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Volumn 378, Issue 2, 1997, Pages 89-98

Glucagon gene G3 enhancer: Evidence that activity depends on combination of an islet-specific factor and a winged helix protein

Author keywords

Insulin; Pancreatic islets; Somatostatin; Transcription; subunit glycoprotein hormone

Indexed keywords

DNA BINDING PROTEIN; GLUCAGON; HELIX LOOP HELIX PROTEIN; INSULIN; NUCLEAR PROTEIN; SOMATOSTATIN; TRANSCRIPTION FACTOR;

EID: 0342618406     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/bchm.1997.378.2.89     Document Type: Article
Times cited : (10)

References (38)
  • 1
    • 0023949396 scopus 로고
    • Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons
    • Alpert, S., Hanahan, D., and Teitelman, G. (1988). Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53, 295-308.
    • (1988) Cell , vol.53 , pp. 295-308
    • Alpert, S.1    Hanahan, D.2    Teitelman, G.3
  • 2
    • 0027322128 scopus 로고
    • Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/fork-head DNA-binding-domain family
    • Clevidence, D.E., Overdier, D.G., Tao, W., Qlan, X., Pani, L., Lai, E., and Costa, R.H. (1993). Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/fork-head DNA-binding-domain family. Proc. Natl. Acad. Sci. USA 90, 3948-3952.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3948-3952
    • Clevidence, D.E.1    Overdier, D.G.2    Tao, W.3    Qlan, X.4    Pani, L.5    Lai, E.6    Costa, R.H.7
  • 3
    • 0028940962 scopus 로고
    • Binding sites for hepatocyte nuclear factor 3 beta or 3 gamma and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase
    • Cockell, M., Stolarczyk, D., Frutiger, S., Hughes, G.J., Hagenbüchle, O., and Wellauer, P.K. (1995). Binding sites for hepatocyte nuclear factor 3 beta or 3 gamma and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase. Mol. Cell. Biol. 15, 1933-1941.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1933-1941
    • Cockell, M.1    Stolarczyk, D.2    Frutiger, S.3    Hughes, G.J.4    Hagenbüchle, O.5    Wellauer, P.K.6
  • 4
    • 0024556115 scopus 로고
    • Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and α1-antitrypsin genes
    • Costa, R.H., Grayson, D.R., and Darnell, J.E., Jr. (1989). Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and α1-antitrypsin genes. Mol. Cell. Biol. 9, 1415-1425.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 1415-1425
    • Costa, R.H.1    Grayson, D.R.2    Darnell Jr., J.E.3
  • 5
    • 0021100690 scopus 로고
    • Accurate transcriptional initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J.D., Lebovitz, R.M., and Roeder, R.G. (1983). Accurate transcriptional initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 6
    • 0022377642 scopus 로고
    • Cell-specific expression of the rat insulin gene: Evidence for the role of two distinct 5′-flanking sequences
    • Edlund, T., Walker, M.D., Barr, P.J., and Rutter, W.J. (1985). Cell-specific expression of the rat insulin gene: evidence for the role of two distinct 5′-flanking sequences. Science 230, 912-916.
    • (1985) Science , vol.230 , pp. 912-916
    • Edlund, T.1    Walker, M.D.2    Barr, P.J.3    Rutter, W.J.4
  • 7
    • 0024074541 scopus 로고
    • Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic a cells
    • Efrat, S., Teitelman, G., Anwar, M., Ruggiero, D., and Hanahan, D. (1988). Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic a cells. Neuron 1, 605-613.
    • (1988) Neuron , vol.1 , pp. 605-613
    • Efrat, S.1    Teitelman, G.2    Anwar, M.3    Ruggiero, D.4    Hanahan, D.5
  • 8
    • 0028854837 scopus 로고
    • A B-cell coactivator of octamer-binding transcription factors
    • Gstaiger, M., Knoepfel, L., Georgiev, O., Schaffner, W., and Hovens, C.M. (1995). A B-cell coactivator of octamer-binding transcription factors. Nature 373, 360-362.
    • (1995) Nature , vol.373 , pp. 360-362
    • Gstaiger, M.1    Knoepfel, L.2    Georgiev, O.3    Schaffner, W.4    Hovens, C.M.5
  • 9
    • 0023477391 scopus 로고
    • A mutational analysis of the insulin gene transcription control region: Expression in beta cells is dependent on two related sequences within the enhancer
