Immunity to Candida albicans: Th1, Th2 cells and beyond

Current Opinion in Microbiology

Volumn 2, Issue 4, 1999, Pages 363-367

  Romani, Luigina ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

CANDIDA ALBICANS; CELL MATURATION; HELPER CELL; IMMUNITY; INFECTION SENSITIVITY; MACROPHAGE; MOUSE; MYCOSIS; NEUTROPHIL; NONHUMAN; PHAGOCYTE; REVIEW;

EID: 0033179414     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(99)80064-2     Document Type: Review

References (56)

1. H2-like switch in candidiasis: New perspectives for therapy. Trends Microbiol 1995, 3:237-240.
2. Romani L: The T cell responses to fungi. Curr Opin Immunol 1997, 9:484-490.
3. Kunkl A, Mortara L, Valle MT, Fenogli D, Terranova MP, Megiovanni AM, Alessandrini A, Li Pira G, Mazzarello G, Del Bono V et al.: Recognition of antigenic clusters of Candida albicans by T lymphocytes from human immunodeficiency virus-infected persons. J Infect Dis 1998, 178:488-496.
4. Raszka WV, Moriarty RA, Ottolini MG, Waecker NJ, Ascher DP, Cieslak TJ, Fisher GW, Robb ML: Delayed-type hypersensitivity skin testing in human immunodeficiency virus-infected pediatric patients. J Pediatr 1996, 129:245-250.
5. Romani L: Animal models for candidiasis. Curr Protocol Immunol 1999, in press.
6. Mencacci A, Cenci E, Bistoni F, Del Sero G, Bacci A, Montagnoli C, • Fè D'Ostiani C, Romani L: Specific and non-specific immunity to Candida albicans: A lesson from genetically modified animals. Res Immunol 1998, 149:352-361. An extensive study performed in cytokine-deficient mice that illustrates the existence of a hierarchic pattern of cytokine-mediated regulation of antifungal innate and adaptive T helper cell immunity.
7. Mencacci A, Cenci E, Del Sero G, Fè D'Ostiani C, Montagnoli C, Bacci A, Bistoni F, Romani L: Innate and adaptive immunity to Candida albicans: A new view of an old paradigm. Rev Iberoam Micol 1999, 16:4-7.
8. Wagner RD, Vasquez-Torres A, Jones-Carson J, Warner T, Balish E: B cell knockout mice are resistant to mucosal and systemic candidiasis of endogenous origin but susceptible to experimental systemic candidiasis. J Infect Dis 1996, 174:589-597.
9. 2microglobulin in murine resistance to mucosal and systemic candidiasis. Infect Immun 1996, 64:5092-5097.
10. Romani L, Kaufmann SHE: Immunity to fungi. Editorial overview. Res Immunol 1998, 149:277-281.
11. Schuman P, Sobel JD, Ohmit E, Mayer KH, Carpenter CJ, Rompalo A, Duerr A, Smith DK, Warren D, Klein RS: Mucosal candidal colonization and candidiasis in women with or at risk for immunodeficiency virus infection. J Infect Dis 1998, 27:1161-1167.
12. + type 2 T cells. J Leukoc Biol 1998, 63:723-731.
13. Leigh JE, Steele C, Wormerly FL Jr, Luo W, Gallaher W, Fidel PL Jr: Th1/Th2 cytokine expression in saliva of HIV-positive and HIV-negative individuals: A pilot study in HIV-positive individuals with oropharyngeal candidiasis. J Acquir Immune Defic Syndr Hum Retrovirol 1998, 19:373-380.
14. Lilic D, Cant AJ, Abinun M, Calvert JE, Spickett GP: Chronic mucocutaneous candidiasis. I. Altered antigen-stimulated IL-2, IL-4, IL-6 and interferon-gamma (IFN-γ) production. Clin Exp Immunol 1996, 105:205-212.
15. Kobrynski LJ, Tanimune L, Kilpatrick L, Campbell DE, Douglas SD: Production of T-helper cell subsets and cytokines by lymphocytes from patients with chronic mucocutaneous candidiasis. Clin Diagn Lab Immunol 1996, 3:740-745.
16. Roilides E, Sein T, Schaufele R, Chanock SJ, Walsh TJ: Increased serum concentrations of interleukin-10 in patients with hepatosplenic candidiasis. J Infect Dis 1998, 178:589-592.
17. Ashman RB: Candida albicans: Pathogenesis, immunity and host • defence. Res Immunol 1998, 149:281-288. A study demonstrating the impact of host genetics on susceptibility and resistance to C. albicans infection.
