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Volumn 32, Issue SUPPL. 5, 1996, Pages

Modulated 5-fluorouracil (5-FU) regimens in advanced colorectal cancer: A critical review of comparative studies

Author keywords

5 fluorouracil; colorectal cancer; leucovorin; treatment schedules

Indexed keywords

DIPYRIDAMOLE; FLUOROURACIL; FOLINIC ACID; HYDROXYUREA; INTERFERON; IRINOTECAN; METHOTREXATE; OXALIPLATIN; RALTITREXED;

EID: 0029989892     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(96)00330-9     Document Type: Conference Paper
Times cited : (19)

References (55)
  • 1
    • 0028351657 scopus 로고
    • Chemotherapy for colorectal cancer
    • Moertel CG. Chemotherapy for colorectal cancer. New Engl J Med 1994, 330, 1136-1142.
    • (1994) New Engl J Med , vol.330 , pp. 1136-1142
    • Moertel, C.G.1
  • 2
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion 5-fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma. A MAOP study
    • Lokich JJ, Ahlgren JD, Gullo JJ, et al. A prospective randomized comparison of continuous infusion 5-fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma. A MAOP study. J Clin Oncol 1989, 7, 425-432.
    • (1989) J Clin Oncol , vol.7 , pp. 425-432
    • Lokich, J.J.1    Ahlgren, J.D.2    Gullo, J.J.3
  • 3
    • 0026632283 scopus 로고
    • Controversial issues in 5-fluorouracil infusion use
    • Anderson N, Lokich JJ. Controversial issues in 5-fluorouracil infusion use. Cancer 1992, 70, 998-1002.
    • (1992) Cancer , vol.70 , pp. 998-1002
    • Anderson, N.1    Lokich, J.J.2
  • 4
    • 0019906743 scopus 로고
    • Treatment of advanced colorectal and gastric adenocarcinomas with 5FU combined with high-dose folinic acid: A pilot study
    • Machover D, Schwarzenberg L, Goldschmidt E, et al. Treatment of advanced colorectal and gastric adenocarcinomas with 5FU combined with high-dose folinic acid: a pilot study. Cancer Treat Rep 1982, 66, 1803-1807.
    • (1982) Cancer Treat Rep , vol.66 , pp. 1803-1807
    • Machover, D.1    Schwarzenberg, L.2    Goldschmidt, E.3
  • 5
    • 0021130547 scopus 로고
    • Phase I/II trial of high-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer
    • Madajewicz P. Phase I/II trial of high-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer. Cancer Res 1984, 44, 4667-4669.
    • (1984) Cancer Res , vol.44 , pp. 4667-4669
    • Madajewicz, P.1
  • 6
    • 2642613458 scopus 로고
    • Is fluorouracil as effective as equitoxic doses of 5FU plus high dose oral leucovorin in colorectal carcinoma?
    • Abstract
    • Brenckman WD, Laufman LR, Adamiewicz BB, et al. Is fluorouracil as effective as equitoxic doses of 5FU plus high dose oral leucovorin in colorectal carcinoma? Proceedings ASCO 1990, 9, 421 (Abstract).
    • (1990) Proceedings ASCO , vol.9 , pp. 421
    • Brenckman, W.D.1    Laufman, L.R.2    Adamiewicz, B.B.3
  • 7
    • 0004696282 scopus 로고
    • Treatment of metastatic colorectal cancer: Improvement of 5-fluorouracil activity with modulating agents
    • Luporini G, Labianca R, Pancera G. Treatment of metastatic colorectal cancer: improvement of 5-fluorouracil activity with modulating agents. Forum 1991, 1, 246-256.
    • (1991) Forum , vol.1 , pp. 246-256
    • Luporini, G.1    Labianca, R.2    Pancera, G.3
  • 8
    • 0023520170 scopus 로고
    • A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and leucovorin in previously untreated patients with advanced colorectal carcinoma
    • Petrelli N, Herrera L, Rustum Y, et al. A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and leucovorin in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 1987, 5, 1559-1565.
