: 649-659; 1991.
47. Hagan, P.; Poole, S.; Bristow, A. F. Endotoxin-stimulated production of rat hypothalamic interleukin-1β in vivo and in vitro, measured by specific immunoradiometric assay. J. Mol. Endocrinol. 11:31-36; 1993.
48. Harbuz, M. S.; Stephanou, A.; Sarlis, N.; Lightman, S. L. The effects of recombinant interleukin-1 alpha, IL-beta or IL-6 on hypothalamo-pituitary-adrenal axis activation. J. Endocrinol. 133:349-355; 1992.
49. Hedge, G. A. Hypothalamic and pituitary effects of prostaglandins on ACTH secretion. Prostaglandins 11:293-301; 1976.
50. Hedge, G. A. Stimulation of ACTH secretion by indomethacin and reversal by exogenous prostaglandins. Prostaglandins 14: 145-150; 1977.
51. Imura, H.; Fukata, J.; Mori, T. Cytokines and endocrine function - An interaction between the immune and neuroendocrine system - Review. Clin. Endocrinol. 35:107-115; 1991.
52. Inman, R. D. Immunologic sex differences and the female predominance in systemic lupus erythremetosis. Arthritis Rheum. 21:849-852; 1979.
53. Johnson, M. D.; Gray, M. E.; Pepinsky, R. B.; Stahlman, M. T. Lipocortin 1 immunoreactivity in the human pituitary gland. J. Histochem. Cytochem. 38:1841-1845; 1990.
54. Kakucska, I.; Qu, Y.; Clark, B. D.; Lechan, R. M. Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1. Endocrinology 133:815-821; 1993.
55. Katsuura, G.; Gottschall, P. E.; Dahl, R. R.; Arimura, A. Adrenocorticotropin release induced by intracerebroventricular injection of recombinant human interleukin-1 in rats: Possible involvement of prostaglandin. Endocrinology 122:1773-1779; 1988.
56. 2 and cAMP independent manner. Neuroendocrinology 48:160-168; 1988.
57. Keller-Wood, M. E.; Dallman, M. F. Corticosteroid inhibition of ACTH secretion. Endocr. Rev. 5:1-24; 1984.
58. Kikkert, R.; Loxley, H. D.; Taylor, A. D.; Flower, R. J.; Philip, J.; Buckingham, J. C. Tissue-specific changes in the expression of lipocortin-1 (LC1) during postnatal-development in the rat. Br. J. Pharmacol. 110:176P; 1993.
59. 2 from rat adenohypophysis in vitro. Neuroendocrinology 43:44-48; 1986.
60. Knigge, V.; Kjaer, A.; Jørjensen, H.; Garbarg, M.; Ross, C.; Ronleau, A.; Warberg. Role of hypothalamic histaminergic neurones in mediation of ACTH and beta-endorphin responses to LPS endotoxin in vivo. Neuroendocrinology 60:243-351; 1994.
61. Koenig, J. L.; Snow, K.; Clark, B. D.; Toni, R.; Cannon, J. G.; Shaw, A. R.; Dinarello, C. A.; Reichlin, S.; Lee, S.; Lechan, R. M. Intrinsic pituitary interleukin-1β is induced by bacterial lipopolysaccharide. Endocrinology 126:3053-3058; 1990.
62. Kovács, K. J.; Elenkov, I. J. Differential dependence of ACTH secretion induced by various cytokines on the integrity of the paraventricular nucleus. J. Neuroendocrinol. 7:15-23; 1995.
63. Lee, S.; Rivier, C. Hypophysiotropic role and hypothalamic gene expression of corticotropin releasing factor and vasopressin in rats injected with interleukin-1β systemically or into the brain ventricles. J. Neuroendocrinol. 6:217-224; 1994.
64. Linthorst, A. C. E.; Flachskamm, C.; Holsboer, F.; Reul, J. M. H. M. Local administration of recombinant human interleukin-1β in the rat hippocampus increases serotonergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity and body temperature. Endocrinology 135:520-533; 1994.
65. Lowry, P. J. The new corticotrophin-releasing factor-binding protein: From artefact to new ligand(s) and axis. J. Endocrinol. 144:1-4; 1995.
