Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation: A selective effect on Bcl-x(L) expression

Immunology

Volumn 89, Issue 3, 1996, Pages 397-404

  Gombert, W ^a,d   Borthwick, N J ^a   Wallace, D L ^b   Hyde, H ^a   Bofill, M ^a   Pilling, D ^c   Beverley, P C L ^b   Janossy, G ^a   Salmon, M ^c   Akbar, A N ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; FAS ANTIGEN; INTERLEUKIN 2;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL LINE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 10344240876     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1996.d01-759.x     Document Type: Article

References (37)

1. SPRENT J. (1994) T and B memory cells. Cell 76, 315.
2. AKBAR A.N., SALMON M., SAVILL J. & JANOSSY G. (1993) A possible role for bcl-2 in regulating T-cell memory: a 'balancing act' between cell death and survival. Immunol Today 14, 526.
3. RAZVI E.S. & WELSH R.M. (1995) Apoptosis in viral infections. Adv Virus Res 45, 1.
4. SELIN L.K. & WELSH R.M. (1995) Specificity and editing by apoptosis of virus-induced cytotoxic T lymphocytes. Curr Opin Immunol 6, 553.
5. KORSMEYER S.J. (1992) Bcl-2: a repressor of lymphocyte death. Immunol Today 13, 285.
6. RICKINSON A.B., MOSS D.J., WALLACE L.E. et al. (1981) Long-term T cell mediated immunity to Epstein-Barr virus. Cancer Res 41, 4216.
7. AKBAR A.N., SALMON M. & JANOSSY G. (1994) Role of Bcl-2 and apoptosis in viral infections. Int Arch Allergy Immunol 105, 359.
8. AKBAR A.N., BORTHWICK N., SALMON M. et al. (1993) The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J Exp Med 178, 427.
9. OLTVAI Z.N. & KORSMEYER S.J. (1994) Checkpoints of duelling dimers foil death wishes. Cell 79, 189.
10. KRAMMER P.H., BEHRMANN I., DANIEL P., DHEIN J. & DEBATIN K. (1994) Regulation of apoptosis in the immune system. Curr Opin Immunol 6, 279.
11. SALMON M., PILLING D., BORTHWICK N.J. et al. (1994) The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur J Immunol 24, 892.
12. + T lymphocytes in acute infectious mononucleosis supporting their susceptibility to programmed cell death. Blood 82, 521.
13. MIAWAKI T., UEHARA T., NIBU R. et al. (1992) Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol 149, 3753.
14. AKBAR A.N., BORTHWICK N.J., WICKREMASINGHE R.G. et al. (1996) Interleukin-2 receptor common gamma chain signalling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal. Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur J Immunol 26, 294.
15. BELL E.B. & SPARSHOTT S. (1990) Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 348, 163.
16. AKBAR A.N., TERRY L., TIMMS A., BEVERLEY P.C. & JANOSSY G. (1988) Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol 140, 2171.
17. + T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections. J Exp Med 180, 1943.
18. MACIAG T., HOOVER G.A., STEMERMAN M.B. & WEINSTEIN R. (1995) Serial propagation of human endothelial cells in vitro. J Cell Biol 91, 420.
19. + patients. Am J Pathol 146, 1542.
20. KRAJEWSKI S., KRAJEWSKA M., SHABALIK A. et al. (1994) Immunohistochemical analysis of in vivo patterns of Bcl-x expression. Cancer Res 54, 5501.
21. GERDES J., LEMKE H., BAISCH H., WACKER H.H., SCHWAB U. & STEIN H. (1984) Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133, 1710.
22. SCOTT S., PANDOLFI F. & KURNICK J.T. (1990) Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells. J Exp Med 172, 1873.
23. IMHOF B.A. & DUNON D. (1995) Leukocyte migration and adhesion. Adv Immunol 58, 345.
24. RAFF M.C. (1992) Social controls on cell survival and cell death. Nature 356, 397.
25. AKBAR A.N., SALMON M. & JANOSSY G. (1991) The synergy between naive and memory T cells during activation. Immunol Today 12, 184.
26. + T cells. Immunology 69, 460.
27. WARREN H.S. & SKIPSEY L.J. (1991) Loss of activation-induced CD45RO with maintenance of CD45RA expression during prolonged culture of T cells and NK cells. Immunology 74, 78.
28. BROOME H.E., DARGAN C.M., BESSENT E.F., KRAJEWSKI S. & REED J.C. (1995) Apoptosis and Bcl-2 expression in cultures murine splenic T cells. Immunology 84, 375.
29. L and Bcl-2 repress a common pathway of cell death. J Exp Med 182, 821.
30. WESSELBORG, S., JANSSEN O. & KABELITZ D. (1993) Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells. J Immunol 150, 4338.
31. DHEIN J., WALCZAK H., BAUMLER C., DEBATIN K.M. & KRAMMER P.H. (1995) Autocrine T-cell suicide mediated by APO-1 (Fas CD95). Nature 373, 438.
32. BRUNNER T., MOGIL R.J., LAFACE D. et al. (1995) Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373, 441.
33. JU S.T., PANKA D.J., CUI H. et al. (1995) Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373, 444.
34. BOISE L.H., MINN A.J., NOEL, P.J. et al. (1995) CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL. Immunity 3, 87.
35. VAN PARJIS L.V., IBRAGHIMOV A. & ABBAS A.K. (1996) The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4, 321.
36. ADOLPH V.R., DISanto S.K., BLEACHER J.C., DILLON P.W. & KRUMMEL T.M. (1993) The potential role of the lymphocyte in fetal wound healing. J Pediatr Surgery 28, 1316.
37. MARTIN C.W. & MUIR F.K. (1990) The role of lymphocytes in wound healing. Br J Plastic Surg 43, 655.