    • (1987) J Clin Oncol , vol.5 , pp. 1559-1565
    • Petrelli, N.1    Herrera, L.2    Rustum, Y.3
  • 9
    • 0024385167 scopus 로고
    • The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma. A perspective randomized phase III trial
    • Petrelli N, Douglass HD, Herrera L, et al. The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma. A perspective randomized phase III trial. J Clin Oncol 1989, 7, 1419-1426.
    • (1989) J Clin Oncol , vol.7 , pp. 1419-1426
    • Petrelli, N.1    Douglass, H.D.2    Herrera, L.3
  • 10
    • 0342820632 scopus 로고
    • 5-fluorouracil alone or combined with high-dose folinic acid in advanced colorectal cancer patients: A randomized trial
    • Abstract
    • Nobile MT, Vidili MG, Sobrero A, et al. 5-fluorouracil alone or combined with high-dose folinic acid in advanced colorectal cancer patients: a randomized trial. Proceedings ASCO 1988, 7, 97 (Abstract).
    • (1988) Proceedings ASCO , vol.7 , pp. 97
    • Nobile, M.T.1    Vidili, M.G.2    Sobrero, A.3
  • 11
    • 0024342059 scopus 로고
    • Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil or sequential methotrexate, fluorouracil, leucovorin: A randomized trial of the Northern California Oncology Group
    • Valone FH, Friedman MA, Wittlinger PS, et al. Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil or sequential methotrexate, fluorouracil, leucovorin: a randomized trial of the Northern California Oncology Group. J Clin Oncol 1989, 7, 1427-1436.
    • (1989) J Clin Oncol , vol.7 , pp. 1427-1436
    • Valone, F.H.1    Friedman, M.A.2    Wittlinger, P.S.3
  • 12
    • 15144359350 scopus 로고
    • 5-fluorouracil alone versus high dose folinic acid and 5FU in advanced colorectal cancer. A randomized trial of the Italian Oncology Group for Clinical Research
    • Abstract
    • Di Costanzo F, Bartolucci R, Sofra M, et al. 5-fluorouracil alone versus high dose folinic acid and 5FU in advanced colorectal cancer. A randomized trial of the Italian Oncology Group for Clinical Research. Proceedings ASCO 1989, 8, 410 (Abstract).
    • (1989) Proceedings ASCO , vol.8 , pp. 410
    • Di Costanzo, F.1    Bartolucci, R.2    Sofra, M.3
  • 13
    • 0025991253 scopus 로고
    • Folinic acid + 5-fluorouracil (5FU) versus equidose 5FU in advanced colorectal cancer. Phase III study of GISCAD (Italian Group for the Study of Digestive Tract Cancer)
    • Labianca R, Pancera G, Aitini E, et al. Folinic acid + 5-fluorouracil (5FU) versus equidose 5FU in advanced colorectal cancer. Phase III study of GISCAD (Italian Group for the Study of Digestive Tract Cancer). Ann Oncol 1991, 2, 673-679.
    • (1991) Ann Oncol , vol.2 , pp. 673-679
    • Labianca, R.1    Pancera, G.2    Aitini, E.3
  • 14
    • 0024347268 scopus 로고
    • Biochemical modulation of fluorouracil. Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma
    • Poon MA, O'Connell MJ, Moertel CG, et al. Biochemical modulation of fluorouracil. Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 1989, 7, 1407-1417.
    • (1989) J Clin Oncol , vol.7 , pp. 1407-1417
    • Poon, M.A.1    O'Connell, M.J.2    Moertel, C.G.3
  • 15
    • 0025261244 scopus 로고
    • Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy
    • Doroshow JH, Multhauf P, Leong L, et al. Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy. J Clin Oncol 1990, 8, 491-501.
    • (1990) J Clin Oncol , vol.8 , pp. 491-501
    • Doroshow, J.H.1    Multhauf, P.2    Leong, L.3
  • 16
    • 0023874456 scopus 로고
    • A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma
    • Erlichman C, Fine S, Wong A, et al. A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol 1988, 6, 469-475.
