메뉴 건너뛰기




Volumn 1, Issue 3, 1999, Pages 305-315

β-Cells, Oxidative Stress, Lysosomal Stability, and Apoptotic/Necrotic Cell Death

Author keywords

[No Author keywords available]

Indexed keywords

DEFEROXAMINE; GLUCOSE; HYDROGEN PEROXIDE;

EID: 0033188153     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.1999.1.3-305     Document Type: Article
Times cited : (21)

References (57)
  • 1
    • 0018189864 scopus 로고
    • Isolated mouse pancreatic islets in culture: Effects of serum and different culture on the insulin production of the islets
    • ANDERSSON, A. (1978). Isolated mouse pancreatic islets in culture: Effects of serum and different culture on the insulin production of the islets. Diabetologia 14, 397-404.
    • (1978) Diabetologia , vol.14 , pp. 397-404
    • Andersson, A.1
  • 2
    • 0016354383 scopus 로고
    • Effects of glucose on the ultrastructure and insulin biosynthesis of isolated mouse pancreatic islets maintained in tissue culture
    • ANDERSSON, A., WESTMAN, J., and HELLERSTÖM, C. (1974). Effects of glucose on the ultrastructure and insulin biosynthesis of isolated mouse pancreatic islets maintained in tissue culture. Diabetologia 10, 743-753.
    • (1974) Diabetologia , vol.10 , pp. 743-753
    • Andersson, A.1    Westman, J.2    Hellerstöm, C.3
  • 3
    • 0029978038 scopus 로고    scopus 로고
    • Checkpoints in the progression of autoimmune disease: Lessons from diabetic models
    • ANDRE, I., GONZALES, A., WANG, B., KATZ, J., BENOIST, C., and MATHIS, D. (1996). Checkpoints in the progression of autoimmune disease: lessons from diabetic models. Proc. Natl. Acad. Sci. USA 92, 2260-2263.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2260-2263
    • Andre, I.1    Gonzales, A.2    Wang, B.3    Katz, J.4    Benoist, C.5    Mathis, D.6
  • 5
    • 0018358875 scopus 로고
    • Induction of diabetes in animals by parental administration of ferric nitrilotriacetate
    • AWAI, M., NARASAKI, M., YAMANOI, Y., and SENO, S. (1979). Induction of diabetes in animals by parental administration of ferric nitrilotriacetate. Am. J. Pathol. 95, 663-673.
    • (1979) Am. J. Pathol. , vol.95 , pp. 663-673
    • Awai, M.1    Narasaki, M.2    Yamanoi, Y.3    Seno, S.4
  • 6
    • 0032988381 scopus 로고    scopus 로고
    • Oxidative stress, growth-factor starvation, and fas-activation may all cause apoptosis through lysosomal leak
    • BRUNK, U.T., and SVENSSON, I. (1999). Oxidative stress, growth-factor starvation, and fas-activation may all cause apoptosis through lysosomal leak. Redox Report 4, 3-11.
    • (1999) Redox Report , vol.4 , pp. 3-11
    • Brunk, U.T.1    Svensson, I.2
  • 7
    • 0026663037 scopus 로고
    • A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis
    • BRUNK, U.T., JONES, C.B., and SOHAL, R.S. (1992). A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat. Res. 275, 395-403.
    • (1992) Mutat. Res. , vol.275 , pp. 395-403
    • Brunk, U.T.1    Jones, C.B.2    Sohal, R.S.3
  • 8
    • 0028821967 scopus 로고
    • Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization
    • BRUNK, U.T., ZHANG, H., DALEN, H., and ÖLLINGER, K. (1995a). Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization. Free Radic. Biol. Med. 19, 813-822.
    • (1995) Free Radic. Biol. Med. , vol.19 , pp. 813-822
    • Brunk, U.T.1    Zhang, H.2    Dalen, H.3    Öllinger, K.4
  • 9
    • 0001313069 scopus 로고
    • Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage
    • BRUNK, U.T., ZHANG, H., ROBERG, K., and ÖLLINGER, K. (1995b). Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage. Redox Report. 1, 267-277.