    • Karlsson, O., Edlund, T., Barnett Moss, J., Rutter, W.J., and Walker, M.D. (1987). A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc. Natl. Acad. Sci. USA 84, 8819-8823.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 8819-8823
    • Karlsson, O.1    Edlund, T.2    Barnett Moss, J.3    Rutter, W.J.4    Walker, M.D.5
  • 10
    • 0025259880 scopus 로고
    • The human α subunit glycoprotein hormone gene utilizes a unique CCAAT binding factor
    • Kennedy, G.C., Andersen, B., and Nilson, J.H. (1990). The human α subunit glycoprotein hormone gene utilizes a unique CCAAT binding factor. J. Biol. Chem. 265, 6279-6285.
    • (1990) J. Biol. Chem. , vol.265 , pp. 6279-6285
    • Kennedy, G.C.1    Andersen, B.2    Nilson, J.H.3
  • 11
    • 0025935925 scopus 로고
    • The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I gene
    • Knepel, W., Vallejo, M., Chafitz, J.A., and Habener, J.F. (1991). The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I gene. Mol. Endocrinol. 5, 1457-1466.
    • (1991) Mol. Endocrinol. , vol.5 , pp. 1457-1466
    • Knepel, W.1    Vallejo, M.2    Chafitz, J.A.3    Habener, J.F.4
  • 12
    • 0025358693 scopus 로고
    • A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins
    • Knepel, W., Jepeal, L., and Habener, J.F. (1990). A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins. J. Biol. Chem. 265, 8725-8735.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8725-8735
    • Knepel, W.1    Jepeal, L.2    Habener, J.F.3
  • 13
    • 0027211755 scopus 로고
    • An endocrine-specific element is an integral component of an exocrine-specific pancreatic enhancer
    • Kruse, F., Rose, S.D., Swift, G.H., Hammer, R.E., and MacDonald, J. (1993). An endocrine-specific element is an integral component of an exocrine-specific pancreatic enhancer. Genes Dev. 7, 774-786.
    • (1993) Genes Dev. , vol.7 , pp. 774-786
    • Kruse, F.1    Rose, S.D.2    Swift, G.H.3    Hammer, R.E.4    MacDonald, J.5
  • 14
    • 0027482831 scopus 로고
    • Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: A family of transcription factors of diverse biologic function
    • Lai, E., Clark, K.L., Burley, S.K., and Darnell, J.E., Jr. (1993). Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function. Proc. Natl. Acad. Sci. USA 90, 10421-10423.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10421-10423
    • Lai, E.1    Clark, K.L.2    Burley, S.K.3    Darnell Jr., J.E.4
  • 15
    • 0027373441 scopus 로고
    • Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
    • Leonard, J., Peers, B., Johnson, T., Ferreri, K., Lee, S., and Montminy, M.R. (1993). Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol. Endocrinol. 7, 1275-1283.
    • (1993) Mol. Endocrinol. , vol.7 , pp. 1275-1283
    • Leonard, J.1    Peers, B.2    Johnson, T.3    Ferreri, K.4    Lee, S.5    Montminy, M.R.6
  • 16
    • 0028314969 scopus 로고
    • IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islet and duodenum that transactivates the somatostatin gene
    • Miller, C.P., McGehee, R.E., Jr., and Habener, J.F. (1994). IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islet and duodenum that transactivates the somatostatin gene. EMBO J. 13, 1145-1156.
    • (1994) EMBO J. , vol.13 , pp. 1145-1156
    • Miller, C.P.1    McGehee Jr., R.E.2    Habener, J.F.3
  • 17
    • 0024396320 scopus 로고
    • Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
    • Mitchell, J., and Tjian, R. (1989). Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245, 371-378.
    • (1989) Science , vol.245 , pp. 371-378
    • Mitchell, J.1    Tjian, R.2
  • 18
    • 0024002556 scopus 로고
    • Luciferase reporter gene vectors for analysis of promoters and enhancers
    • Nordeen, S.K. (1988). Luciferase reporter gene vectors for analysis of promoters and enhancers. BioTechniques 6, 454-457.
    • (1988) BioTechniques , vol.6 , pp. 454-457
    • Nordeen, S.K.1
  • 19
    • 0022449158 scopus 로고
    • Sequence-specific interactions of nuclear factors with the insulin gene enhancer
    • Ohlsson, H., and Edlund, T. (1986). Sequence-specific interactions of nuclear factors with the insulin gene enhancer. Cell 45, 35-44.
    • (1986) Cell , vol.45 , pp. 35-44
