Role of caspases in apoptosis and disease

Indian Journal of Physiology and Pharmacology

Volumn 43, Issue 2, 1999, Pages 151-159

  Khanna, Neeru ^a   Singh, Neeta ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Apoptosis; Bcl 2; Caspases

Indexed keywords

ADAPTOR PROTEIN; CASPASE; CASPASE INHIBITOR; CYSTEINE PROTEINASE; DNA; FAS ANTIGEN; PHOSPHOLIPASE A2; PROTEIN P53;

APOPTOSIS; CANCER PREVENTION; ENZYME ACTIVE SITE; ENZYME MECHANISM; MOLECULAR CLONING; PROTEIN DEGRADATION; REVIEW; VIRUS INFECTION;

APOPTOSIS; CASPASES; ENZYME INHIBITORS; HUMANS; LEUKEMIA; NEOPLASMS;

EID: 0033043196     PISSN: 00195499     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (50)

1. Kerr JFR, Wyllie AH, Currie AR. Apoptosis : A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
2. Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell 1997; 88: 347-354.
3. Benoist C, Mathis D. Cell death mediators in autoimmune diabetes-no shortage of suspects. Cell 1997; 89: 1-3.
4. Stellar, H. Mechanisms and genes of cellular suicide. Science 1995; 267: 1445-1449.
5. Azmi S, Bhatia L, Khanna N, Dhawan D, Singh N. Adriamycin induces Apoptosis in rat thymocytes. Cancer Letters 1997; 111: 225-231.
6. Jacobson MD, Evan GI. Apoptosis and HIV disease. Nat Med 1995; 1: 386.
7. Petisch MC, Polzar B, Stellar H, Crompton T, MacDonald HR, Mannherz HG, Tschopp J. Characterization of the deoxyribonuclease involved in nuclear DNA degradation during apoptosis (Programmed cell death). Embo J 1993; 12: 371-377.
8. Barry M, Eastman A. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch Biochem Biophys 1993; 300: 440-450.
9. Chinnaiyan AM, Dixit VM. The cell death machine. Curr Biol 1996 ; 6 : 555-562.
10. Vaux DL, Strasser A. The molecular biology of apoptosis. Proc. Natl. Acad Sci 1996; 83: 2239-2294.
11. White E. Life, death and pursuit of apoptosis. Genes Dev 1996; 10: 1-15.
12. Nicholson DW, Thornberry NA, Caspases-Killer Proteases TIBS 1997; 22: 299-306.
13. Ellis RF, Yuan Y, Horvitz R, Mechanisms and functions of cell death. Annu Rev Cell Biol 1991; 7: 663-698.
14. Horvitz HR, Shaham S, Hengartner MO. The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harbor Symp Quant Biol 1994; 56: 377-385.
15. Hengartner MO, Ellis RE, Horvitz RH. Caenorhabditis elegans gene Ced-9 protects cells from programmed cell death. Nature 1992; 356: 484-499.
16. Yuan J, Shaham S, S. Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene Ced-3 encodes a protein similar to mammalian interleukin-1-β converting enzyme. Cell 1993; 75: 641-652.
17. Alnemri ES, Livington DJ, Nicholson DW, G. Thornbery NA, Wong WW, J. Human ICE/CED-3 protease nomenclature. Cell 1996; 87: 171.
18. Martin SJ, Green DE. Protease activation during apoptosis : Death by a thousand cuts ? Cell 1995; 82: 349-352.
19. Chinnaiyan AM, Ortho K, O'Rourke K, Duan H, Poirer GG, Dixit VM. Molecular ordering of the cell death pathway: Bcl-2 and Bcl-xL function upstream of the Ced-3 like apoptotic proteases J Biol Chem 1996; 271: 4573-4576.
20. Fraser A, Evan G. A license to kill. Cell 1996; 85: 781-784.
21. Henkart PA. ICE family proteases: mediators of all apoptotic cell death ? Immunity 1996; 4: 195-201.
22. Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. FASEB J 1996; 10: 587-597.
23. Salvesan GS, Dixit VM. Caspases: Intracellular signalling by proteolysis. Cell 1997; 91: 443-446.
24. Porter AG, Patrick NG, Janicke RU. Death substrate comes alive. Bioassays 1997; 19: 501-507.
25. Cohen GM. Caspases : the executioners of apoptosis. Biochem J 1997; 326: 1-16.
26. Vilta P, Kaufmann SH, Earnshaw WC. Caspases and caspase inhibitors. TIBS 1997; 22: 388-392.
27. Robertson NM, Zangrilli J, Alnemri TP, Friesen PD, Litwack G, Alnemri ES Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death. Cancer Res 1997; 57: 43-47.