    • (1995) Redox Report , vol.1 , pp. 267-277
    • Brunk, U.T.1    Zhang, H.2    Roberg, K.3    Öllinger, K.4
  • 10
    • 0030757986 scopus 로고    scopus 로고
    • Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
    • BRUNK, U.T., DALEN, H., ROBERG, K., and HELLQUIST, H.B. (1997). Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic. Biol. Med. 23, 616-626.
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 616-626
    • Brunk, U.T.1    Dalen, H.2    Roberg, K.3    Hellquist, H.B.4
  • 11
    • 0025272539 scopus 로고
    • Determination of the length of the histological stages of apoptosis in normal liver and altered hepatic foci of rats
    • BURSCH, W., PAFFE, S., PUTZ, B., BARTHEL, G., and SCHULTE-HERMANN, R. (1990). Determination of the length of the histological stages of apoptosis in normal liver and altered hepatic foci of rats. Carcinogenesis 11, 847-853.
    • (1990) Carcinogenesis , vol.11 , pp. 847-853
    • Bursch, W.1    Paffe, S.2    Putz, B.3    Barthel, G.4    Schulte-Hermann, R.5
  • 12
    • 0023784346 scopus 로고
    • IFN-γ and tumor necrosis factor-α: Cytotoxicity to murine islets of Langerhans
    • CAMPBELL, I.L., ISCALO, A., HARRISON, L.C. (1988). IFN-γ and tumor necrosis factor-α: cytotoxicity to murine islets of Langerhans. J. Immunol. 141, 2325-2329.
    • (1988) J. Immunol. , vol.141 , pp. 2325-2329
    • Campbell, I.L.1    Iscalo, A.2    Harrison, L.C.3
  • 13
    • 0014682868 scopus 로고
    • In vivo effect of zinc on iron-induced ferritin synthesis in rat liver
    • COLEMAN, C.B., and MATRONE, G. (1969). In vivo effect of zinc on iron-induced ferritin synthesis in rat liver. Biochim. Biophys. Acta 177, 106-112.
    • (1969) Biochim. Biophys. Acta , vol.177 , pp. 106-112
    • Coleman, C.B.1    Matrone, G.2
  • 14
    • 0029782494 scopus 로고    scopus 로고
    • Cathepsin D protease mediates programmed cell death induced by interferon-γ, Fas/APO-1 and TNF-α
    • DEISS, L.P., GALINKA, H., BERISSI, H., COHEN, H., and KIMCHI, A. (1996). Cathepsin D protease mediates programmed cell death induced by interferon-γ, Fas/APO-1 and TNF-α. EMBO J. 15, 3861-3870.
    • (1996) EMBO J. , vol.15 , pp. 3861-3870
    • Deiss, L.P.1    Galinka, H.2    Berissi, H.3    Cohen, H.4    Kimchi, A.5
  • 15
    • 0030923812 scopus 로고    scopus 로고
    • Cytokines induce Deoxyribonucleic acid strands breaks and apoptosis in human pancreatic islet cells
    • DELANEY, C.A., PAVLOVIC, D., HOORENS, A., PIPELEERS, D., and EIZIRIK, E.L. (1997). Cytokines induce Deoxyribonucleic acid strands breaks and apoptosis in human pancreatic islet cells. Endocrinology 138, 2610-2614.
    • (1997) Endocrinology , vol.138 , pp. 2610-2614
    • Delaney, C.A.1    Pavlovic, D.2    Hoorens, A.3    Pipeleers, D.4    Eizirik, E.L.5
  • 16
    • 0026543962 scopus 로고
    • Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry
    • DIVE, C., GREGORY, C.D., PHIPPS, D.J., EVANS, D.L., MILNER, A.E., and WYLLIE, A.H. (1992). Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim. Biophys. Acta 1133, 275-285.