    • Ohlsson, H.1    Edlund, T.2
  • 20
    • 0028353904 scopus 로고
    • The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix
    • Overdier, D.G., Porcella, A., and Costa, R.H. (1994). The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix. Mol. Cell. Biol. 14, 2755-2766.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2755-2766
    • Overdier, D.G.1    Porcella, A.2    Costa, R.H.3
  • 21
    • 0026672433 scopus 로고
    • Hepatocyte nuclear factor 3β contains two transcriptional activation domains, one of which is novel and conserved with the drosophila fork head protein
    • Pani, L., Overdier, D.G., Porcella, A., Qian, X., Lai, E., and Costa, R.H. (1992). Hepatocyte nuclear factor 3β contains two transcriptional activation domains, one of which is novel and conserved with the drosophila fork head protein. Mol. Cell. Biol. 12, 3723-3732.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3723-3732
    • Pani, L.1    Overdier, D.G.2    Porcella, A.3    Qian, X.4    Lai, E.5    Costa, R.H.6
  • 22
    • 0028986108 scopus 로고
    • Hepatocyte-nuclear factor 3β gene transcripts generate protein isoforms with different transactivation properties on the glucagon gene
    • Philipe, J. (1995). Hepatocyte-nuclear factor 3β gene transcripts generate protein isoforms with different transactivation properties on the glucagon gene. Mol. Endocrinol. 9, 368-374.
    • (1995) Mol. Endocrinol. , vol.9 , pp. 368-374
    • Philipe, J.1
  • 23
    • 0023723641 scopus 로고
    • Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins
    • Philippe, J., Drucker, D.J., Knepel, W., Jepeal, L., Misulovin, Z., and Habener, J.F. (1988). Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins. Mol. Cell. Biol. 8, 4877-4888.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 4877-4888
    • Philippe, J.1    Drucker, D.J.2    Knepel, W.3    Jepeal, L.4    Misulovin, Z.5    Habener, J.F.6
  • 24
    • 0028280977 scopus 로고
    • Glucagon gene expression is negatively regulated by hepatocyte nuclear factor 3β
    • Philippe, J., Morel, C., and Prezioso, V.R. (1994). Glucagon gene expression is negatively regulated by hepatocyte nuclear factor 3β. Mol. Cell. Biol. 14, 3514-3523.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3514-3523
    • Philippe, J.1    Morel, C.2    Prezioso, V.R.3
  • 25
    • 0028873948 scopus 로고
    • Islet-specific proteins interact with the insulin-response element of the glucagon gene
    • Philippe, J., Morel, C., and Cordier-Bussat, M. (1995). Islet-specific proteins interact with the insulin-response element of the glucagon gene. J. Biol. Chem. 270, 3039-3045.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3039-3045
    • Philippe, J.1    Morel, C.2    Cordier-Bussat, M.3
  • 26
    • 0024319163 scopus 로고
    • Somatostatin gene expression in pancreatic islet cells is directed by cell-specific DNA control elements and DNA-binding proteins
    • Powers, A.C., Tedeschi, F., Wright, K.E., Chan, J.S., and Habener, J.F. (1989). Somatostatin gene expression in pancreatic islet cells is directed by cell-specific DNA control elements and DNA-binding proteins. J. Biol. Chem. 264, 10048-10056.
    • (1989) J. Biol. Chem. , vol.264 , pp. 10048-10056
    • Powers, A.C.1    Tedeschi, F.2    Wright, K.E.3    Chan, J.S.4    Habener, J.F.5
  • 27
    • 0025349639 scopus 로고
    • Proglucagon processing similar to normal islets in pancreatic α-like cell line derived from transgenic mouse tumor
    • Powers, A.C., Efrat, S., Mojsov, S., Spector, D., Habener, J.F., and Hanahan, D. (1990). Proglucagon processing similar to normal islets in pancreatic α-like cell line derived from transgenic mouse tumor. Diabetes 39, 406-414.
    • (1990) Diabetes , vol.39 , pp. 406-414
    • Powers, A.C.1    Efrat, S.2    Mojsov, S.3    Spector, D.4    Habener, J.F.5    Hanahan, D.6
  • 28
    • 0023739967 scopus 로고
    • A family of human CCAAT-box-binding proteins active in transcription and DNA replication: Cloning and expression of multiple cDNAs
    • Santoro, C., Mermod, N., Andrews, P.C., and Tjian, R. (1988). A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature 334, 218-324.
    • (1988) Nature , vol.334 , pp. 218-324
