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Volumn 10, Issue 4, 1999, Pages 337-354

Which 5-fluorouracil regimen? The great debate

Author keywords

5 fluorouracil; Advanced colorectal cancer; Regimens; Treatment

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; FLUOROURACIL; FOLINIC ACID;

EID: 0033113876     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199904000-00001     Document Type: Article
Times cited : (19)

References (85)
  • 3
    • 5544237608 scopus 로고    scopus 로고
    • Final results of a randomised trial comparing Tomudex'1' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer
    • Cunningham D, Zalcberg JR, Rath U, et al. Final results of a randomised trial comparing Tomudex'1' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. Ann Oncol 1996; 7: 961-5.
    • (1996) Ann Oncol , vol.7 , pp. 961-965
    • Cunningham, D.1    Zalcberg, J.R.2    Rath, U.3
  • 4
    • 0030966645 scopus 로고    scopus 로고
    • Colorectal cancer-is there an alternative to 5FU?
    • Bleiberg H. Colorectal cancer-is there an alternative to 5FU? EiirJ Cancer 1997; 33: 536-41.
    • (1997) EiirJ Cancer , vol.33 , pp. 536-541
    • Bleiberg, H.1
  • 5
    • 0031014682 scopus 로고    scopus 로고
    • Thymidylate synthase inhibitors in cancer therapy: Direct and indirect inhibitors
    • Rustum YM, Harstrick A, Cao S, et al. Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors./C7/w Oncol 1997; 15: 389-400.
    • (1997) /C7/w Oncol , vol.15 , pp. 389-400
    • Rustum, Y.M.1    Harstrick, A.2    Cao, S.3
  • 7
    • 0029989892 scopus 로고    scopus 로고
    • Modulated 5-fluorouracil (5-FU) regimens in advanced colorectal cancer: A critical review of comparative studies
    • Labianca R, Pessi A, Facendola G, Pirovano M, Luporini G. Modulated 5-fluorouracil (5-FU) regimens in advanced colorectal cancer: a critical review of comparative studies. EnrJ Cancer 1996; 32A (suppl 5): S7-12.
    • (1996) EnrJ Cancer , vol.32 A , Issue.5 SUPPL.
    • Labianca, R.1    Pessi, A.2    Facendola, G.3    Pirovano, M.4    Luporini, G.5
  • 8
    • 0028351657 scopus 로고
    • Chemotherapy for colorectal cancer
    • Moertel CG. Chemotherapy for colorectal cancer. N Engl JMed 1994; 330: 1136-42.
    • (1994) N Engl JMed , vol.330 , pp. 1136-1142
    • Moertel, C.G.1
  • 9
    • 0030881538 scopus 로고    scopus 로고
    • On behalf of the Colorectal Cancer Working Part' of the UK Medical Research Council. Attitudes and practice in the management of metastatic colorectal cancer in Britain
    • Seymour MT, Stenning SP, Gissidy J on behalf of the Colorectal Cancer Working Part)' of the UK Medical Research Council. Attitudes and practice in the management of metastatic colorectal cancer in Britain. Clin Oncol 1997; 9: 248-51.
    • (1997) Clin Oncol , vol.9 , pp. 248-251
    • Seymour, M.T.1    Stenning, S.P.2    Gissidy, J.3
  • 10
    • 0003153363 scopus 로고    scopus 로고
    • Chemotherapy for colorectal cancer relationship between toxicity and quality of life
    • abstr 1540
    • Ross P, Webb A, Cunningliam D, et al. Chemotherapy for colorectal cancer relationship between toxicity and quality of life. Ann Oncol 1996; 7 (suppl 5): 34 (abstr 1540).
    • (1996) Ann Oncol , vol.7 , Issue.5 SUPPL. , pp. 34
    • Ross, P.1    Webb, A.2    Cunningliam, D.3
  • 11
    • 0031935179 scopus 로고    scopus 로고
    • Assessing patients' needs and preferences in the management of advanced colorectal cancer
    • Redmond K. Assessing patients' needs and preferences in the management of advanced colorectal cancer. Br J Cancer 1998; 77 (suppl 2): 5-7.
    • (1998) Br J Cancer , vol.77 , Issue.2 SUPPL. , pp. 5-7
    • Redmond, K.1
  • 12
    • 0001553706 scopus 로고    scopus 로고
    • A survey of patients' perceptions of the convenience of different chemotherapy regimens for advanced colorectal cancer
    • Topham C. A survey of patients' perceptions of the convenience of different chemotherapy regimens for advanced colorectal cancer. EnrJ Cancer Care 1997; 6: 208-11.
    • (1997) EnrJ Cancer Care , vol.6 , pp. 208-211
    • Topham, C.1
  • 13
    • 0031837358 scopus 로고    scopus 로고
    • Evaluation of clinical efficacy of new medical treatments in advanced colorectal cancer. Results of a workshop organized by the EORTC GITCCG. European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group
    • Wils J, Sahmoud T, Sobrero A, et al. Evaluation of clinical efficacy of new medical treatments in advanced colorectal cancer. Results of a workshop organized by the EORTC GITCCG. European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group. Timiori 1998; 84: 335-47.
