Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display

Journal of Biological Chemistry

Volumn 273, Issue 19, 1998, Pages 11675-11684

  Ballinger, Marcus D ^a,b   Jones, Jennifer T ^a   Lofgren, Julie A ^a   Fairbrother, Wayne J ^a   Akita, Robert W ^a   Sliwkowski, Mark X ^a   Wells, James A ^a  

^a GENENTECH INC   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERBB RECEPTOR; NEU DIFFERENTIATION FACTOR; RECEPTOR PROTEIN; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; DNA LIBRARY; GENE MUTATION; HUMAN; PHAGE DISPLAY; PHAGEMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN VARIANT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIOPHAGE M13; BINDING SITES; CARRIER PROTEINS; GLYCOPROTEINS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUREGULIN-1; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE LIBRARY; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-3; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032496168     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.19.11675     Document Type: Article

References (41)

1. Falls, D. L., Rosen, K. M., Corfas, G., Lane, W. S., and Fischbach, G. D. (1993) Cell 72, 801-815
2. Marchionni, M. A., Goodearl, A. D., Chen, M. S., Bermingham-McDonogh, O., Kirk, C., Hendricks, M., Danehy, F., Misumi, D., Sudhalter, J., Kobayashi, K., Wroblewski, D., Lynch, C., Baldassare, M., Hiles, I., Davis, J. B., Hsuan, J. J., Totty, N. F., Otsu, M., McBurney, R. N., Waterfield, M. D., Stoobant, P., and Gwynne, D. (1993) Nature 362, 312-318
3. Meyer, D., and Birchmeier, C. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 1064-1068
4. Wen, D., Suggs, S. V., Karunagaran, D., Liu, N., Cupples, R. L., Luo, Y., Janssen, A. M., Ben-Baruch, N., Trollinger, D. B., Jacobsen, V. L., Meng, S.-Y., Lu, H. S., Hu, S., Chang, D., Yang, W., Yanigahara, D., Koski, R. A., and Yarden, Y. (1994) Mol. Cell. Biol. 14, 1909-1919
5. Morrissey, T. K., Levi, A. D., Nuijens, A., Sliwkowski, M. X., and Bunge, R. P. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1431-1435
6. Holmes, W. E., Sliwkowski, M. X., Akita, R. W., Henzel, W. J., Lee, J., Park, J. W., Yansura, D., Abadi, N., Raab, H., Lewis, G. D., Shepard, H. M., Kuang, W.-J., Wood, W. I., Goeddel, D. V., and Vandlen, R. L. (1992) Science 256, 1205-1210
7. Wen, D., Peles, E., Cupples, R., Suggs, S. V., Bacus, S. S., Luo, Y., Trail, G., Hu, S., Silbiger, S. M., Levy, R. B., Ben Levy, R., Koski, R. A., Lu, H. S., and Yarden, Y. (1992) Cell 69, 559-572
8. Hynes, N. E., and Stern, D. F. (1994) Biochim. Biophys. Acta 1198, 165-184
9. Lewis, G. D., Lofgren, J. A., McMurtrey, A. E., Nuijens, A., Fendly, B. M., Bauer, K. D., and Sliwkowski, M. X. (1996) Cancer Res. 56, 1457-1465
10. Peles, E., Bacus, S. S., Koski, R. A., Lu, H. S., Wen, D., Ogden, S. G., Levy, R. B., and Yarden, Y. (1992) Cell 69, 205-216
11. Peles, E., Ben-Levy, R., Tzahar, E., Liu, N., Wen, D., and Yarden, Y. (1993) EMBO J. 12, 961-971
12. Dougall, W. C., Qian, X., and Greene, M. I. (1993) J. Cell Biochem. 53, 61-73
13. Tzahar, E., Levkowitz, G., Karunagaran, D., Yi, L., Peles, E., Lavi, S., Chang, D., Liu, N., Yayon, A., Wen, D., and Yarden, Y. (1994) J. Biol. Chem. 269, 25226-25233
14. Plowman, G. D., Green, J. M., Culouscou, J. M., Carlton, G. W., Rothwell, V. M., and Buckley, S. (1993) Nature 366, 473-475
