The growth hormone axis and cognition: Empirical results and integrated theory derived from giant transgenic mice

Canadian Journal of Zoology

Volumn 77, Issue 12, 1999, Pages 1874-1890

  Rollo, C D ^a   Ko, C V ^a   Tyerman, J G A ^b   Kajiura, L J ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MUS MUSCULUS;

EID: 0033494074     PISSN: 00084301     EISSN: None     Source Type: Journal    
DOI: 10.1139/z99-153     Document Type: Article

References (300)

1. Acs, Z., Lonart, G., and Makara, G.B. 1990. Role of hypothalamic factors (growth-hormone-releasing hormone and gammaaminobutyric acid) in the regulation of growth hormone secretion in the neonatal and adult rat. Neuroendocrinology, 52: 156-160.
2. Adams, J.D., Mukherjee, S.K., Klaidman, L.K., Chang, M.L., and Yasharel, R. 1996. Apoptosis and oxidative stress in the aging brain. Ann. N.Y. Acad. Sci. No. 786. pp. 135-151.
3. Aigner, T.G. 1995. Pharmacology of memory: cholinergicglutamatergic interactions. Curr. Opin. Neurobiol. 5: 155-160.
4. Akama, K.T., Albanese, C., Pestell, R.G., and Van Eldik, L.J. 1998. Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NF KB-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 95: 5795-5800.
5. Almqvist, O., Thoren, M., Saaf, M., and Eriksson, O. 1986. Effects of growth hormone substitution on mental performance in adults with growth hormone deficiency: a pilot study. Psychoneuroendocrinology, 11: 347-352.
6. 2 on short-term memory: neuroendocrine and neuropsychological assessment in healthy young subjects. Methods Find. Exp. Clin. Pharmacol. 12: 493-499.
7. Alves, S.E., Akbari, H.M, Anderson, G.M., Azmitia, E.G., McEwen, B.C., and Strand, F.L. 1997. Neonatal ACTH administration elicits long-term changes in forebrain monoamine innervation: subsequent disruptions in hypothalamic-pituitaryadrenal and gonadal function. Ann. N.Y. Acad. Sci. No. 814. pp. 226-251.
8. Andronikof-Sanglade, A., Fjellestad-Paulsen, A., Ricard-Malivoir, S., and Evain-Brion, D. 1997. Specific abnormalities in a visual motor psychological test in short children with abnormal growth hormone secretion. Acta Paediatr. 86: 154-159.
9. Araujo, D.M., Lapchak, P.A., Collier, B., Chabot, T.G., and Quirion, R. 1989. Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system. Brain Res. 484: 130-138.
10. Arnsten, A.F.T. 1997. Catecholamine regulation of the prefrontal cortex. J. Psychopharmacol. 11: 151-162.
11. Astrom, C. 1995. Interaction between sleep and growth hormone. Acta Neurol. Scand. 92: 281-296.
12. Astrom, C., and Trojaborg, W. 1992. Effect of growth hormone on human sleep EEG energy. Clin. Endocrinol. 36: 241-245.
13. Atack, J.R., Beal, M.F., May, C., Kaye, J.A, Mazurek, M.F., Kay, A.D., and Rapoport, S.I. 1988. Cerebrospinal fluid somatostatin and neuropeptide Y. Concentrations in aging and in dementia of the Alzheimer type with and without extrapyramidal signs. Arch. Neurol. 45: 269-274.
14. Bains, J.S., and Shaw, C.A. 1997. Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res. Rev. 25: 335-358.
15. Baker, J., Liu, J.P., Roberston, E.J., and Efstratiadis, A. 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell, 75: 73-82.
16. Bakhit, C., and Swerdlow, N. 1986. Behavioral changes following central injection of cysteamine in rats. Brain Res. 365: 159-163.
17. Barinaga, M. 1994. To sleep, perchance to learn? New studies say yes. Science (Washington, D.C.), 265: 603-604.
18. Barns, H.H.F., and Swyer, G.I.M. 1952. Effects on foetal weight of growth-hormone-containing anterior pituitary extracts given to pregnant rats. Br. Med. J. 2: 914-915.
19. Bartke, A., Cecim, M., Tang, K., Steger, R.W., Chandrashekar, V., and Turyn, D. 1994. Neuroendocrine and reproductive consequences of overexpression of growth hormone in transgenic mice. Proc. Soc. Exp. Biol. Med. 206: 345-359.
20. Beal, M.F. 1990. Somatostatin in neurodegenerative illnesses. Metabolism, 39(Suppl. 2): 116-119.
21. Beal, M.F. 1992. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31: 119-130.
22. Bear, M.F., Cooper, L.N., and Ebner, F.F. 1987. A physiological basis for a theory of synapse modification. Science (Washington, D.C.), 237: 42-48.
23. Bennington, J.H., and Heller, H.C. 1995. Monoaminergic and cholinergic modulation of REM-sleep timing in rats. Brain Res. 681: 141-146.
24. Beranek, L., Obal, F., Jr., Bodosi, B., Taishi, P., and Krueger, J.M. 1996. Inhibition of non-REM sleep in response to a long-acting somatostatin analog, sandostatin, in the rat. J. Sleep Res. 5(Suppl.1): 14.
25. Berelowitz, M., Firestone, S.L., and Frohman, L.A. 1981. Effects of growth hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution. Endocrinology, 109: 714-719.
26. Bertherat, J., Bluet-Pajot, M.T., and Epelbaum, J. 1995. Neuroendocrine regulation of growth hormone. Europ. J. Endocrinol. 132: 12-24.
27. Best, P.J., and White, A.M. 1998. Hippocampal cellular activity: a brief history of space. Proc. Natl. Acad. Sci. U.S.A. 95: 2717-2719.
28. Bissette, G., and Myers, B. 1992. Somatostatin in Alzheimer's disease and depression. Life Sci. 51: 1389-1410.
29. Bjorklund, A., and Dunnett, S.B. 1995. Acetylcholine revisited. Nature (Lond.), 375: 446.
30. Block, J.B., and Essman, W.B. 1965. Growth hormone administration during pregnancy: a behavioural difference in offspring rats. Nature (Lond.), 205: 1136-1137.
31. Bondy, C.A., and Lee, W. 1993. Patterns of insulin-like growth factor and IGF receptor gene expression in the brain. Ann. N.Y. Acad. Sci. No. 692. pp. 33-43.
32. Bouchon, R., and Will, B. 1981. Learning performance in dwarf mice. Behav. Brain Res. 2: 247-248.
33. Bredow, S., Taishi, P., Obal, F., Guha-Thakurta, N., and Krueger, J.M. 1996. Hypothalamic growth hormone-releasing hormone mRNA varies across the day in rats. NeuroReport, 7: 2501-2505.
34. Brown, M. 1981. Neuropeptides: central nervous system effects on nutrient metabolism. Diabetologia, 20: 299-304.
35. Brown, M., Rivier, J., and Vale, W. 1979. Somatostatin: central nervous system actions on glucoregulation. Endocrinology, 104: 1709-1715.
36. Brown-Borg, H., Borg, K.E., and Bartke, A. 1995. Introduction of bGH transgene to Ames dwarf mice compensates growth and produces a new model of isolated PRL deficiency. In Abstracts of the 77th Annual Meeting of the Endocrine Society. Abstr. P2-243. p. 351. [Abstr.]
37. Buck, S.H., Deshmukh, P.P., Burks, T.F., and Yamamura, H.I. 1981. A survey of substance P, somatostatin, and neurotensin levels in aging in the rat and human central nervous system. Neurobiol. Aging, 2: 257-264.
38. Buhot, M.C. 1997. Serotonin receptors in cognitive behaviors. Curr. Opin. Neurobiol. 7: 243-254.
39. Buonomano, D.V., and Merzenich, M.M. 1998. Cortical plasticity: from synapses to maps. Annu. Rev. Neurosci. 21: 149-186.