    • (1992) Biochim. Biophys. Acta , vol.1133 , pp. 275-285
    • Dive, C.1    Gregory, C.D.2    Phipps, D.J.3    Evans, D.L.4    Milner, A.E.5    Wyllie, A.H.6
  • 17
    • 0028032254 scopus 로고
    • Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells
    • DYPBUKT, J.M., ANKARCRONA, M., BURKITT, M., SJÖHOLM, Ä., and STRÖM, K. (1994). Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. J. Biol. Chem. 269, 30553-30560.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30553-30560
    • Dypbukt, J.M.1    Ankarcrona, M.2    Burkitt, M.3    Sjöholm, Ä.4    Ström, K.5
  • 18
    • 0022475906 scopus 로고
    • The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: A 25-yr review of deaths in patients under 20 years of age in the United Kingdom
    • FOULIS, A.K., LIDDLE, C.N., and FARQUHARSON, M.A. (1986). The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-yr review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 29, 267-274.
    • (1986) Diabetologia , vol.29 , pp. 267-274
    • Foulis, A.K.1    Liddle, C.N.2    Farquharson, M.A.3
  • 19
    • 0031709850 scopus 로고    scopus 로고
    • Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress
    • GARNER, B., ROBERG, K., and BRUNK, U.T. (1998). Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress. Free Rad. Res. 29, 103-114.
    • (1998) Free Rad. Res. , vol.29 , pp. 103-114
    • Garner, B.1    Roberg, K.2    Brunk, U.T.3
  • 20
    • 0019852821 scopus 로고
    • CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse
    • GRANKVIST, K., MARKLUND, S.L., and TÄLJEDAL, I-B. (1981). CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem. J. 199, 393-398.
    • (1981) Biochem. J. , vol.199 , pp. 393-398
    • Grankvist, K.1    Marklund, S.L.2    Täljedal, I.-B.3
  • 21
    • 0031004573 scopus 로고    scopus 로고
    • Oxidant-induced apoptosis: A consequence of lethal lysosomal leak?
    • HELLQUIST, H.B., SVENSSON, I., and BRUNK, U.T. (1997). Oxidant-induced apoptosis: a consequence of lethal lysosomal leak? Redox Report. 3, 65-70.
    • (1997) Redox Report , vol.3 , pp. 65-70
    • Hellquist, H.B.1    Svensson, I.2    Brunk, U.T.3
  • 22
    • 23444462519 scopus 로고
    • Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells
    • HORIO, F., FUKUDA, M., KATOH, H., PETRUZZELLI, M., YANO, N., RITTERSHAUS, C., BONNER-WEIR, S., and HATTORI, M. (1994). Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells. Diabetologia 37, 22-31.
    • (1994) Diabetologia , vol.37 , pp. 22-31
    • Horio, F.1    Fukuda, M.2    Katoh, H.3    Petruzzelli, M.4    Yano, N.5    Rittershaus, C.6    Bonner-Weir, S.7    Hattori, M.8
  • 23
    • 0032547768 scopus 로고    scopus 로고
    • Pancreatic β cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes
    • HOTTA, M., TASHIRO, F., IKEGAMI, H., NIWA, H., OGIHARA, T., YODOI, J., and MIYAZAKI, J. (1998). Pancreatic β cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J. Exp. Med. 188, 1445-1451.
    • (1998) J. Exp. Med. , vol.188 , pp. 1445-1451
    • Hotta, M.1    Tashiro, F.2    Ikegami, H.3    Niwa, H.4    Ogihara, T.5    Yodoi, J.6    Miyazaki, J.7
  • 24
    • 0014492886 scopus 로고
    • Isolation and properties of secretory granules from rat islets of Langerhans. III
    • HOWELL, S.L., YOUNG, D.A., and LACY, P.E. (1969). Isolation and properties of secretory granules from rat islets of Langerhans. III. J. Cell Biol. 41, 154-161.
    • (1969) J. Cell Biol. , vol.41 , pp. 154-161
    • Howell, S.L.1    Young, D.A.2    Lacy, P.E.3
  • 25
    • 0017808254 scopus 로고
    • Role of zinc and calcium in the formation and storage of insulin in the pancreatic beta-cell
    • HOWELL, S.L., TYHURST, M., DUVEFELT, H., ANDERSSON, A., and HELLERSTROM, C. (1978). Role of zinc and calcium in the formation and storage of insulin in the pancreatic beta-cell. Cell Tissue Res. 188, 107-18.
