Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-γ

Journal of Immunology

Volumn 160, Issue 8, 1998, Pages 3869-3873

  Penton Rol, Giselle ^a   Polentarutti, Nadia ^a   Luini, Walter ^a   Borsatti, Alessandro ^a   Mancinelli, Roberta ^a   Sica, Antonio ^a   Sozzani, Silvano ^a   Mantovani, Alberto ^a,b,c  

^a Ist Ric Farmacologiche Mario Negri ^*  (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CHEMOKINE; CHEMOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; DOWN-REGULATION; GENE EXPRESSION; HUMANS; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MONOCYTES; RECEPTORS, CHEMOKINE; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032522651     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Baggiolini, M., B. Dewald, and B. Moser. 1997. Human chemokines: an update. Annu. Rev. Immunol. 15:675.
2. Schall, T. J. 1994. The Cytokine Handbook, 2nd Ed. A. Thomson, ed. Academic Press, London.
3. Ben-Baruch, A., D. F. Michiel, and J. J. Oppenheim. 1995. Signals and receptors involved in recruitment of inflammatory cells. J. Biol. Chem. 270:11703.
4. Sozzani, S., M. Locati, P. Allavena, J. Van Damme, and A. Mantovani. 1996. Chemokines: a superfamily of chemotactic cytokines. Int. J. Clin. Lab. Res. 26: 69.
5. Bazan, J. F., K. B. Bacon, G. Hardiman, W. Wang, K. Soo, D. Rossi, D. R. Greaves, A. Zlotnik, and T. J. Schall. 1997. A new class of membrane-bound chemokine with a CX3C motif. Nature 385:640.
6. Keiner, G. S., J. Kennedy, K. B. Bacon, S. Kleyensteuber, D. A. Largaespada, N. A. Jenkins, N. G. Copeland, J. F. Bazan, K. W. Moore, T. J. Schall, and A. Zlotnik. 1994. Lymphotactin: a cytokine that represents a new class of chemokine. Science 266:1395.
7. Bianchi, G., S. Sozzani, A. Zlotnik, A. Mantovani, and P. Allavena. 1996. Migratory response of human NK cells to lymphotactin. Eur. J. Immunol. 26:3238.
8. Sozzani, S., M. Locati, D. Zhou, M. Rieppi, W. Luini, G. Lamorte, G. Blanchi, N. Polentarutti, P. Allavena, and A. Mantovani. 1995. Receptors, signal transduction and spectrum of action of monocyte chemotactic protein-1 and related chemokines. J. Leukoc. Biol. 57:788.
9. Murphy, P. M. 1994. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12:593.
10. Gerard, C., and N. P. Gerard. 1994. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12:775.
11. Power, C. A., A. E. I. Proudfoot, E. Magnenat, K. B. Bacon, and T. N. C. Wells. 1994. Molecular cloning and characterisation of a neutrophil chemotactic protein from porcine platelets. Eur. J. Biochem. 221:713.
12. Ponath, P. D., S. X. Qin, D. J. Ringler, I. Clark-Lewis, J. Wang, N. Kassam, H. Smith, X. J. Shi, J. A. Gonzalo, W. Newman, J. C. Gutierrez-Ramos, and C. R. Mackay. 1996. Cloning of the human eosinophil chemoattractant, eotaxin: expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J. Clin. Invest. 97:604.
13. Loetscher, P., M. Seitz, M. Baggiolini, and B. Moser. 1996. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J. Exp. Med. 184:569.
14. Sica, A., A. Saccani, A. Borsatti, C. A. Power, T. N. C. Wells, W. Luini, N. Polentarutti, S. Sozzani, and A. Mantovani. 1997. Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes. J. Exp. Med. 185:969.
15. Loetscher, M., T. Geiser, T. O'Reilly, R. Zwahlen, M. Baggiolini, and B. Moser. 1994. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J. Biol. Chem. 269:232.
16. Samson, M., O. Labbe, C. Mollereau, G. Vassart, and M. Parmentier. 1996. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35:3362.
17. Lloyd, A. R., A. Biragyn, J. A. Johnston, D. D. Taub, L. L. Xu, D. Michiel, H. Sprenger, J. J. Oppenheim, and D. J. Kelvin. 1995. Granulocyte-colony stimulating factor and lipopolysaccharide regulate the expression of interleukin 8 receptors on polymorphonuclear leukocytes. J. Biol. Chem. 270:28188.
18. Polentarutti, N., P. Allavena, G. Bianchi, G. Giardina, A. Basile, S. Sozzani, A. Mantovani, and M. Introna. 1997. lL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4 kb transcript containing CCR2B and CCR2A sequences. J. Immunol. 158:2689.
19. Yoshida, R., T. Imai, K. Hieshima, J. Kusuda, M. Baba, M. Kitaura, M. Nishimura, M. Kakizaki, H. Nomiyama, and O. Yoshie. 1997. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 272:13803.
20. Roos, R. S., M. Loetscher, D. F. Legler, I. Clark-Lewis, and M. Baggiolini. 1997. Identification of CCR8, the receptor for the human CC chemokine I-309. J. Biol. Chem. 272:17251.