40. Burke, R.E., and Fahn, S. 1983. Studies of somatostatin-induced barrel rotation in rats. Regul. Pept. 7: 207-220.
41. Buzsaki, G. 1998. Memory consolidation during sleep: a neurophysiological perspective. J. Sleep Res. 7(Suppl. 1): 17-23.
42. Cabib, S., and Puglisi-Allegra, S. 1996. Stress, depression and the mesolimbic dopamine system. Psychopharmacology, 128: 331-342.
43. Cacabelos, R., Niigawa, H., Rodoriguez-Arnao, M.D., Gomez-Pan, A., and Nishimura, T. 1988. Influence of somatostatin and growth-hormone-releasing factor on behaviour: clinical and therapeutic implications in neuropsychiatrie disorders. Horm. Res. (Basel), 29: 129-132.
44. Cacabelos, R., Nigawa, H., Alvarez, X.A., Munoz, M.D., Nishimura, T., and Rubia, F.J. 1990. Antagonistic effects of growth hormone-releasing factor (GRF) and somatostatin on locomotor activity: GRF-induced hyperkinetic syndrome. Methods Find. Clin. Pharmacol. 12: 425-434.
45. Cahill, L., and McGaugh, J.L. 1996. Modulation of memory storage. Curr. Opin. Neurobiol. 6: 237-242.
46. Cain, D.P. 1997. LTP, NMDA, genes and learning. Curr. Opin. Neurobiol. 7: 235-242.
47. Cassel, J.C., and Jeltsch, H. 1995. Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience, 69: 1-41.
48. Castellano, C., Cabib, S., and Puglisi-Allegra, S. 1996. Psychopharmacology of memory modulation: evidence for multiple interaction among neurotransmitters and hormones. Behav. Brain Res. 77: 1-21.
49. Castro-Alamancos, M.A., and Torres-Aleman, I. 1993. Long-term depression of glutamate-induced γ-aminobutyric acid release in cerebellum by insulin-like growth factor I. Proc. Natl. Acad. Sci. U.S.A. 90: 7386-7390.
50. Cecim, M., Alvarez-Sanz, M., Van de Kar, L., Milton, S., and Bartke, A. 1996. Increased plasma corticosterone levels in bovine growth hormone (bGH) transgenic mice: effects of ACTH, GH and IGF-I in in vitro adrenal corticosterone production. Transgenic Res. 5: 187-192.
51. Chan-Palay, V. 1987. Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratone sections: coexistence with neuropeptide Y neurons, and effects in Alzheimer's-type dermentia. J. Comp. Neurol. 260: 201-223.
52. Chen, C., and Tonegawa, S. 1997. Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain. Annu. Rev. Neurosci. 20: 157-184.
53. Cheng, B., and Mattson, M.P. 1992. IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage. J. Neurosci. 12: 1558-1566.
54. Choi, D.W. 1988. Glutamate neurotoxicity and diseases of the nervous system. Neuron, 1: 623-634.
55. Clark, R. 1997. The somatogenic hormones and insulin-like growth factor-1: stimulators of lymphopoiesis and immune function. Endocr. Rev. 18: 157-179.
56. Clemmons, D.R., and Underwood, L.E. 1991. Nutritional regulation of IGF-I and IGF binding proteins. Annu. Rev. Nutr. 11: 393-412.
57. Clendinnen, B.G., and Eayrs, J.T. 1961. The anatomical and physiological effects of prenatally administered somatotrophin on cerebral development in rats. J. Endocrinol. 22: 183-193.
58. Cohen, A.M.L. 1995. Neuronal activities underlying the electroencephalogram and evoked potentials of sleeping and waking: implications for information processing. Neurosci. Biobehav. Rev. No. 19. pp. 447-463.
59. Corpas, E., Harman, S.M., and Blackman, M.R. 1993. Human growth hormone and aging. Endocr. Rev. 14: 20-39.
60. Coyle, J.T., and Puttfarcken, P. 1993. Oxidative stress, glutamate and neurodegenerative disorders. Science (Washington, D.C.), 262: 689-695.
61. Crespi, F. 1993. Functional in vivo interaction between growth hormone and dopamine systems are correlated to changes in striatal somatostatin levels as detected by voltammetry. Exp. Brain. Res. 94: 363-370.
62. Croskerry, P.G., and Smith, G.K. 1975. Prolongation of gestation by growth hormone: a confounding factor in the assessment of its prenatal action. Science (Washington, D.C.), 189: 648-650.
63. Crusio, W.E., Schwegler, H., and Lipp, H.P. 1987. Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution. Brain Res. 425: 182-185.
64. Danguir, J. 1986. Intracerebroventricular infusion of somatostatin selectively increases paradoxical sleep in rats. Brain Res. 367: 26-30.
65. Daughaday, W.H., and Harvey, S. 1995. Growth hormone release: pathophysiological dysfunction. In Growth hormone. Edited by S. Harvey, C.G. Scanes, and W.H. Daughaday. CRC Press, Boca Raton, Fla. pp. 225-255.
66. Dawson, V.L., Dawson, T.M., London, E.D., Bredt, D.S., and Synder, S.H. 1991. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. U.S.A. 88: 6368-6371.
67. D'Costa, A.P., Ingram, R.L., Lenham, J.E., and Sonntag, W.E. 1993. The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing. J. Reprod. Fertil. 46(Suppl.): 87-98.
68. Decker, M.W., and McGaugh, J.L. 1991. The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse (N.Y.), 7: 151-168.
69. Deijen, J.B., deBoer, H., Blok, G.J., and van der Veen, E.A. 1996. Cognitive impairments and mood disturbances in growth hormone deficient men. Psychoneuroendocrinology, 21: 313-322.
70. D'Ercole, A.J. 1993. Expression of insulin-like growth factor I in transgenic mice. Ann. N.Y. Acad. Sci. No. 692. pp. 149-160.
71. De Wied, D. 1997. Neuropeptides in learning and memory processes. Behav. Brain Res. 83: 83-90.
72. Drago, J., Murphy, M., Carroll, S.M., Harvey, R.P., and Bartlett, P.F. 1991. Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I. Proc. Natl. Acad. Sci. U.S.A. 88: 2199-2203.
73. Eichenbaum, H., Schoenbaum, G., Young, B., and Bunsey, M. 1996. Functional organization of the hippocampal memory system. Proc. Natl. Acad. Sci. U.S.A. 93: 13 500 - 13 507.
74. Epelbaum, J., Tapia-Arancibia, L., and Kordon, C. 1981. Noradrenaline stimulates somatostatin release from incubated slices of the amygdala and the hypothalamic preoptic area. Brain Res. 215: 393-397.
75. Epelbaum, J., Lamour, Y, Enjalbert, A., Hamon, M., Dutar, P., and Kordon, C. 1986. Modifications in the cortical regional distribution of choline acetyltransferase, somatostatin and somatostatin binding sites in the normal rat and following lesion of the nucleus basalis. Brain Res. 371: 376-379.
76. Epelbaum, J., Doumaud, P., Fodor, M., and Viollet, C. 1994. The neurobiology of somatostatin. Clin. Rev. Neurobiol. 8: 24-44.
77. Espino, A., Calopa, M., Ambrosio, S., Ortola, J., Peres, J., and Navarro, M.A. 1995. CSF somatostatin increase in patients with early Parkinsonian syndrome. J. Neural Transm. 9: 189-196.
78. Feifel, D., and Vaccarino, F.J. 1990. Central injections of growth hormone-releasing factor increase operant responding for food reward. Prog. Neuro-Psychopharmacol. Biol. Psychiatr. 14: 813-820.
79. Feifel, D., and Vaccarino, F.J. 1994. Growth hormone-regulatory peptides (GHRH and somatostatin) and feeding: a model for the integration of central and peripheral function. Neurosci. Biobehav. Rev. No. 18. pp. 421-433.