    • (1988) J Clin Oncol , vol.6 , pp. 469-475
    • Erlichman, C.1    Fine, S.2    Wong, A.3
  • 17
    • 0343255343 scopus 로고
    • Randomized clinical trial of 5FU + folinic acid versus 5FU in advanced gastrointestinal cancers
    • Abstract
    • Cricca A, Martoni A, Guaraldi M, et al. Randomized clinical trial of 5FU + folinic acid versus 5FU in advanced gastrointestinal cancers. Proceedings ESMO 1988, 13, 427 (Abstract).
    • (1988) Proceedings ESMO , vol.13 , pp. 427
    • Cricca, A.1    Martoni, A.2    Guaraldi, M.3
  • 18
    • 0001480844 scopus 로고
    • An intergroup trial of intensive course 5FU and low-dose leucovorin as surgical adjuvant therapy for high risk colon cancer
    • Abstract
    • O'Connell MJ, Maillard J, MacDonald J, et al. An intergroup trial of intensive course 5FU and low-dose leucovorin as surgical adjuvant therapy for high risk colon cancer. Proceedings ASCO 1993, 12, 552 (Abstract).
    • (1993) Proceedings ASCO , vol.12 , pp. 552
    • O'Connell, M.J.1    Maillard, J.2    MacDonald, J.3
  • 19
    • 0027436244 scopus 로고
    • The benefit of leucovorin-modulated fluorouracil as post operative adjuvant therapy for primary colon cancer: Results from the national surgical adjuvant breast and bowel project protocol C-03
    • Wolmark N, Rockette H, Fisher B, et al. The benefit of leucovorin-modulated fluorouracil as post operative adjuvant therapy for primary colon cancer: results from the National Surgical Adjuvant Breast and Bowel Project protocol C-03. J Clin Oncol 1993, 11, 1879-1887.
    • (1993) J Clin Oncol , vol.11 , pp. 1879-1887
    • Wolmark, N.1    Rockette, H.2    Fisher, B.3
  • 20
    • 0028274802 scopus 로고
    • Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer
    • Francini G, Petrioli R, Lorenzini L, et al. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology 1994, 106, 899-906.
    • (1994) Gastroenterology , vol.106 , pp. 899-906
    • Francini, G.1    Petrioli, R.2    Lorenzini, L.3
  • 21
    • 0029644482 scopus 로고
    • Efficacy of adjuvant fluorouracil and folinic acid in colon cancer
    • IMPACT investigators (Labianca R, Marsoni S, Pancera G, et al.). Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 1995, 345, 939-944.
    • (1995) Lancet , vol.345 , pp. 939-944
    • Labianca, R.1    Marsoni, S.2    Pancera, G.3
  • 22
    • 0026721532 scopus 로고
    • Advanced colorectal cancer meta-analysis project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
    • Advanced Colorectal Cancer Meta-Analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J Clin Oncol 1992, 10, 896-903.
    • (1992) J Clin Oncol , vol.10 , pp. 896-903
  • 23
    • 0343691049 scopus 로고
    • Weekly high-dose folinic acid (FA)/5-fluorouracil (FU) versus low-dose FA/FU in advanced colorectal cancer. Results of randomized multicenter trial
    • Abstract
    • Jaeger E, Klein O, Bernhard H, et al. Weekly high-dose folinic acid (FA)/5-fluorouracil (FU) versus low-dose FA/FU in advanced colorectal cancer. Results of randomized multicenter trial. Proceedings ASCO 1994, 13, 556 (Abstract).
    • (1994) Proceedings ASCO , vol.13 , pp. 556
    • Jaeger, E.1    Klein, O.2    Bernhard, H.3
  • 24
    • 0026006962 scopus 로고
    • Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
    • Poon MA, O'Connell MJ, Wieand HS, et al. Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Oncol 1991, 9, 1967-1972.
    • (1991) J Clin Oncol , vol.9 , pp. 1967-1972
    • Poon, Ma.1    O'Connell, M.J.2    Wieand, H.S.3
  • 25
    • 0343809235 scopus 로고
    • High-dose versus low-dose L-leucovorin as a modulator of 5 days' 5-fluorouracil in advanced colorectal cancer: A GISCAD phase III study
    • Abstract
    • Valsecchi R, Labianca R, Cascinu S, et al. High-dose versus low-dose L-leucovorin as a modulator of 5 days' 5-fluorouracil in advanced colorectal cancer: a GISCAD phase III study. Proceedings ASCO 1995, 14, 457 (Abstract).