    • (1998) Timiori , vol.84 , pp. 335-347
    • Wils, J.1    Sahmoud, T.2    Sobrero, A.3
  • 14
    • 0002620999 scopus 로고    scopus 로고
    • Principles of cancer management: Chemotherapy
    • DeVita VT, Hellman S, Rosenberg SA, eds. Philadelpliia: Lippincott-Raven
    • DeVita VT Jr. Principles of cancer management: chemotherapy. In: DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: principles and practice of oncology, 3rd edn. Philadelpliia: Lippincott-Raven 1997: 333-47.
    • (1997) Cancer: Principles and Practice of Oncology, 3rd Edn. , pp. 333-347
    • DeVita Jr., V.T.1
  • 15
    • 0026632646 scopus 로고
    • Cancer chemotherapy and quality of life
    • Byrne M. Cancer chemotherapy and quality of life. Br MedJ 1992; 304: 1523-4.
    • (1992) Br MedJ , vol.304 , pp. 1523-1524
    • Byrne, M.1
  • 17
    • 0025991253 scopus 로고
    • Folinic acid + 5fluorouracil (5-FU) versus equidose 5-FU in advanced colorectal cancer. Phase III study of 'GISCAD' (Italian Group for the Study of Digestive Tract Cancer)
    • Labianca R, Pancera G, Aitini E, et al. Folinic acid + 5fluorouracil (5-FU) versus equidose 5-FU in advanced colorectal cancer. Phase III study of 'GISCAD' (Italian Group for the Study of Digestive Tract Cancer). Ann Oncol 1991; 2: 673-9-
    • (1991) Ann Oncol , vol.2
    • Labianca, R.1    Pancera, G.2    Aitini, E.3
  • 18
    • 0024513402 scopus 로고
    • A phase III trial of 5-fluorouraciI and leucovorin in the treatment of advanced colorectal cancer a Mayo Clinic/North Central Cancer Treatment Group Study
    • O'Connell MJ. A phase III trial of 5-fluorouraciI and leucovorin in the treatment of advanced colorectal cancer a Mayo Clinic/North Central Cancer Treatment Group Study. Cancer 1989; 63: 1026-30.
    • (1989) Cancer , vol.63 , pp. 1026-1030
    • O'Connell, M.J.1
  • 19
    • 9044251980 scopus 로고
    • Treatment of advanced colorectal cancer with high-dose intensity folinic acid and 5-fluorouracil plus supportive care
    • Petrioli R, Lorenzi M, Aquino A, et al. Treatment of advanced colorectal cancer with high-dose intensity folinic acid and 5-fluorouracil plus supportive care. Enr J Cancer 1995; 12: 2105-8.
    • (1995) Enr J Cancer , vol.12 , pp. 2105-2108
    • Petrioli, R.1    Lorenzi, M.2    Aquino, A.3
  • 20
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A MidAtlantic Oncology Program study
    • Lokich JJ, Alilgren JD, Gullo JJ, Philips JA, Fryer JG. A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a MidAtlantic Oncology Program study. / Clin Oncol 1989; 7: 425-32.
    • (1989) / Clin Oncol , vol.7 , pp. 425-432
    • Lokich, J.J.1    Alilgren, J.D.2    Gullo, J.J.3    Philips, J.A.4    Fryer, J.G.5
  • 21
    • 0029012118 scopus 로고
    • Phase U study of fluorouracil and its modulation in advanced colorectal cancer, a Southwest Oncology Group study
    • Leichman CG, Fleming TR, Muggia FM, ct al. Phase U study of fluorouracil and its modulation in advanced colorectal cancer, a Southwest Oncology Group study. / atn Oncol 1995; 13: 1303-11.
    • (1995) / Atn Oncol , vol.13 , pp. 1303-1311
    • Leichman, C.G.1    Fleming, T.R.2    Muggia, F.M.3
  • 22
    • 0023874456 scopus 로고
    • A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma
    • Eriichman C, Fine S, Wong A, Elhakim T. A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol 1988; 6: 469-75.
    • (1988) J Clin Oncol , vol.6 , pp. 469-475
    • Eriichman, C.1    Fine, S.2    Wong, A.3    Elhakim, T.4
  • 23
    • 0027412002 scopus 로고
    • Folinic acid does improve 5fluorouracil activity in vivo. Results of a phase III trial comparing 5-fluorouracil to 5-fiuorouracil and folinic acid in advanced colon cancer patients
    • Bobbio-Pallavicini E, Porta C, Moroni M, Spaglii A, Casagranda I, Nastasi G. Folinic acid does improve 5fluorouracil activity in vivo. Results of a phase III trial comparing 5-fluorouracil to 5-fiuorouracil and folinic acid in advanced colon cancer patients./ Cbemother 1993; 5: 52-5.
    • (1993) / Cbemother , vol.5 , pp. 52-55
    • Bobbio-Pallavicini, E.1    Porta, C.2    Moroni, M.3    Spaglii, A.4    Casagranda, I.5    Nastasi, G.6
  • 24
    • 0025261244 scopus 로고
    • Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy
    • Doroshow JH, Multhauf P, Leong L, et al. Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy./ Clin Oncol 1990; 8: 491-501.
    • (1990) / Clin Oncol , vol.8 , pp. 491-501
    • Doroshow, J.H.1    Multhauf, P.2    Leong, L.3
  • 25
    • 0029923720 scopus 로고    scopus 로고
    • Phase m study of bolus versus infusion fluorouracil with or without cisplatin in advanced colorectal cancer
    • Hansen RM, Ryan L, Anderson T, et al. Phase m study of bolus versus infusion fluorouracil with or without cisplatin in advanced colorectal cancer. / Natl Cancer Iiist 1996; 88: 668-74.
