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Volumn 15, Issue 10, 1996, Pages 2476-2487

An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif

Author keywords

Cooperative binding; Homeodomain; Homeotic; Labial; PBX

Indexed keywords

HEXAPEPTIDE; HOMEODOMAIN PROTEIN; MUTANT PROTEIN;

EID: 0029925624     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00605.x     Document Type: Article
Times cited : (109)

References (28)
  • 1
    • 0026603768 scopus 로고
    • Downstream of the homeotic genes
    • Andrew,D.J. and Scott,M.P. (1992) Downstream of the homeotic genes. New Biol., 4, 5-15.
    • (1992) New Biol. , vol.4 , pp. 5-15
    • Andrew, D.J.1    Scott, M.P.2
  • 2
    • 0342759569 scopus 로고
    • Isolation and sequence-specific DNA binding of the Antennapedia homeodomain
    • Muller,M., Affolter,M., Leupin,W., Otting,G., Wuthrich,K. and Gehring,W.J. (1988) Isolation and sequence-specific DNA binding of the Antennapedia homeodomain. EMBO J., 7, 4299-4304.
    • (1988) EMBO J. , vol.7 , pp. 4299-4304
    • Muller, M.1    Affolter, M.2    Leupin, W.3    Otting, G.4    Wuthrich, K.5    Gehring, W.J.6
  • 3
    • 0029079663 scopus 로고
    • The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins
    • Neuteboom,S., Peltenburg,L., van Dijk,M. and Murre,C. (1995) The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins. Proc. Natl Acad. Sci. USA, 92, 9166-9170.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 9166-9170
    • Neuteboom, S.1    Peltenburg, L.2    Van Dijk, M.3    Murre, C.4
  • 4
    • 0025064238 scopus 로고
    • Chromosomal translocation t(1:19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
    • Nourse,J., Mellentin,J., Galili,N., Wilkinson,J., Stanbridge,E., Smith,S. and Cleary,M. (1990) Chromosomal translocation t(1:19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell, 60, 535-545.
    • (1990) Cell , vol.60 , pp. 535-545
    • Nourse, J.1    Mellentin, J.2    Galili, N.3    Wilkinson, J.4    Stanbridge, E.5    Smith, S.6    Cleary, M.7
  • 5
    • 0028722641 scopus 로고
    • Imaging neuronal subsets and other cell types in whole mount Drosophila embryos and larvae using antibody probes
    • Goldstein,L.S.B. and Fyrberg,E. (eds). Academic Press, New York
    • Patel,N.H. (1994) Imaging neuronal subsets and other cell types in whole mount Drosophila embryos and larvae using antibody probes. In Goldstein,L.S.B. and Fyrberg,E. (eds). Drasophila melanogaster: Practical Uses in Cell Biology. Academic Press, New York, pp. 445-487.
    • (1994) Drasophila Melanogaster: Practical Uses in Cell Biology , pp. 445-487
    • Patel, N.H.1
  • 6
    • 0025365228 scopus 로고
    • Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity
    • Peifer,M. and Wieschaus,E. (1990) Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity. Genes Dev., 4, 1209-1223.
    • (1990) Genes Dev. , vol.4 , pp. 1209-1223
    • Peifer, M.1    Wieschaus, E.2
  • 7
    • 0028146174 scopus 로고
    • Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm
    • Phelan,M.L., Sadoul,R. and Featherstone,M.S. (1994) Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm. Mol. Cell. Biol., 14, 5066-5075.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5066-5075
    • Phelan, M.L.1    Sadoul, R.2    Featherstone, M.S.3
  • 8
    • 0029008293 scopus 로고
    • Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif
    • Phelan,M.L., Ramhaldi,I. and Fealherstone,M. (1995) Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol. Cell. Biol., 15, 3989-3997.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3989-3997
    • Phelan, M.L.1    Ramhaldi, I.2    Fealherstone, M.3
  • 9
    • 0029055810 scopus 로고
    • Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/Pbx
    • Popperl,H., Bienz,M., Sluder,M., Chan,S.-K., Aparicio,S., Brenner,S., Mann,R. and Krumlauf,R. (1995) Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/Pbx. Cell, 81, 1031-1042.