    • (1978) Cell Tissue Res. , vol.188 , pp. 107-118
    • Howell, S.L.1    Tyhurst, M.2    Duvefelt, H.3    Andersson, A.4    Hellerstrom, C.5
  • 27
    • 0027361654 scopus 로고
    • Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients
    • ITOH, N., HANAFUSA, T., and MIYAZAKI, A. (1993). Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J. Clin. Invest. 9, 2313-2322.
    • (1993) J. Clin. Invest. , vol.9 , pp. 2313-2322
    • Itoh, N.1    Hanafusa, T.2    Miyazaki, A.3
  • 28
    • 0023071795 scopus 로고
    • Proton microprobe analysis of 15 elements in pancreatic B cells and exocrine pancreas in diabetic chinese hamsters
    • JUNTTI-BERGGREN, L., LINDH, U., BERGGREN, P-O., and FRANKEL, B.J. (1987). Proton microprobe analysis of 15 elements in pancreatic B cells and exocrine pancreas in diabetic chinese hamsters. Biosci. Rep. 7, 33-41.
    • (1987) Biosci. Rep. , vol.7 , pp. 33-41
    • Juntti-Berggren, L.1    Lindh, U.2    Berggren, P.-O.3    Frankel, B.J.4
  • 30
    • 0028329172 scopus 로고
    • Apoptosis: Its significance in cancer and cancer therapy
    • KERR, J.F.R., WINTERFORD, C.M., and HARMON, B.V. (1994). Apoptosis: its significance in cancer and cancer therapy. Cancer 73, 2013-2026.
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.R.1    Winterford, C.M.2    Harmon, B.V.3
  • 31
    • 0030798658 scopus 로고    scopus 로고
    • Target overexpression in Cu/Zn superoxide dismutase protects pancreatic β-cells against oxidative stress
    • KUBISCH, H-M., WANG, J., BRAY, T.M., and PHILIPS, J.P. (1997). Target overexpression in Cu/Zn superoxide dismutase protects pancreatic β-cells against oxidative stress. Diabetes 46, 1563-1566.
    • (1997) Diabetes , vol.46 , pp. 1563-1566
    • Kubisch, H.-M.1    Wang, J.2    Bray, T.M.3    Philips, J.P.4
  • 32
    • 0023857907 scopus 로고
    • Lysosomes and pancreatic islets function. Time course of insulin biosynthesis, insulin secretion, and lysosomal transformation after rapid changes in D-glucose concentration
    • LANDSTRÖM, A.H., WESTMAN, J., and BORG, L.A.H. (1988). Lysosomes and pancreatic islets function. Time course of insulin biosynthesis, insulin secretion, and lysosomal transformation after rapid changes in D-glucose concentration. Diabetes 37, 309-316.
    • (1988) Diabetes , vol.37 , pp. 309-316
    • Landström, A.H.1    Westman, J.2    Borg, L.A.H.3
  • 33
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • LENZEN, S., DRINKGERN, J., and TIEDGE, M. (1996). Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic. Biol. Med. 20, 463-466.
    • (1996) Free Radic. Biol. Med. , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 34
    • 17344370810 scopus 로고    scopus 로고
    • Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation
    • LI, W., YUAN, X.M., OLSSON, A.G., and BRUNK, U.T. (1998). Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation. Arterioscler. Thromb. Vasc. Biol. 18, 177-184.
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 177-184
    • Li, W.1    Yuan, X.M.2    Olsson, A.G.3    Brunk, U.T.4
  • 35
    • 0028219852 scopus 로고
    • Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases
    • LU, J.-P., and HAYASHI, K. (1994). Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases. Pathol. Int. 44, 194-199.
    • (1994) Pathol. Int. , vol.44 , pp. 194-199
    • Lu, J.-P.1    Hayashi, K.2
  • 36
    • 0025933977 scopus 로고
    • Transferrin receptors and selective iron deposition in pancreatic B cells of iron-overloaded rats
    • LU, J-P., HAYASHI, K., OKADA, S., and AWAI MICHIYASU. (1991). Transferrin receptors and selective iron deposition in pancreatic B cells of iron-overloaded rats. Acta Pathol. Jpn. 41, 647-652.