21. Tiffany, H. L., L. L. Lautens, J. L. Gao, J. Pease, M. Locati, C. Combadiere, W. Modi, T. I. Bonner, and P. M. Murphy. 1997. Identification of a human monocyte and thymus receptor for the CC chemokine I-309. J. Exp. Med. 186:1.
22. Colotta, F., A. Borre, J. M. Wang, M. Tattanelli, F. Maddalena, N. Polentarutti, G. Peri, and A. Mantovani. 1992. Expression of a monocyte chemotactic cytokine by human mononuclear phagocytes. J. Immunol. 148:760.
23. Sozzani, S., P. Allavena, P. Proost, J. Van Damme, and A. Mantovani. 1996. Progress in Drug Research, Vol. 45. Birkhaüser Verlag, Basel.
24. Romagnani, S. 1992. Induction of TH1 and TH2 responses: a key role for the "natural" immune response? Immunol. Today 13:379.
25. Young, H. A., and K. J. Hardy. 1995. Role of interferon-gamma in immune cell regulation. J. Leukoc. Biol. 58:373.
26. Adams, D. O., and T. A. Hamilton. 1992. The Natural Immune System. Vol. 2: The Macrophage. Oxford University Press, Oxford, U.K., p. 75.
27. Polentarutti, N., M. Introna, S. Sozzani, R. Mancinelli, G. Mantovani, and A. Mantovani. 1997. Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells. Eur. Cytokine Netw. 8:271.
28. Oliveira, I. C., P. J. Sciavolino, T. H. Lee, and J. Vilcek. 1992. Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon. Proc. Natl. Acad. Sci. USA 89:9049.
29. Schnyder-Candrian, S., R. M. Strieter, S. L. Kunkel, and A. Walz. 1995. Interferon-alpha and interferon-gamma down-regulate the production of interleukin-8 and ENA-78 in human monocytes. J. Leukocyte Biol 57:929.
30. Gusella, G. L., T. Musso, M. C. Bosco, I. Espinoza-Delgado, K. Matsushima, and L. Varesio. 1993. IL-2 up-regulates but IFN-gamma suppresses IL-8 expression in human monocytes. J. Immunol. 151:2725.
31. Colotta, F., F. Re, M. Muzio, R. Bertini, N. Polentarutti, M. Sironi, J. G. Giri, S. K. Dower, J. E. Sims, and A. Mantovani. 1993. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261:472.
32. Sica, A., J. M. Wang, F. Colotta, E. Dejana, A. Mantovani, J. J. Oppenheim, C. G. Larsen, C. O. Zachariae, and K. Matsushima. 1990. Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor. J. Immunol. 144:3034.
33. Charo, I. F., S. J. Myers, A. Herman, C. Franci, A. J. Connolly, and S. R. Coughlin. 1994. Molecular cloning and functional expression of two monocyte chemoattractant protein-1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. USA 91:2752.
34. Sozzani, S., D. Zhou, M. Locati, M. Rieppi, P. Proost, M. Magazin, N. Vita, J. Van Damme, and A. Mantovani. 1994. Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3: similarities and differences with MCP-1. J. Immunol. 152:3615.
35. Falk, W., R. H. Goodwin, Jr., and E. J. Leonard. 1980. A 48-well microchemotaxis assembly for rapid and accurate measurement of leukocyte migration. J. Immunol. Methods 33:239.
36. Musso, T., R. Badolato, D. L. Longo, G. L. Gusella, and L. Varesio. 1995. Leukemia inhibitory factor induces interleukin-8 and monocyte chemotactic and activating factor in human monocytes: differential regulation by interferon-gamma. Blood 86:1961.
37. Mantovani, A., F. Bussolino, and M. Introna. 1997. Cytokine regulation of endothelial cell function: from molecular level to the bed side. Immunol. Today 18:231.
38. Dewald, B., B. Moser, L. Barella, C. Schumacher, M. Baggiolini, and I. Clark-Lewis. 1992. IP-10, a gamma-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties. Immunol. Lett. 32:81.
39. Luster, A. D., J. C. Unkeless, and J. V. Ravetch. 1985. Gamma-interferon trascriptionally regulates an early gene containing homology to platelet proteins. Nature 315:672.
40. Ohmori, Y., and T. A. Hamilton. 1990. A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. Biochem. Biophys. Res. Commun. 168: 1261.
41. Farber, J. M. 1990. A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc. Natl. Acad. Sci. USA 87:5238.
42. Loetscher, M., B. Gerber, P. Loetscher, S. A. Jones, L. Piali, I. Clark-Lewis, M. Baggiolini, and B. Moser. 1996. Chemokine receptor specific for IP10 and Mig: structure, function, and expression in activated T-lymphocytes. J. Exp. Med. 184:963.
43. Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659.
44. Ohmori, Y., and T. A. Hamilton. 1994. IFN-gamma selectively inhibits lipopolysaccharide-inducible JE/monocyte chemoattractant protein-1 and KC/GRO/ melanoma growth-stimulating activity gene expression in mouse peritoneal macrophages. J. Immunol. 153:2204.
45. Karpus, W. J., N. W. Lukacs, K. J. Kennedy, W. S. Smith, S. D. Hurst, and T. A. Barrett. 1997. Differential CC chemokine-induced enhancement of T helper cell cytokine production. J. Immunol. 158:4129.