Specificity of the H-2 Ld-restricted cytotoxic T-lymphocyte response to the mouse hepatitis virus nucleocapsid protein

Journal of Virology

Volumn 70, Issue 5, 1996, Pages 3252-3257

  Bergmann, Cornelia C ^a   Stohlman, Stephen A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; H2 ANTIGEN; T LYMPHOCYTE RECEPTOR; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOREACTIVITY; MOUSE; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; VIRUS NUCLEOCAPSID;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CAPSID; EPITOPES; H-2 ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS I; MICE; MOLECULAR SEQUENCE DATA; MURINE HEPATITIS VIRUS; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, CYTOTOXIC; VIRAL CORE PROTEINS;

EID: 0029925845     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.5.3252-3257.1996     Document Type: Article

References (41)

1. Adami, C., J. Pooley, J. Glomb, E. Stecker, F. Fazal, J. O. Fleming, and S. C. Baker. 1995. Evolution of mouse hepatitis virus (MHV) during chronic infection: quasispecies nature of the persisting MHV RNA. Virology 209: 337-346.
2. Bastin, J., J. Rothbard, J. Davey, I. Jones, and A. Townsend. 1987. Use of synthetic peptides of influenza nucleoprotem to define epitopes recognized by class I restricted cytotoxic T lymphocytes. J. Exp. Med. 165:1508-1523.
3. + cytotoxic T lymphocyte response to two specific epitopes. Virology 200:281-283.
4. d-restncted nucleoprotem epitope. J. Gen. Virol. 74:2357-2363
5. d-restricted CTL epitope in the mouse hepatitis virus nucleocapsid protein. J. Virol. 67:7041-7049.
6. Bergmann, C. C., L. Tong, R. Cua, J. Sensintaffer, and S. Stohlman. 1994. Cytotoxic T cell repertoire selection A single amino acid determines alternative class I restriction. J. Immunol. 152:5603-5612.
7. b-restricted cytotoxic T cell response. J. Gen Virol. 77:315-325.
8. Bertoletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, M. De Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature (London) 369:407-410.
9. Bouvier, M., and D. C. Wiley. 1994. Importance of peptide amino and carboxyl termini to the stability of MHC class I molecules. Science 265:398-402.
10. Buchmeier, M. J., H. A. Lewiicki, P. J. Talbot, and R. L. Knobler. 1984. Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in vivo by monoclonal antibody. Virology 132:261-270
11. - T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity. J. Virol. 69:8127-8131.
12. Chen, W., S. Khilko, J. Feconde, D. H. Margulies, and J. McCluskey. 1994. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J. Exp. Med. 180:1471-1483.
13. ds: sequence motif quantitative binding, and molecular modeling of the complex. J. Exp. Med. 176:1681-1692
14. Couillin, I., B. Culmann-Penciolelli, E. Gomard, J. Choppin, J.-P. Levy, J.-G. Guillet. and S. Saragosti. 1994. Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein. J. Exp. Med. 180:1129-1134
15. Del Val, M., H.-J. Schlicht H. Volkmer, M. Messerle, M. J. Reddehase, and U. H. Koszinowski. 1991. Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope. J. Virol. 65:3641-3646.
16. Frazakerly, J. K., and M. J. Buchmeier. 1993. Pathogenesis of virus-induced demyelination. Adv. Virus Res. 42:249-324.
17. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287-299
18. b-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs. Eur. J. Immunol. 22:2663-2667.
19. Koup, R. A. 1994. Virus escape from CTL recognition. J. Exp. Med 180: 779-782.
20. Kyuwa, S., and S. A. Stohlman. 1990. Pathogenesis of a neurotropic murine coronavirus strain JHM in the central nervous system. Semin. Virol 1:273-280.
21. Lewicki, H., A. Tishon, P. Borrow, C. Evans, J. E. Gairin, K. M. Hahn, D. A. Jewell, I. A. Wilson, and M. B. A. Oldstone. 1995. CTL escape variants I. Generation and molecular characterization. Virology 210:29-40