66. Loxley, H. D.; Cowell, A.-M.; Flower, R. J.; Buckingham, J. C. Effects of lipocortin 1 and dexamethasone on the secretion of corticotrophin releasing factors in the rat: In vitro and in vivo studies. J. Neuroendocrinol. 5:51-61; 1993.
67. Loxley, H. D.; Cowell, A.-M.; Flower, R. J.; Buckingham, J. C. Modulation of the hypothalamo-pituitary adrenocortical responses to cytokines in the rat by lipocortin 1 and glucocorticoids: A role for lipocortin 1 in the feedback inhibition of CRF-41 release? Neuroendocrinology 57:801-813; 1993.
68. 2-induced CRF-41 and AVP release from rat hypothalamic tissue in vitro. J. Endocrinol. 139:P36; 1993.
69. Loxley, H. D.; Taylor, A. D.; Flower, R. J.; Buckingham, J. C. Secretion of CRH-41 and AVP by the neonatal rat hypothalamus: Effects of cytokines, dexamethasone and lipocortin 1. J. Endocrinol. 147:58; 1995.
70. Luini, A. G.; Axelrod, J. Inhibitors of the cytochrome P-450 enzymes block the secretagogue-induced release of corticotropin in mouse pituitary tumor cells. Proc. Natl. Acad. Sci. USA 82: 1012-1014; 1985.
71. Lyson, K.; McCann, S. M. Involvement of arachidonic acid cascade pathways in interleukin-6-stimulated corticotrophin releasing factor release in vitro. Neuroendocrinology 55:708-713; 1992.
72. Mason, D. W.; MacPhee, I.; Antoni, F. A. The role of the neuroendocrine system in determining the genetic susceptibility in the rat. Immunology 70:1-5; 1990.
73. Matta, S. G.; Linner, K. M.; Sharp, B. Interleukin-1α and 1β stimulate adrenocorticotropin secretion in the rat through a similar hypothalamic receptor(s): Effect of interleukin-1 receptor antagonist protein. Neuroendocrinology 57:14-22; 1992.
74. McCoy, J. G.; Matta, S. G.; Sharp, B. Prostaglandins mediate the ACTH response to interleukin-1-beta instilled into the hypothalamic median eminence. Neuroendocrinology 60:426-435; 1994.
75. Meany, M. J.; Aitken, D. H.; Sharma, S.; Viau, V. Basal ACTH, corticosterone and corticosterone binding globulin levels over diurnal cycle and hippocampal type I and type II corticosteroid receptors in young and old handled and nonhandled rats. Neuroendocrinology 55:204-213; 1992.
76. Meyer, J. S. Biochemical effects of corticosteroids on neural tissues. Physiol. Rev. 65:946-1021; 1985.
77. Munck, A.; Guyre, P. M. Glucocorticoids and immune function. In: Ader, R.; Felton, D. L.; Cohen, N., eds. Psychoneuroimmunology. New York: Academic Press; 1991:447-474.
78. Munck, A.; Guyre, P. M.; Holbrook, N. J. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 5:25-44; 1984.
79. Muramani, N.; Fukata, J.; Tsukada, T., Kobayashi, H.; Ebisui, O.; Segawa, H., Muro, S.; Imura, H.; Nakao, K. Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic acid in the rat hypothalamus, pituitary, adrenal gland and spleen. Endocrinology 133:2574-2578; 1993.
80. Naitoh, Y.; Fukata, J.; Tominaga, T.; Nakai, Y.; Tamai, S.; Mori, K.; Imura, H. Interleukin-6 stimulates adrenocorticotrophin hormone in conscious, freely moving rats. Biochem. Biophys. Res. Commun. 155:1459-1463; 1988.
81. Naitoh, Y.; Tamai, S.; Shingu, K.; Shindo, K.; Matsui, Z. T.; Segawa, H.; Nakai, Y.; Mari, K. Responses of plasma adrenocorticotropic hormone, cortisol and cytokines during and after upper abdominal surgery. Anaesthesiology 77:426-431; 1992.
82. 2 from rat hypothalamic explants in vitro. Neuroendocrinology 56:61-68; 1992.
83. Navarra, P.; Tsagarakis, S.; Faria, M. S.; Rees, L.; Besser, G. M.; Grossman, A. B. Interleukins-1 and -6 stimulate the release of corticotropin releasing hormone -41 from the rat hypothalamus in vitro via the eicosanoid cyclo-oxygenase pathway. Endocrinology 128:37-47; 1991.
