Immune function in elderly smokers and nonsmokers improves during supplementation with fruit and vegetable extracts

Integrative Medicine

Volumn 2, Issue 1, 1999, Pages 3-10

  Inserra, Paula F ^a   Jiang, Shuguang ^a   Solkoff, David ^a   Lee, Jeongmin ^a   Zhang, Zhen ^a   Xu, Minjan ^b   Hesslink JR , Robert ^a   Wise, John ^a   Watson, Ronald R ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Aging; Carotenoids; fruits and vegetables; Immune function; Smoking; Tocopherol

Indexed keywords

ALPHA CAROTENE; ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; CAROTENOID; INTERLEUKIN 2; JUICE PLUS; PLANT EXTRACT; UNCLASSIFIED DRUG; VITAMIN; XANTHOPHYLL; ZEAXANTHIN;

ADULT; AGED; AGING; BLOOD LEVEL; CANCER; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; EFFECTOR CELL; FEMALE; FRUIT; HUMAN; HUMAN EXPERIMENT; IMMUNITY; LYMPHOCYTE PROLIFERATION; MALE; NATURAL KILLER CELL; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; SMOKING; TARGET CELL; VEGETABLE;

EID: 0033486392     PISSN: 10962190     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-2190(99)00010-4     Document Type: Conference Paper

References (46)