    • (1996) / Natl Cancer Iiist , vol.88 , pp. 668-674
    • Hansen, R.M.1    Ryan, L.2    Anderson, T.3
  • 26
    • 0025881101 scopus 로고
    • Advanced colorectal carcinoma: A prospective randomized trial of sequential methotrexate, 5-fluorouracil, and leucovorin versus 5-fluorouracil alone
    • Macliiavelli M, Leone BA, Romero A, et al. Advanced colorectal carcinoma: a prospective randomized trial of sequential methotrexate, 5-fluorouracil, and leucovorin versus 5-fluorouracil alone. Am J Clin Oncol 1991; 14: 211-7.
    • (1991) Am J Clin Oncol , vol.14 , pp. 211-217
    • Macliiavelli, M.1    Leone, B.A.2    Romero, A.3
  • 27
    • 0023520170 scopus 로고
    • A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and liigh-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma
    • Petrelli N, Herrera L, Rustum Y, et al. A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and liigh-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. / Clin Oncol 1987; 5: 1559-65.
    • (1987) / Clin Oncol , vol.5 , pp. 1559-1565
    • Petrelli, N.1    Herrera, L.2    Rustum, Y.3
  • 28
    • 0026503408 scopus 로고
    • Fluorouracil alone versus high-dose folinic acid and fluorouracil in advanced colorectal cancer a randomized trial of the Italian Onclology Group for Clinical Research GOIRQ
    • Di Costanzo F, Bartolucci R, Calabresi F, et al. Fluorouracil alone versus high-dose folinic acid and fluorouracil in advanced colorectal cancer a randomized trial of the Italian Onclology Group for Clinical Research (GOIRQ. Ann Oncol 1992; 3: 371-6.
    • (1992) Ann Oncol , vol.3 , pp. 371-376
    • Di Costanzo, F.1    Bartolucci, R.2    Calabresi, F.3
  • 29
    • 0024342059 scopus 로고
    • Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: A randomized trial of the Northern California Oncology Group
    • Valone FH, Friedman MA, Wittlinger PS, et al. Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: a randomized trial of the Northern California Oncology Group./C7/H Oncol 1989; 7: 1427-36.
    • (1989) /C7/H Oncol , vol.7 , pp. 1427-1436
    • Valone, F.H.1    Friedman, M.A.2    Wittlinger, P.S.3
  • 30
    • 9444283120 scopus 로고    scopus 로고
    • For the Spanish Cooperative Group for Gastrointestinal Tumor Therapy (TTD)
    • Aranda E, Cervantes A, Carrato A, et al. for the Spanish Cooperative Group for Gastrointestinal Tumor Therapy (TTD). Ann Oncol 1996; 7: 581-5.
    • (1996) Ann Oncol , vol.7 , pp. 581-585
    • Aranda, E.1    Cervantes, A.2    Carrato, A.3
  • 31
    • 0030894390 scopus 로고    scopus 로고
    • For the Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs (GERCOD). Bimonthly high dose leucovorin and 5-fluorouracil 48-hour continuous infusion in patients with advanced colorectal carcinoma
    • Beerblock K, Rinaldi Y, André T, et al. for the Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs (GERCOD). Bimonthly high dose leucovorin and 5-fluorouracil 48-hour continuous infusion in patients with advanced colorectal carcinoma. Cancer 1997; 79: 1100-5.
    • (1997) Cancer , vol.79 , pp. 1100-1105
    • Beerblock, K.1    Rinaldi, Y.2    André, T.3
  • 32
    • 9444270969 scopus 로고    scopus 로고
    • Modulation of highdose infusional fluorouracil by low-dose methotrexate in patients with advanced or metastatic colorectal cancer final results of a randomized European Organization for Research and Treatment of Cancer Study
    • Blijham G, Wagener T, Wils J, et al. Modulation of highdose infusional fluorouracil by low-dose methotrexate in patients with advanced or metastatic colorectal cancer final results of a randomized European Organization for Research and Treatment of Cancer Study. / Gin Oncol 1996; 14: 2266-73.
    • (1996) / Gin Oncol , vol.14 , pp. 2266-2273
    • Blijham, G.1    Wagener, T.2    Wils, J.3
  • 33
    • 0028175144 scopus 로고
    • Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer
    • BurokerTR, O'Connell MJ, Wieand HS, etal. Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. / Gin Oncol 1994; 12: 14-20.
    • (1994) / Gin Oncol , vol.12 , pp. 14-20
    • Buroker, T.R.1    O'Connell, M.J.2    Wieand, H.S.3
  • 34
    • 0028940258 scopus 로고
    • A randomized study of bolus fluorouracil plus folinic acid versus 21-day fluorouracil infusion alone or in association with cyclophosphamide and mitomycin C in advanced colorectal carcinoma
    • Caudry M, Bonnel C, Floquet A, et al. A randomized study of bolus fluorouracil plus folinic acid versus 21-day fluorouracil infusion alone or in association with cyclophosphamide and mitomycin C in advanced colorectal carcinoma. Am J Clin Oncol 1995; 18: 118-25.
    • (1995) Am J Clin Oncol , vol.18 , pp. 118-125
    • Caudry, M.1    Bonnel, C.2    Floquet, A.3
  • 35
    • 0028956096 scopus 로고
    • Phase HI randomized study of two fluorouracil combinations with either interferon alfa-2a or leucovorin for advanced colorectal cancer
    • Corfu-A Study Group. Phase HI randomized study of two fluorouracil combinations with either interferon alfa-2a or leucovorin for advanced colorectal cancer. / Clin Oncol 1995; 13: 921-8.