22. Lewicki, H. A., M. G. Von Herrath, C. Evans, J. L. Whitton, and M. B. A. Oldstone. 1995. CTL escape variants II. Biologic activity in vivo. Virology 211:443-450.
23. Madden, D. R., D. N. Garboczi, and D. C. Wiley. 1993. The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 75:693-708.
24. Moskophidis. D., and R. Zinkernagel. 1995. Immunobiology of cytotoxic T-cell escape mutants of Jvmphocytic choriomeningitis virus. J. Virol 69: 2187-2193
25. Parker, K. C., M. A. Bednarek, and J. E. Coligan. 1994. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains. J. Immunol. 152:163-175.
26. Rammensee, H.-G., K. Falk, and O. Rötzschke. 1993. Peptides naturally presented by MHC class I molecules. Annu. Rev. Immunol. 11:213-244
27. Reddehase, M. J., and U. H. Koszinowski. 1991. Redistribution of critical major histocompatibility complex and T cell receptor-binding functions of residues in an antigenic sequence after biterminal substitution. Eur J Immunol. 21:1697-1701.
28. Reddehase, M. J., J. B. Rothbard, and U. H. Koszinowski. 1989. A pentapeptide as minimal antigenic determinant for MHC class I-restnaed T lymphocytes Nature (London) 337:651-653.
29. Sadovnikova, E., X. Zhu, S. M. Collins, J. Zhou, K. Vousden, L. Crawford, P. Beverly, and H. J. Stauss. 1994 Limitations of predictive motifs revealed by cytotoxic T lymphocyte epitope mapping of the human papilloma virus E7 protein Intern. Immunol. 6:289-296.
30. + cytotoxic T lymphocyte responses in vivo. J. Immunol. 152:1110-1119.
31. Schulz, M., P. Aichele, R. Schneider, T. H. Hansen, R. M. Zinkernagel, and H. Hengartner. 1991. Major histocompatibility complex binding and T cell recognition of a viral nonapeptide containing a minimal tetrapeptide Eur. J. Immunol 21:1181-1185
32. Schulz, M., P. Aichele, M. Vollenweider, F. W. Bobe, F. Cardinaux, H. Hengartner, and R. M. Zinkernagel. 1989. Major histocompatibility complex-dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease. Eur. J. Immunol 19:1657-1667
33. Sette, A., A. Vitiello, B. Reherman, P. Fowler, R. Nayersina, W. M. Kast, C. J. M. Melief, C. Oseroff, L. Yuan, J. Ruppert, J. Sidney, M.-F. del Guercio, S. Southwood, R. T. Kubo, R. W. Chesnut, H. M. Grey, and F. V. Chisari. 1994. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. J Immunol. 153:5586-5592.
34. b molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus. Proc. Natl. Acad. Sci. USA 89:3135-3139.
35. Stohlman, S. A., C. C. Bergmann, D. Cua, R. van der Veen, and D. R. Hinton. 1995. Mouse hepatitis virus nucleocapsid-specific cytotoxic T cells protect from lethal infection without eliminating virus from oligodendroglia. J. Virol. 69:684-694.
36. Stohlman, S. A., S. Kynwa, J. M. Polo, D. Brady, M. M. C. Lai, and C. C. Bergmann. 1993 Characterization of mouse hepatitis virus-specific T cells derived from the central nervous system of mice infected with the JHM strain. J. Virol. 67:7050-7059.
37. Stohlman, S., G. Matsushima, N. Casteel, and L. Weiner. 1986. In vivo effects of coronavirus-specific T cell clones: DTH inducer cells prevent a lethal infection but do not inhibit virus replication 1. J. Immunol. 136:3052-3056.
38. Udaka, K., T. J. Tsomides, P. Walden, N. Fukusen, and H. N. Eisen. 1993. A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone. Proc. Natl. Acad. Sci. USA 90:11272-11276.
39. d and is recognized by cytotoxic T Iymphocytes against mouse tumor P815. Eur. J. Immunol 24: 2740-2745.
40. Villanueva, M. S., P. Fischer, K. Feen, and E. G. Palmer. 1994. Efficiency of MHC class I antigen processing: a quantitative analysis. Immunity 1:459-489.
41. Whitton, J. L., A. Tishon, H. Lewicki, J. Gebhard, T. Cook, M. Salvato, E. Joly, and M. B. A. Oldstone. 1989 Molecular analysis of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity. J. Virol. 63:4303-4310.