    • (1995) Proceedings ASCO , vol.14 , pp. 457
    • Valsecchi, R.1    Labianca, R.2    Cascinu, S.3
  • 26
    • 0028175144 scopus 로고
    • Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer
    • Buroker TR, O'Connell MJ, Wieand HS, et al. Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 1994, 12, 14-20.
    • (1994) J Clin Oncol , vol.12 , pp. 14-20
    • Buroker, T.R.1    O'Connell, M.J.2    Wieand, H.S.3
  • 27
    • 0000259297 scopus 로고
    • A prospective randomized trial comparing 5FU bolus with low-dose folinic acid (FUFOL1d) and 5FU bolus plus continuous infusion with high-dose folinic acid (LV5FU2) for advanced colorectal cancer
    • Abstract
    • de Gramont A, Bosset JF, Milan C, et al. A prospective randomized trial comparing 5FU bolus with low-dose folinic acid (FUFOL1d) and 5FU bolus plus continuous infusion with high-dose folinic acid (LV5FU2) for advanced colorectal cancer. Proceedings ASCO 1995, 14, 455 (Abstract).
    • (1995) Proceedings ASCO , vol.14 , pp. 455
    • De Gramont, A.1    Bosset, J.F.2    Milan, C.3
  • 28
    • 0029012118 scopus 로고
    • Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A Southwest Oncology Group study
    • Leichman CG, Fleming TR, Muggia FM, et al. Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study. J Clin Oncol 1995, 13, 1303-1311.
    • (1995) J Clin Oncol , vol.13 , pp. 1303-1311
    • Leichman, C.G.1    Fleming, T.R.2    Muggia, F.M.3
  • 29
    • 0027410654 scopus 로고
    • More is not always better: A case for low-dose leucovorin
    • Borner MM, Sartor O. More is not always better: a case for low-dose leucovorin. J Clin Oncol 1993, 11, 382-383.
    • (1993) J Clin Oncol , vol.11 , pp. 382-383
    • Borner, M.M.1    Sartor, O.2
  • 30
    • 0027207582 scopus 로고
    • Fluorouracil and leucovorin: There is a choice
    • Petrelli N, Rustum Y. Fluorouracil and leucovorin: there is a choice. J Clin Oncol 1993, 11, 1434.
    • (1993) J Clin Oncol , vol.11 , pp. 1434
    • Petrelli, N.1    Rustum, Y.2
  • 31
    • 0029042796 scopus 로고
    • Fluorouracil and low-dose leucovorin versus fluorouracil and high-dose leucovorin. What is the real cost? What is the answer?
    • Brook J. Fluorouracil and low-dose leucovorin versus fluorouracil and high-dose leucovorin. What is the real cost? What is the answer? J Clin Oncol 1995, 13, 1830-1831.
    • (1995) J Clin Oncol , vol.13 , pp. 1830-1831
    • Brook, J.1
  • 32
    • 0001252836 scopus 로고
    • 'Tomudex' (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. The 'Tomudex' Colorectal Cancer Study Group
    • Cunningham D, Zalcberg J, Rath U, et al. 'Tomudex' (ZD1694): results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. The 'Tomudex' Colorectal Cancer Study Group. Eur J Cancer 1995, 31A, (12), 1945-1954.
    • (1995) Eur J Cancer , vol.31 A , Issue.12 , pp. 1945-1954
    • Cunningham, D.1    Zalcberg, J.2    Rath, U.3
  • 33
    • 0024414365 scopus 로고
    • Superiority of sequential methotrexate, fluorouracil and leucovorin to fluorouracil alone in advanced symptomatic colorectal carcinoma: A randomized trial
    • Nordic Gastrointestinal Tumour Adjuvant Therapy Group. Superiority of sequential methotrexate, fluorouracil and leucovorin to fluorouracil alone in advanced symptomatic colorectal carcinoma: a randomized trial. J Clin Oncol 1989, 7, 1437-1446.
