Identification and characterization of an active soluble form of human CD38 in normal and pathological fluids

International Immunology

Volumn 8, Issue 11, 1996, Pages 1643-1650

  Funaro, Ada ^a   Horenstein, Alberto L ^a,b   Calosso, Liliana ^a   Morra, Massimo ^a   Tarocco, Renzo P ^c   Franco, Luisa ^d   De Flora, Antonio ^d,e   Malavasi, Fabio ^a,f  

^a UNIVERSITY OF TURIN   (Italy)

^b DEPARTAMENTO DE FÍSICA   (Argentina)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e ADVANCED BIOTECHNOLOGY CENTER   (Italy)

^f UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Bifunctional ectoenzyme; CD38 ligand; Down modulation; Enzymatic cleavage; Soluble receptor

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CD38 ANTIGEN; GLYCOPROTEIN; MEMBRANE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMNION FLUID; ANTIGEN EXPRESSION; ANTIGEN PURIFICATION; ARTICLE; ASCITES; BINDING AFFINITY; BODY FLUID; CELL ADHESION; CELL CULTURE; CONTROLLED STUDY; CROSS LINKING; DOWN REGULATION; DRUG HYDROLYSIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOBLOTTING; LYMPHOCYTE ACTIVATION; MEMBRANE POTENTIAL; MULTIPLE MYELOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; TUMOR CELL LINE;

ADP-RIBOSYL CYCLASE; AMNIOTIC FLUID; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD38; ANTIGENS, DIFFERENTIATION; ASCITIC FLUID; BODY FLUIDS; HUMANS; LIGANDS; MEMBRANE GLYCOPROTEINS; N-GLYCOSYL HYDROLASES; SOLUBILITY; TUMOR CELLS, CULTURED;

EID: 0029849688     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.11.1643     Document Type: Article

References (39)