15. Carraway, K. L., III, Sliwkowski, M. X., Akita, R., Platko, J. V., Guy, P. M., Nuijens, A., Diamonti, A. J., Vandlen, R. L., Cantley, L. C., and Cerione, R. A. (1994) J. Biol. Chem. 269, 14303-14306
16. Sliwkowski, M. X., Schaefer, G., Akita, R. W., Lofgren, J. A., Fitzpatrick, V. D., Nuijens, A., Fendly, B. M., Cerione, R. A., Vandlen, R. L., and Carraway, K. L., III (1994) J. Biol. Chem. 269, 14661-14665
17. Chan, S. D. H., Antoniucci, D. M., Fok, K. S., Alajoki, M. L., Harkins, R. N., Thompson, S. A., and Wada, H. G. (1995) J. Biol. Chem. 270, 22608-22613
18. Karunagaran, D., Tzahar, E., Beerli, R. R., Chen, X., Graus-Porta, D., Ratzkin, B. J., Seger, R., Hynes, N. E., and Yarden, Y. (1996) EMBO J. 15, 254-264
19. Nagata, K., Kohda, D., Hatanaka, H., Ichikawa, S., Matsuda, S., Yamamoto, T., Suzuki, A., and Inagaki, F. (1994) EMBO J. 13, 3517-3523
20. Jacobsen, N. E., Abadi, N., Sliwkowski, M. X., Reilly, D., Skelton, N. J., and Fairbrother, W. J. (1996) Biochemistry 35, 3402-3417
21. Barbacci, E. G., Guarino, B. C., Stroh, J. G., Singleton, D. H., Rosnack, K. J., Moyer, J. D., and Andrews, G. C. (1995) J. Biol Chem. 270, 9585-5989
22. Clackson, T., and Wells, J. A. (1994) Trends Biochem. Sci. 12, 173-184
23. Souriau, C., Fort, P., Roux, P., Hartley, O., Lefranc, M.-P., and Weill, M. (1997) Nucleic Acids Res. 25, 1585-1590
24. Kunkel, T. A., Bebenek, K., and McClary, J. (1991) Methods Enzymol. 204, 125-139
25. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 5463-5467
26. Cunningham, B. C., Lowe, D. G., Li, B., Bennett, B. D., and Wells, J. A. (1994) EMBO J. 13, 2508-2515
27. Pearce, K. H., Potts, B., Presta, L., Bald, L., Fendly, B., and Wells, J. A. (1997) J. Biol. Chem. 272, 20595-20602
28. Sadick, M. D., Sliwkowski, M. X., Nuijens, A., Bald, L., Chiang, N., Lofgren, J. A., and Wong, W. L. T. (1996) Anal. Biochem. 235, 207-214
29. Bass, S., Greene, R., and Wells, J. A. (1990) Proteins 8, 309-314
30. Lowman, H. B., Bass, S. H., Simpson, N., and Wells, J. A. (1991) Biochemistry 30, 10832-10838
31. Li, B., Tom, J. Y., Oare, D., Yen, R., Fairbrother, W. J., Wells, J. A., and Cunningham, B. C. (1995) Science 270, 1657-1660
32. Lowman, H. B., and Wells, J. A. (1991) Methods, A Companion to Methods Enzymol. 3, 205-216
33. Campion, S. R., Biamonti, C., Montelione, G. T., and Niyogi, S. K. (1993) Protein Eng. 6, 651-659
34. Puddicombe, S. M., Chamberlin, S. G., MacGarvie, J., Richter, A., Drurnmond, D. R., Collins, J., Wood, L., and Davies, D. E. (1996) J. Biol. Chem 271 15367-15372
35. Braisted, A. C., and Wells, J. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 5688-5692
36. Carraway, K. L., III, and Cantley, L. C. (1994) Cell 78, 5-8
37. Plowman, G. D., Culouscou, J. M., Whitney, G. S., Green, J. M., Carlton, G. W., Foy, L., Neubauer, M. G., and Shoyab, M. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 1746-1750
38. Lemmon, M. A., Bu, Z., Ladbury, J. E., Zhou, M., Pinchasi, D., Lax, I., Engelman, D. M., and Schlessinger, J. (1997) EMBO J. 16, 281-294
39. Sherill, J. M., and Kyte, J. (1996) Biochem. 35, 5705-5718
40. Tzahar, E., Pinkas-Kramarski, R., Moyer, J. D., Klapper, L. N., Alroy, I., Levkowitz, G., Shelly, M., Henis, S., Eisenstein, M., Ratzkin, B. J., Sela, M., and Yarden, Y. (1997) EMBO J. 16, 4938-4950
41. Jones, J. T., Ballinger, M. D., Pisacane, P. I., Lofgren, J. A., Fitzpatrick, V. D., Fairbrother, W. J., Wells, J. A., and Sliwkowski, M. X. (1998) J. Biol. Chem. 273, 11667-11674