80. File, S.E. 1993. The interplay of learning and anxiety in the elevated plus-maze. Behav. Brain Res. 58: 199-202.
81. File, S.E. 1996. Recent developments in anxiety, stress and depression. Pharmacol. Biochem. Behav. 54: 3-12.
82. Fischer, W., Wictorin, K., Bjorklund, A., Williams, L.R., Varon, S., and Gage, F.H. 1987. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature (Lond.), 329: 65-68.
83. Fischer, W., Bjorklund, A., Chen, K., and Gage, F.H. 1991. NGF improves spatial memory in aged rodents as a function of age. J. Neurosci. 11: 1889-1906.
84. Fitzgerald, L.W., and Dokla, C.P.J. 1989. Morris water task impairment and hypoactivity following cysteamine-induced reductions in somatostatin-like immunoreactivity. Brain Res. 505: 246-250.
85. Flood, J.F., and Morley, J.E. 1990. Pharmacological enhancement of long-term memory retention in old mice. J. Gerontol. B, 45: 101-104.
86. Florio, T., Magri, G., Landolfi, E., Mencci, O., Grimaldi, M., Schettini, G., and Marino, A. 1988. Depletion of brain somatostatin (SRIF) by cysteamine (CSH) induces impairment of cognitive functions in rat: reversal by administration of exogenous SRIF or its analogue SMS 202-995. Pharmacol. Res. Commun. 20: 241-242.
87. Florio, T., Ventra, C., Postiglione, A., and Schettini, G. 1991. Age-related alterations of somatostatin gene-expression in different rat brain areas. Brain Res. 557: 64-68.
88. Floyd, R.A. 1991. Oxidative damage to behaviour during aging. Science (Washington, D.C.), 254: 1597.
89. Frieboes, R.M., Murck, H., Maier, P., Schier, T., Holsboer, F., and Steiger, A. 1995. Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology, 61: 584-589.
90. Fuhrmann, G., Durkin, T., Thiriet, G., Kempf, E., and Ebel, A. 1985a. Cholinergic neurotransmission in the central nervous system of the Snell dwarf mouse. J. Neurosci. Res. 13: 417-430.
91. Fuhrmann, G., Scala-Guenot, D.D., and Ebel, A. 1985b. Somatostatin levels in the central nervous system of the Snell dwarf mouse; is somatostatin excess the primary molecular defect in the dw/dw dwarfism? Brain Res. 328: 161-164.
92. Gargosky, S.E., Owens, J.A., Walton, P.E., Owens, P.C., Wallace, J.C., and Ballard, F.J. 1991. Administration of insulin-like growth factor-I, but not growth hormone, increases maternal weight gain in late pregnancy without affecting fetal or placental growth. J. Endocrinol. 130: 395-400.
93. Ginalska-Malinowska, M., and Romer, T.E. 1981. Prenatal brain development: effect of maternal growth hormone administration: study in albino rats. Endokrinologie, 77: 341-345.
94. Gold, P.E. 1992. Modulation of memory processing: enhancement of memory in rodents and humans. In Neuropsychology of memory. Edited by L.R. Squire and N. Butters. Guilford Press, New York. pp. 402-414.
95. Greenlund, L.J.S., Deckworth, T.L., and Johnson, E.M. 1995. Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron, 14: 303-315.
96. Harman, D. 1996. Aging and disease: extending functional life span. Ann. N.Y. Acad. Sci. No. 786. pp. 321-336.
97. Haroutunian, V., Mantin, R., Campbell, G.A., Tsuboyama, G.K., and Davis, K.L. 1987. Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behaviour, learning, memory and brain neurochemistry. Brain Res. 403: 234-242.
98. Hartmann, A., Dietl, T., Krumrey, K., Vogl, L., Dirlich, G., Holsboer, F., and Heuser-Link, M. 1995. Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH), but not somatostatin (SRIF) after peripheral administration in male controls. Peptides (Tarryt.), 16: 657-663.
99. Harvey, S. 1995. Growth hormone action: neural function. In Growth hormone. Edited by S. Harvey, C.G. Scanes, and W.H. Daughaday. CRC Press, Boca Raton, Fla. pp. 437-449.
100. Havelicek, V., Rezek, M., and Friesen, H. 1976. Somatostatin and thyrotropin releasing hormone: central effect on sleep and motor system. Pharmacol. Biochem. Behav. 4: 455-459.
101. Heggestad, C.B., and Wells, L.J. 1965. Experiments on the contribution of somatotrophin to prenatal growth in the rat. Acta Anat. 60: 348-361.
102. Heinrichs, S.C., Stenzel-Poore, M.P., Gold, L.H., Battenberg, E., Bloom, F.E., Koob, G.F., Vale, W.W., and Pich, E.M. 1996. Learning impairment in transgenic mice with overexpression of corticotropin-releasing factor. Neuroscience, 74: 303-311.
103. Hendrich, C.E., Jackson, W.J., and Porterfield, S.P. 1984. Behavioural testing of progenies of Tx (hypothyroid) and growth hormone-treated Tx rats: an animal model for mental retardation. Neuroendocrinology, 38: 429-437.
104. Hennevin, E., Hars, B., Maho, C., and Bloch, V. 1995. Processing of learned information in paradoxical sleep: relevance for memory. Behav. Brain Res. 69: 125-135.
105. Hensley, K., Butterfield, D.A., Hall, N., Cole, P., Subramaniam, R., Mark, R., Mattson, M.P., Markesbery, W.R., Harris, M.E., Akenov, M., Akenova, M., Wu, J.F., and Carney, J.M. 1996. Reactive oxygen species as causal agents in the neurotoxicity of the Alzheimer's disease-associated amyloid beta peptide. Ann. N.Y. Acad. Sci. No. 786. pp. 120-134.
106. Herman, B.H., and Nagy, Z.M. 1977. Development of learning and memory in mice genetically selected for differences in brain weight. Dev. Psychol. 10: 65-75.
107. Hill, D.J. 1992a. What is the role of growth hormone and related peptides in implantation and the development of the embryo and fetus? Horm. Res. (Basel), 38(Suppl. 1): 28-34.
108. Hill, D.J. 1992b. Peptide growth factor interactions in embryonic and fetal growth. Horm. Res. (Basel), 38: 197-202.
109. Hoddes, E.S. 1979. Effect of growth hormone on memory in mice. Sleep (Rochester), 1: 287-297.
110. Hoffman, A.R., Lieberman, S.A., Butterfield, G., Thompson, J., Hintz, R.L., Ceda, G.P., and Marcus, R. 1997. Functional consequences of the somatopause and its treatement. Endocrine, 7: 73-76.
111. Hosler, B.A., and Brown, R.H. 1996. Superoxide dismutase and oxygen radical neurotoxicity. Curr. Opin. Neurobiol. 9: 486-491.
112. Hultquist, G.T., and Engfeldt, B. 1949. Giant growth of rat fetuses produced experimentally by means of administration of hormones to the mother during pregnancy. Acta Endocrinol. 3: 365-376.
113. Hurley, D.L., and Phelps, C.J. 1992. Hypothalamic preprosomatostatin messenger ribonucleic acid expression in mice transgenic for excess or deficient endogenous growth hormone. Endocrinology, 130: 1809-1815.
114. Hurley, D.L., Bartke, A., Wagner, T.E., Wee, B.E.F., and Phelps, C.J. 1994. Increased hypothalamic somatostatin expression in mice transgenic for bovine or human GH. J. Neuroendocrinol. 6: 539-548.
115. Ikegami, S. 1994. Behavioural impairment in radial-arm maze learning and acetylcholine content of the hippocampus and cerebral cortex in aged mice. Behav. Brain Res. 65: 103-111.
116. Ingram, D.K. 1988. Complex maze learning in rodents as a model of age-related memory impairment. Neurobiol. Aging, 9: 475-485.