1. Funaro, A., Spagnoli, G. C., Ausiello, C. M., Alessio, M., Roggero, S., Delia, D., Zaccolo, M. and Malavasi, F. 1990. Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation. J. Immunol. 145:2390.
2. + lymphocytes: role of the human CD38 molecule. J. Immunol. 154:952.
3. Howard, M., Grimaldi, J. C., Bazan, J., Lund, E., Santos-Argumedo, L., Parkhouse, R. M. E., Walseth, T. and Lee, H. C. 1993. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 262:1056
4. +- glycohydrolase, ADP ribosyl cyclase and cyclic ADP-ribose hydrolase activities in human red cells. Biochem. Biophys. Res. Commun. 196:1459.
5. Lee, H. C. Galione, A. and Walseth, T.F. 1994. Cyclic ADP-ribose: metabolism and calcium mobilizing function. In Litwack, G. ed., Vitamins and Hormones 48, p. 199. Academic Press, Orlando, FL.
6. Malavasi, F., Funaro, A., Roggero, S., Horenstein, A. L., Calosso, L. and Mehta, K. 1994. Human CD38: one molecule in search of a function Immunol. Today 15:95.
7. Alessio, M., Roggero, S., Funaro, A., De Monte, L. B., Peruzzi, L., Geuna, M. and Malavasi, F. 1990. CD38 molecule: structural and biochemical analysis on human T lymphocytes, thymocytes, and plasma cells, J. Immunol. 145:878.
8. Funaro, A., De Monte, L. B., Dianzani, U., Forni, M. and Malavasi, F. 1993. Human CD38 is associated to distinct molecules which mediate transmembrane signaling in different lineages. Eur. J. Immunol. 23:2407.
9. Tohgo, A., Takasawa, S., Noguchi, N., Koguma, T., Nata, K., Sugimoto, T., Furuya, Y., Yonekura, H. and Okamoto, H. 1994. Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38. J. Biol. Chem. 269:28555.
10. Kontani, K., Nishina, H., Ohoka, Y., Takahasi, K. and Katada, T. 1993. NAD glycohydrolase specifically induced by retinoic acid in human leukemic HL-60 cells. J. Biol. Chem. 268: 16895.
11. Drach, J., McQueen, C., Engel, H., Andreef, M., Robertson, K. A., Collins, S. J., Malavasi, F. and Mehta, K. 1994. Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-α. Cancer Res. 54:1746.
12. Bazil, V. and Strominger, J. L. 1993. CD43, the major sialoglycoprotein of human lymphocytes, is proteolytic cleaved from the surface of stimulated lymphocytes and granulocytes. Proc. Natl Acad. Sci. USA 90:3792.
13. Müllberg, J., Schoolitink, H., Stoyan, T., Günter, M., Graeve, L., Buse, G., Mackiewicz, A., Heinrich, P. C. and Rose-John, S. 1993. The soluble interleukin-6 receptor is generated by shedding. Eur. J. Immunol. 23:473.
14. Malavasi, F., Caligaris-Cappio, F., Dellabona, P., Richiardi, P. and Carbonara, A. O. 1984. Characterization of a murine monoclonal antibody specific for early lymphohemopoietic cells. Human Immunol. 9:9.
15. Malavasi, F., Funaro, A., Alessio, M., De Monte, L. B., Ausiello, C. M., Dianzani, U., Lanza, F., Magrini, E., Momo, M. and Roggero, S. 1992. CD38: a multi-lineage cell activation molecule with a split personality. Int. J. Clin. Lab. Res. 22:73.
16. Laemmli, U. K. 1970. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227:680.
17. Harlow, E. and Lane, D. 1988. Antibodies. A Laboratory Manual. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY.
18. Guida, L., Franco, L., Zocchi, E. and De Flora, A. 1995. Structural role of disulfide bridges in the cyclic ADP-ribose related bifunctional ectoenzyme CD38. FEBS Lett. 368:481.
19. Graeff, R.M., Walseth, T. F., Frysell, K., Dale Branton, W. and Lee, H. C. 1994. Enzymatic synthesis and characterization of cGDP-ribose, J. Biol. Chem. 269:30260.
20. Lee, H. C., Zocchi, E., Guida, L., Franco, L., Benatti, U. and De Flora, A. 1993, Production and hydrolysis of cyclic ADP-ribose at the outer surface of human erythrocytes. Biochem Biophys Res. Commun. 191: 639.
21. Jackson D. G. and Bell, J. I. 1990. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J. Immunol. 144:2811.
22. States, D. J., Walseth, T. F. and Lee, H. C. 1992. Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38. Trends Biochem. Sci. 17:495.
23. Funaro, A., Roggero, S., Horenstein, A. L., Calosso, L., Dianzani, U., DeMonte, L., Zocchi, E., Franco, L., Guida, L., Ausiello, C. M., Drach, J., Mehta, K., Bargellesi, A. and Malavasi, F 1995. Human CD38: a transmembrane glycoprotein with pleiotropic ectoenzyme functions. In Schlossmann, S. F., Boumsell, L., Gieks, W., Harlan, J. M., Kishimoto, T., Morimoto, C., Ritz, J., Shaw, S., Silverstein, R., Springer, T., Tedder, T. F. and Todd, R. F., eds. Leukocyte Typing V: White Cell Differentiation Antigen, p. 381. Oxford University Press, Oxford.
24. Lund, F., Solvason, N., Grimaldi, J. C., Parkhouse, R. M. E. and Howard, M. 1995. Murine CD38: an immunoregulatory enzyme. Immunol. Today 16:469.
25. + and cyclic ADP-ribose at the outer surface of human red blood cells. In Papa, S. and Tager, J. M., eds. Biochemistry of Cell Membranes. Birkhauser Verlag, Basel.
26. Lee, H. C., Graeff, R. and Walseth, T. F. 1995. Cyclic ADP-ribose and its metabolic enzymes. Biochimie 77:345.
27. Pascal, M. and Schuber, F. 1976. The stereochemistry of calf spleen NAD-glycohydrolase-catalyzed NAD methanolysis. FEBS Lett. 66:107.
28. Kim, H., Jacobson, E. L. and Jacobson, M. K. 1993. Synthesis and degradation of cyclic ADP-ribose by NAD glycohydrolases. Science 261:1330.
29. Bazil, V. and Horejsi, V. 1992. Shedding of the CD44 adhesion molecule from leukocytes induced by anti-CD44 monoclonal antibody stimulating the effect of a natural receptor ligand. J. Immunol. 149:747.
30. Hintzen, R. Q., De Jong, R., Hack, C. E., Chamuleau, M., De Vries, E. F. R., Ten Berge, I. J. M., Borst, J. and van Lier, R. A. W. 1991. A soluble form of the human T cell differentiation antigen CD27 is released after triggering of TCR/CD3 complex. J. Immunol. 147:29.
31. Higuchi, M. and Aggarwal, B. B. 1994. TNF induces internalization of the p60 receptor and shedding of the p80 receptor. J. Immunol. 152:3550.
32. Bazil, V. and Strominger, J. L. 1994. Metalloprotease and serine protease are involved in cleavage of CD43, CD44 and CD16 from stimulated human granulocytes. J. Immunol. 152:1314.
33. Gearing, A. J. H. and Newman, W. 1993. Circulating adhesion molecules in diseases. Immunol. Today 114:506.
34. Berg, M. and James, S. P. 1990. Human neutrophils release the Leu-8 lymph node homing receptor during cell activation. Blood 76:2381.
35. Bazil, V. and Strominger, J. L. 1991. Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J. Immunol. 147:1567.
36. Levacher, M., Hulstaer, F., Tallet, S., Ullery, S., Pocidalo, J. J. and Bach, B. A. 1992. The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome: staining and prognostic value. Clin. Exp. Immunol. 90:376.
37. Ausiello, C. M., Urbani, F., La Sala, A., Funaro, A. and Malavasi, F. 1995. CD38 ligation induces cytokine mRNA expression in human cultured lymphocytes. Eur. J. Immunol. 25: 1477.
38. Silvennoinen, O., Nishigaki, H., Kitanaka, A., Kumagai, M., Ito, C., Malavasi, F., Lin, Q., Conley, M. and Campana, D. 1995. CD38 signal transduction in human B-cell precursors: Rapid induction of tyrosine phosphorylation, activation of syktyrosine kinase, and phophorylation of phospholipase C-γ and phosphatidylinositol 3-kinase. J. Immunol. 156:100.
39. Deaglio, S., Dianziani, U., Horenstein, A. L., Fernandez, J. E., van Kooten, C., Bragardo, M., Garbarino, G., Funaro, A., DiVirgilio, F., Banchereau, J, and Malavasi, F. 1996. Human CD38 ligand: a 120 kDa protein predominantly expressed by endothelial cells. J. Immunol. 156:727.