    • (1995) Cell , vol.81 , pp. 1031-1042
    • Popperl, H.1    Bienz, M.2    Sluder, M.3    Chan, S.-K.4    Aparicio, S.5    Brenner, S.6    Mann, R.7    Krumlauf, R.8
  • 10
    • 0027934301 scopus 로고
    • Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins
    • Rauskolb,C. and Wieschaus,E. (1994) Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins. EMBO J., 13, 3561-3569.
    • (1994) EMBO J. , vol.13 , pp. 3561-3569
    • Rauskolb, C.1    Wieschaus, E.2
  • 11
    • 0027519720 scopus 로고
    • extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
    • Rauskolb,C., Peifer,M. and Wieschaus,E. (1993) extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell, 74, 1-20.
    • (1993) Cell , vol.74 , pp. 1-20
    • Rauskolb, C.1    Peifer, M.2    Wieschaus, E.3
  • 12
    • 0025975559 scopus 로고
    • High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene
    • Regulski,M., Dessain,S., McGinnis,N. and McGinnis,W. (1991) High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene. Genes Dev., 5, 278-286.
    • (1991) Genes Dev. , vol.5 , pp. 278-286
    • Regulski, M.1    Dessain, S.2    McGinnis, N.3    McGinnis, W.4
  • 13
    • 0025602161 scopus 로고
    • Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos
    • Reuter,R., Panganiban,G.E., Hoffmann,F.M. and Scott.M.P. (1990) Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos. Development, 110, 1031-1040.
    • (1990) Development , vol.110 , pp. 1031-1040
    • Reuter, R.1    Panganiban, G.E.2    Hoffmann, F.M.3    Scott, M.P.4
  • 14
    • 0028079760 scopus 로고
    • Activator-induced conformational change in general transcription factor TFIIB
    • Roberts,S. and Green,M. (1994) Activator-induced conformational change in general transcription factor TFIIB. Nature, 371, 717-720.
    • (1994) Nature , vol.371 , pp. 717-720
    • Roberts, S.1    Green, M.2
  • 15
    • 0027439276 scopus 로고
    • The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1
    • Sánchez-García,I., Osada,H., Forster,A. and Rabbitts,J.H. (1993) The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1. EMBO J., 12, 4243-4250.
    • (1993) EMBO J. , vol.12 , pp. 4243-4250
    • Sánchez-García, I.1    Osada, H.2    Forster, A.3    Rabbitts, J.H.4
  • 16
    • 0025071850 scopus 로고
    • Evidence of changes in protease sensitivity and subunil exchange rale on DNA binding by CI EBP
    • Shuman,J., Vinson,C. and McKnight,S. (1990) Evidence of changes in protease sensitivity and subunil exchange rale on DNA binding by CI EBP. Science, 249, 771-774.
    • (1990) Science , vol.249 , pp. 771-774
    • Shuman, J.1    Vinson, C.2    McKnight, S.3
  • 17
    • 0024296676 scopus 로고
    • Chelating peptide-immobilized metal ion affinity chromatography. A new concept in affinity chromatography for recombinant proteins
    • Smith,M.C., Furman,T.C., Ingolia,T.D. and Pidgeon,C. (1988) Chelating peptide-immobilized metal ion affinity chromatography. A new concept in affinity chromatography for recombinant proteins. J. Biol. Chem, 263, 7211-7215.
    • (1988) J. Biol. Chem , vol.263 , pp. 7211-7215
    • Smith, M.C.1    Furman, T.C.2    Ingolia, T.D.3    Pidgeon, C.4
  • 18
    • 0028821180 scopus 로고
    • Ultrabithorax protein is necessary but not sufficient for full activalion of decapentaptegic expression in the visceral mesoderm
    • Sun,B., Hursh,D.A., Jackson,D. and Beachy,P.A. (1995) Ultrabithorax protein is necessary but not sufficient for full activalion of decapentaptegic expression in the visceral mesoderm. EMBO J., 14, 520-535.
    • (1995) EMBO J. , vol.14 , pp. 520-535
    • Sun, B.1    Hursh, D.A.2    Jackson, D.3    Beachy, P.A.4
  • 19
    • 0028587878 scopus 로고
    • Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus
    • Taira,M., Otani,H., Saint-Jeannet,J.P. and Dawid,I.B. (1994) Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus. Nature, 372, 677-679.
