Phase III study of bolus versus infusion fluorouracil with or without cisplatin in advanced colorectal cancer

Journal of the National Cancer Institute

Volumn 88, Issue 10, 1996, Pages 668-674

  Hansen, Richard M ^a   Ryan, Louise ^b   Anderson, Tom ^c   Krzywda, Beth ^c   Quebbeman, Edward ^c   Benson III, Al ^d   Haller, Daniel G ^e   Tormey, Douglass C ^f  

^a Waukesha Memorial Hospital   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FLUOROURACIL;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BOLUS INJECTION; CANCER SURVIVAL; CLINICAL TRIAL; COLORECTAL CANCER; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; METASTASIS; MUCOSA INFLAMMATION; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; CISPLATIN; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; FLUOROURACIL; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; MALE; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0029923720     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/88.10.668     Document Type: Article

References (27)

1. Moertel CG. Chemotherapy of gastrointestinal cancer. N Engl J Med 1978;299:1049-52.
2. Lokich J, Bothe A, Fine N, Perri J, Phase I study of protracted venous infusion of 5-fluorouracil. Cancer 1981;48:2565-8.
3. Lokich J, Fine N, Perri J, Bothe A Jr. Protracted ambulatory venous infusion of 5-fluorouracil. Am J Clin Oncol 1983;6:103-7.
4. Caballero GA, Ausman RK, Quebbeman EJ. Long-term, ambulatory, continuous IV infusion of 5-FU for the treatment of advanced adenocarcinomas. Cancer Treat Rep 1985;69: 13-5.
5. Quebbeman E, Ausman R, Hansen R, Becker T, Caballero G, Ritch P, et al. Long-term ambulatory treatment of metastatic colorectal adenocarcinoma by continuous intravenous infusion of 5-fluorouracil. J Surg Oncol 1985; 30:60-5.
6. Wade JL, Herbst S, Greenburg A. Prolonged venous infusion (PVI) of 5-fluorouracil (5-FU) for metastatic colon cancer. A follow-up report. Proc ASCO 1988;7:94.
7. Hansen R, Quebbeman E, Ausman R, Frick J, Ritch P, Schulte W, et al. Continuous systemic 5-fluorouracil infusion in advanced colorectal cancer: results in 91 patients. J Surg Oncol 1989;40:177-81.
8. Benedetto P, Bogos M, Morillo F, Sfakianakis G. Chronic continuous infusion of 5-fluorouracil (CCl-FU) in previously untreated patients with measurable metastatic colorectal cancer. Proc ASCO 1986;5:92.
9. Faintuch JS, Shepard KV, Gaynor E, O'Laughlin K, Beshomer J, Levin B. Continuous infusion 5-FU a dose escalating schedule. Proc ASCO 1986;5:93.
10. Reiter B, Schreibman S, Adler S, Starrett S. Treatment of colorectal cancer with 5-FU by infusion in a community oncology practice. Proc ASCO 1987;6:74.
11. Belt RJ, Davidner ML, Myron MC, Barrett S. Continuous low-dose 5-fluorouracil (5-FU) for adenocarcinoma: confirmation of activity. Proc ASCO 1985;4:90.
12. Leichman L, Leichman CG, Kinzie J, Weaver D, Evans L. Long-term low dose 5-fluorouracil (5-FU) in advanced measurable colon cancer: no correlation between toxicity and efficacy. Proc ASCO 1985;4:86.
13. Lokich J, Ahlgren J, Gullo J, Phillips JA, Fryer JC. A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program study. J Clin Oncol 1989;7:425-32.
14. Canttell JE Jr, Hart RD, Taylor RF, Harvey JH Jr. Pilot trial of prolonged continuous-infusion 5-fluorouracil and weekly cisplatin in advanced colorectal cancer. Cancer Treat Rep 1987;71:615-8.
15. Zubrod GC, Scheideman M, Frei E III, Brindley C, Gold LG, Schnider B, et al. Appraisal of methods for the study of chemotherapy of cancer in man: comparative therapeutic trial of nitrogen mustard and triethylene thio phosphoramide. J Chron Dis 1960;11:7-33.
16. Cox D, Analysis of binary data. New York: Chapman Hall, 1970.
17. Cox D, Oakes D. Analysis of survival data. New York: Chapman Hall, 1984.
18. Vogelzang NJ. Continuous infusion chemotherapy: a critical review. J Clin Oncol 1984;2:1289-304.
19. Ardalan B, Waldman S, Sklaver L. The pyrimidine antagonists: 5-fluorouracil and floxuridine. In: Lokich J, editor. Cancer chemotherapy by infusion, 2nd ed, Chicago: Precept Press, 1990;85-121.
20. Weinerman B, Shah A, Fields A, Kerr I, Cripps C, Shepherd F, et al. A randomized trial of continuous systemic infusion (SI) vs bolus therapy (B) with 5-fluorouracil (5-FU) in metastatic measurable colorectal cancer (MCC). Proc ASCO 1990;9:103.
21. Leichman CG, Fleming TR, Muggia FM, Tangen CM, Ardalan B, Doroshaw JH, et al. Phase H study of fluorouracil and its modulation in advanced colorectal cancer: a South-west Oncology Group study [see comment citation in Medline]. J Clin Oncol 1995;13: 1303-11.
22. Loehrer PJ Sr, Turner S, Kubilis P, Hui S, Correa J, Ansari R, et al. A prospective randomized trial of fluorouracil versus fluorouracil plus cisplatin in the treatment of metastatic colorectal cancer: a Hoosier Oncology Group trial. J Clin Oncol 1988;6:642-8.
23. Diaz-Rubio E, Milla A, Jimeno J, Belon J, Aranda E, Diaz Faes J, et al. Lack of clinical synergism between cisplatin (CDDP) and 5-fluorouracil (5-FU) in advanced colorectal cancer (CRC): results of a randomized study. Proc ASCO 1988;7:110.
24. Labianca R, Pancera G, Cesana B, Clerici M, Montinari F, Luporini G. Cisplatin + 5-fluorouracil versus 5-fluorouracil alone in advanced colorectal cancer: a randomized study. Eur J Cancer Clin Oncol 1988;24:1579-81.
25. Lokich J, Cantrell J, Ahlgren J, Phillips J. A phase III trial of protracted infusional 5-FU (PIF) vs PIF plus weekly bolus cisplatin (CDDP) in advanced measurable colon cancer (MAOP protocol 5286). Proc ASCO 1989;8: 104.
26. Kemeny N, Israel K, Niedzwiecki D, Chapman D, Botet T, Minsky B, et al. Randomized study of continuous infusion fluorouracil versus fluorouracil plus cisplatin in patients with metastatic colorectal cancer. J Clin Oncol 1990;8:313-8.
27. O'Connell MJ, Martenson JA, Wieand HS, Krook JE, Macdonald JS, Haller DG, et al. Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 1994;331:502-7.