Mannoproteins from Candida albicans elicit a Th-type-1 cytokine profile in human Candida specific long term T cell cultures

Journal of Biological Regulators and Homeostatic Agents

Volumn 10, Issue 1, 1996, Pages 8-12

  La Sala, A ^b   Urbani, F ^b   Torosantucci, A ^b   Cassone, A ^a   Ausiello, C M ^b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b NONE

Author keywords

Candida albicans; Cytokines; T cell cultures

Indexed keywords

ANTIGEN; CANDIDA ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 5;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; BLOOD CELL; CANDIDA ALBICANS; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE CULTURE; MEMORY CELL; MONONUCLEAR CELL; PHENOTYPE; T LYMPHOCYTE;

EID: 0030464545     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Cassone A. Cell wall of Candida albicans: its function and its impact on the host. Curr Top Mycol 1989; 3: 249-314.
2. Ashman RB, Papadimitriou JM. Production and function of cytokines in natural and acquired immunity to Candida albicans infection. Microbiol Rev 1995; 59: 646-72.
3. Dieu JY. Modulators of immune responses. In: Murphy JW, Frieman H, Bendinelli M, eds. Fungal infections and immune responses. New York: Plenum Press, 1992; 521-32.
4. Cassatella MA. The production of cytokines by polymorphonuclear neutrophil. Immunol Today 1995; 16: 21-6.
5. Ausiello CM, Urbani F, Gessani S, Spagnoli GC, Gomez MJ, Cassone A. Cytokine gene expression in human peripheral blood mononuclear cells stimulated by mannoprotein constituents from Candida albicans. Infect Immun 1993; 61: 4105-11.
6. Murphy JW, Wu-Hsieh BA, Singer-Vermes LM, et al. Cytokines in the host response to mycotic agents. J Med Vet Mycol 1994; 32 (suppl 1): 203-10.
7. Ausiello CM, Spagnoli GC, Boccanera M, et al. Proliferation of human peripheral blood mononuclear cells induced by Candida albicans and its cell wall fractions. J Med Microbiol 1986; 22; 195-202.
8. Podzorski RP, Gray GR, Nelson RD. Different effects on native Candida albicans mamman-derived oligosaccharides on antigen-stimulated lymphoproliferation in vitro. J Immunol 1990; 144: 707-16.
9. Torosantucci A, Bromuro C, Gomez MJ, Ausiello CM, Urbani F, Cassone A. Identification of a 65-kDa mannoprotein as a main target of human cell-mediated immune-response to Candida albicans. J Infect Dis 1993; 168: 427-35.
10. Gomez MJ, Torosantucci A, Arancia S, Maras B, Parisi L, Cassone A. Purification and biochemical characterization of a (MP-65), a main target of anti-candida cell mediated immune response in man. Infect Immun 1996; 64: 2577-84.
11. Quinti I, Palma C, Guerra EC, et al. Proliferative and cytotoxic responses to mannoproteins of Candida albicans by peripheral blood lymphocytes of HIV-infected subjects. Clin Exp Immunol 1991; 85: 485-92.
12. Romani L, Howard DH. Mechanisms of resistance to fungal infections. Curr Opinion Immunol 1995; 7: 517-23.
13. La Sala A, Urbani F, Lande R, Ausiello CM. A semiquantitative reverse transcriptase-polymerase chain reaction method to detect low abundance cytokine mRNA. Minerva Biotec 1995; 7: 207-13.
14. Sieck TG, Moors MA, Buckley HR and Blank KJ. Protection against murine disseminated Candidiasis mediated by a Candida albicans-specific T-cell line. Infect Immun 1993; 61: 3540-3.
15. Levitz SM, Mathews HL, Murphy JW. Direct antimicrobial activity of T cells. Immunol Today 1995; 16: 387-91.