p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma

Blood

Volumn 91, Issue 5, 1998, Pages 1680-1687

  Klangby, Ulf ^b   Okan, Ismail ^b   Magnusson, Kristinn P ^b   Wendland, Martin ^b   Lind, Peter ^b   Wiman, Klas G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ARTICLE; B CELL LYMPHOMA; BURKITT LYMPHOMA; CELL CYCLE G1 PHASE; CHROMOSOME TRANSLOCATION; COMPLEX FORMATION; GENE DELETION; GENE MUTATION; GENETIC REGULATION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; METHYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANDEM REPEAT; TUMOR SUPPRESSOR GENE;

EID: 0032030648     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.5.1680.1680_1680_1687     Document Type: Article

References (32)

1. Sherr CJ: Cancer cell cycles. Science 274:1672, 1996
2. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81:323, 1995
3. Sherr CJ, Roberts JM: Inhibitors of mammalian G1 cyclindependent kinases. Genes Dev 9:1149, 1995
4. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/cdk4. Nature 366:704, 1993
5. Hannon GJ, Beach D: p15/INK4b is a potential effector of cell cycle arrest mediated by TGF-β. Nature 371:257, 1994
6. Hall M, Bates S, Peters G: Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene 11:1581, 1995
7. Kamb A, Gruis NE, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day III RS, Johnson BE, Skolnick MH: A cell cycle regulator potentially involved in genesis of many tumor types. Science 264:436, 1994
8. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368:753. 1994
9. Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM, Jones PA: Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55:4531, 1995
10. Herman JG, Merlo A, Mao L, Lapidus RG, Issa JP, Davidson NE, Sidransky D, Baylin SB: Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55:4525, 1995
11. Herman JG, Jen J, Merlo A, Baylin SB: Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 56:722, 1996
12. Lo KW, Cheung ST, Leung SF, van Hasselt A, Tsang YS, Mak KF, Chung YF, Woo JKS, Lee JCK, Huang DP: Hypermethylation of the p16 gene in nasopharyngeal carcinoma. Cancer Res 56:2721, 1996
13. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nature Med 1:686, 1995
14. Duro D, Bernard O, Della Valle V, Berger R, Larsen CJ: A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies. Oncogene 11:21, 1995
15. Mao L, Merlo A, Bedi G, Shapiro GI, Edwards CD, Rollins BJ, Sidransky D: A novel p16INK4A transcript. Cancer Res. 55:2995-7, 1995
16. Stone S, Jiang P, Dayananth P, Tavtigian SV, Katcher H, Parry D, Peters G, Kamb A: Complex structure and regulation of the P16 (MTS1) locus. Cancer Res 55:2988, 1995
17. Quelle DE, Zindy F, Ashmun RA, Sherr CJ: Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83:993, 1995
18. Serrano M, Lee HW, Chin L, Cordon-Cardo C, Beach D, DePinho RA: Role of the lNK4a locus in tumor suppression and cell mortality. Cell 86:27, 1996
19. Klein G: Epstein-Barr virus strategy in normal and neoplastic B cells. Cell 77:791, 1994
20. Farrell PJ, Allan GJ, Shanahan F, Vousden KH, Crook T: p53 is frequently mutated in Burkitt's lymphoma cell lines. EMBO J 10:2879, 1991
21. Gaidano G, Ballerini P, Gong JZ, Inghirami G, Neri A, Newcomb EW, Magrath IT, Knowles DM, Dalla-Favera R: p53 mutations in human lymphoid malignancies: Association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci USA 88:5413, 1991
22. Wiman KG, Magnusson KP, Ramqvist T, Klein G: Mutant p53 detected in a majority of Burkitt lymphoma cell lines by monoclonal antibody PAb240. Oncogene 6:1633, 1991
23. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual (ed 2). Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1989
24. Harlow E, Lane D: Antibodies: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1988
25. Stranks G, Height SE, Mitchell P, Jadayel D, Yuille MA, De Lord C, Clutterbuck RD, Treleaven JG, Powles RL, Nacheva E, Oscier DG, Karpas A, Lenoir GM, Smith SD, Millar JL, Catovsky D, Dyer MJS: Deletions and rearrangement of CDKN2 in lymphoid malignancy. Blood 85:893, 1995
26. Herman JG, Civin CI, Issa J-PJ, Collector MI, Sharkis SJ, Baylin SB: Distinct patterns of inactivation of p15INK4A and p16INK4A characterize the major types of hematological malignancies. Cancer Res 57:837, 1997
27. Rasool O, Heyman M, Brandter LB, Liu Y, Grander D, Soderhall S, Einhorn S: p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia. Blood 85:3431, 1995
28. Bhatia KG, Gutierrez MI, Huppi K, Siwarski D, Magrath IT: The pattern of p53 mutations in Burkitt's lymphoma differs from that of solid tumors. Cancer Res 52:4273, 1992
29. Galaktionov K, Chen X, Beach D: Cdc25A cell-cycle phosphatase as a target of c-myc. Nature 382:511, 1996
30. Serrano M, Gómez-Lahoz E, DePinho RA, Beach D, Bar-Sagi D: Inhibition of Ras-induced proliferation and cellular transformation by p16INK4A. Science 267:249, 1995
31. Hermeking H, Eick D: Mediation of c-myc-induced apoptosis by p53. Science 265:2091, 1994
32. Haupt Y, Rowan S, Oren M: p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene 10:1563, 1995