117. Ingram, D.K., Spangler, E.L., Iijima, S., Kuo, H., Bresnahan, E.L., Greig, N.H., and London, E.D. 1994. New pharmacological strategies for cognitive enhancement using a rat model of age-related memory impairment. Ann. N.Y. Acad. Sci. No. 717. pp. 16-32.
118. Ingram, D.K., Shimada, A., Spangler, E.L., Ikari, H., Hengemihle, J., Kuo, H., and Greig, N. 1996. Cognitive enhancement: new strategies for stimulating cholinergic, glutamatergic and nitric oxide systems. Ann. N.Y. Acad. Sci. No. 786. pp. 348-361.
119. Inoue, S. 1995. Pharmacology of the CNS peptides. In The pharmacology of sleep. Edited by A. Kales. Springer-Verlag, Berlin. pp. 243-277.
120. Iranmanesh, A., and Veldhuis, J.D. 1992. Clinical pathophysiology of the somatotropic (GH) axis in adults. Endocrinol. Metab. Clin. N. Am. 21: 783-816.
121. Issa, A.M., Rowe, W., Gauthier, S., and Meaney, M.J. 1990. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. J. Neurosci. 10: 3247-3254.
122. Izquierdo, I., Medina, J.H., Bianchin, M., Walz, R., Zanatta, M.S., DaSilva, R.C., Silva, B.M.E., Ruschel, A.C., and Paczko, N. 1993. Memory processing by the limbic system: role of specific neurotransmitter systems. Behav. Brain. Res. 58: 91-98.
123. Jaber, M., Robinson, S.W., Missale, C., and Caron, M.G. 1996. Dopamine receptors and brain function. Neuropharmacology, 35: 1503-1519.
124. Jorgensen, K.D, Svendsen, O., Agergaard, N., and Skydsgaard, K. 1991. Effect of human growth hormone on the reproduction of female rats. Pharmacol. Toxicol. 68: 14-20.
125. Joseph, J.A., Villalobos-Molina, R., Denisova, N., Erat, S., Jimenez, N., and Strain, J. 1996. Increased sensitivity to oxidative stress and the loss of muscarinic responsiveness in senescence. Ann. N.Y. Acad. Sci. No. 786. pp. 112-119.
126. Karni, A., Tanne, D., Rubenstein, B.S., Askenacy, J.J.M., and Sagi, D. 1994. Dependence on REM sleep of overnight improvement of a perceptual skill. Science (Washington, D.C.), 265: 679-682.
127. Kavanau, J.L. 1996. Memory, sleep and dynamic stabilization of neural circuitry: evolutionary perspectives. Neurosci. Biobehav. Rev. No. 20. pp. 289-311.
128. Kavanau, J.L. 1997. Memory, sleep and the evolution of mechanisms of synaptic efficacy maintenance. Neuroscience, 79: 7-44.
129. Kerkhofs, M., Van Cauter, E., Van Onderbergen, A., Caufriez, A., Thorner, M.O., and Copinschi, G. 1993. Sleep-promoting effects of growth hormone-releasing hormone in normal men. Am. J. Physiol. 264: E594-E598.
130. Kern, W., Dodt, C., Born, J., and Fehm, H.L. 1996. Changes in cortisol and growth hormone secretion during nocturnal sleep in the course of aging. J. Gerontol. A, 51: M3-M9.
131. Kirschbaum, C., Wolf, O.T., May, M., Wippich, W., and Hellhammer, D.H. 1996. Stress-and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci. 58: 1475-1483.
132. Knusel, B., and Gao, H. 1996. Neurotrophine and Alzheimer's disease: beyond the cholinergic neurons. Life Sci. 58: 2019-2027.
133. Komoly, S., Hudso, L.D., Webster, H.deF., and Bondy, C.A. 1992. Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination. Proc. Natl. Acad. Sci. U.S.A. 89: 1894-1898.
134. Kovacs, G.L., and DeWied, D. 1994. Peptidergic modulation of learning and memory. Pharmacol. Rev. 46: 269-291.
135. Krueger, J.M., and Obal, F., Jr. 1993. Growth hormone-releasing hormone and interleukin-1 in sleep regulation. FASEB J. 7: 645-652.
136. Laakmann G., Zygen, K., Schoen, H.W., Weiss, A., Wittmann, M., Meissner, R., and Blaschke, D. 1986. Effect of receptor blockers (methysergide, propranolol, phentolamine, yohimbine and prazosin) on desimipramine-induced piuitary hormone stimulation in humans-I. Growth hormone. Psychoneuroendocrinology, 11: 447-461.
137. Lachmansingh, E., and Rollo, C.D. 1994. Evidence for a trade-off between growth and behavioural activity in Giant "supermice" genetically engineered with extra growth hormone genes. Can. J. Zool. 72: 2158-2168.
138. Laron, Z., and Galatzer, A. 1980. Aspects of brain development in children and adolescents with pituitary growth hormone deficiency. In Hormones and the brain. Edited by D. DeWied and P.A. VanKeep. MTP, Lancaster, England, pp. 293-302.
139. Leidy, J.W., Jr., and Robbins, R.J. 1988. Growth hormone-releasing factor immunoreactivity in the hypothalamus and cortex of the rat: in vivo and in vitro studies. Endocrinology, 122: 1652-1657.
140. Lewis, M.E., Neff, N.T., Contreras, P.C., Strong, D.B., Oppenheim, R.W., Grebow, P.E., and Vaught, J.L. 1993a. Insulin-like growth factor-1: potential for treatment of motor neuronal disorders. Exp. Neurol. 124: 73-88.
141. Lewis, M.E., Vaught, J.L., Neff, N.T., Grebow, P.E., Callison, K.V., Yu, E., Contreras, P.C., and Baldino, F. 1993b. The potential of insulin-like growth factor-1 as a therapeutic for the treatment of neuromuscular disorders. Ann. N.Y. Acad. Sci. No. 692. pp. 201-208.
142. Lin, M.T., Chen, J.J., and Ho, L.T. 1987. Hypothalamic involvement in the hyperglycemia and satiety actions of somatostatin in rats. Neuroendocrinology, 45: 62-65.
143. Liu, J.P., Baker, J., Perkins, A.S., Robertson, E.J., and Efstratiadis, A. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor 1 (Igf-1) and type 1 IGF receptor (Igflr). Cell, 75: 59-72.
144. Locatelli, V., Torsello, A., Redaelli, M., Ghigo, E., Massawa, F., and Muller, E.E. 1986. Cholinergic agonist and anatagonist drugs modulate the growth hormone response to growth hormone-releasing hormone in the rat: evidence for mediation by somatostatin. J. Endocrinol. 111: 271-278.
145. Lupien, S., Lecours, A.R., Lussier, O., Schwartz, G., Nair, N.P.V., and Meaney, J.J. 1994. Basal cortisol levels and cognitive deficits in human aging. J. Neurosci. 14: 2893-2903.
146. Magiakou, M.A., Mastorakos, G., Gomez, M.T., Rose, S.R., and Chrousos, G.P. 1994. Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing's disease before and after surgical cure. J. Clin. Endocrinol. Metab. 78: 131-137.
147. Malthe-Sorenssen, D., Wood, P.L., Cheney, D.L., and Costa, E. 1978. Modulation of the turnover rate of acetylcholine in rat brain by intraventricular injections of thyrotropin-releasing hormone, somatostatin, neurotensin and angiotensin II. J. Neurochem. 31: 685-691.
148. Mancillas, J.R., Siggins, G.R., and Bloom, F.E. 1986. Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex. Proc. Natl. Acad. Sci. U.S.A. 83: 7518-7521.
149. Marshall, L., Molle, M., Boschen, G., Steiger, A., Fehm, H.L., and Born, J. 1996. Greater efficacy of episodic than continuous growth hormone-releasing hormone (GHRH) administration in promoting slow-wave sleep (SWS). J. Clin. Endocrinol. Metab. 81: 1009-1013.
