Randomized trial assessing the addition of interferon α-2a to fluorouracil and leucovorin in advanced colorectal cancer

Journal of Clinical Oncology

Volumn 14, Issue 8, 1996, Pages 2280-2288

  Seymour, M T ^a   Slevin, M L ^a   Kerr, D J ^a   Cunningham, D ^a   James, R D ^a   Ledermann, J A ^a   Perren, T J ^a   McAdam, W A ^a   Harper, P G ^a   Neoptolemos, J P ^a   Nicholson, M ^a   Duffy, A M ^a   Stephens, R J ^a   Stenning, S P ^a   Taylor, I ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; CODEINE; FLUOROURACIL; FOLINIC ACID; LOPERAMIDE; PARACETAMOL;

ADULT; AGED; ALOPECIA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CLINICAL TRIAL; COLORECTAL CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; FATIGUE; FEMALE; HUMAN; INFLUENZA; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PATIENT SATISFACTION; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SEXUAL DYSFUNCTION; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME; XEROSTOMIA;

EID: 9444220779     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1996.14.8.2280     Document Type: Article

References (26)

1. Advanced Colorectal Cancer Meta-analysis Project: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. J Clin Oncol 10:896-903, 1992
2. International Multicentre Pooled Analysis of Colon Cancer Trials Investigators: Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 345:939-944, 1995
3. Wolmark N, Rockette H, Fisher B, et al: The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: Results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. J Clin Oncol 11:1879-1887, 1993
4. Wadler S, Schwartz EL: Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: A review. Cancer Res 50:3473-3486, 1990
5. Schwartz EL, Huffman M, O'Connor CJ, et al: Stimulation of 5-fluorouracil metabolic activation by interferon-α in human colon carcinoma cells. Biochem Biophys Res Commun 182:1232-1239, 1992
6. Chu E, Zinn S, Boarman D, et al: Interaction of γ interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer Res 50:5834-5840, 1990
7. Houghton JA, Morton CL, Adkins DA, et al: Locus of the interaction among 5-fluorouracil, leucovorin, and interferon-α2a in colon carcinoma cells. Cancer Res 53:4243-4250, 1993
8. Wadler S, Wiernik PH: Clinical update on the role of fluorouracil and recombinant interferon-a2a in the treatment of colorectal carcinoma. Semin Oncol 17:6-21, 1990 (suppl 1)
9. Wadler S, Lembersky B, Atkins M, et al: Phase II trial of fluorouracil and recombinant interferon-α2a in patients with advanced colorectal carcinoma: An Eastern Cooperative Oncology Group study. J Clin Oncol 9:1806-1810, 1991
10. De Gramont A, Krulik M, Cady J, et al: High-dose leucovorin and 5-fluorouracil bolus and infusion in advanced colorectal cancer. Eur J Clin Oncol 24:1499-1503, 1988
11. Seymour MT, Johnson PWM, Hall MR, et al: Double modulation of 5-fluorouracil with interferon-α2a and high-dose leucovorin: A phase I/II study in advanced gastrointestinal cancer. Br J Cancer 70:719-723, 1994
12. Seymour MT, Patel N, Johnston A, et al: Lack of effect of interferon-α2a upon fluorouracil pharmacokinetics. Br J Cancer 70:724-728, 1994
13. Grem JL, Jordan E, Robson ME, et al: Phase II study of fluorouracil, leucovorin and interferon alfa-2a in metastatic colorectal carcinoma. J Clin Oncol 11:1737-1745, 1993
14. Wadler S, Wersto R, Weinberg V, et al: Interaction of fluorouracil and interferon in human colon cancer cell lines: Cytotoxic and cytokinetic effects. Cancer Res 50:5735-5737, 1990
15. Trown PW, Wills RJ, Kamm JJ: The preclinical development of Roferon®-A. Cancer 57:1648-1656, 1986
16. Cascinu S, Del Ferro E, Fedeli A, et al: Cytokinetic effects of interferon in colorectal cancer tumours: Implications in the design of the interferon/5-fluorouracil combinations. Cancer Res 53:5429-5432, 1993
17. York M, Greco FA, Figlin RA, et al: A randomized phase III trial comparing 5FU with or without interferon-α2a for advanced colorectal cancer. Proc Am Soc Clin Oncol 12:200, 1993 (abstr 590)
18. Dreyfus B, Dufour P, Husseini F, et al: Randomised study of 5-fluorouracil versus 5FU plus alpha 2a interferon as treatment for metastatic colorectal carcinoma. Proc Intl Congr Anticancer Chemother 5:113, 1995 (abstr O-262)
19. Hill M, Norman A, Cunningham D, et al: Royal Marsden Phase III trial of fluorouracil with or without interferon alfa-2b in advanced colorectal cancer. J Clin Oncol 13:1297-1302, 1995
20. Hill ME, Norman AR, Cunningham D, et al: The clinical impact of protracted venous infusion 5-fluorouracil with or without interferon-α2b on response, survival and quality of life in advanced colorectal cancer. J Clin Oncol 13:2317-2323, 1995
21. The Corfu-A Study Group: Phase III randomized study of two fluorouracil combinations with either interferon alfa-2a or leucovorin for advanced colorectal cancer. J Clin Oncol 13:921-928, 1995
22. Kreuser ED, Streit M, Kuchler T, et al: A multicentre randomised trial with the assessment of the quality of life in patients with metastatic colorectal carcinoma given either folinic acid or interferon-α2b as a modulator of 5-fluorouracil. Proc Am Soc Clin Oncol 14:202, 1995 (abstr 485)
23. Kohne CH, Schmoll HJ, Wilke H, et al: Weekly high dose infusional 5-fluorouracil plus leucovorin vs FU plus α-interferon vs FU plus LV plus IFN in advanced colorectal cancer: Results of a multi-centre randomised trial. Proc Am Soc Clin Oncol 14:194, 1995 (abstr 453)
24. Johnson PMW, Thompson PI, Seymour MT, et al: A less toxic regimen of 5-fluorouracil and high dose folinic acid for gastrointestinal adenocarcinomas. Br J Cancer 64:603-605, 1991
25. Joderell DI, Murray LS, Reed NS, et al: Bolus/infusion al 5-fluorouracil and folinic acid for metastatic colorectal carcinoma: Are suboptimal dosages being used in the UK? Br J Cancer 70:749-752, 1994
26. De Gramont A, Bosset JF, Milan C, et al: A prospectively randomised trial comparing 5FU bolus with low dose folinic acid and 5FU bolus plus continuous infusion with high dose folinic acid for advanced colorectal cancer. Proc Am Soc Clin Oncol 14:194, 1995 (abstr 455)