    • Santoro, C.1    Mermod, N.2    Andrews, P.C.3    Tjian, R.4
  • 29
    • 0027416480 scopus 로고
    • Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element
    • Schwaninger, M., Lux, G., Blume, R., Oetjen, E., Hidaka, H., and Knepel, W. (1993). Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element. J. Biol. Chem. 268, 5168-5177.
    • (1993) J. Biol. Chem. , vol.268 , pp. 5168-5177
    • Schwaninger, M.1    Lux, G.2    Blume, R.3    Oetjen, E.4    Hidaka, H.5    Knepel, W.6
  • 30
    • 0028988020 scopus 로고
    • 2+-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements
    • 2+-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. J. Biol. Chem. 270, 8860-8866.
    • (1995) J. Biol. Chem. , vol.270 , pp. 8860-8866
    • Schwaninger, M.1    Blume, R.2    Krüger, M.3    Lux, G.4    Oetjen, E.5    Knepel, W.6
  • 31
    • 0028920041 scopus 로고
    • Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3
    • Sinha, S., Maity, S.N., Lu, J., and DeCrombrugghe, B. (1995). Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc. Natl. Acad. Sci. USA 92, 1624-1628.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1624-1628
    • Sinha, S.1    Maity, S.N.2    Lu, J.3    DeCrombrugghe, B.4
  • 32
    • 0025690311 scopus 로고
    • Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
    • Sladek, F.M., Zhong, W., Lai, E., and Darnell, J.E., Jr. (1990). Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4, 2353-2365.
    • (1990) Genes Dev. , vol.4 , pp. 2353-2365
    • Sladek, F.M.1    Zhong, W.2    Lai, E.3    Darnell Jr., J.E.4
  • 33
    • 0026031601 scopus 로고
    • CCAAT-enhancer binding protein: A component of a differentiation switch
    • Umek, R.M., Friedman, A.D., and McKnight, S.L. (1991). CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251, 288-292.
    • (1991) Science , vol.251 , pp. 288-292
    • Umek, R.M.1    Friedman, A.D.2    McKnight, S.L.3
  • 34
    • 0026723466 scopus 로고
    • Somatostatin gene transcription regulated by a bipartite pancreatic islet D-cell-specific enhancer coupled synergetically to a cAMP response element
    • Vallejo, M., Miller, C.P., and Habener, J.F. (1992a). Somatostatin gene transcription regulated by a bipartite pancreatic islet D-cell-specific enhancer coupled synergetically to a cAMP response element. J. Biol. Chem. 267, 12868-12875.
    • (1992) J. Biol. Chem. , vol.267 , pp. 12868-12875
    • Vallejo, M.1    Miller, C.P.2    Habener, J.F.3
  • 35
    • 0026776285 scopus 로고
    • Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB, IsI-1, and αCBF-like transcription factors
    • Vallejo, M., Penchuk, L., and Habener, J.F. (1992b). Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB, IsI-1, and αCBF-like transcription factors. J. Biol. Chem. 267, 12876-12884.
    • (1992) J. Biol. Chem. , vol.267 , pp. 12876-12884
    • Vallejo, M.1    Penchuk, L.2    Habener, J.F.3
  • 36
    • 0026657816 scopus 로고
    • Anterior pituitary development: Short tales from dwarf mice
    • Voss, J.W., and Rosenfeld, M.G. (1992). Anterior pituitary development: short tales from dwarf mice. Cell 70, 527-530.
    • (1992) Cell , vol.70 , pp. 527-530
    • Voss, J.W.1    Rosenfeld, M.G.2
  • 37
    • 0022595271 scopus 로고
    • Structure of the human glucagon gene
    • White, J.W., and Saunders, G.F. (1986). Structure of the human glucagon gene. Nucleic Acids Res. 14, 4719-4730.
    • (1986) Nucleic Acids Res. , vol.14 , pp. 4719-4730
    • White, J.W.1    Saunders, G.F.2
  • 38
    • 0029134311 scopus 로고
    • Transcriptional activity of domain A of the rat glucagon G3 element conferred by an islet-specific nuclear protein that also binds to similar pancreatic islet cell-specific enhancer sequences (PISCES)
    • Wrege, A., Diedrich, T., Hochhuth, C., and Knepel, W. (1995). Transcriptional activity of domain A of the rat glucagon G3 element conferred by an islet-specific nuclear protein that also binds to similar pancreatic islet cell-specific enhancer sequences (PISCES). Gene Expr. 4, 205-216.
    • (1995) Gene Expr. , vol.4 , pp. 205-216
    • Wrege, A.1    Diedrich, T.2    Hochhuth, C.3    Knepel, W.4


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