150. Matsukawa, M., Ogawa, M., Nakadate, K., Maeshima, T., Ichitani, Y., Kawai, N., and Okado, N. 1997. Serotonin and acetylcholine are crucial to maintain hippocampal synapses and memory aquisition in rats. Neurosci. Lett. 230: 13-16.
151. 2+ influx in cultured hippocampal neurons. Neuron, 2: 105-117.
152. McEwen, B.S., and Sapolsky, R.M. 1995. Stress and cognitive function. Curr. Opin. Neurobiol. 5: 205-216.
153. McGaugh, J.L. 1989a. Involvement of hormonal and neuromodulatory systems in the regulation of memory storage. Annu. Rev. Neurosci. 12: 255-287.
154. McGaugh, J.L. 1989b. Dissociating learning and performance: drug and hormone enhancement of memory storage. Brain Res. Bull. 23: 339-345.
155. McGaugh, J.L., Cahill, L., and Roozendaal, B. 1996. Involvement of the amygdala in memory storage: interactions with other brain systems. Proc. Natl. Acad. Sci. U.S.A. 93: 13 508-13 514.
156. McHugh, T.J., Blum, K.I., Tsien, J.Z., Tonegawa, S., and Wilson, M.A. 1996. Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell, 87: 1339-1349.
157. McNamara, R.K., and Skelton, R.W. 1993. The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain Res. Rev. 18: 33-49.
158. Meites, J. 1990. Aging: hypothalamic catecholamines, neuroendocrineimmune interactions, and dietary restriction. Proc. Soc. Exp. Biol. Med. 195: 304-311.
159. Meites, J. 1993. Anti-aging interventions and their neuroendocrine aspects in mammals. J. Reprod. Fertil. Suppl. 46: 1-9.
160. Meliska, C.J., Bartke, A., Vandergruff, J.L., and Jensen, R.A. 1995. Ethanol and nicotine consumption and preference in transgenic mice overexpressing the bovine growth hormone gene. Pharmacol. Biochem. Behav. 50: 563-570.
161. Meliska, C.J., Burke, P.A., Bartke, A., and Jensen, R.A. 1997. Inhibitory avoidance and appetitive learning in aged normal mice: comparison with transgenic mice having elevated plasma growth hormone levels. Neurobiol. Learn. Mem. 68: 1-12.
162. Melmed, S., Yamashita, S., Yamasaki, H., Fagin, J., Namba, H., Yamamoto, H., Weber, M., Morita, S., Webster, J., and Prager, D. 1996. IGF-1 receptor signalling: lessons from the somatotroph. Recent Prog. Horm. Res. 51: 189-215.
163. Minthon, L., Edvinsson, L., and Gustafson, L. 1997. Somatostatin and neuropeptide Y in cerebrospinal fluid: correlations with severity of disease and clinical signs in Alzheimer's disease and frontotemporal dementia. Dement. Geriatr. Cogn. Disord. 8: 232-239.
164. Morris, R.G.M., Garrud, P., Rawlins, J.N.P., and O'Keefe, J.O. 1982. Place navigation impaired in rats with hippocampal lesions. Nature (Lond.), 297: 681-683.
165. Morrison, J.H., Rogers, J., Scherr, S., Benoit, R., and Bloom, F.E. 1985. Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients. Nature (Lond.), 314: 90-92.
166. Muller, E.E., Locatelli, V., Ghigo, E., Cella, S.G., Loche, S., Pintor, C., and Camanni, F. 1991. Involvement of brain catecholamines and acetylcholine in growth hormone deficiency states. Drugs, 41: 161-177.
167. Muller, E.E., Rolla, M., Ghigo, E., Belliti, D., Arvat, E., Andreoni, A., Torsello, A., Locatelli, V., and Camanni, F. 1995a. Involvement of brain catecholamines and acetylcholine in growth hormone hypersecretory states: pathophysiological, diagnostic and therapeutic implications. Drugs, 50: 805-837.
168. Muller, E.E., Cella, S.G., Parenti, M., Deghenghi, R., Locatelli, V., De Gennaro Colonna, V., Torsello, A., and Cocchi, D. 1995b. Somatotropic dysregulation in old mammals. Horm. Res. (Basel), 43: 39-45.
169. Nilsson, L., Sara, V.R., and Norberg, A. 1988. Insulin-like growth factor I stimulates the release of acetylcholine from rat cortical slices. Neurosci. Lett. 88: 221-226.
170. Noguchi, T. 1996. Effects of growth hormone on cerebral development: morphological studies. Horm. Res. (Basel), 45: 5-17.
171. Noguchi, T., and Sugisaki, T. 1985. Abnormal neuronal growth in the Little (lit) cerebrum. Exp. Neurol. 89: 274-278.
172. Noguchi, T., Sugisaki, T., and Tsukada, Y. 1982a. Effects of bovine growth hormone on the retarded cerebral development induced by neonatal hydrocortisone-intoxication. J. Neurochem. 38: 246-256.
173. Noguchi, T., Sugisaki, T., and Tsukada, Y. 1982b. Factors contributing to the poor myelination in the brain of the Snell dwarf mouse. J. Neurochem. 39: 1693-1699.
174. Noguchi, T., Sugisaki, T., and Tusukada, Y 1982c. Postnatal action of growth and thyroid hormones on the retarded cerebral myelinogenesis of Snell dwarf mice (dw). J. Neurochem. 38: 257-263.
175. Noguchi, T., Sekiguchi, M., Sugisaki, T., Tsukada, Y, and Shimai, K. 1983. Faulty development of cortical neurons in the Snell dwarf cerebrum. Dev. Brain. Res. 10: 125-138.
176. Noguchi, T., Sugisaki, T., and Tsukada, Y. 1984. Stimulation of Snell dwarf mouse neuronal growth by GH and T4. Neurochem. Pathol. 2: 123-138.
177. Noguchi, T., Sugisaki, T., and Tsukada, T. 1985. Microcephalic cerebrum with hypomyelination in the growth hormone-deficient mouse (lit). Neurochem. Res. 10: 1097-1106.
178. Noguchi, T., Sugisaki, T., Nishikawa, N., and Tsukada, Y. 1988. Restoration of microcephalic cerebrum with hypomyelination in the growth hormone-deficient mouse (lit): stimulatory effects of GH restricted to the first 20 days of postnatal life. Neurochem. Res. 13: 249-252.
179. Nyberg, F., and Burman, P. 1996. Growth hormone and its receptors in the central nervous system - location and functional significance. Horm. Res. (Basel), 45: 18-22.
180. Obal, F., Jr., Payne, L., Kapas, L, Opp, M., and Krueger, J.M. 1991. Inhibition of growth hormone-releasing factor suppresses both sleep and growth hormone secretion in the rat. Brain Res. 557: 149-153.
181. Obal, F., Jr., Fang, J., Payne, L.C., and Krueger, J.M. 1995. Growth-hormone-releasing hormone mediates the sleep-promoting activity of interleukin-1 in rats. Neuroendocrinology, 61: 559-565.
182. Obal, F., Jr., Floyd, R., Kapas, L., Bodosi, B., and Krueger, J.M. 1996. Effects of systemic GHRH on sleep in intact and hypophysectomized rats. Am. J. Physiol. 270: E230-E237.
183. Obal, F., Jr., Bodosi, B., Szilagyi, A., Kacsoh, B., and Krueger, J.M. 1997. Antiserum to growth hormone decreases sleep in the rat. Neuroendocrinology, 66: 9-16.
184. O'Hara, B.F., Bendotti, C., Reeves, R.H., Oster-Granite, M.L., Coyle, J.T., and Gearhart, J.D. 1988. Genetic mapping and analysis of somatostatin expression in Snell dwarf mice. Mol. Brain. Res. 4: 283-292.
185. Ohyama, T., Sato, M., Wada, Y., and Takahara, J. 1996. Diverse effects of glucocorticoids on the hypothalamic pituitary axis in rat growth hormone secretion. Endocr. J. 43(Suppl.): S115-S117.
