Phage libraries - A new route to clinically useful antibodies

New England Journal of Medicine

Volumn 335, Issue 10, 1996, Pages 730-733

  Marks, Cara ^b   Marks, James D ^a  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; MONOCLONAL ANTIBODY;

ANTIBODY PRODUCTION; B LYMPHOCYTE; BACTERIOPHAGE; ESCHERICHIA COLI; HYBRIDOMA; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANTIBODIES; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; BACTERIOPHAGES; ESCHERICHIA COLI; GENE LIBRARY; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN G;

EID: 0029844521     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199609053351008     Document Type: Review

References (5)

1. Hoogenboom HR, Marks JD, Griffiths AD, Winter G. Building antibodies from their genes. Immunol Rev 1992;130:41-68.
2. Marks JD, Hoogenboom HR, Griffiths AD, Winter G. Molecular evolution of proteins on filamentous phage: mimicking the strategy of the immune system. J Biol Chem 1992;267:16007-10.
3. Richardson JH, Marasco WA. Intracellular antibodies: development and therapeutic potential. Trends Biotechnol 1995;13:306-10.
4. Schier R, McCall A, Adams GP, et al. Isolation of picomolar affinity anti-c-erbB-2 by molecular evolution of the complementary determining regions in the center of the antibody binding site. J Mol Biol (in press).
5. Winter G, Griffiths AD, Hawkins RE, Hoogenboom HR. Making antibodies by phage display technology. Annu Rev Immunol 1994;12:433-55.