    • (1989) J Clin Oncol , vol.7 , pp. 1437-1446
  • 34
    • 0028219974 scopus 로고
    • Advanced colorectal cancer meta-analysis project. Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer
    • Advanced Colorectal Cancer Meta-analysis Project. Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer. J Clin Oncol 1994, 12, 960-969.
    • (1994) J Clin Oncol , vol.12 , pp. 960-969
  • 35
    • 0343691047 scopus 로고
    • The modulation of high-dose 5-fluorouracil with low-dose methotrexate in metastatic colorectal cancer. A phase III study of the EORTC GI Cancer Cooperative Group
    • Abstract
    • Blijham GH, Stellestags J, Sahmoud T, et al. The modulation of high-dose 5-fluorouracil with low-dose methotrexate in metastatic colorectal cancer. A phase III study of the EORTC GI Cancer Cooperative Group. Proc Am Soc Clin Oncol 1993, 12, 586 (Abstract).
    • (1993) Proc Am Soc Clin Oncol , vol.12 , pp. 586
    • Blijham, G.H.1    Stellestags, J.2    Sahmoud, T.3
  • 36
    • 0026651533 scopus 로고
    • Sequential methotrexate and 5-fluorouracil (FU) vs FU alone in metastatic colorectal cancer
    • Herrmann R, Knuth A, Kleeberg U, et al. Sequential methotrexate and 5-fluorouracil (FU) vs FU alone in metastatic colorectal cancer. Ann Oncol 1992, 3, 539-543.
    • (1992) Ann Oncol , vol.3 , pp. 539-543
    • Herrmann, R.1    Knuth, A.2    Kleeberg, U.3
  • 37
    • 0025881101 scopus 로고
    • Advanced colorectal carcinoma: A prospective randomized trial of sequential methotrexate, 5-fluorouracil, and leucovorin versus 5-fluorouracil alone
    • Machiavelli M, Leone BA, Romero A, et al. Advanced colorectal carcinoma: a prospective randomized trial of sequential methotrexate, 5-fluorouracil, and leucovorin versus 5-fluorouracil alone. Am J Clin Oncol 1991, 14, 211-217.
    • (1991) Am J Clin Oncol , vol.14 , pp. 211-217
    • Machiavelli, M.1    Leone, B.A.2    Romero, A.3
  • 38
    • 0342820626 scopus 로고
    • 5-fluorouracil alone versus methotrexate + leucovorin + FU in patients with metastatic colorectal cancer
    • Abstract
    • Delfino C, Caccia G, Maniago O. 5-fluorouracil alone versus methotrexate + leucovorin + FU in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 1992, 11, 521 (Abstract).
    • (1992) Proc Am Soc Clin Oncol , vol.11 , pp. 521
    • Delfino, C.1    Caccia, G.2    Maniago, O.3
  • 39
    • 0342820625 scopus 로고
    • Phase III trial with methotrexate, 5-FU and high-dose leucovorin vs. 5-FU, leucovorin vs. 5-FU in advanced and metastatic colorectal cancer
    • Abstract
    • Abad A, Garcia P, Gravalos C, et al. Phase III trial with methotrexate, 5-FU and high-dose leucovorin vs. 5-FU, leucovorin vs. 5-FU in advanced and metastatic colorectal cancer. Proc Am Soc Clin Oncol 1992, 11, 459 (Abstract).
    • (1992) Proc Am Soc Clin Oncol , vol.11 , pp. 459
    • Abad, A.1    Garcia, P.2    Gravalos, C.3
  • 40
    • 0026100241 scopus 로고
    • The influence of drug interval on the effect of methotrexate and 5-fluorouracil in the treatment of advanced colorectal cancer
    • Marsh J, Bertino J, Katz KH, et al. The influence of drug interval on the effect of methotrexate and 5-fluorouracil in the treatment of advanced colorectal cancer. J Clin Oncol 1991, 9, 371-380.