    • (1995) / Clin Oncol , vol.13 , pp. 921-928
  • 36
    • 0024834136 scopus 로고
    • Fluorouracil and recombinant alfa-2a-interferon: An active regimen against advanced colorectal carcinoma
    • Wacller S, Schwanz EL, Goldman M, et al. Fluorouracil and recombinant alfa-2a-interferon: an active regimen against advanced colorectal carcinoma. / Clin Oncol 1989; 7: 1769-75.
    • (1989) / Clin Oncol , vol.7 , pp. 1769-1775
    • Wacller, S.1    Schwanz, E.L.2    Goldman, M.3
  • 37
    • 0031019918 scopus 로고    scopus 로고
    • Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer a French intergroup study
    • de Gramont A, Bosset JF, Milan C, et al. Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer a French intergroup study. / Clin Oncol 1997; 15: 808-15.
    • (1997) / Clin Oncol , vol.15 , pp. 808-815
    • De Gramont, A.1    Bosset, J.F.2    Milan, C.3
  • 38
    • 0029151845 scopus 로고
    • High-dose folinic acid and 5-fluorouracil bolus and continuous infusion in advanced colorectal cancer poor response rate in unselected patients
    • Hanna CL, McKinna FE, Williams LB, et al. High-dose folinic acid and 5-fluorouracil bolus and continuous infusion in advanced colorectal cancer poor response rate in unselected patients. BrJ Cancer 1995; 72: 774-6.
    • (1995) BrJ Cancer , vol.72 , pp. 774-776
    • Hanna, C.L.1    McKinna, F.E.2    Williams, L.B.3
  • 39
    • 0029131435 scopus 로고
    • Impact of protracted venous infusion fluorouracil with or without interferon alfa-2b on tumor response, survival, and quality of life in advanced colorectal cancer
    • Hill M, Norman A, Cunningham D, et al. Impact of protracted venous infusion fluorouracil with or without interferon alfa-2b on tumor response, survival, and quality of life in advanced colorectal cancer./ Clin Oncol 1995; 13: 2317-23.
    • (1995) / Clin Oncol , vol.13 , pp. 2317-2323
    • Hill, M.1    Norman, A.2    Cunningham, D.3
  • 40
    • 0029813416 scopus 로고    scopus 로고
    • For the Study Group for Palliative Treatment of Metastatic Colorectal Cancer Study Protocol 1. Weekly liigh-dose leucovorin versus low-dose leucovorin combined with fluorouracil in advanced colorectal cancer, results of a randomized multicenter trial
    • Jäger E, Heike M, Bernhard H, et al for the Study Group for Palliative Treatment of Metastatic Colorectal Cancer Study Protocol 1. Weekly liigh-dose leucovorin versus low-dose leucovorin combined with fluorouracil in advanced colorectal cancer, results of a randomized multicenter trial. J Clin Oncol 1996; 14: 2274-9.
    • (1996) J Clin Oncol , vol.14 , pp. 2274-2279
    • Jäger, E.1    Heike, M.2    Bernhard, H.3
  • 41
    • 0345403552 scopus 로고    scopus 로고
    • Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: Results of a randomized trial in patients with advanced colorectal cancer
    • Köline CH, Schöffski P, Wilke H, et al. Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer./ Clin Oncol 1998; 16: 418-6.
    • (1998) / Clin Oncol , vol.16 , pp. 418-426
    • Köline, C.H.1    Schöffski, P.2    Wilke, H.3
  • 42
    • 0023491911 scopus 로고
    • Treatment of advanced colorectal and gastric adenocarcinomas with 5fluorouracil and high-dose folinic acid
    • Machover D, Goldschmidt E, Chollet P, et al. Treatment of advanced colorectal and gastric adenocarcinomas with 5fluorouracil and high-dose folinic acid. NCI Monogr 1987; 5: 193-8.
    • (1987) NCI Monogr , vol.5 , pp. 193-198
    • Machover, D.1    Goldschmidt, E.2    Chollet, P.3
  • 43
    • 0026006962 scopus 로고
    • Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
    • Poon MA, O'Connell MJ, Wieand HS, et al. Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Oncol 1991; 9: 1967-72.
    • (1991) J Clin Oncol , vol.9 , pp. 1967-1972
    • Poon, M.A.1    O'Connell, M.J.2    Wieand, H.S.3
  • 44
    • 9344221617 scopus 로고    scopus 로고
    • Randomized trial of 5fluorouracil and high-dose folinic acid with or without alpha-2B interferon in advanced colorectal cancer
    • Reccliia F, Nuzzo A, Lalli A, et al. Randomized trial of 5fluorouracil and high-dose folinic acid with or without alpha-2B interferon in advanced colorectal cancer. Am J Clin Oncol 1996; 19: 301-4.
    • (1996) Am J Clin Oncol , vol.19 , pp. 301-304
    • Reccliia, F.1    Nuzzo, A.2    Lalli, A.3
  • 45
    • 9444220779 scopus 로고    scopus 로고
    • For the Colorectal Cancer Working Party of the United Kingdom Medical Research Council. Randomized trial assessing the addition of interferon a-2a to fluorouracil and leucovorin in advanced colorectal cancer
    • Seymour MT, Slevin ML, Kerr DJ, et al. for the Colorectal Cancer Working Party of the United Kingdom Medical Research Council. Randomized trial assessing the addition of interferon a-2a to fluorouracil and leucovorin in advanced colorectal cancer. / Clin Oncol 1996; 14: 2280-8.