    • (1994) Nature , vol.372 , pp. 677-679
    • Taira, M.1    Otani, H.2    Saint-Jeannet, J.P.3    Dawid, I.B.4
  • 20
    • 0024319520 scopus 로고
    • A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
    • Tautz,D. and Pfeifle,C. (1989) A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma, 98, 81-85.
    • (1989) Chromosoma , vol.98 , pp. 81-85
    • Tautz, D.1    Pfeifle, C.2
  • 21
    • 0026489666 scopus 로고
    • Induction of labial expression in the Drosophila endoderm: Response elements for dpp signalling and for autoregulation
    • Tremml,G. and Bienz,M. (1992) Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation. Development, 116, 447-456.
    • (1992) Development , vol.116 , pp. 447-456
    • Tremml, G.1    Bienz, M.2
  • 22
    • 0026492021 scopus 로고
    • Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene distal-less
    • Vachon,G., Cohen,B., Pfeifle,C., McGuffin,M.E., Botas,J. and Cohen,S. (1992) Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene distal-less. Cell. 71, 437-450.
    • (1992) Cell , vol.71 , pp. 437-450
    • Vachon, G.1    Cohen, B.2    Pfeifle, C.3    McGuffin, M.E.4    Botas, J.5    Cohen, S.6
  • 23
    • 0028169993 scopus 로고
    • extradenticle raises the DNA binding specificity of homeotic selector gene products
    • van Dijk,M. and Murre,C. (1994) extradenticle raises the DNA binding specificity of homeotic selector gene products. Cell, 78, 617-624.
    • (1994) Cell , vol.78 , pp. 617-624
    • Van Dijk, M.1    Murre, C.2
  • 24
    • 0019880194 scopus 로고
    • Analysis of larval segmentation in lethal genotypes associated with the antennapedia gene complex in Drosophila melanogaster
    • Wakimoto,B.T. and Kaufman,T.C. (1981) Analysis of larval segmentation in lethal genotypes associated with the antennapedia gene complex in Drosophila melanogaster. Dev. Biol., 81, 51-64.
    • (1981) Dev. Biol. , vol.81 , pp. 51-64
    • Wakimoto, B.T.1    Kaufman, T.C.2
  • 25
    • 0024043341 scopus 로고
    • mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans
    • Way,J.C. and Chalfie,M. (1988) mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Cell, 54, 5-16.
    • (1988) Cell , vol.54 , pp. 5-16
    • Way, J.C.1    Chalfie, M.2
  • 26
    • 0026002757 scopus 로고
    • Crystal structure of a MAT alpha 2 homeodomain-operalor complex suggests a general model for homeodomain-DNA interactions
    • Wolberger,C., Vershon,A.K., Liu,B., Johnson,A.D. and Pabo,C.O. (1991) Crystal structure of a MAT alpha 2 homeodomain-operalor complex suggests a general model for homeodomain-DNA interactions. Cell, 67, 517-528.
    • (1991) Cell , vol.67 , pp. 517-528
    • Wolberger, C.1    Vershon, A.K.2    Liu, B.3    Johnson, A.D.4    Pabo, C.O.5
  • 27
    • 0027288479 scopus 로고
    • Ectopic expression and function of the Antp and Scr homeotic genes: The N terminus of the homeodomian is critical to functional specificity
    • Zeng,W., Andrew,D.J., Mathies,L.D., Horner,M.A. and Scott,M.P. (1993) Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomian is critical to functional specificity. Development, 118, 339-352.
    • (1993) Development , vol.118 , pp. 339-352
    • Zeng, W.1    Andrew, D.J.2    Mathies, L.D.3    Horner, M.A.4    Scott, M.P.5
  • 28
    • 0028278228 scopus 로고
    • Deformed protein binding sites and cofactor binding sites are required for the function of a small segment-specific regulatory element in Drosophila embryos
    • Zeng,C. Pinsonneault,J., Gellon,G., McGinnis,N. and McGinnis,W. (1994) Deformed protein binding sites and cofactor binding sites are required for the function of a small segment-specific regulatory element in Drosophila embryos. EMBO J., 13, 2362-2377.
    • (1994) EMBO J. , vol.13 , pp. 2362-2377
    • Zeng, C.1    Pinsonneault, J.2    Gellon, G.3    McGinnis, N.4    McGinnis, W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.