    • (1991) J Clin Oncol , vol.9 , pp. 371-380
    • Marsh, J.1    Bertino, J.2    Katz, K.H.3
  • 41
    • 0023718558 scopus 로고
    • Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: Antiproliferative responses and synergistic interaction with halogenated pyrimidine antimetabolites
    • Elias L. Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interaction with halogenated pyrimidine antimetabolites. Cancer Res 1988, 48, 4868-4873.
    • (1988) Cancer Res , vol.48 , pp. 4868-4873
    • Elias, L.1
  • 42
    • 0024834136 scopus 로고
    • Fluorouracil and recombinant alpha-2a interferon: An active regimen against advanced colorectal carcinoma
    • Wadler S, Schwartz EL, Goldman M, et al. Fluorouracil and recombinant alpha-2a interferon: an active regimen against advanced colorectal carcinoma. J Clin Oncol 1989, 7, 1769-1775.
    • (1989) J Clin Oncol , vol.7 , pp. 1769-1775
    • Wadler, S.1    Schwartz, E.L.2    Goldman, M.3
  • 43
    • 0025060896 scopus 로고
    • Clinical update on the role of fluorouracil and recurrent interferon alpha-2a in the treatment of colorectal cancer
    • Wadler S, Wiernik PM. Clinical update on the role of fluorouracil and recurrent interferon alpha-2a in the treatment of colorectal cancer. Semin Oncol 1990, 18 (suppl), 16-23.
    • (1990) Semin Oncol , vol.18 , Issue.SUPPL. , pp. 16-23
    • Wadler, S.1    Wiernik, P.M.2
  • 44
    • 0025668632 scopus 로고
    • Interferon alpha-2a and 5-flurouracil for advanced colorectal carcinoma. Assessment of activity and toxicity
    • Kemeny N, Younes A, Seiter K, et al. Interferon alpha-2a and 5-flurouracil for advanced colorectal carcinoma. Assessment of activity and toxicity. Cancer 1990, 66, 2470-2475.
    • (1990) Cancer , vol.66 , pp. 2470-2475
    • Kemeny, N.1    Younes, A.2    Seiter, K.3
  • 45
    • 0025606259 scopus 로고
    • Phase II study of fluorouracil and recombinant interferon alpha-2a in previously untreated advanced colorectal carcinoma
    • Pazdur R, Ajani JA, Patt YZ. Phase II study of fluorouracil and recombinant interferon alpha-2a in previously untreated advanced colorectal carcinoma. J Clin Oncol 1990, 8, 2027-2031.
    • (1990) J Clin Oncol , vol.8 , pp. 2027-2031
    • Pazdur, R.1    Ajani, J.A.2    Patt, Y.Z.3
  • 46
    • 17044451081 scopus 로고
    • Double modulation of 5-fluorouracil in advanced colorectal cancer with low-dose interferon alpha-2b and folinic acid. The GISCAD experience
    • Labianca R, Giaccon G, Barni S, et al. Double modulation of 5-fluorouracil in advanced colorectal cancer with low-dose interferon alpha-2b and folinic acid. The GISCAD experience. Eur J Cancer 1994, 30A, 1611-1616.
    • (1994) Eur J Cancer , vol.30 A , pp. 1611-1616
    • Labianca, R.1    Giaccon, G.2    Barni, S.3
  • 47
    • 0000319013 scopus 로고
    • A randomized phase III trial comparing 5FU with or without interferon alpha-2a for advanced colorectal cancer
    • Abstract
    • York M, Greco FA, Figlin RA, et al. A randomized phase III trial comparing 5FU with or without interferon alpha-2a for advanced colorectal cancer. Proceedings ASCO 1993, 12, 590 (Abstract).
    • (1993) Proceedings ASCO , vol.12 , pp. 590
    • York, M.1    Greco, F.A.2    Figlin, R.A.3
  • 48
    • 0029016021 scopus 로고
    • Royal marsden phase III trial of fluorouracil with or without interferon alpha-2b in advanced colorectal cancer
    • Hill M, Norman A, Cunningham D, et al. Royal Marsden phase III trial of fluorouracil with or without interferon alpha-2b in advanced colorectal cancer. J Clin Oncol 1995, 13, 1297-1302.