186. Olney, J.W. 1994. Excitotoxins in foods. Neurotoxicology (Little Rock), 15: 535-544.
187. Olton, D.S. 1987. The radial arm maze as a tool in behavioral pharmacology. Physiol. Behav. 40: 793-797.
188. Olton, D.S., and Papas, B.C. 1979. Spatial memory and hippocampal function. Neuropsychologia, 17: 669-682.
189. Olton, D.S., and Samuelson, R.J. 1976. Remembrance of places passed: spatial memory in rats. J. Exp. Psychol. 2: 97-116.
190. Olton, D.S., Becker, J.T., and Handelmann, G.E. 1979. Hippocampus, space, and memory. Behav. Brain Sci. 2: 313-365.
191. Oomura, Y., Sasaki, K., Li, A., Yoshii, H., Fukata, Y., Yago, H., Kimura, H., Tooyama, I., Hanai, K., Nomura, Y., and Yanashara, N. 1996. Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidic fibroblast growth factor. Ann. N.Y. Acad. Sci. No. 786. pp. 337-347.
192. Owen, A.D., Schapira, A.H.V., Jenner, P., and Marsen, C.D. 1996. Oxidative stress and Parkinson's disease. Ann. N.Y. Acad. Sci. No. 786. pp. 217-223.
193. Pagel, J., Pegram, V., Vaughn, S., Donaldson, P., and Bridgers, W. 1973. The relationship of REM sleep with learning and memory in mice. Behav. Biol. 9: 383-388.
194. Palmiter, R.D., Brinster, R.L., Hammer, R.E., Trumbauer, M.E., Rosenfeld, M.G., Brinberg, N.C., and Evans, R.M. 1982. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (Lond.), 300: 611-615.
195. Pavlides, C., and Winson, J. 1989. Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep episodes. J. Neurosci. 9: 2907-2918.
196. Pendergrass, W.R., Li, Y., Jiang, D., and Wolf, N.S. 1993. Decrease in cellular replicative potential in "Giant" mice transfected with the bovine growth hormone gene correlates to shortened life span. J. Cell. Physiol. 156: 96-103.
197. Perry, E.K., Blessed, G., Tomlinson, B.E., Perry, R.H., Crow, T.J., Cross, A.J., Dockray, G.J., Dimaline, R., and Arrequi, A. 1981. Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes. Neurobiol. Aging, 2: 251-256.
198. Phelps, C.J., and Bartke, A. 1997. Stimulatory effect of human, but not bovine growth hormone expression on numbers of tuberoinfundibular dopaminergic neurons in transgenic mice. Endocrinolology, 138: 2849-2855.
199. Phelps, C.J., Saleh, M.N.M.A., and Romero, M.I. 1994. Hypophysiotropic somatostatin expression during postnatal development in growth hormone-deficient Ames dwarf mice: peptide immunocytochemistry. Neuroendocrinolology, 64: 364-378.
200. Prinz, P.N., Moe, K.E., Dulberg, E.M., Larsen, L.H., Vitiello, M.V., Toivola, B., and Merrian, G.R. 1995. Higher plasma IGF-1 levels are associated with increased delta sleep in healthy older men. J. Gerontol. A, 50: M222-M226.
201. Ramm, P., and Smith, C.T. 1990. Rates of cerebral protein synthesis are linked to slow wave sleep in the rat. Physiol. Behav. 48: 749-753.
202. Reiter, R.J. 1995. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J. 9: 526-533.
203. Rezek, M., Havlicek, V., Hughes, K.R., and Friesen, H. 1976a. Central site of action of somatostatin (SRIF): role of hippocampus. Neuropharmacology, 15: 499-504.
204. Rezek, M., Havlicek, V., Hughes, K.R., and Friesen, H. 1976b. Cortical administration of somatostatin (SRIF): effect on sleep and motor behavior. Pharmacol. Biochem. Behav. 5: 73-77.
205. Richardson, S.B., Hollander, C.S., D'Eletto, R., Greenleaf, P.W., and Thaw, C. 1980. Acetylcholine inhibits release of somatostatin from rat hypothalamus in vitro. Endocrinology, 107: 122-129.
206. Roberts, G.W., Crow, T.J., and Polak, J.M. 1985. Location of neuronal tangles in somatostatin neurons in Alzheimer's disease. Nature (Lond.), 314: 92-94.
207. Roger, L.J., and Fellows, R.E. 1979. Evidence for thyroxine - growth hormone interaction during brain development. Nature (Lond.), 282: 414-415.
208. Rollo, C.D. 1994. Phenotypes: their epigenetics, ecology, and evolution. Chapman and Hall, London.
209. Rollo, C.D., Carlson, J., and Sawada, M. 1996. Accelerated aging of giant transgenic mice is associated with elevated free radical processes. Can. J. Zool. 74: 606-620.
210. Rollo, C.D., Foss, J., Lachmansingh, E., and Singh, R. 1997a. Behavioural rhythmicity in transgenic growth hormone mice: trade-offs, energetics, and sleep-wake cycles. Can. J. Zool. 75: 1020-1034.
211. Rollo, C.D., Rintoul, J., and Kajiura, L.J. 1997b. Lifetime reproduction of giant transgenic mice: the energety stress paradigm. Can. J. Zool. 75: 1336-1345.
212. Rosen, T., Johannsson, G., Johansson, J.O., and Bengtsson, B.A. 1995. Consequences of growth hormone deficiency in adults and the benefits and risks of recombinant human growth hormone treatment. Horm. Res. (Basel), 43: 93-99.
213. Rosenfeld, R.G. 1997. An endocrinologist's approach to the growth hormone - insulin-like growth factor axis. Acta Paediatr. Suppl. 423: 17-19.
214. Rotenberg, A., Mayford, M., Hawkins, R.D., Kandel, E.R., and Muller, R.U. 1996. Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. Cell, 87: 1351-1361.
215. Rotenberg, V.S. 1992. Sleep and memory I: the influence of different sleep stages on memory. Neurosci. Biobehav. Rev. No. 16. pp. 497-502.
216. Roullet, P., and Lassalle, J.M. 1992. Behavioural strategies, sensorial processes and hippocampal mossy fibre distribution in radial maze performance in mice. Behav. Brain Res. 48: 77-85.
217. Rubinow, D.R., Post, R.M., Davis, C.L., and Doran, A.R. 1987. Somatostatin and GHRH: mood and behavioral regulation. In Hypothalamic dysfunction in neuropsychiatrie disorders. Vol. 43. Edited by D. Neozzi, F.K. Goodwin, and E. Costa. Raven Press, New York. pp. 137-152.
218. Sadow, T.F., and Rubin, R.T. 1992. Effects of hypothalamic peptides on the aging brain. Psychoneuroendocrinology, 17: 293-314.
219. Sandman, C.A., Wadhwa, P.D., Chicz-DeMet, A., Dunkel-Schetter, C., and Porto, M. 1997. Maternal stress, HPA activity, and fetal/infant outcome. Ann. N.Y. Acad. Sci. No. 814. pp. 266-275.
220. Sapolsky, R.M. 1992. Stress, the aging brain, and the mechanisms of neuron death. Massachusetts Institute of Technology Press, Cambridge.
221. Sara, V.R., and Lazarus, L. 1974. Prenatal action of growth hormone on brain and behaviour. Nature (Lond.), 250: 257-258.
222. Sara, V.R., Lazarus, L., Stuart, M.C., and King, T. 1974. Fetal brain growth: selective action by growth hormone. Science (Washington, D.C.), 186: 446-447.
223. Sarter, M., and Bruno, J.P. 1997. Cognitive functions of cortical acetylcholine: toward a unifying hypothesis. Brain Res. Rev. 23: 28-46.
