Oxidant-induced apoptosis: A consequence of lethal lysosomal leak?

Redox Report

Volumn 3, Issue 1, 1997, Pages 65-70

  Hellquist, H B ^a   Svensson, I ^a   Brunk, U T ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; CATHEPSIN D; DEFEROXAMINE; FERRIC ION; HYDROGEN PEROXIDE; HYDROLASE; IRON; LYSOSOME ENZYME; OXIDIZING AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; CHELATION; CONTROLLED STUDY; CYTOSOL; ENDOCYTOSIS; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALIA;

EID: 0031004573     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1080/13510002.1997.11747092     Document Type: Article

References (28)

1. 32P induces massive apoptosis in a Burkitt's lymphoma cell line. Int J Radiat Biol 1992; 61: 365-367.
2. Hockenbery D M, Oltvai Z N, Yin X-M, Milliman C L, Korsmeyer S J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993; 75: 241-251.
3. Kane D J, Sarafian T A, Anton R et al. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science 1993; 262: 1274-1277.
4. Sandstrom P A, Manme M D, Buttke T M. Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J Leukocyte Biol 1994; 55: 221-226.
5. Willie A H. Cell death: a new classification separating apoptosis from necrosis. In: Cell Death in Biology and Pathology. Bowen ID, Lockshin R A, eds. London: Chapman & Hall, 1981; 9-34.
6. Cohen JJ Overview: Mechanisms of apoptosis Immunol Today 1993; 14: 126-130
7. Gavrieli Y, Sherman Y, Ben-Sasson S A. Identification of programmed cell death in situ via specific labeling of nuclear fragmentation. J Cell Biol 1992; 119: 493-501.
8. Lennon S V, Martin S J, Cotter T G. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif 1991; 24: 203-214
9. Zhong L-T, Sarafian T, Kane D J et al. Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA 1993; 90: 4533-4537.
10. Buttke T M, Sandstrom P A. Oxidative stress as a mediator of apoptosis. Immunol Today 1994; 15: 7-10.
11. Zdolsek J M, Olsson G M, Brunk U T. Photooxidative damage to lysosomes of cultured macrophages by acridine orange. Photochem Photobiol 1990; 51: 67-76.
12. 2-mediated damage to lysosomal membranes of J-774 cells. Free Radic Res Commun 1993, 18: 71-85.
13. Brunk U T, Zhang H, Roberg K, Öllinger K. Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage. Redox Report 1995; 1: 267-277.
14. Öllinger K, Brunk U T. Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic Biol Med 1995; 19. 565-574
15. Brunk U T, Zhang H, Dalen H, Öllinger K. Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization. Free Radic Biol Med 1995; 19 813-822.
16. Zhang H, Olejnicka B, Öllinger K, Brunk U T. Starvation-induced autophagocytosis enhances the susceptibility of insulinoma cells to oxidative stress. Redox Report 1996; 2: 235-247.
17. Zdolsek J M, Roberg K, Brunk U T. Visualization of iron in cultured macrophages: a cytochemical light and electron microscopic study using autometallography Free Radic Biol Med 1993; 15: 1-11.
18. Encsson J L E. Mechanisms of cellular autophagy. In: Lysosomes in Biology and Pathology, vol 2. Dingle JT, Fell HB, eds. Amsterdam: North-Holland Publishing Company, 1969; 345-394.
19. Brunk U T, Jones C B, Sohal R S. A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutan Res 1992; 275: 395-403.
20. Fridovich I. Superoxide radical: an endogenous toxicant. Review. Ann Rev Pharmacol Toxicol 1983; 23: 239-257.
21. Olive P L. DNA precipitation assay: A rapid and simple method for detecting DNA damage in mammalian cells Environ Mol Mutagen 1988; 11: 487-495.
22. Burton K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 1956; 62: 315-323.
23. Brunk U T, Ericsson J L E. Cytochemical evidence for the leakage of acid phosphatase through ultrastructurally intact lysosomal membranes. Histochem J 1972; 4: 479-491.
24. de Duve C, Wattiaux R V. Functions of lysosomes. Ann Rev Physiol 1960; 28: 435-492.
25. de Duve C. The lysosome in retrospect. In: Lysosomes in Biology and Pathology, vol 1. Dingle J T, Fell H B, eds. Amsterdam: North-Holland Publishing Company, 1969; 3-40.
26. Halliwell B, Gutteridge J M C Free radicals as useful species. In. Free Radicals in Biology and Medicine. 2nd edn. Oxford: Oxford University Press, 1989; 366-415.
27. Sheen V L, Macklis J D. Apoptotic mechanisms in targeted neuronal cell death by chromophore-activated photolysis. Exp Neurol 1994; 130: 67-81.
28. Brunk U T, Dalen H, Roberg K, Hellquist H B. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic Biol Med, in press.