Bimonthly high dose leucovorin and 5-fluorouracil 48-hour continuous infusion in patients with advanced colorectal carcinoma

Cancer

Volumn 79, Issue 6, 1997, Pages 1100-1105

  Beerblock, Karine ^a   Rinaldi, Yves ^b   André, Thierry ^c   Louvet, Christophe ^a   Raymond, Eric ^a   Tournigand, Christophe ^a   Carola, Elisabeth ^d   Favre, Roger ^b   De Gramont, Aimery ^a   Krulik, Marcel ^a  

^a HÔPITAL SAINT ANTOINE   (France)

^b TIMONE HOSPITAL   (France)

^c HÔPITAL TENON   (France)

^d Hopital de Senlis   (France)

Author keywords

5 fluorouracil infusion; colorectal carcinoma; high dose 5 fluorouracil; high dose leucovorin; leucovorin

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ARTICLE; BRAIN DISEASE; CANCER CHEMOTHERAPY; CANCER LOCALIZATION; CANCER SURVIVAL; CLINICAL FEATURE; CLINICAL TRIAL; COLORECTAL CARCINOMA; DRUG MEGADOSE; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER METASTASIS; LUNG METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; INFUSIONS, INTRAVENOUS; LEUCOVORIN; MALE; MIDDLE AGED; SURVIVAL ANALYSIS;

EID: 0030894390     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1100::AID-CNCR7>3.0.CO;2-J     Document Type: Article

References (20)

1. Lokich JJ, Ahlgren JD, Gullo JJ, Philips JA, Fryer JG. A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program study. J Clin Oncol 1989;7:425-32.
2. Rougier Ph, Paillot B, Laplanche A, Morvan F, Benhamed M, Seitz JF, et al. End results of a multicentric randomized trial comparing 5-FU in continuous infusion to bolus administration in measurable metastatic colorectal cancer. In: Perry MC, editor. Program/Proceedings of the American Society of Clinical Oncology; 1992 May 17-19; San Diego, CA: Alexandria: American Society of Clinical Oncology, 1992:163.
3. Machover D, Goldschmidt E, Chollet P, Metzger G, Zittoun J, Marguet J, et al. Treatment of advanced colorectal cancer and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid. J Clin Oncol 1986;4:685-96.
4. Petrelli N, Herrera L, Rustum Y, Burke P, Creaven P, Stule J, et al. A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 1987; 5:1559-65.
5. Budd GT, Fleming TR, Bukowski RM, McCracken JD, Rivkin SE, O'Bryan RM, et al. 5 Fluorouracil and folinic acid in the treatment of metastatic colorectal cancer: a randomized comparison: a Southwest Oncology Group study. J Clin Oncol 1987;5:272-7.
6. de Gramont A, Krulik M, Cady J, Lagadec B, Maisani JE, Loiseau JP, et al. High-dose folinic acid and 5-fluorouracil bolus and continuous infusion in advanced colorectal cancer. Eur J Cancer Clin Oncol 1988;24:1499-503.
7. de Gramont A, Bosset JF, Milan C, Rougier P, Bouché O, Etienne PL, et al. A prospectively randomized trial comparing 5-FU bolus with low dose folinic acid and 5-FU bolus plus continuous infusion with high-dose folinic acid for advanced colorectal cancer. In: Perry MC, editor. Program/ Proceedings of the American Society of Clinical Oncology; 1995 May 20-23; Los Angeles, CA. Alexandria: American Society of Clinical Oncology, 1995:194.
8. Gamelin E, Danquechin-Dorval EM, Dumesnil Y, Maillart PJ, Goudier MJ, Burtin PC, et al. Relationship between 5-fluorouracil dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU. Cancer 1996;77:441-51.
9. Diaz-Rubio E, Aranda E, Martin M, Gonzalez-Mancha R, Gonzalez-Larriba J, Barneto I. Weekly high-dose infusion of 5-fluorouracil in advanced colorectal cancer. Eur J Cancer 1990;26:727-9.
10. Ardalan B, Chua L, Tiang E, Reddy R, Srudhar K, Benedetto P, et al. A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorectal carcinoma. J Clin Oncol 1991;9:625-30.
11. World Health Organization. WHO handbook for reporting results of cancer treatment. Geneva: World Health Organization, 1979.
12. Leichman CG, Fleming TR, Muggia FM, Tangen CM, Ardalan B, Doroshow JH, et al. Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study. J Clin Oncol 1995; 13:1303-11.
13. Könne CH, Schmoll HJ, Wilke H, Käufer C, Rauschecker H, Andreesen R, et al. Weekly high-dose infusional 5-fluorouracil plus leucovorin vs FU plus α-interferon vs FU plus LV plus IFN in advanced colorectal cancer: results of a multicenter randomized trial. In: Perry MC, editor. Program/ Proceedings of the American Society of Clinical Oncology; 1995 May 20-23; Los Angeles. CA. Alexandria: American Society of Clinical Oncology, 1995:194.
14. Weh HJ, Hoffknecht M, Hölzer P, Braumann D, Hoffman R, Gellerman HJ, et al. 5-FU/FA bolus therapy vs weekly high-dose 5FU/FA 24-hour infusion in metastatic colorectal carcinoma: preliminary results of an ongoing randomized phase III study. Eur J Cancer 1995;31A:S158.
15. Weh HJ, Bittner S, Hoffknecht M, Hossfeld DK. Neurotoxicity following therapy with folinic acid and high-dose 5-fluorouracil 24-h infusion in patients with gastrointestinal malignancies. Eur J Cancer 1993;29A:1218-9.
16. Conroy T, Adenis A, Brucker P, Luporsi E, Untereiner M, Platini C, et al. A prospective randomized trial of protracted infusional 5FU with allopurinol versus bolus and high-dose leucovorin in metastatic colorectal cancers. In: Perry MC, editor. Program/Proceedings of the American Society of Clinical Oncology; 1992 May 17-19; San Diego, CA. Alexandria: American Society of Clinical Oncology, 1992:162.
17. Louvet C, de Gramont A, Bennamoun M, Demuynck B, Varette C, Cady J, et al. High-dose folinic acid, 5FU bolus and continuous infusion in metastatic colorectal cancer: a 3 day/ 3 week schedule. Eur J Cancer 1992;28:612-3.
18. Poon MA, O'Connell MJ, Wieand HS, Krook JE, Gerstner JB, Tschetter LK, et al. Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Oncol 1991;9:1967-72.
19. Tournigand C, de Gramont A, Louvet C, Raymond E, Mal F, Seitz JF, et al. High-dose folinic acid and 5-FU 48h infusion and interferon-α in metastatic colorectal cancer [abstract 268]. In: Program and Abstracts of the Fifth International Congress on Anticancer Chemotherapy, January 1995, Paris, France.
20. de Gramont A, Tournigand C, Louvet C, Varette C, Raymond E, Vignoud J, et al. Oxaliplatin with high-dose folinic acid and 5-fluorouracil. 48h infusion in pretreated metastatic colorectal cancer [abstract]. Canadian Journal of Infectious Diseases 1995;6(Suppl C):458C.