18. Mulero-Marchese RD, Blank KJ, Siek TG: Genetic basis for protection against experimental vaginal candidiasis by peripheral immunization. J Infect Dis 1998, 178:227-234.
19. Cenci E, Mencacci A, Del Sero G, Fè D'Ostiani C, Mosci P, Kopf M, Romani L: IFN-γ is required for IL-12 responsiveness in mice with Candida albicans infection. J Immunol 1998, 161:3543-3550.
20. Jones-Carson J, Vasquez-Torres FA, Balish E: B cell-independent selection of memory T cells after mucosal immunization with Candida albicans. J Immunol 1997, 158:4328-4335.
21. Rosati E, Scaringi L, Cornacchione P, Fettucciari K, Sabatini R, Mezzasoma L, Benedetti C, Cianetti S, Rossi R, Marconi P: Activation of cytokine genes during primary and anamnestic immune response to inactivated C. albicans. Immunology 1996, 89:142-151.
22. Fidel PL, Ginsburg KA, Cutright JL, Wolf NA, Leaman D, Dunlap K, Sobel JD: Vaginal-associated immunity in women with recurrent vulvovaginal candidiasis: Evidence for vaginal Th1-type responses following intravaginal challenge with Candida antigen. J Infect Dis 1997, 176:728-739.
23. La Sala A, Urbani F, Torosantucci A, Cassone A, Ausiello C: Mannoproteins from Candida albicans elicit a Th1-type-1 cytokine profile in human Candida specific long-term T cell cultures. J Biol Regul Homeost Agents 1997, 10:8-12.
24. + T helper type 1 cell responses to Candida albicans. J Exp Med 1998, 187:307-317. A provocative study suggesting that interleukin-4 is required for sustained anticandidal T helper type 1 cell responses. A teaching example on how cytokines may have opposing effects in the immune response to C. albicans.
25. + T-helper-cell responses in mice with low-level Candida albicans infection. Infect Immun 1996, 64:4907-4914.
26. Bromuro C, La Valle R, Sandini S, Urbani F, Ausiello CM, Morelli L, Fè D'Ostiani C, Romani L, Cassone A: A 70-kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic candidiasis. Infect Immun 1998, 66:2154-2162.
27. Cassone A, De Bernardis F, Ausiello C, Gomez MJ, Boccanera M, La Valle R, Torosantucci A: Immunogenic and protective Candida albicans constituents. Res Immunol 1998, 149:289-299.
28. Romani L, Bistoni F, Puccetti P: Initiation of T helper cell immunity to Candida albicans by IL-12: The role of neutrophils. Chem Immunol 1997, 68:110-135.
29. Mencacci A, Cenci E, Del Sero G, Fè D'Ostiani C, Mosci P, Montagnoli C, Bacci A, Bistoni F, Quesneaux VFJ, Ryffel B, Romani L: Defective co-stimulation and impaired Th1 development in tumor necrosis factor/lymphotoxin-α double-deficient mice infected with Candida albicans. Int Immunol 1998, 10:37-48.
30. Mencacci A, Cenci E, Del Sero G, Fè D'Ostiani C, Mosci P, Bistoni F, • Trinchieri G, Adorini L, Romani L: IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida albicans infection. J Immunol 1998, 161:6228-6237. This paper demonstrates the existence of a positive regulatory loop between interleukin (IL)-12 and IL-10 in mice with candidiasis, and shows that IL-10 may have both positive and negative effects on anticandidal Th1 responses.
31. Kaposzta R, Tree P, Marodi L, Gordon S: Characteristics of invasive candidiasis in gamma interferon- And interleukin-4-deficient mice: Role of macrophages in host defense against Candida albicans. Infect Immun 1998, 66:1708-1717.
32. -/-) mice. J Infect Dis 1998, 178:478-487.
33. QIan Q, Cutler JE: Gamma-interferon is not essential in host defense against disseminated candidiasis in mice. Infect Immun 1997, 65:1748-1753.
34. Vasquez-Torres A, Jones-Carson J, Wagner RD, Warner T, Balish E: Early resistance of interleukin-10 knockout mice to acute systemic candidiasis. Infect Immun 1999, 67:670-674.
35. Fidel PL, Sobel JD: Protective immunity in experimental Candida vaginitis. Res Immunol 1998, 149:361-373.