84. Payne, L. C.; Weigent, D. A.; Blalock, J. E. Induction of pituitary sensitivity to interleukin-1. A new function for corticotropin releasing hormone. Biochem. Biophys. Res. Commun. 198: 480-484; 1994.
85. Perlstein, R. S.; Whitnall, M. H.; Abrams, J. S.; Moougey, E. H. Synergistic roles of interleukin-6, interleukin-1 and tumor necrosis factor in adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinology 132:946-952; 1993.
86. Philip, J. G.; Flower, R. J.; Buckingham, J. C. Evidence for different molecular species of lipocortin 1 in the rat. Pharmacol. Res. 31:84P; 1995.
87. Regnouf, F.; Rendon, A.; Pradal, L. A. Biochemical characterization of annexins I and II isolated from pig nervous tissue. J. Neurochem. 56:1985-1996; 1991.
88. Rivier, C. Stimulatory effect of interleukin-1β on the hypothalamic-pituitary-adrenal axis of the rat: Influence of age, gender and circulating sex steroids. J. Endocrinol. 140:365-372; 1994.
89. Rivier, C.; Vale, W. Stimulatory effect of interleukin-1 an adrenocorticotropin secretion in the rat: Is it modulated by prostaglandins? Endocrinology 129:384-388; 1991.
90. Rosenfeld, P.; Suchecki, A. J.; Levine, S. Multifactorial regulation of the hypothalamic-pituitary-adrenal axis during development. Neurosci. Behav. Rev. 16:553-568; 1992.
91. Rothwell, N. J.; Luheshi, G.; Toulmond, S. Cytokines and their receptors in the CNS: Physiology, pharmacology and pathology. In: Bowman, W. C.; Breckenridge, A. M.; Sartorelli, A. C.; Gillies, G.; Buckingham, J. C., eds. Pharmacology and therapeutics. New York: Pergamon Press (in press).
92. 2 in the blood simultaneously with the onset of fever. Eur. J. Pharmacol. 154:145-152; 1988.
93. Ruzicka, B. B.; Akil, H. Differential cellular regulation of proopiomelanocortin by interleukin-1-beta and corticotropin releasing hormone. Neuroendocrinology 61:136-151; 1995.
94. Salas, M. A.; Evans, S. W.; Levell, M. J.; Whicher, J. T. Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells. Clin. Exp. Immunol. 79:470-473; 1990.
95. Sapolsky, R.; Rivier, C.; Yamomoto, G.; Platsky, P.; Vale, W. Interleukin-1 stimulates the secretion of hypothalamic corticotrophin releasing factor. Science 238:522-524; 1987.
96. Satoh, J.; Seino, H.; Abo, T.; Tanaka, S. I.; Shinata, S.; Ohta, S.; Tamura, K.; Sawai, T.; Nobunaga, T.; Oteki, T.; Kumagai, K.; Toyoto T. Recombinant tumor necrosis α: Suppresses autoimmune diabetes in nonobese diabetic mice. J. Clin. Invest. 84: 1345-1348; 1989.
97. Schobitz, B.; van den Dabbelsteen, M.; Holsbaer, F.; Sutanto, W.; de Kloet, E. R. Regulation of interleukin-6 gene expression in rat. Endocrinology 132:1569-1576; 1993.
98. Sharp, B. M.; Matta, S. G.; Peterson, P. K.; Newton, R.; Chao, C.; McAllen, K. Tumor necrosis factor-α is a potent ACTH secretagogue: Comparison to interleukin-1-β. Endocrinology 124:3131-3133; 1989.
99. Shek, P. N.; Sabiston, B. H. Neuroendocrine regulation of immune processes: Changes in circulating corticosterone levels induced by the primary antibody response in mice. Int. J. Immunopharmacol. 5:23-33; 1983.
100. Smith, T.; Flower, R. J.; Buckingham, J. C. Lipocortins 1, 2 and 5 in the central nervous system and pituitary gland of the rat: Selective induction by dexamethasone of lipocortin 1 in the anterior pituitary gland. Mol. Neuropharmacol. 3:45-55; 1993.
101. Smith, T.; Smith, S. F.; Buckingham, J. C. A competitive enzyme-linked-immunosorbent-assay for the estimation of rat lipocortin-1. Biochem. Soc. Transact. 18:1230-1231; 1990.