224. Sartorio, A., Conti, A., Molinari, E., Riva, G., Morabito, F., and Faglia, G. 1996. Growth, growth hormone and cognitive functions. Horm. Res. (Basel), 45: 23-29.
225. Sasaki, K., Oomura, Y., Figurov, A., and Yagi, H. 1994. Acidic fibroblast growth factor facilitates generation of long-term potentiation in rat hippocampal slices. Brain Res. Bull. 33: 505-511.
226. Sato, M., Murao, K., Matsubara, S., Niimi, M., Chihara, K., and Takahara, J. 1995. Central glucopenia induced by 2-deoxy-D-glucose stimulates somatostatin secretion in the rat. J. Neuroendocrinol. 7: 801-805.
227. Sawada, M., Sester, U., and Carlson, J.C. 1992. Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat. J. Cell. Biochem. 48: 296-304.
228. Sawchenko, P.E., Swanson, L.W., Rivier, J., and Vale, W.W. 1985. The distribution of growth-hormone-releasing factor (GRF) immunoreactivity in the central nervous system of the rat: an immunohistochemical study using antisera directed against rat hypothalamic GRF. J. Comp. Neurol. 237: 100-115.
229. Scanlon, M.F., Issa, B.G., and Dieguez, C. 1996. Regulation of growth hormone secretion. Horm. Res. (Basel), 46: 149-154.
230. Schapira, A.H.V. 1996. Oxidative stress and mitochondrial dysfunction in neurodegeneration. Curr. Opin. Neurobiol. 9: 260-264.
231. Scharfman, H.E., and Schwartzkroin, P.A. 1989. Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampal slices. Brain Res. 493: 205-211.
232. Schettini, G. 1991. Brain somatostatin: receptor-coupled transducing mechanisms and role in cognitive functions. Pharmacol. Res. 23: 203-215.
233. Schneider-Rivas, S., Rivas-Arancibia, S., Vazquez-Pereyra, F., Vizquez-Sandoval, R., and Borgonio-Perez, G. 1995. Modulation of long-term memory and extinction responses induced by growth hormone (GH) and growth hormone releasing hormone (GHRH) in rats. Life Sci. 56: 433-441.
234. Schor, N.F. 1988. Inactivation of mammalian brain glutamine synthetase by oxygen radicals. Brain Res. 456: 17-21.
235. Schwegler, H., and Crusio, W.E. 1995. Correlations between radial-maze learning and structural variations of septum and hippocampus in rodents. Behav. Brain Res. 67: 29-41.
236. Schwegler, H., Crusio, W.E., and Brust, I. 1990. Hippocampal mossy fibers and radial-maze learning in the mouse: a correlation with spatial working memory but not with non-spatial reference memory. Neuroscience, 34: 293-298.
237. Schwegler, H., Crusio, W.E., Lipp, H.P., Brust, I., and Mueller, G.G. 1991. Early postnatal hyperthyroidism alters hippocampal circuitry and improves radial-maze learning in adult mice. J. Neurosci. 11: 2102-2106.
238. Shea, B.T., Hammer, R.E., and Brinster, R.L. 1987. Growth allometry of the organs in giant transgenic mice. Endocrinology, 121: 1924-1930.
239. Sherin, J.E., Shiromani, P.J., McCarley, R.W., and Saper, C.B. 1996. Activation of ventrolateral preoptic neurons during sleep. Science (Washington, D.C.), 271: 216-219.
240. Sirnonian, N.A., and Coyle, J.T. 1996. Oxidative stress in neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol. 36: 83-106.
241. Sirvio, J., Jolkkonen, J., Pikamen, A., and Riekkinen, P.J. 1987. Age-dependent changes in somatostatin levels and somatostatin binding in the rat brain. Comp. Biochem. Physiol. A, 87: 355-357.
242. Sirvio, J., Riekkinen, P., Jakala, P., and Riekkinen, P.J. 1994. Experimental studies on the role of serotonin in cognition. Prog. Neurobiol. (N.Y.), 43: 363-379.
243. Slama, A., Bluet-Pajot, M.T., Mounier, F., Videau, C., Kordan, C., and Epelbaum, J. 1996. Effects of neonatal administration of octreotide, a long-lasting somatostatin analogue, on growth hormone regulation in the adult rat. Neuroendocrinology, 63: 173-180.
244. Smith, C. 1985. Sleep states and learning: a review of the literature. Neurosci. Biobehav. Rev. No. 9. pp. 157-168.
245. Smith, C. 1995. Sleep states and memory processes. Behav. Brain Res. 69: 137-145.
246. Sonntag, W.E., Lynch, C.D., Cooney, P.T., and Hutchins, P.M. 1997. Decreases in cerebral microvascularization with age are associated with decline in growth hormone and insulin-like growth factor 1. Endocrinology, 138: 3515-3520.
247. Sontag, L.W., and Munson, P.L. 1934. The effect on the weight of the offspring of administration of Antuitrin G to the pregnant rat. Am. J. Physiol. 108: 593-598.
248. Sortino, M.A., and Canonico, P.L. 1996. Neuroprotective effect of insulin-like growth factor I in immortalized hypothalamic cells. Endocrinology, 137: 1418-1422.
249. Spence, S., Mattson, B., Vetter, C., Cukierski, M., and Prahalada, S. 1995. Effects of porcine growth hormone on pregnancy and fetal/neonatal development in the rat. Biol. Neonate, 68: 62-74.
250. Squire, L.R., and Alvarez, P. 1995. Retrograde amnesia and memory consolidation: a neurobiological perspective. Curr. Opin. Neurobiol. 5: 169-177.
251. Starkman, M.N., Gebarski, S.S., Berent, S., and Schteingart, D.E. 1992. Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biol. Psychiatr. 32: 756-765.
252. Steckler, T., and Sahgal, A. 1995. The role of serotonergic-cholinergic interactions in the mediation of cognitive behavior. Behav. Brain Res. 67: 165-199.
253. Steger, R.W., Bartke, A., and Cecim, M. 1993. Premature ageing in transgenic mice expressing different growth hormone genes. J. Reprod. Fertil. Suppl. 46: 61-75.
254. Steger, R.W., Bartke, A., Parkening, T.A., Collins, T., Cerven, R., Yun, J.S., and Wagner, T.E. 1994. Effects of chronic exposure to bovine growth hormone (bGH) on the hypothalamic-pituitary axis in transgenic mice: relationship to the degree of expression of the PEPCK.bGH hybrid gene. Transgenics, 1: 245-253.
255. Steiger, A., Guldner, J., Hemmeter, U., Rothe, B., Wiedemann, K., and Holsboer, F. 1992. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology, 56: 566-573.
256. Steriade, M., McCormick, D.A., and Sejnowski, T. 1993. Thalamocortical oscillations in the sleeping and aroused brain. Science (Washington, D.C.), 262: 679-685.
257. Stern, W.C., and Morgane, P.J. 1977. Sleep and memory: effects of growth hormone on sleep, brain neurochemistry and behavior. In Neurobiology of sleep and memory. Edited by R.R. Drucker-Colin and J.L. McGaugh. Academic Press, New York. pp. 373-400.
258. Stern, W.C., Forbes, W.B., Jalowiec, J.E., and Morgan, P.J. 1975. Growth hormone administration and sleep in the rat. Sleep Res. 4: 286.
259. Stevens, C.F. 1996. Spatial learning and memory: the beginning of a dream. Cell, 87: 1147-1148.
260. Stoll, S., Rostock, A., Bartsch, R., Korn, E., Meichelbock, A., and Muller, W.E. 1994. The potent free radical scavenger α-lipoic acid improves cognition in rodents. Ann. N.Y. Acad. Sci. No. 717. pp. 122-128.
261. Stone, W.S., Rudd, R.J., and Gold, P.E. 1995. Glucose attenuation of atropine-induced deficits in paradoxical sleep and memory. Brain Res. 694: 133-138.