36. + T helper subset selection in mice with candidiasis. J Immunol 1997, 158:2356-2362.
37. Romani L, Mencacci A, Cenci E, Spaccapelo R, Del Sero G, Nicoletti I, Trinchieri G, Bistoni F, Puccetti P: Neutrophils production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice. J Immunol 1997, 49:5349-5356.
38. Kawamura MS, Aiba S, Tagami H: The importance of CD54 and CD86 costimulation in T cells stimulated with Candida albicans and dermatophagoides farinae in patients with atopic dermatitis. Arch Dermatol Res 1998, 290:603-609.
39. Van Neerven RJ, Van de Pol MM, Van der Zee JS, Stiekema FE, De Boer M, Kapsenberg ML: Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression. Clin Exp Allergy 1998, 28:808-816.
40. Gaspari AA, Burns B, Nasir A, Ramirez D, Barth RK, Haidaris CG: CD86 (B7-2), but not CD80 (B7-1), expression in the epidermis of transgenic mice enhances the immunogenicity of primary cutaneous Candida albicans infections. Infect Immun 1998, 66:4440-4449.
41. + T cells in vitro. Blood 1998, 91:4652-4661.
42. Vasquez-Torres A, Balish E: Macrophages in resistance to candidiasis. Microbiol Mol Rev 1997, 61:170-192.
43. Cassone A, Chiani P, Quinti I, Torosantucci A: A possible participation of polymorphonuclear cells stimulated by microbial immunomodulators in cytokine dysregulated patterns of AIDS patients. J Leukocyte Biol 1997, 62:60-66.
44. Mencacci A, Cenci E, Boelaert JR, Bucci P, Mosci P, Fè' D'Ostiani C, Bistoni F, Romani L: Iron overload alters innate and T helper cell responses to Candida albicans in mice. J Infect Dis 1997, 175:1467-1476.
45. De Bernardis F, Boccanera M, Adriani D, Spreghini E, Santoni G, Cassone A: Protective role of anti-mannan and anti-aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats. Infect Immun 1997, 65:3399-3405.
46. Magliani W, Conti S, De Bernardis F, Gerloni M, Bertolotti D, Mozzoni P, Cassone A, Polonelli L: Therapeutic potential of anti-idiotypic chain antibodies with yeast killer toxin activity. Nat Biotechnol 1997, 15:155-158.
47. Han Y, Cutler JE: Assessment of a mouse model of neutropenia and the effect of an anti-candidiasis monoclonal antibody in these animals. J Infect Dis 1997, 175:1169-1175.
48. Matthews R, Burnie J: The role of antibodies in protection against candidiasis. Res Immunol 1998, 149:343-352.
49. Casadevall A, Cassone A, Bistoni B, Cutler JE, Magliani W, Murphy JW, Polonelli L, Romani L: Antibody- and/or cell-mediated immunity-protective mechanisms in fungal disease: An ongoing dilemma or an unnecessary dispute? Med Mycol 1998, 36(supp 1):95-105.
50. Cardenas-Freytag L, Cheng E, Mayeux P, Domer EJ, Clements JD: Effectiveness of a vaccine composed of heat-killed Candida albicans and a novel mucosal adjuvant, LT (R192G), against systemic candidiasis. Infect Immun 1999, 67:826-833.
51. Deepe GS Jr: Prospect for the development of fungal vaccines. Clin Microbiol Rev 1997, 10:585-596.
52. Akiyama K, Shida T, Yasueda H, Mita H, Yanagihara Y, Hasegawa M, Maeda Y, Yamamoto T, Takesako K, Yamaguchi H: Allergenicity of acid protease secreted by Candida albicans. Allergy 1996, 51:887-892.
53. Cenci E, Mencacci A, Del Sero G, Bistoni F, Romani L: Induction of protective Th1 responses to Candida albicans by antifungal therapy alone or in combination with an interleukin-4 antagonist. J Infect Dis 1997, 176:217-226.
54. Kullberg BJ, Anaissie EJ: Cytokines as therapy for opportunistic fungal infections. Res Immunol 1998, 149:478-488.
55. Stevens DA: Combination immunotherapy and antifungal chemotherapy. Clin Infect Dis 1998, 26:1266-1269.
56. Polonelli L, Cassone A: Novel strategies for treating candidiasis. • Curr Infect Dis 1999, 12:61-66. An up-to-date review on chemotherapy and immunotherapy of candidiasis.