Mitochondrial ultra condensation, but not swelling, is involved in TNFα-induced apoptosis in human T-lymphoblastic leukaemic cells

Leukemia Research

Volumn 21, Issue 10, 1997, Pages 973-983

  Jia, Li ^a   Dourmashkin, Robert R ^a   Newland, Adrian C ^a   Kelsey, Stephen M ^a,b  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Leukaemic cells; Mitochondrial conformation; Mitochondrial ultracondensation; Transmission electron microscopy (TEM); Tumour necrosis factor (TNF )

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA; VINBLASTINE; 3 METHYLADENINE; 3-METHYLADENINE; ADENINE; DNA FRAGMENT; DRUG DERIVATIVE; RECOMBINANT PROTEIN;

APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL SWELLING; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; RESPIRATORY CHAIN; T CELL LEUKEMIA; TRANSMISSION ELECTRON MICROSCOPY; CELL CULTURE; DRUG EFFECT; DRUG RESISTANCE; MITOCHONDRION SWELLING; PATHOLOGY; ULTRASTRUCTURE;

ADENINE; APOPTOSIS; DNA FRAGMENTATION; DRUG RESISTANCE, NEOPLASM; HUMANS; LEUKEMIA, T-CELL, ACUTE; MITOCHONDRIA; MITOCHONDRIAL SWELLING; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030608832     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(97)00078-7     Document Type: Article

References (40)

1. Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N. and Williamson, B., An endotoxin-induced serum factor that causes necrosis of tumours. Proceedings of the National Academy of Sciences of the USA, 1975, 72, 3666.
2. Lancaster, J. R. Jr., Laster, S. M. and Gooding, L. R., Inhibition of target cell mitochondrial electron transfer by tumour necrosis factor. FEBS Letters, 1989, 248, 169.
3. Schulze-Osthoff, K., Bakker, A. C., Vanhaesebroeck, B., Beyaert, R., Jacob, W. A. and Fiers, W., Cytotoxic activity of tumour necrosis factor is mediated by early damage of mitochondrial functions. Journal of Biological Chemistry, 1992, 267, 5317.
4. Kennet, T., Richarter, C. and Peterhons, E., Tumour necrosis factor-a induces superoxide anion generation in the mitochondria of L929 cells. Biochemical Journal, 1993, 289, 587.
5. Jia, L., Kelsey, S. M., Grahn, M. F., Jiang, X. R. and Newland, A. C., Increased activity and sensitivity of mitochondrial respiratory enzymes to TNFα-induced inhibition is associated with cytotoxicity in drug-resistant leukaemic cell lines. Blood, 1996, 87, 2401.
6. Goossens, V., Grooten, J. and Fiers, W., The oxidative mechanism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumour necrosis factor L929 fibrosarcoma cells. Journal of Biological Chemistry, 1996, 271, 192.
7. Cossarizza, A., Franceschi, C., Monti, D., Salvioli, S., Bellesia, E., Rivabene, R., Biondo, L., Rainaldi, G., Tinari, A. and Malorni, W., Protective effect of N-acetylcysteine in tumour necrosis factor-α-induced apoptosis in U937 cells: the role of mitochondria. Experimental Cell Research, 1995, 220, 232.
8. Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssière, J. L., Petit, P. X. and Kroemer, G., Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. Journal of Experimental Medicine, 1995, 181, 1661.
9. Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignotte, B. and Kroemer, G., Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. Journal of Experimental Medicine, 1995, 182, 367.
10. Kerr, J. F. R., Shrinkage necrosis: a distinct mode of cellular death. Journal of Pathology, 1971, 105, 13.
11. Shimizu, S., Eguchi, Y., Kosaka, H., Kamiike, W., Matsuda, H. and Tsujimoto, Y., Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature, 1996, 374, 811.
12. Jacobson, M. D. and Raff, M. C., Programmed cell death and Bcl-2 protection in very low oxygen. Nature, 1995, 374, 814.
13. Muschel, R. J., Bernahard, E. J., Garza, L., Mckenna, W. G. and Koch, C. J., Induction of apoptosis at different oxygen tensions: evidence that oxygen radicals do not mediate apoptotic signalling. Cancer Research, 1995, 55, 995.
14. Zamzami, N., Susin, S. A., Marchetti, P., Hirsch, T., Gömez-Monterrey, I., Castedo, M. and Kroemer, G., Mitochondrial control of nuclear apoptosis. Journal of Experimental Medicine, 1996, 183, 1533.
15. Susin, S., Zamzami, N., Castedo, M., Hirsch, T., Marchetti, P., Macho, A., Daugas, E., Geuskens, M. and Kroemer, G., Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. Journal of Experimental Medicine, 1996, 184, 1331.
16. Liu, X., Kim, C. N., Yang, J., Jemmerson, R. and Wang, X., Induction of apoptotic program in cell free extracts: requirement for dATP and cytochrome c. Cell, 1996, 86, 147.
17. Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T. I., Jones, D. P. and Wang, X., Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science, 1997, 275, 1129.
18. Kluck, R. M., Bossy-Wetzel, E., Green, D. R. and Newmeyer, D. D., The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science, 1997, 275, 1132.
19. Henkart, P. A. and Grinstein, S., Apoptosis: mitochondria resurrected?. Journal of Experimental Medicine, 1996, 183, 1293.
20. Jia, L., Jiang, X. R., Razak, K., Wu, Y. L., Newland, A. C. and Kelsey, S. M., TNF-mediated killing of human leukaemic cells: effects of endogenous antioxidant levels and TNFα expression in leukaemic cell lines. Leukaemia Research, 1995, 19, 187.
21. Amador, E., Dorfman, L. E. and Wacker, W. E. C., Serum lactate dehydrogenase: an analytical assessment of current assays. Clinical Chemistry, 1963, 9, 391.
22. Dourmashkin, R. R., Bucher, D. and Oxford, J. S., Small virus-like particles bud from the cell membranes of normal as well as HIV-infected human lymphoid cells. Journal of Medical Virology, 1993, 39, 229.
23. Laiho, K. U. and Trump, B. F., Studies on the pathogenesis of cell injury: effects of inhibitors of metabolism and membrane function on the mitochondria of Ehrlich Ascites tumor cells. Laboratory Investigations, 1975, 32, 163.
24. Trump, B. F., Berezesky, I. K. and Osornio-Vargas, A. R., Cell death and the disease process. The role of calcium. In Cell Death in Biology and Pathology, eds, I. D. Bowen and R. A. Lockshin, Chapman and Hall, 1981, p. 209.
25. Jia, L., Dourmashkin, R. R., Allen, P. D., Gray, A. B., Newland, A. C. and Kelsey, S. M., Inhibition of autophagy abrogates tumour necrosis factor-α-induced apoptosis in human T-lymphoblastic leukaemic cells. British Journal of Haematology (in press).
26. Seglen, P. O., Regulation of autophagic protein degeneration in isolated liver cells. In Lysosomes: Their Role in Protein Breakdown, eds H. Glaumann and F. J. Ballard, Academic press Inc. Ltd., London, 1987, p. 371.
27. Aggarmal, B. B. and Natarajan, K., Tumour necrosis factors: developments during the last decade. European Cytokine Network, 1996, 7, 93.
28. Richter, C., Schweizer, M., Cossarizza, A. and Franceschi, C., Control of apoptosis by the cellular ATP level. FEBS Letters, 1996, 378, 107.
29. Schulze-Osthoff, K., Krammer, P. H. and Drogue, W., Divergent signals via APO/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO Journal, 1994, 13, 4587.
30. Buttke, T. M. and Sandstrom, P. A., Oxidative stress as a mediator of apoptosis. Immunology Today, 1994, 15, 7.
31. Jacobson, M. D., Reactive oxygen species and programmed cell death. TIBS, 1996, 21, 83.
32. Kantrow, S. P. and Piantadosi, C. A., Release of cytochrome c from liver mitochondria during permeability transition. Biochemical and Biophysical Research Communications, 1997, 232, 669.
33. Higuchi, M., Aggarwal, B. B. and Yeh, E. T. H., Activation of CPP32-like protease in tumour necrosis factor-induced apoptosis is dependent on mitochondrial function. Journal of Clinical Investigation, 1997, 99, 1751.
34. Uhrik, B., Tribulova, N., Klobusicka, M., Barancik, M. and Breier, A., Characterization of morphological and histochemical changes induced by over-expression of P-glycoprotein in mouse leukaemic cell line L1210. Neoplasma, 1994, 41, 83.
35. Schneider, M., Hoffmann, H. and Zimmer, G., ATP contents and condensed configuration of rat liver mitochondria induced by rising ionic strength. Arzneimittel-Forschung, 1979, 29, 1574.
36. Candipan, R. C. and Sjostrand, F. S., An analysis of the contribution of the preparatory technique to the appearance of condensed and orthodox conformations of liver mitochondria. Journal of Ultrastructure Research, 1984, 89, 281.
37. Sheeler, P. and Bianchi, D. E., The mitochondrion. In Cell and Molecular Biology, eds P. Sheeler and D. E. Bianchi, John Wiley and Sons, Inc., New York, 1987, p. 377.
38. Garrett, R. H. and Grisham, C. M., Electron transport and oxidative phosphorylation. In Biochemistry, eds R. H. Garrett and C. M. Grisham, Saunders College Publishing and Harcount Brace College Publishing, 1987, p. 627.
39. Jia, L., Allen, P. D., Macey, M. G., Grahn, M. F., Newland, A. C. and Kelsey, S. M., Mitochondrial electron transport chain activity, but not ATP synthesis, is required for drug-induced apoptosis in human leukaemic cells: a possible novel mechanism of regulating drug resistance. British Journal of Haematology (in press).
40. Kroemer, G., Zamzami, N. and Susin, S. A., Mitochondrial control of apoptosis. Immunology Today, 1997, 18, 44.