Induction of the human ARF protein by serum starvation

Anticancer Research

Volumn 19, Issue 4 B, 1999, Pages 2939-2943

  Inoue, Rie ^a,c   Asker, Charlotte ^a   Klangby, Ulf ^a   Pisa, Pavel ^b   Wiman, Klas G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

Human ARF; Serum starvation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; MESSENGER RNA; VIRUS LARGE T ANTIGEN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE INDUCTION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN INDUCTION; SERUM; SIMIAN VIRUS 40;

CULTURE MEDIA, SERUM-FREE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE EXPRESSION REGULATION; HUMANS; TUMOR CELLS, CULTURED;

EID: 0033403839     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Serrano M, Hannon GJ, and Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707, 1993.
2. Koh J, Enders GH, Dynlacht BD, and Harlow E: Tumor-drived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375: 506-510, 1995.
3. Serrano M: The tumor suppressor protein p161NK4. Experimental Cell Research 237: 1-13, 1997.
4. Mao L, Merlo A, Bedi G, Shapiro GI, Edwards CD, Rollins BJ and Sidransky D: A novel p16INK4A transcript. Cancer Research 55: 2995-2997, 1995.
5. Stone S, Jiang P, Dayananth P, Tavtigian SV, Katcher H, Parry D, Peters G, and Kamb A: Complex structure and regulation of the P16 (MTS1) locus. Cancer Research 55: 2988-2994, 1995.
6. ARF. Cell 91: 649-659, 1997.
7. Quelle DE, Zindy F, Ashmun RA and Sherr CJ: Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83: 993-1000, 1995.
8. Liggett WH, Jr, Sewell DA, Rocco J, Ahrendt SA, Koch W and Sidransky D: p16 and p16 beta are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Research 56: 4119-4123, 1996.
9. Honda R and Yasuda H: Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p5. The EMBO Journal 18: 22-27, 1999.
10. Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92: 713-723, 1998.
11. Zhang Y, Xiong Y, and Yarbrough WG: ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4α locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92: 725-734, 1998.
12. Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel M, and Sherr CJ: Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2: Proceedings of the National Academy of Sciences of the United States of America 95: 8292-8297, 1998.
13. Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ and Roussel MF: Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes and Development 12: 2424-2433, 1998.
14. ARF tumor suppressor. Gene and Development 12: 2434-2442, 1998.
15. DeGregori J, Leone G, Miron A, Jakoi L, and Nevins JR: Distinct roles for E2F proteins in cell growth control and apoptosis. Proceedings of the National Academy of Sciences of the United States of America 94: 7245-7250, 1997.
16. Bates S, Phillips AC, Clark PA, Stott FJ, Peters G, Ludwig RL, and Vousden KH: p14ARF links the tumor suppressors RB and p53. Nature 395: 124-125, 1998.
17. Sherr CJ: Tumor surveillance via the ARF-p53 pathway Genes and Development 12: 2984-2991, 1998.
18. Klangby U, Okan I, Magnusson P, Wendland M, Lind P, and Wiman KG: p15/INK4a and p15/INK4b gene methylation and absentee of p16/INK4a mRNA and protein expression in Burkitt's lymphoma. Blood. 91: 1680-1687, 1998.
19. ARF, participates in a regulatory feedback loop with p53 and MDM2. The EMBO Journal 17: 5001-5014, 1998.
20. Robertson KD and Jones PA: The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down regulated by wild-type p53. Molecular and Cellular Biology 18: 6457-6473, 1998.
21. Tsai KY, Hu Y, Macleod KF, Crowley D, Yamasaki L, and Jacks T: Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Molecular Cell 2: 293-304, 1998.
22. Gray-Bablin J, Zalvide J, Fox MP, Knickerbocker CJ, DeCaprio JA, and Keyomarsi K: Cyclin E a redundant cyclin in breast cancer. Proceedings of the National Academy of Sciences of the United States of America 93: 15215-15220, 1996.
23. Rhim JS, Jay G, Arnstein P, Price FM, Sanford KK, and Aaronson SA: Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses. Science 227: 1250-1252, 1985.
24. INK4a/MTSI gene. Oncogene 15: 2475-2481, 1997.