1. Holvoet P., Collan B. Oxidation of low density lipoprotein in the pathogenesis of atherosclerosis. Atherosclerosis. 137:1998;S33-S38.
2. Agudo A., Esteve M.G., Pallares C.et al. Vegetable and fruit intake and the risk of lung cancer in women in Barcelona, Spain. Eur J Cancer. 33:1997;1256-1261.
3. Ocke M.C., Bueno-de-Mesquita H.B., Feskens J.M., van Staveren W.A., Kromhout D. Repeated measurements of vegetables, fruits, β-carotene, and vitamins C and E in relation to lung cancer. Am J Epidemiol. 145:1997;358-365.
4. Deneo-Pellegrini H., De Stefani E., Ronco A. Vegetables, fruits, and risk of colorectal cancer. A case-control study from Uruguay Nutr Cancer. 25:1996;297-303.
5. Hertog M.J., Bueno-de-Mesquita H.B., Fehily A.M., Sweetnam P.M., Elwood P.C., Kromhout D. Fruit and vegetable consumption and cancer mortality in the caerphilly study. Cancer Epidemiol Biomarkers Prev. 5:1996;673-677.
6. Gaziano M.J., Manson J.E., Branch L.G.et al. A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly. Ann Epidemiol. 5:1995;255-260.
7. Hennekens C.H., Burning J.E., Manson J.E.et al. Lack of an effective long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 334:1996;1145-1149.
8. Omenn G.S., Goodman G.E., Thornquist M.D.et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 334:1996;1150-1155.
9. The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 330:1994;1029-1035.
10. Knekt P., Jarvinen R., Seppanen R.et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol. 146:1997;223-230.
11. Sakai S., Moriguchi S. Long-term feeding of high vitamin E diet improves the decreased mitogen response of rat splenic lymphocytes with age. J Nutr Sci Vitaminol. 43:1997;113-122.
12. Wang Y., Huang D.S., Wood S., Watson R.R. Modulation of immune function and cytokine production by various levels of vitamin E supplementation during murine AIDS. Immunopharmacology. 29:1995;225-233.
13. Beharka A.A., Wu D., Han S.N., Meydani S.N. Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E. Mech Ageing Dev. 93:1997;59-77.
14. Okai Y., Higashi-Okai K. Possible immunomodulating activities of carotenoids in in vitro cell culture experiments. Int J Immunopharmacol. 18:1996;753-758.
15. De Waart F.G., Portengen L., Doekes G., Verwaal C.J., Kok F.J. Effect of 3 months vitamin E supplementation on indices of cellular and humoral immune response in elderly subjects. Br J Nutr. 78:1997;761-774.
16. Santos M.S., Leka L., Ribaya-Mercado J.D.et al. Short- and long-term beta-carotene supplementation do not influence T-mediated immunity in healthy elderly persons. Am J Clin Nutr. 66:1997;917-924.
17. Dietary Guidelines Advisory Committee Report on the Dietary Guidelines Advisory Committee. Dietary guidelines for Americans, 1995 Nutr Rev. 53:1995;376-379.
18. Breslow R.A., Subar A.F., Patterson B.H., Block G. Trends in food intake. The 1987 and 1992 national health interview surveys Nutr Cancer. 28:1997;86-92.
19. Neumark-Sztainer D., Story M., Resnick M.D., Blum R.W. Correlates of inadequate fruit and vegetable consumption among adolescents. Prev Med. 25:1996;497-505.
20. Matthew J.A., Fellows I.W., Prior A., Kennedy H.J., Bobbin R., Johnson I.T. Habitual intake of fruits and vegetables amongst patients at increased risk of colorectal neoplasia. Cancer Lett. 114:1997;255-258.
21. Lechner L., Brug J. Consumption of fruit and vegetables. How to motivate the population to change their behavior Cancer Lett. 114:1997;335-336.
22. Wise J.A., Morin R.J., Sanderson R., Blum K. Changes in plasma carotenoid, alpha-tocopherol, and lipid peroxide levels in response to supplementation with concentrated fruit and vegetable extracts. A pilot study Curr Ther Res Clin Exp. 57:1996;445-461.
23. Martinez F., Thomas N.M., Darban H., Cox T.J., Wood S., Watson R.R. Interleukin-6 and interleukin-8 production by mononuclear cells of chronic alcoholics during AIDS. Alcohol Clin Exp Res. 17:1993;1193-1197.
24. Wang Y., Huang D.S., Woos S., Watson R.R. Modulation of immune function and cytokine production by various levels of vitamin E supplementation during murine AIDS. Immunopharmacology. 29:1995;223-226.
25. + T cells from young and aged mice. J Immunol. 145:1990;1295-1302.
26. Poet T.S., Pillai R., Wood S., Watson R.R. Stimulation of natural killer cell activity by murine retroviral infections and cocaine. Toxicol Lett. 59:1991;147-152.
27. Xu M.J., Albertsa D.S., Peng Y.M., Liu Y., Canfield L.M. Simultaneous analysis of plasma retinol, retinyl palmitate, δ-γ-α-tocopherol and six major carotenoids by isocratic non-aqueous reversed-phase HPLC method. Proc Am Assoc Cancer Res. 37:1996;277.
28. Lopez M.C., Huang D.S., Watzl B., Chen G.J., Watson R.R. Splenocytes subsets in normal and protein malnourished mice after long term exposure to cocaine or morphine. Life Sci. 49:1991;1253-1263.
29. Nunez C., Nishimoto N., Gartland G.L.et al. B cells are generated throughout life in humans. J Immunol. 156:1996;866-872.
30. Pike J., Chandra R.K. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vitam Nutr Res. 65:1995;117-121.
31. Geiselhart L.A., Christian T., Minnear F., Freed B.M. The cigarette tar component p-benzoquinone blocks T-lymphocyte activation by interleukin-2 production, but not CD25, ICAM-1, or LFA-1 expression. Toxicol Appl Pharmacol. 143:1997;30-36.
32. Madretsma G.S., Donze G.J., van Dijk A.P., Tak C.J., Wilson J.H., Zijlstra F.J. Nicotine inhibits the invitro production of interleukin-2 and tumour necrosis factor-alpha by human mononuclear cells. Immunopharmacology. 35:1996;47-51.
33. Patki A.H., Quinones-Mateu M.E., Dorazio D.et al. Activation of antigen-induced lymphocyte proliferation by interleukin-15 without the mitogenic effect of interluekin-2 that may induce human immunodeficiency virus-1 expression. J Clin Invest. 98:1996;616-621.
34. Rea I.M., Stewart M., Campbell P., Alexander H.D., Crockard A.D., Morris T.C. Changes in lymphocyte subsets, interleukin-2, and soluble interleukin-2 receptor in old and very old age. Gerontology. 42:1996;69-78.
35. Hirano T. Interleukin-6. Thomson A. The cytokine handbook. 1994;Academic Press, San Diego, CA.
36. Roubenoff R., Harris T.B., Abad L.W., Wilson P.W., Dallal G.E., Dinarello C.A. Monocyte cytokine production in an elderly population. Effect of age and inflammation J Gerontol A Biol Sci Med Sci. 53:1998;M20-M26.
37. Albright J.W., Albright J.F. Impaired natural killer cell function as a consequence of aging. Exp Gerontol. 33:1998;13-25.
38. Ogata K., Yokose N., Tamura H.et al. Natural killer cells in the late decades of human life. Clin Immunol Immunopathol. 84:1997;269-275.
39. Chakraborty A., Chakraborty N.G., Chattopadhyay U. Prolactin response of NK cells, but not of LAK cells, is deficient in patients with carcinoma of oral cavity and during aging. Int J Cancer. 66:1996;65-69.
40. Santos M.S., Meydani S.N., Leka L.et al. Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation. Am J Clin Nutr. 64:1996;772-777.
41. Santos M.S., Gaziano J.M., Leka L., Beharka A.A., Hennekens C.H., Meydani M. β-Carotene-induced enhancement of natural killer cell activity in elderly men. An investigation of the role of cytokines Am J Clin Nutr. 68:1998;164-170.
42. Carlos T.F., Riondel J., Mathieu J., Guiraud P., Mestries J.C., Favier A. Beta-carotene enhances natural killer cell activity in athymic mice. In Vivo. 11:1997;87-91.
43. Kutza J., Murasko D.M. Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples. Mech Ageing Dev. 90:1996;209-222.
44. Riso P., Porrini M. Determination of carotenoids in vegetable foods and plasma. Int J Vitamin Nutr Res. 67:1997;47-54.
45. Yeum K.J., Booth S.L., Sadowski J.A.et al. Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables. Am J Clin Nutr. 64:1996;594-602.
46. Smith M.J., Inserra P.F., Bowden R.D., Watson R.R. O'Neill K. Supplementation with fruit and vegetable extracts reduces DNA damage in the peripheral lymphocytes of an elderly population. Nutr. Res. 19:1999;1507-1518.