    • (1996) / Clin Oncol , vol.14 , pp. 2280-2288
    • Seymour, M.T.1    Slevin, M.L.2    Kerr, D.J.3
  • 46
    • 0028205751 scopus 로고
    • Randomized comparison of fluorouracil and leucovorin therapy versus fluorouracil, leucovorin, and cisplatin therapy in patients with advanced colorectal cancer
    • Scheithauer W, Depisch D, Kornek G, et al. Randomized comparison of fluorouracil and leucovorin therapy versus fluorouracil, leucovorin, and cisplatin therapy in patients with advanced colorectal cancer. Cancer 1994; 73: 15628.
    • (1994) Cancer , vol.73 , pp. 15628
    • Scheithauer, W.1    Depisch, D.2    Kornek, G.3
  • 47
    • 0028213430 scopus 로고
    • Weekly therapy with folinic acid (FA) and high-dose 5-fluorouracil (5-FU) 24hour infusion in ptretreated patients with metastatic colorectal carcinoma
    • Weh HJ, Wilke HJ, Dierlamm J, et al. Weekly therapy with folinic acid (FA) and high-dose 5-fluorouracil (5-FU) 24hour infusion in ptretreated patients with metastatic colorectal carcinoma. Ann Oncol 1994; 5: 233-7.
    • (1994) Ann Oncol , vol.5 , pp. 233-237
    • Weh, H.J.1    Wilke, H.J.2    Dierlamm, J.3
  • 48
    • 33744510106 scopus 로고
    • A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorcctal carcinoma
    • Ardalan B, Chua L, Tian EM, et al. A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorcctal carcinoma./ Clin Oncol 1991; 9625-30.
    • (1991) / Clin Oncol , pp. 9625-9630
    • Ardalan, B.1    Chua, L.2    Tian, E.M.3
  • 49
    • 0030661574 scopus 로고    scopus 로고
    • Prospectively randomized North Central Cancer Treatment Group trial of intensive-course fluorouracil combined with the lisomer of intravenous leucovorin, oral leucovorin, or intravenous leucovorin for the treatment of advanced colorectal cancer
    • Goldberg RM, Hatfield AK, Kaiin M, et al. Prospectively randomized North Central Cancer Treatment Group trial of intensive-course fluorouracil combined with the lisomer of intravenous leucovorin, oral leucovorin, or intravenous leucovorin for the treatment of advanced colorectal cancer./ Clin Oncol 1997; 15: 3320-9.
    • (1997) / Clin Oncol , vol.15 , pp. 3320-3329
    • Goldberg, R.M.1    Hatfield, A.K.2    Kaiin, M.3
  • 50
    • 0013405202 scopus 로고    scopus 로고
    • On behalf of GISCAD (Italian Group for the Study of Digestive Tract Cancer). High- Versus low-dose levo-leucovorin as a modulator of 5-fluorouracil in advanced colorectal cancer a 'GISCAD' phase m study
    • Labianca R, Cascinu S, Frontini L, et al. on behalf of GISCAD (Italian Group for the Study of Digestive Tract Cancer). High- versus low-dose levo-leucovorin as a modulator of 5-fluorouracil in advanced colorectal cancer a 'GISCAD' phase m study. Ann Oncol 1997; 8: 169-74.
    • (1997) Ann Oncol , vol.8 , pp. 169-174
    • Labianca, R.1    Cascinu, S.2    Frontini, L.3
  • 51
    • 0027360285 scopus 로고
    • A randomized, double-blind trial of fluorouracil plus placebo versus fluorouracil plus oral leucovorin in patients with metastatic colorectal cancer
    • Laufman LR, Bukowski RM, Collier MA, et al. A randomized, double-blind trial of fluorouracil plus placebo versus fluorouracil plus oral leucovorin in patients with metastatic colorectal cancer. / Clin Oncol 1993; 11: 1888-93.
    • (1993) / Clin Oncol , vol.11 , pp. 1888-1893
    • Laufman, L.R.1    Bukowski, R.M.2    Collier, M.A.3
  • 52
    • 0031471150 scopus 로고    scopus 로고
    • Systemic treatment options in advanced colorectal cancer perspectives on combination 5-fluorouracil plus leucovorin
    • Grem JL Systemic treatment options in advanced colorectal cancer perspectives on combination 5-fluorouracil plus leucovorin. Semin Oncol 1997; 24 (suppl 18): 8-18.
    • (1997) Semin Oncol , vol.24 , Issue.18 SUPPL. , pp. 8-18
    • Grem, J.L.1
  • 53
    • 0024347268 scopus 로고
    • Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma
    • Poon MA, O'Connell MJ, Moertel CG, et al. Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. / Clin Oncol 1989; 7: 1407-17.
    • (1989) / Clin Oncol , vol.7 , pp. 1407-1417
    • Poon, M.A.1    O'Connell, M.J.2    Moertel, C.G.3
  • 54
    • 0019906743 scopus 로고
    • Treatment of advanced colorectal and gastric adenocarcinomas with 5-FU combined with high-dose folinic acid: A pilot study
    • Machover D, Schwarzenberg L, Goldschmidt E, et al. Treatment of advanced colorectal and gastric adenocarcinomas with 5-FU combined with high-dose folinic acid: a pilot study. Cancer Treat Rep 1982; 66: 1803-7.