28. Ray CA, Black R, Kronheim SR, Greenstreet TA, Sleath PR, Salvesan GS, Pickup DJ. Viral inhibition of inflammation : cowpox virus encodes an inhibitor of the interlukin 1-β converting enzyme. Cell 1992; 69: 597-604.
29. Bump NJ, Hackett M, Hugunin M, Seshagiri S, Brady K, Chen P, Frerenz C, Franklin S, Ghayur T, Li P, Lican P, Mankovich NSL, Greenberg AH, Miller LK, Wong WW. Inhibition of ICE family proteases by baculovirus antiapoptotic protein P35. Science 1995; 269: 1885-1888.
30. Beidler DR, Tewari M, Friesen PD, Poirier G, Dixit VM. The baculovirus P35 protein inhibits fas-and tumor necrosis factor induced apoptosis. J Biol Chem 1995; 270: 16526-16528.
31. Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of cell death proteases. Nature 1997; 388: 300-304.
32. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993; 75: 241-251.
33. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993; 262: 1274-1277.
34. Kroemer G. The protooncogone Bcl-2 and its role in regulating apoptosis. Nature Med 1997; 3: 614-620.
35. Cheng EHY, Kirsch DH, Clem RJ, Ravi R, Kastan MB, Bedi A, Uneo K, Hardwick JM. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 1997; 278: 1966-1968.
36. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456-1462.
37. Boldin MP, Goncharov TM, Goltsev YV, Walach D. Involvement of MACH, a novel MORT 1/FADD-interacting protease in Fas/APO-1 and TNF receptor induced cell death. Cell 1996; 85: 803-815.
38. Muzio M, Chinnaiyan AM, Kishkel FC, O' Rourke K, Shevchenko A, Scaffidi C, Zhang M, Ni J, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM, FLICE : A novel FADD-homologous ICE/CED-3 like protease is recruited to the CD95 (Fas/APO-1) death inducing signalling complex. Cell 1996; 85: 817-827.
39. Nagata S. Apoptosis by Death Factor. Cell 1997; 88: 355-365.
40. Krajewski M, Wang HG, Krajewski S. Zapata JM, Shabaik A, Gascoyne R, Reed JC. Immunohistochemical analysis of invivo patterns of expression of CPP32 (caspase 3), a cell death protease. Cancer Research 1997; 57: 1605-1613.
41. Wissing D, Mouritzen H, Egeblad M, Poirier GG, Jaatela M. Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. Proc Natl Acad Sci USA 1997; 94: 5073-5077.
42. Mundle S, Venugopal P, Cartlidge JD, Pandav DV, Robinson L, Gezer S, Robin EL, Rifkin SR, Klein M, Alston DE, Hernandez BM, Rosi D, Alvi S, Shetty VT, Gregory SA, Raza A. Indication of an involvement of Interlukin 1-β converting enzyme linked protease in intramedullary apoptotic cell death in the bone marrow of patients with Myelodysplastic syndromes. Blood 1996; 88: 2640-2647.
43. Nakagawara A, Nakamura Y, Ikeda T, Kuida K, Michael S-S. Su, Zhao H, Cnaan A, and Sakiyama S. High Levels of Expression and Nuclear Localization of Interleukin-I β. Converting Enzyme (ICE) and CPP32 in Favorable Human Neuroblastomas. Cancer Res 1997; 57: 4578-4584.
44. Marlangue CC, Zouaoui A, Represa A, Ari BY. Apoptotic features of selective neuronal death in ischemia, epilepsy and gp 120 toxicity. Trends in Neuro Sci 1996; 19: 109-114.
45. Nicholson DW. ICE/CED-3 like proteases as targets for the control of inappropriate apoptosis. Nat Biotech 1996; 14: 297-301.
46. Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Huang W, Sasamate MS, Yuan J. Moskowitz MA. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Nail Acad Sci USA 197; 94: 2007-2012.
47. Holtzman DM, Deshmukh M. Caspases : A treatment target for neurodegenerative diseases. Nat Med 1997; 3: 954-955.
48. Chinnajyan AM, Dixit VM, Nabel GJ. The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication. Nat Med 1997; 3: 333-337.
49. Mendes GPA, Kim CN, Huang Y, Perkins CL, Green DR, Bhalla K. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome c and activation of caspse3. Blood 1998; 91: 1700-1705.
50. MacCorkle RA, Freeman KW, Spencer DM, Synthetic activation of caspases: Artificial death switches. Proc Natl Acad Sci USA 1998; 95: 3655-3660.