    • (1995) J Clin Oncol , vol.13 , pp. 1297-1302
    • Hill, M.1    Norman, A.2    Cunningham, D.3
  • 49
    • 0343691041 scopus 로고
    • 5-fluorouracil plus interferon alpha-2a (Roferon-a) versus 5-fluorouracil plus leucovorin in metastatic colorectal cancer. Results of a multicentre, multinational phase III study
    • Abstract
    • Kocha W. 5-fluorouracil plus interferon alpha-2a (Roferon-A) versus 5-fluorouracil plus leucovorin in metastatic colorectal cancer. Results of a multicentre, multinational phase III study. Proceedings ASCO 1993, 12, 562 (Abstract).
    • (1993) Proceedings ASCO , vol.12 , pp. 562
    • Kocha, W.1
  • 50
    • 0029003849 scopus 로고
    • Interferon alpha does not improve the antineoplastic efficacy of high-dose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer
    • Kohne CH, Wilke H, Hecker H, et al. Interferon alpha does not improve the antineoplastic efficacy of high-dose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer. Ann Oncol 1995, 6, 461-466.
    • (1995) Ann Oncol , vol.6 , pp. 461-466
    • Kohne, C.H.1    Wilke, H.2    Hecker, H.3
  • 51
    • 0024992069 scopus 로고
    • Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer
    • O'Dwyer PJ, Paul AR, Walczac J, et al. Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer. J Clin Oncol 1990, 8, 1497-1503.
    • (1990) J Clin Oncol , vol.8 , pp. 1497-1503
    • O'Dwyer, P.J.1    Paul, A.R.2    Walczac, J.3
  • 52
    • 0029028267 scopus 로고
    • Failure of orally administered dipyridamole to enhance the antineoplastic activity of fluorouracil in combination with leucovorin in patients with advanced colorectal cancer: A prospective randomized trial
    • Kohne CH, Hiddemann W, Schuller J, et al. Failure of orally administered dipyridamole to enhance the antineoplastic activity of fluorouracil in combination with leucovorin in patients with advanced colorectal cancer: a prospective randomized trial. J Clin Oncol 1995, 13, 1201-1208.
    • (1995) J Clin Oncol , vol.13 , pp. 1201-1208
    • Kohne, Ch.1    Hiddemann, W.2    Schuller, J.3
  • 53
    • 0026637845 scopus 로고
    • Novel mechanism of resistance to 5-fluorouracil in human colon cancer (HCT-8) sub-lines following exposure to two different clinically relevant dose schedules
    • Aschele C, Sobrero A, Faderan MA, et al. Novel mechanism of resistance to 5-fluorouracil in human colon cancer (HCT-8) sub-lines following exposure to two different clinically relevant dose schedules. Cancer Res 1992, 52, 1855-1864.
    • (1992) Cancer Res , vol.52 , pp. 1855-1864
    • Aschele, C.1    Sobrero, A.2    Faderan, M.A.3
  • 54
    • 0027358836 scopus 로고
    • Activity of continuous infusion 5-fluorouracil in patients with advanced colorectal cancer clinically resistant to bolus 5-fluorouracil
    • Mori A, Bertoglio S, Guglielmi A, et al. Activity of continuous infusion 5-fluorouracil in patients with advanced colorectal cancer clinically resistant to bolus 5-fluorouracil. Cancer Chemother Pharmacol 1993, 33, 179-180.
    • (1993) Cancer Chemother Pharmacol , vol.33 , pp. 179-180
    • Mori, A.1    Bertoglio, S.2    Guglielmi, A.3
  • 55
    • 0029099290 scopus 로고
    • Schedule selective biochemical modulation of 5-fluorouracil: A phase II study in advanced colorectal cancer
    • Sobrero A, Aschele C, Guglielmi A, et al. Schedule selective biochemical modulation of 5-fluorouracil: a phase II study in advanced colorectal cancer. Clin Cancer Res 1995, 1, 955-960.
    • (1995) Clin Cancer Res , vol.1 , pp. 955-960
    • Sobrero, A.1    Aschele, C.2    Guglielmi, A.3


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