    • (1982) Cancer Treat Rep , vol.66 , pp. 1803-1807
    • Machover, D.1    Schwarzenberg, L.2    Goldschmidt, E.3
  • 55
    • 0021130547 scopus 로고
    • Phase I/II trial of liigh-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer
    • iMadajewicz P. Phase I/II trial of liigh-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer. Cancer Res 1984; 44: 4667-5669.
    • (1984) Cancer Res , vol.44 , pp. 4667-5669
    • Madajewicz, P.1
  • 56
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer, evidence in terms of response me
    • Advanced Colorectal Cancer Meta-Analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer, evidence in terms of response me. J Clin Oncol 1992; 10: 896-903-
    • (1992) J Clin Oncol , vol.10
  • 57
    • 0031015454 scopus 로고    scopus 로고
    • Fluorouracil in colorectal cancer-a tale of two drugs: Implications for biochemical modulation
    • Sobrero AF, Aschele C, Bertino JR. Fluorouracil in colorectal cancer-a tale of two drugs: implications for biochemical modulation. / Clin Oncol 1997; 15: 368-81.
    • (1997) / Clin Oncol , vol.15 , pp. 368-381
    • Sobrero, A.F.1    Aschele, C.2    Bertino, J.R.3
  • 58
    • 0030983311 scopus 로고    scopus 로고
    • Protracted infusional 5-fluorouracil for colorectal cancer
    • Lokich J. Protracted infusional 5-fluorouracil for colorectal cancer. Tinnori 1997; 83 (suppl): S53-5-
    • (1997) Tinnori , vol.83 , Issue.SUPPL.
    • Lokich, J.1
  • 59
    • 0016768026 scopus 로고
    • Comparison of continuously infused 5-fluorouracil with bolus injection in patients with colorectal adenocarcinoma
    • Seifen P, Baker LH, Reed MD, Vaitkevikius VK. Comparison of continuously infused 5-fluorouracil with bolus injection in patients with colorectal adenocarcinoma. Cancer 1975; 36: 123-8.
    • (1975) Cancer , vol.36 , pp. 123-128
    • Seifen, P.1    Baker, L.H.2    Reed, M.D.3    Vaitkevikius, V.K.4
  • 60
    • 14444267315 scopus 로고    scopus 로고
    • Scheduleselective biochemical modulation of 5-fluorouracil in advanced colorectal cancer a multicentric phase II study
    • Aschele C, Guglielmi A, Frassineti GL, et al. Scheduleselective biochemical modulation of 5-fluorouracil in advanced colorectal cancer a multicentric phase II study. BrJ Cancer 1998; 77: 341-6.
    • (1998) BrJ Cancer , vol.77 , pp. 341-346
    • Aschele, C.1    Guglielmi, A.2    Frassineti, G.L.3
  • 61
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • Meta-Analysis Group in Cancer. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. -J Clin Oncol 1998; 16: 301-8.
    • (1998) -J Clin Oncol , vol.16 , pp. 301-308
  • 62
    • 0344726126 scopus 로고    scopus 로고
    • Pooled analysis of phase II trials with low-dose 5-fluorouracil continuous infusion (LD 5-FU CI) as a second line chemotherapy in advanced colorectal cancer ACQ
    • abstr 1047
    • Tliirion P, Cunningham D, Findlay M, et al. Pooled analysis of phase II trials with low-dose 5-fluorouracil continuous infusion (LD 5-FU CI) as a second line chemotherapy in advanced colorectal cancer (ACQ. Proc Am Soc Clin Oncol 1998; 17: 272a (abstr 1047).
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Tliirion, P.1    Cunningham, D.2    Findlay, M.3
  • 63
    • 0032055888 scopus 로고    scopus 로고
    • From tlie Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire and Digestifs (GERCOD). A review of GERCOD trials of bimonthly leucovorin plus 5-fluorouracil 48-h continuous infusion in advanced colorectal cancer evolution of a regimen
    • de Gramont A, Louvet C, André T, Toumigand C, Krulik M, from tlie Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire and Digestifs (GERCOD). A review of GERCOD trials of bimonthly leucovorin plus 5-fluorouracil 48-h continuous infusion in advanced colorectal cancer evolution of a regimen. EurJ Cancer 1998; 34: 619-26.
    • (1998) EurJ Cancer , vol.34 , pp. 619-626
    • De Gramont, A.1    Louvet, C.2    André, T.3    Toumigand, C.4    Krulik, M.5
  • 64
    • 0023802172 scopus 로고
    • Higli-dose folinic acid and 5-fluorouracil bolus and continuous infusion in advanced colorectal cancer
    • de Gramont A, Krulik M, Cady J, et al. Higli-dose folinic acid and 5-fluorouracil bolus and continuous infusion in advanced colorectal cancer. Eur J Cancer Clin Oncol 1988; 24: 1499-503.
    • (1988) Eur J Cancer Clin Oncol , vol.24 , pp. 1499-1503
    • De Gramont, A.1    Krulik, M.2    Cady, J.3
  • 65
    • 7344268229 scopus 로고    scopus 로고
    • Randomized comparison between methotrexate-fluorouracil and schedule-specific biochemical modulation in advanced colorectal cancer
    • abstr 964
    • Sobrero A, Labianca R, Frassineti GL, et al. Randomized comparison between methotrexate-fluorouracil and schedule-specific biochemical modulation in advanced colorectal cancer. ProcAm Soc Clin Oncol 1997; 16: 272a (abstr 964).