102. Smith, T.; Smith, S. F.; Flower, R. J.; Buckingham, J. C. Endotoxin and the expression of lipocortins in central and peripheral tissues of the rat. Br. J. Pharmacol. 104:218P; 1991.
103. Spangelo, B.; MacLeod, R. Regulation of the acute phase response and neuroendocrine function by IL-6. Prog. Neuroendocrinimmunol. 3:167-175; 1990.
104. Spangelo, B. L.; Gorospe, W. C. Role of the cytokines in the neuroendocrine-immune system axis. Front. Neuroendocrinol. 16:1-22; 1995.
105. Spinedi, E.; Hadid, R.; Daneva, T.; Gaillard, R. C. Cytokines stimulate the CRH but not the vasopressin neuronal system: Evidence for a median eminence site of interleukin-6 action. Neuroendocrinology 56:46-53; 1992.
106. Spinedi, E.; Suescun, M. O.; Hadid, R.; Daneva, T.; Gaillard, R. C. Effects of gonadectomy and sex hormone therapy on the endotoxin-stimulated hypothalamo-pituitary-adrenal axis: Evidence for a neuroendocrine-immunological sexual dimorphism. Endocrinology 131:2430-2436; 1992.
107. Stenzel-Poore, M.; Vale, W. W.; Rivier, C. Relationship between antigen-induced immune stimulation and activation of the hypothalamic-pituitary-adrenal axis in the rat. Endocrinology 132:1313-1318; 1993.
108. 2 in the stimulation of ACTH secretion from isolated pituitary cells. Br. J. Pharmacol. 96:162P; 1989.
109. Strijbos, P. J. L. M.; Tilders, F. J. H.; Carey, F.; Forder, R.; Rothwell, N. J. Localization of immunoreactive lipocortin 1 in the brain and pituitary gland of the rat. Effects of adrenalectomy, dexamethasone and colchicine treatment. Brain Res. 553: 249-260; 1991.
110. Taylor, A. D.; Loxley, H. D.; Flower, R. J.; Buckingham, J. C. Immunoneutralization of lipocortin 1 reverses the inhibitory effects of dexamethasone on cytokine-induced hypothalamo-pituitary-adrenocortical activity in vitro and in vivo. Neuroendocrinology 62:19-31; 1995.
111. Taylor, A. D.; Cowell, A.-M.; Flower, R. J.; Buckingham, J. C. Dexamethasone suppresses the release of prolactin from the rat anterior pituitary gland by lipocortin 1 dependent and independent mechanisms. Neuroendocrinology 62:530-542; 1995.
112. Taylor, A. D.; Cowell, A.-M.; Flower, R. J.; Buckingham, J. C. Lipocortin 1 mediates an early inhibitory action of glucocorticoids on the secretion of ACTH by the rat anterior pituitary gland in vitro. Neuroendocrinology 58:430-439; 1993.
113. Taylor, A. D.; Flower, R. J.; Buckingham, J. C. Eicosanoid regulation of ACTH release in vitro. Pharmacol. Res. 31:81P; 1995.
114. Thompson, M. E.; Hedge, G. A. Inhibition of corticotropin secretion by hypothalamic administration of indomethacin. Neuroendocrinology 25:212-220; 1978.
115. Tsagariskis, S.; Gillies, G. E.; Rees, L. H.; Besser, G. M.; Grossman, A. Interleukin-1 directly stimulates the release of corticotrophin releasing factor from rat hypothalamus. Neuroendocrinology 49:98-101; 1989.
116. Turgeon, J. L.; Cooper, R. H.; Waring, D. W. Membrane specific association of annexin-1 and annexin-2 in anterior pituitary cells. Endocrinology 128:96-102; 1990.
117. Turnbull, A. V.; Dow, R. C.; Hopkins, S. J.; White, A.; Fink, G.; Rothwell, N. J. Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat. Psychoneuroendocrinology 19:165-178; 1994.
118. 2 in the pathogenesis of the hemodynamic changes in endotoxin shock. Can. J. Physiol. 61:561-566; 1982.
119. Vamvakopoulos, N. C.; Chrousos, G. P. Evidence of direct estrogenic regulation of human corticotropin releasing hormone gene expression. Potential implications for the sexual dimorphism of the stress response and immune/inflammatory action. J. Clin. Invest. 92:1896-1902; 1993.