262. Strand, F.L., Rose, K.J., Zuccarelli, L.A., Kume, J., Alves, S.E., Antonavich, F.J., and Garrett, L.Y 1991. Neuropeptide hormones as neurotrophic factors. Physiol. Rev. 71: 1017-1046.
263. Strobl, J.S., and Thomas, M.J. 1994. Human growth hormone. Pharmacol. Rev. 46: 1-34.
264. Sugisaki, T., Noguchi, T., and Tsukada, Y. 1985. Cerebral myelinogenesis in the Snell dwarf mouse: stimulatory effects of GH and T4 restricted to the first 20 days of postnatal life. Neurochem. Res. 10: 767-778.
265. Takahashi, T., Okimura, Y., Yoshimura, K., Shigeyoshi, Y., Kaji, H., Abe, H., and Chihara, K. 1995. Regional distribution of growth hormone-releasing hormone (GHRH) receptor mRNA in the rat brain. Endocrinology, 136: 4721-4724.
266. Tamminga, C.A., Foster, N.L., Fedio, P., Bird, E.D., and Chase, T.N. 1987. Alzheimer's disease: low cerebral somatostatin levels correlate with impaired cognitive function and cortical metabolism. Neurology, 37: 161-165.
267. Tanaka, S., and Tsujimoto, A. 1981. Somatostatin facilitates the serotonin release from rat cerebral cortex, hippocampus and hypothalamic slices. Brain Res. 208: 219-222.
268. Theill, L.E., and Karin, M. 1993. Transcriptional control of GH expression and anterior pituitary development. Endocr. Rev. 14: 670-689.
269. Thissen, J.P., Ketelslegers, J.M., and Underwood, L.E. 1994. Nutritional regulation of the insulin-like growth factors. Endocr. Rev. 15: 80-101.
270. Thompson, M.C., Norton, N.S., Rodriguez-Sierra, J.F., and Lippiello, L. 1994. Is glutamate-induced reduction in growth hormone-releasing hormone a neuroendocrine model of aging in the rat? Proc. Soc. Exp. Biol. Med. 206: 69-75.
271. Tilley, A.J., Brown, S., Donald, M., Ferguson, S., Piccone, J., Plasto, K., and Statham, D. 1992. Human sleep and memory processes. In Sleep, arousal and performance. Edited by R. Broughton and R. Ogilvie. Birkhauser, Basel, pp. 117-127.
272. Toppila, J., Alanko, L., Asikainen, M., Tobler, I., Stenberg, D., and Porkka-Heiskanen, T. 1997. Sleep deprivation increases somatostatin and growth hormone-releasing hormone messenger RNA in the rat hypothalamus. J. Sleep Res. 6: 171-178.
273. Tsien, J.Z., Huerta, P.T., and Tonegawa, S. 1996. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell, 87: 1327-1338.
274. Tucek, S. 1985. Regulation of acetylcholine synthesis in the brain. J. Neurochem. 44: 11-24.
275. Tuggle, C.K., and Trenkle, A. 1996. Control of growth hormone synthesis. Domest. Anim. Endocrinol. 13: 1-33.
276. Tulving, E., and Markowitsch, H.J. 1997. Memory beyond the hippocampus. Curr. Opin. Neurobiol. 7: 209-216.
277. Twery, M.J., and Moss, R.L. 1986. Effects of human pancreatic growth hormone-releasing hormone and fragments of rat hypothalamic growth hormone-releasing hormone on the activity of rat brain neurons. Neurosci. Lett. 69: 176-181.
278. Unsicker, K., Krisch, B., Otten, U., and Thoenen, H. 1978. Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoids. Proc. Natl. Acad. Sci. U.S.A. 75: 3498-3502.
279. Vaccarino, F.J., Sovran, P., Baird, J.P., and Ralph, M.R. 1995. Growth hormone-releasing hormone mediates feeding-specific feedback to the suprachiasmatic circadian clock. Peptides (Tarryt.), 16: 595-598.
280. Van Buul-Offers, S., and Van den Brande, J.L. 1981. The growth of different organs of normal and dwarfed Snell mice, before and during growth hormone therapy. Acta Endocrinol. 96: 46-58.
281. Vanderwolf, C.H., and Cain, D.P. 1994. The behavioral neurobiology of learning and memory: a conceptual reorientation. Brain. Res. Rev. 19: 264-297.
282. Van Hulzen, Z.J.M., and Van der Staay, F.J. 1991. Spatial memory processing during hippocampal long-term potentiation in rats. Physiol. Behav. 50: 121-127.
283. Vecsei, L., and Widerlov, E. 1988a. Brain and CSF somatostatin concentrations in patients with psychiatric or neurological illness. Acta Psychiatr. Scand. 78: 657-667.
284. Vecsei, L., and Widerlov, E. 1988b. Effects of intracerebroventricularly administered somatostatin on passive avoidance, shuttle-box behaviour and open-field activity in rats. Neuropeptides, 12: 237-242.
285. Vecsei, L., Bollok, I., and Telegdy, G. 1983. Intracerebroventricular somatostatin attenuates electroconvulsive shock-induced amnesia in rats. Peptides (Elmsf.), 4: 293-295.
286. Vecsei, L., Kiraly, C., Bollok, I., Nagy, A., Varga, J., Penke, B., and Telegdy, G. 1984. Comparative studies with somatostatin and cysteamine in different behavioural tests on rats. Pharmacol. Biochem. Behav. 21: 833-837.
287. 14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats. Psychoneuroendocrinology, 1: 111-115.
288. Vecsei, L., Balazs, M., and Telegdy, G. 1987. Action of somatostatin on the central nervous system. Front. Horm. Res. 15: 36-57.
289. Veldhuis, J.D., Iranmanesh, A., and Weltman, A. 1997. Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans. Endocrine, 7: 41-48.
290. Ward, A., Bates, P., Fisher, R., Richardson, L., and Graham, C.F. 1994. Disproportionate growth in mice with Igf-2 transgenes. Proc. Natl. Acad. Sci. U.S.A. 91: 10 365 - 10 369.
291. Warden, C.J., Rass, S., and Zamenhof, S. 1942. The effect of artificial changes in the brain of maze-learning in the white rat. Science (Washington, D.C.), 95: 2468-2469.
292. Williams, M.T., Hennessy, M.B., and Davis, H.N. 1995. CRF administration to pregnant rats alters offspring behavior and morphology. Pharmacol. Biochem. Behav. 52: 161-167.
293. Wilson, M.A., and McNaughton, B.L. 1994. Reactivation of hippocampal ensemble memories during sleep. Science (Washington, D.C.), 265: 676-679.
294. Wood, P.L., Cheney, D.L., and Costa, E. 1979. Modulation of the turnover rate of hippocampal acetylcholine by neuropeptides: possible site of action of α-melanocyte-stimulating hormone, adrenocorticotrophic hormone and somatostatin. J. Pharmacol. Exp. Ther. 209: 97-103.
295. ras. Proc. Natl. Acad. Sci. U.S.A. 95: 5773-5778.
296. Zamenhof, S. 1942. Stimlulation of cortical-cell proliferation by the growth hormone. III. Experiments on albino rats. Physiol. Zool. 15: 281-292.
297. Zamenhof, S., Mosley, J., and Schuller, E. 1966. Stimulation of the proliferation of cortical neurons by prenatal treatment with growth hormone. Science (Washington, D.C.), 152: 1396-1397.
298. Zarrilli, R., Bruni, B.B., and Riccio, A. 1994. Multiple levels of control of insulin-like growth factor gene expression. Mol. Cell. Endocrinol. 101: R1-R14.
299. Zhang, Y., Tatsuno, T., Carney, J.M., and Mattson, M.P. 1993. Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration. J. Cereb. Blood Flow Metab. 13: 378-388.
300. Zhang, J., Obal, F., Jr., Fang, J., Collins, B.J., and Krueger, J.M. 1996. Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system. Neurosci. Lett. 220: 97-100.