    • (1997) ProcAm Soc Clin Oncol , vol.16
    • Sobrero, A.1    Labianca, R.2    Frassineti, G.L.3
  • 67
    • 85037469877 scopus 로고    scopus 로고
    • Standard dose (Mayo regimen) 5-FU and folinic acid: Prohibitive toxicity?
    • abstr 1062
    • Tomiak A, Vincent M, Kocha W, et al. Standard dose (Mayo regimen) 5-FU and folinic acid: prohibitive toxicity? ProcAm Soc Clin Oncol 1998; 17: 276a (abstr 1062).
    • (1998) ProcAm Soc Clin Oncol , vol.17
    • Tomiak, A.1    Vincent, M.2    Kocha, W.3
  • 68
    • 7144227957 scopus 로고    scopus 로고
    • The impact of adding low-dose leucovorin to montlily 5-flurouracil in advanced colorectal cancer, results of a phase III trial
    • Bonier MM, Castiglione M, Bacclii M, et al. The impact of adding low-dose leucovorin to montlily 5-flurouracil in advanced colorectal cancer, results of a phase III trial. Ann Oncol 1998; 9: 535-41.
    • (1998) Ann Oncol , vol.9 , pp. 535-541
    • Bonier, M.M.1    Castiglione, M.2    Bacclii, M.3
  • 69
    • 0023902287 scopus 로고
    • Familial deficiency of dihydropyrimidine dehydrogenase: Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity
    • Diasio RB, Beavers TL, Carpenter T. Familial deficiency of dihydropyrimidine dehydrogenase: biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity./ Clin Invest 1988; 81: 47.
    • (1988) / Clin Invest , vol.81 , pp. 47
    • Diasio, R.B.1    Beavers, T.L.2    Carpenter, T.3
  • 70
    • 0029143511 scopus 로고
    • Current chemotherapeutic possibilities in the treatment of colorectal cancer
    • \nn Triest B, van Groeningen CJ, Pinedo HM. Current chemotherapeutic possibilities in the treatment of colorectal cancer. EurJ Cancer 1995; 31A: 1193-7.
    • (1995) EurJ Cancer , vol.31 A , pp. 1193-1197
    • Triest, B.1    Van Groeningen, C.J.2    Pinedo, H.M.3
  • 71
    • 0028022165 scopus 로고
    • Bolus/infusional 5-fluorouracil and folinic acid for metastatic colorectal carcinoma: Are suboptimal dosages being used in the UK?
    • Jodrell DI, Murray LS, Reed NS, Canney PA, Kaye SB, CassidyJ. Bolus/infusional 5-fluorouracil and folinic acid for metastatic colorectal carcinoma: are suboptimal dosages being used in the UK? BrJ Cancer 1994; 70: 749-52.
    • (1994) BrJ Cancer , vol.70 , pp. 749-752
    • Jodrell, D.I.1    Murray, L.S.2    Reed, N.S.3    Canney, P.A.4    Kaye, S.B.5    CassidyJ6
  • 72
    • 0031935180 scopus 로고    scopus 로고
    • The establishment of a large collaborative trial programme in the adjuvant treatment of colon cancer
    • Wils J. The establishment of a large collaborative trial programme in the adjuvant treatment of colon cancer. Br J Cancer 1998; 77 (suppl 2): 23-8.
    • (1998) Br J Cancer , vol.77 , Issue.2 SUPPL. , pp. 23-28
    • Wils, J.1
  • 73
    • 33744542057 scopus 로고    scopus 로고
    • Oxford: QUASAR Office, Clinical Trials Service Unit, Radcliffe Infirmary
    • QUASAR. A UKCCCR study of colorectal cancer treatment. Oxford: QUASAR Office, Clinical Trials Service Unit, Radcliffe Infirmary 1996.
    • (1996) UKCCCR Study of Colorectal Cancer Treatment.
    • Quasar, A.1
  • 74
    • 0029084773 scopus 로고
    • CPT11 (irinotecan) in the treatment of colorectal cancer
    • Armand J, Ducreux M, Mahjoubi M, et al. CPT11 (irinotecan) in the treatment of colorectal cancer. EurJ Cancer 1995; 31Ä: 1283-7.
    • (1995) EurJ Cancer , vol.31 , pp. 1283-1287
    • Armand, J.1    Ducreux, M.2    Mahjoubi, M.3
  • 75
    • 0029919195 scopus 로고    scopus 로고
    • CPT-11 in the treatment of colorectal cancer clinical efficacy and safety profile
    • Rougier PH, Bugat R. CPT-11 in the treatment of colorectal cancer clinical efficacy and safety profile. Semin Oncol 1996; 23: 34-41.
    • (1996) Semin Oncol , vol.23 , pp. 34-41
    • Rougier, P.H.1    Bugat, R.2
  • 76
    • 0343255312 scopus 로고    scopus 로고
    • Irinotecan (CPT-11) multicenter phase II study in colorectal cancer patients with documented progressive disease on prior 5FU: Preliminary results
    • Van Cutsem E, Cunningham D, Ten Bokkel Huinink W, et al. Irinotecan (CPT-11) multicenter phase II study in colorectal cancer patients with documented progressive disease on prior 5FU: preliminary results. Proc Am Soc Clin Oncol 1996; 15: 562.
