HBV-specific lymphoproliferative and cytokine responses in patients with chronic hepatitis B

Journal of Hepatology

Volumn 28, Issue 1, 1998, Pages 8-16

  Vingerhoets, Johan ^a   Michielsen, Peter ^b   Vanham, Guido ^a   Bosmans, Eugène ^c   Paulij, Wilma ^d   Ramon, Albert ^e   Pelckmans, Paul ^b   Kestens, Luc ^a   Leroux Roels, Geert ^f  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c Eurogenetics   (Belgium)

^d Organon Teknika   (Netherlands)

^e Intl Institute of Immunopathology   (Belgium)

^f GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

HBeAg; HBsAg; Hepatitis B virus; Interferon ; Interleukin 12; Interleukin 10; T cell responses

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0031913497     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(98)80196-7     Document Type: Article

References (33)

1. Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol. 13:1995;29-60.
2. Ferrari C, Penna A, Bertoletti A, Valli A, Degli Antoni A, Giuberti T, et al. Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J Immunol. 145:1990;3442-3449.
3. Löhr HF, Weber W, Schlaak J, Goergen B, Meyer zum Büschenfelde KH, Gerken G. Proliferative response of CD4(+) T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants. Hepatology. 22:1995;61-68.
4. Vento S, Hegarty JE, Alberti A, O'Brien CJ, Alexander GJM, Eddleston ALWF, et al. T lymphocyte sensitization to HBcAg and T cell-mediated unresponsiveness to HBsAg in hepatitis B virus-related chronic liver disease. Hepatology. 5:1985;192.
5. Ferrari C, Penna A, Sansoni P, Giuberti T, Neri TM, Chisari FV, et al. Selective sensitization of peripheral blood T lymphocytes to hepatitis B core antigen in patients with chronic active hepatitis type B. Clin exp Immunol. 67:1986;497-506.
6. Jung MC, Diepolder HM, Spengler U, Wierenga EA, Zachoval R, Hoffmann RM, et al. Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4(+) T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J Virol. 69:1995;3358-3368.
7. Tsai SL, Chen PJ, Lai MY, Yang PM, Sung JL, Huang JH, et al. Acute exacerbations of chronic type B-hepatitis are accompanied by increased T-cell responses to hepatitis B core and e antigens - implications for hepatitis B e antigen seroconversion. J Clin Invest. 89:1992;87-96.
8. Takehara T, Hayashi N, Katayama K, Kasahara A, Fusamoto H, Kamada T. Hepatitis-B core antigen-specific interferon-gamma production of peripheral blood mononuclear cells during acute exacerbation of chronic hepatitis B. Scand J Gastroenterol. 27:1992;727-731.
9. Marinos G, Torre F, Chokshi S, Hussain M, Clarke BE, Rowlands DJ, et al. Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus. Hepatology. 22:1995;1040-1049.
10. Löhr HF, Schlaak JF, Gerken G, Fleischer B, Dienes MP, Meyer-zum-Büschenfelde KH. Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver. 14:1994;161-166.
11. Bertoletti A, D'Elios MM, Boni C, De Carli M, Zignego AL, Durazzo M, et al. Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C infections. Gastroenterology. 112:1997;193-199.
12. Vingerhoets J, Vanham G, Kestens L, Gigase P. A convenient and economical freezing procedure for mononuclear cells. Cryobiology. 32:1995;105-108.
13. Vingerhoets J, Vanham G, Kestens L, Penne G, Leroux-Roels G, Gigase P. Deficient T-cell responses in non-responders to hepatitis B vaccination - absence of Th1 cytokine production. Immunol Lett. 39:1994;163-168.
14. Inoue M, Kakumu S, Yoshioka K, Tsutsumi Y, Wakita T, Arao M. Hepatitis B core antigen-specific IFN-gamma production of peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection. J Immunol. 142:1989;4006-4011.
15. Sheron N, Lau J, Daniels H, Goka J, Eddleston A, Alexander GJM, et al. Increased production of tumour necrosis factor alpha in chronic hepatitis B virus infection. J Hepatol. 12:1991;241-245.
16. Hayashi Y, Koike K. Interferon inhibits hepatitis-B virus replication in a stable expression system of transfected viral DNA. J Virol. 63:1989;2936-2940.
17. Romero R, Lavine JE. Cytokine inhibition of the hepatitis B virus core promoter. Hepatology. 23:1996;17-23.
18. Guidotti LG, Guilhot S, Chisari FV. Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways. J Virol. 68:1994;1265-1270.
19. Wakita T, Kakumu S, Yoshioka K, Ishikawa T, Ito Y, Shinagawa T. Cellular immune responses of peripheral blood mononuclear cells to HBV antigens during chronic and acute HBV infection. Digestion. 52:1992;26-33.
20. Del Prete G, De Carli M, Almerigogna F, Giudizi MG, Biagiotti R, Romagnani S. Human IL-10 is produced by both type-1 helper (Th1) and type-2 helper (Th2) T-cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol. 150:1993;353-360.
21. Milich DR, McLachlan A, Raney AK, Houghten R, Thornton GB, Maruyama T, et al. Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides. Proc Natl Acad Sci USA. 88:1991;4348-4352.
22. Milich DR, Schodel F, Peterson DL, Jones JE, Hughes JL. Characterization of self-reactive T cells that evade tolerance in hepatitis B e antigen transgenic mice. Eur J Immunol. 25:1995;1663-1672.
23. Milich DR, Wolf SF, Hughes JL, Jones JE. Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B e antigen transgenic mice. Proc Natl Acad Sci USA. 92:1995;6847-6851.
24. Maruyama T, McLachlan A, Lino S, Koike K, Kurokawa K, Milich DR. The serology of chronic hepatitis B infection revisited. J Clin Invest. 91:1993;2586-2595.
25. Penna A, Artini M, Cavalli A, Levrero M, Bertoletti A, Pilli N, et al. Long-lasting memory T cell responses following self-limited acute hepatitis B. J Clin Invest. 98:1996;1185-1194.
26. Penna A, Del Prete G, Cavalli A, Bertoletti A, D'Elios MM, Sorrentino R, et al. Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology. 25:1997;1022-1027.
27. Sieling PA, Wang XH, Gately MK, Oliveros JL, Mchugh T, Barnes PF, et al. IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J Immunol. 153:1994;3639-3647.
28. Rossol S, Marinos G, Carucci P, Singer MV, Williams R, Naoumov NV. Interleukin-12 induction of TH1 cytokines is important for viral clearance in chronic hepatitis B. J Clin Invest. 99:1997;3025-3033.
29. + T-lymphocytes with Th-1 lymphokine profile [abstract]. Hepatology. 24:1996;279. (Suppl. 2).
30. + T cells in vitro. J Virol. 70:1996;7540-7548.
31. Böcher WO, Herzog-Hauff S, Herr W, Heermann K, Gerken G, Zum Büschenfelde KHM, et al. Regulation of the neutralizing anti-hepatitis B surface (HBs) antibody response in vitro in HBs vaccine recipients and patients with acute or chron hepatitis B virus (HBV) infection. Clin Exp Immunol. 105:1996;52-58.
32. Cavanaugh VJ, Guidotti LG, Chisari FV. Interleukin-12 inhibits hepatitis B virus replication in transgenic mice. J Virol. 71:1997;3236-3243.
33. Marinos G, Naoumov NV, Williams R. Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection. Hepatology. 24:1996;991-995.