120. Vamvakopoulos, N. C.; Chrousos, G. P. Hormonal regulation of human corticotropin releasing hormone gene expression: Implications for the stress response and immune/inflammatory reaction. Endocr. Rev. 15:409-420; 1994.
121. Van der Meer, M. J. M.; Sweep, C.-G. J.; Pesman, G. J.; Borm, G. F.; Hermus, A. R. M. Synergism between IL-1β and TNFα on the activity of the pituitary adrenal axis and on food intake of rats. Am. J. Physiol. 268:E551-E557; 1995.
122. 2 formed locally in response to vasopressin and corticotrophin-releasing factor. Endocrinology 115: 895-903; 1984.
123. Walker, C. D.; Sapolsky, R. M.; Meany, M. J.; Vale, W. W.; Rivier, C. L. Increased pituitary sensitivity to glucocorticoid feedback during the stress nonresponsive period in the neonatal rat. Endocrinology 119:1816-1821; 1986.
124. Walker, C. D.; Scriber, K. A.; Cascio, C. S.; Dallman, M. F. The pituitary-adrenocortical system of the neonatal rat is responsive to stress throughout development in a time-dependent and stressor specific fashion. Endocrinology 128:1385-1395; 1991.
125. 2. J. Physiol. 443:431-439; 1991.
126. 2, corticotropin-releasing factor and arginine vasopressin in several hypothalamic areas of freely moving rats: Estimation by push-pull perfusion. Neuroendocrinology 60:8-15; 1994.
127. Watanobe, H.; Takebe, K. Intrahypothalamic perfusion with interleukin-1-beta stimulates the local release of corticotropin-releasing hormone and arginine vasopressin and plasma corticotropin in freely moving rat: A comparative perfusion of the paraventricular nucleus and the median eminence. Neuroendocrinology 57:593-599; 1993.
128. Watanobe, H.; Takebe, K. Intravenous administration of tumor necrosis factor-alpha stimulates corticotrophin releasing hormone secrtion in the push-pull cannulated median eminence of freely moving rats. Neuropeptides 22:81-84; 1992.
129. Weidenfeld, J.; Abramsky, O.; Ovadia, H. Evidence for the involvement of central adrenergic system in interleukin-1 induced adrenocortical response. Neuropharmacology 28:1411-1414; 1989.
130. Wick, G.; Hu, Y. H.; Gruber, J. Altered immunoendocrine communication in autoimmune disease. Isr. J. Med. Sci. 29: 136-142; 1993.
131. Widmaier, E. P. Changes in responsiveness of the hypothalamic-pituitary-adrenal axis to 2-deoxy-D-glucose in developing rats. Endocrinology 126:3116-3123; 1990.
132. Wilder, R. L.; Calandra, G. B.; Garvin, J. A.; Wright, K. D.; Hansen, C. T. Strain and sex variation in the susceptibility to streptococcal cell wall-induced polyarthritis in the rat. Arthritis Rheum. 25:1064-1072; 1982.
133. Witek-Janusek, L. Pituitary-adrenal response to bacterial endotoxin in developing rats. Am. J. Physiol. 255:E525-E530; 1988.
134. Wolff, S. M. Biological effects of bacterial endotoxin in man. J. Infect. Dis. 128:8259-8264; 1973.
135. Woods, M. D.; Kiss, J. Z.; Smith, T.; Buckingham, J. C.; Flower, R. J.; Antoni, F. A. Localization of lipocortin-1 in rat hypothalamus and pituitary-gland. Biochem. Soc. Transact. 18: 1236-1237; 1990.
136. Yasin, S. A.; Costa, M. L.; Forsling, M. L.; Grossman, A. Interleukin-1β and interleukin-6 stimulate neurohypophyseal hormone release in vitro. J. Neuroendocrinol. 6:179-184; 1994.
137. Yasuda, N.; Greer, M. A. Evidence that the hypothalamus mediates endotoxin stimulation of adrenocorticotropic hormone secretion. Endocrinology 102:947-953; 1978.
138. Zhou, D.; Kusnecov, A. W.; Shurin, M. R.; DePaoli, M.; Rabin, B. Exposure to physical and psychological stressors elevates plasma interleukin-6; Relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 133:2523-2530; 1993.