    • (1991) Acta Pathol. Jpn. , vol.41 , pp. 647-652
    • Lu, J.-P.1    Hayashi, K.2    Okada, S.3    Michiyasu, A.4
  • 38
    • 0028180612 scopus 로고
    • Large amount of (Apo)ferritin in the pancreatic insulin cell and its stimulation by glucose
    • MACDONALDS, M.J., COOK, J.D., EPSTEIN, M.L., and FLOWERS, C.H. (1994). Large amount of (Apo)ferritin in the pancreatic insulin cell and its stimulation by glucose. FASEB J. 8, 777-781.
    • (1994) FASEB J. , vol.8 , pp. 777-781
    • Macdonalds, M.J.1    Cook, J.D.2    Epstein, M.L.3    Flowers, C.H.4
  • 39
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • MANDRUP-POULSEN, T. (1996). The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39, 1005-1029.
    • (1996) Diabetologia , vol.39 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 40
    • 0033052252 scopus 로고    scopus 로고
    • α-Tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation
    • NEUZIL, J., SVENSSON, I., WEBER, T., WEBER, C., and BRUNK, U.T. (1999). α-Tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation. FEBS Lett. 4455, 295-300.
    • (1999) FEBS Lett. , vol.4455 , pp. 295-300
    • Neuzil, J.1    Svensson, I.2    Weber, T.3    Weber, C.4    Brunk, U.T.5
  • 41
    • 0030937468 scopus 로고    scopus 로고
    • Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
    • O'BRIEN, B.A., HARMON, B.V., CAMERON, D.P., and ALLAN, D.J. (1997). Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46, 750-757.
    • (1997) Diabetes , vol.46 , pp. 750-757
    • O'Brien, B.A.1    Harmon, B.V.2    Cameron, D.P.3    Allan, D.J.4
  • 42
    • 0030782935 scopus 로고    scopus 로고
    • A short exposure to a high-glucose milieu stabilizes the acidic vacuolar apparatus of insulinoma cells in culture to ensuing oxidative stress
    • OLEJNICKA, B.T., ÖLLINGER, K., and BRUNK, U.T. (1997). A short exposure to a high-glucose milieu stabilizes the acidic vacuolar apparatus of insulinoma cells in culture to ensuing oxidative stress. APMIS 105, 689-698.
    • (1997) APMIS , vol.105 , pp. 689-698
    • Olejnicka, B.T.1    Öllinger, K.2    Brunk, U.T.3
  • 43
    • 0031370708 scopus 로고    scopus 로고
    • Starvation-induced autophagocytosis paradoxically decreases the susceptibility to oxidative stress of the extremely oxidative stress-sensitive NIT insulinoma cells
    • OLEJNICKA, B.T., DALEN, H., BARANOWSKI, M.M., and BRUNK, U.T. (1998). Starvation-induced autophagocytosis paradoxically decreases the susceptibility to oxidative stress of the extremely oxidative stress-sensitive NIT insulinoma cells. Redox Rep. 3, 311-318.
    • (1998) Redox Rep. , vol.3 , pp. 311-318
    • Olejnicka, B.T.1    Dalen, H.2    Baranowski, M.M.3    Brunk, U.T.4
  • 44
    • 0032849841 scopus 로고    scopus 로고
    • Minute oxidative stress is sufficient to induce apoptotic death of NIT-1 insulinoma cells
    • in press
    • OLEJNICKA, B.T., DALEN, H., and BRUNK, U.T. (1999). Minute oxidative stress is sufficient to induce apoptotic death of NIT-1 insulinoma cells. APMIS (in press).
    • (1999) APMIS
    • Olejnicka, B.T.1    Dalen, H.2    Brunk, U.T.3
  • 45
    • 0029133790 scopus 로고
    • Cellular injury induced by oxidative stress is mediated through lysosomal damage
    • ÖLLINGER, K., and BRUNK, U.T. (1995). Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic. Biol. Med. 19, 565-574.