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 562
    • Van Cutsem, E.1    Cunningham, D.2    Ten Bokkel Huinink, W.3
  • 77
    • 0344783805 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients
    • Becouran Y, Ychou M, Ducreux M, et al. Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. / Clin Oncol 1998; 16: 2739-44.
    • (1998) / Clin Oncol , vol.16 , pp. 2739-2744
    • Becouran, Y.1    Ychou, M.2    Ducreux, M.3
  • 78
    • 0342519979 scopus 로고
    • Multicentric phase II study with oxaliplatin (L-OHP11) in 5-FU refractory patients with advanced colorectal cancer
    • abstr 514
    • Diaz-Rubio E, Many M, Extra JM, et al. Multicentric phase II study with oxaliplatin (L-OHP11) in 5-FU refractory patients with advanced colorectal cancer. Proc At n Soc Clin Oijcol 1995; 14: 209 (abstr 514).
    • (1995) Proc at N Soc Clin Oijcol , vol.14 , pp. 209
    • Diaz-Rubio, E.1    Many, M.2    Extra, J.M.3
  • 79
    • 0000449676 scopus 로고    scopus 로고
    • A randomized trial of leucovorin (LV) and 5-fluorouracil (5FU) with or witliout oxaliplatin in advanced colorectal cancer (CRC)
    • abstr 985
    • de Gramont A, Figer A, Seymour M, et al. A randomized trial of leucovorin (LV) and 5-fluorouracil (5FU) with or witliout oxaliplatin in advanced colorectal cancer (CRC). Proc Am Soc Clin Oncol 1998; 17: 257a (abstr 985).
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • De Gramont, A.1    Figer, A.2    Seymour, M.3
  • 80
    • 0031671255 scopus 로고    scopus 로고
    • Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group
    • Cocconi G, Cunningham D, Van Cutsem E, et al. Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group./ din Oncol 1998; 16: 2943-52.
    • (1998) / Din Oncol , vol.16 , pp. 2943-2952
    • Cocconi, G.1    Cunningham, D.2    Van Cutsem, E.3
  • 81
    • 0000704914 scopus 로고    scopus 로고
    • Interim results of a phase i trial suggest that Tomudex (raltitrexed) may act synergistically with 5-fluorouracil (5-FU) in patients with advanced colorectal cancer (ACC)
    • abstr 868
    • Dragnev KH, Schwanz J, Bertino N, et al. Interim results of a phase I trial suggest that Tomudex (raltitrexed) may act synergistically with 5-fluorouracil (5-FU) in patients with advanced colorectal cancer (ACC). Proc Am Soc Clin Oncol 1998; 17: 225a (abstr 868).
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Dragnev, K.H.1    Schwanz, J.2    Bertino, N.3
  • 82
    • 0343343088 scopus 로고    scopus 로고
    • Combination therapy with infusional 5-FU and 'Tomudex' for patients with advanced colorectal cancer-a phase i study
    • abstr 772
    • Harstrick A, Mayer S, Müller C, et al. Combination therapy with infusional 5-FU and 'Tomudex' for patients with advanced colorectal cancer-a phase I study. Proc Am Soc Clin Oncol 1998; 17: 200a (abstr 772).
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Harstrick, A.1    Mayer, S.2    Müller, C.3
  • 83
    • 0000419697 scopus 로고    scopus 로고
    • Bimonthly CPT11 with leucovorin (LV) and 5-fluorouracil (5-FU) in pretreated metastatic colorectal cancer (FOLFIRI)
    • abstr 1051
    • André T, de Gramont A, Louvet C, et al. Bimonthly CPT11 with leucovorin (LV) and 5-fluorouracil (5-FU) in pretreated metastatic colorectal cancer (FOLFIRI)- Proc Am Soc Clin Oncol 1998; 17: 273a (abstr 1051).
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • André, T.1    De Gramont, A.2    Louvet, C.3
  • 84
    • 0023917467 scopus 로고
    • A randomized phase i and II study of short-term infusion of high-dose fluorouracil with or without A phosphonacetylX-aspartic acid in patients with advanced pancreatic and colorectal cancers
    • Ardalan B, Singh G, Silberman H. A randomized phase I and II study of short-term infusion of high-dose fluorouracil with or without A phosphonacetylX-aspartic acid in patients with advanced pancreatic and colorectal cancers. / Clin Oncol 1988; 6: 1053-8.
    • (1988) / Clin Oncol , vol.6 , pp. 1053-1058
    • Ardalan, B.1    Singh, G.2    Silberman, H.3
  • 85
    • 0343530451 scopus 로고    scopus 로고
    • Weekly highdose (HD) 5-fluorouracü (5-FU) and folinic acid (FA) with addition of oxaliplatin (LOHP) after documented progression under high-dose infusional 5-FU/FA in patients (PTS) with advanced colorectal cancer CRQ
    • abstr 1106
    • Buechele T, Schoeber C, Kroening H, et al. Weekly highdose (HD) 5-fluorouracü (5-FU) and folinic acid (FA) with addition of oxaliplatin (LOHP) after documented progression under high-dose infusional 5-FU/FA in patients (PTS) with advanced colorectal cancer (CRQ. Proc Am Soc Clin Oncol 1998; 17: 287a (abstr 1106).
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Buechele, T.1    Schoeber, C.2    Kroening, H.3


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