    • (1995) Free Radic. Biol. Med. , vol.19 , pp. 565-574
    • Öllinger, K.1    Brunk, U.T.2
  • 46
    • 0022979193 scopus 로고
    • Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory granules
    • ORCI, L., RAVAZZOLA, M., and AMHERDT, M. (1986). Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory granules. J. Cell Biol. 103, 2273-2281.
    • (1986) J. Cell Biol. , vol.103 , pp. 2273-2281
    • Orci, L.1    Ravazzola, M.2    Amherdt, M.3
  • 47
    • 0026719297 scopus 로고
    • Free radicals as mediators of pancreatic islets β-cell injury in autoimmune diabetes
    • RABINOVITCH, A. (1992). Free radicals as mediators of pancreatic islets β-cell injury in autoimmune diabetes. J. Lab. Clin. Med. 119, 455-456.
    • (1992) J. Lab. Clin. Med. , vol.119 , pp. 455-456
    • Rabinovitch, A.1
  • 48
    • 0029795599 scopus 로고    scopus 로고
    • Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production
    • RABINOVITCH, A., SUAREZ-PINZON, W.L., STRYNADKA, K., LAKEY, J.R., and RAJOTTE, R.V. (1996). Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production. J. Clin. Endocrin. Metabol. 81, 3197-3202.
    • (1996) J. Clin. Endocrin. Metabol. , vol.81 , pp. 3197-3202
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Strynadka, K.3    Lakey, J.R.4    Rajotte, R.V.5
  • 49
    • 0023113440 scopus 로고
    • The haemochromatic human pancreas: A quantitative immunohistochemical and ultrastructural study
    • RAHIER, J., LOOZEN, S., GOEBBELS, R.M., and ABRAHEM, M. (1987). The haemochromatic human pancreas: a quantitative immunohistochemical and ultrastructural study. Diabetologia 30, 5-12.
    • (1987) Diabetologia , vol.30 , pp. 5-12
    • Rahier, J.1    Loozen, S.2    Goebbels, R.M.3    Abrahem, M.4
  • 50
    • 0028147329 scopus 로고
    • Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: Oxidative stress as a mediator of apoptosis
    • SANDSTRÖM, P.A., MANNIE, M.D., and BUTTKE, T.M. (1994). Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J. Leukocyte Biol. 55, 221-226.
    • (1994) J. Leukocyte Biol. , vol.55 , pp. 221-226
    • Sandström, P.A.1    Mannie, M.D.2    Buttke, T.M.3
  • 51
    • 0025340706 scopus 로고
    • Free radicals and antioxidant systems in health and disease
    • SINCLAIR, A.J., BARNETT, A.H., and LUNEC, J. (1990). Free radicals and antioxidant systems in health and disease. Br. J. Hospital Med. 43, 334-343.
    • (1990) Br. J. Hospital Med. , vol.43 , pp. 334-343
    • Sinclair, A.J.1    Barnett, A.H.2    Lunec, J.3
  • 53
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin producing cells
    • TIEDGE, M., LORTZ, S., DRINKGERN, J., and LENZEN, S. (1997). Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin producing cells. Diabetes 46, 1733-1742.
    • (1997) Diabetes , vol.46 , pp. 1733-1742
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 55
  • 56
    • 0026581844 scopus 로고
    • Alloxan cytotoxicity involves lysosomal damage
    • ZHANG, H., ZDOLSEK, J.M., and BRUNK, U.T. (1992). Alloxan cytotoxicity involves lysosomal damage. APMIS 100, 309-316.
    • (1992) APMIS , vol.100 , pp. 309-316
    • Zhang, H.1    Zdolsek, J.M.2    Brunk, U.T.3
  • 57
    • 0000604342 scopus 로고    scopus 로고
    • Starvation-induced autophagocytosis enhances the susceptibility of insulinoma cells to oxidative stress
    • ZHANG, H., OLEJNICKA, B., ÖLLINGER, K., and BRUNK, U.T. (1996). Starvation-induced autophagocytosis enhances the susceptibility of insulinoma cells to oxidative stress. Redox Rep. 2, 235-247.
    • (1996) Redox Rep. , vol.2 , pp. 235-247
    • Zhang, H.1    Olejnicka, B.2    Öllinger, K.3    Brunk, U.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.