메뉴 건너뛰기




Volumn 13, Issue 8, 1999, Pages 909-917

The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling

Author keywords

Apoptosis; CXCR4; G protein; HIV 1

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; DNA NUCLEOTIDYLEXOTRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PROPIDIUM IODIDE; VIRUS ENVELOPE PROTEIN;

EID: 0033040696     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199905280-00006     Document Type: Article
Times cited : (79)

References (48)
  • 1
    • 0029820873 scopus 로고    scopus 로고
    • Immunopathogenesis of HIV infection
    • Pantaleo G, Fauci AS. Immunopathogenesis of HIV infection. Annu Rev Microbiol 1996, 50:825-854.
    • (1996) Annu Rev Microbiol , vol.50 , pp. 825-854
    • Pantaleo, G.1    Fauci, A.S.2
  • 2
    • 0030053308 scopus 로고    scopus 로고
    • Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1
    • Cao J, Park IW, Cooper A, Sodroski J. Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1. J Virol 1996, 70:1340-1354.
    • (1996) J Virol , vol.70 , pp. 1340-1354
    • Cao, J.1    Park, I.W.2    Cooper, A.3    Sodroski, J.4
  • 3
    • 0030785487 scopus 로고    scopus 로고
    • A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis
    • Kolesnitchenko V, King I, Riva A, Tani Y, Korsmeyer SJ, Cohen DI. A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis. J Virol 1997, 71:9753-9763.
    • (1997) J Virol , vol.71 , pp. 9753-9763
    • Kolesnitchenko, V.1    King, I.2    Riva, A.3    Tani, Y.4    Korsmeyer, S.J.5    Cohen, D.I.6
  • 4
    • 0031903406 scopus 로고    scopus 로고
    • Role of the Fas/Fas ligand apoptotic pathway in human immunodeficiency virus type 1 disease
    • Kaplan D, Sieg S. Role of the Fas/Fas ligand apoptotic pathway in human immunodeficiency virus type 1 disease. J Virol 1998, 72:6279-6282.
    • (1998) J Virol , vol.72 , pp. 6279-6282
    • Kaplan, D.1    Sieg, S.2
  • 5
    • 0026318584 scopus 로고
    • The cytopathic effect of HIV is associated with apoptosis
    • Laurent-Crawford AG, Krust B, Muller S, et al. The cytopathic effect of HIV is associated with apoptosis. Virology 1991, 185:829-839.
    • (1991) Virology , vol.185 , pp. 829-839
    • Laurent-Crawford, A.G.1    Krust, B.2    Muller, S.3
  • 6
    • 0025830099 scopus 로고
    • Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1
    • Terai C, Kornbluth RS, Pauza CD, Richman DD, Carson DA. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J Clin Invest 1991, 87:1710-1715.
    • (1991) J Clin Invest , vol.87 , pp. 1710-1715
    • Terai, C.1    Kornbluth, R.S.2    Pauza, C.D.3    Richman, D.D.4    Carson, D.A.5
  • 7
    • 0030267308 scopus 로고    scopus 로고
    • Apoptosis induced by HIV infection in H9 T cells is blocked by ICE-family protease inhibition but not by a Fas(CD95) antagonist
    • Glynn JM, McElligott DL, Mosier DE. Apoptosis induced by HIV infection in H9 T cells is blocked by ICE-family protease inhibition but not by a Fas(CD95) antagonist. J Immunol 1996, 157:2754-2758.
    • (1996) J Immunol , vol.157 , pp. 2754-2758
    • Glynn, J.M.1    McElligott, D.L.2    Mosier, D.E.3
  • 8
    • 0031964793 scopus 로고    scopus 로고
    • Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T lymphocytes
    • Herbein G, Van Lint C, Lo+vetl JL, Verdin E. Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T lymphocytes. J Virol 1998, 72:660-670.
    • (1998) J Virol , vol.72 , pp. 660-670
    • Herbein, G.1    Van Lint, C.2    Lovetl, J.L.3    Verdin, E.4
  • 9
    • 0027255535 scopus 로고
    • Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells
    • Laurent-Crawford AG, Krust B, Riviere Y, et al. Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells. AIDS Res Hum Retroviruses 1993, 9:761-773.
    • (1993) AIDS Res Hum Retroviruses , vol.9 , pp. 761-773
    • Laurent-Crawford, A.G.1    Krust, B.2    Riviere, Y.3
  • 10
    • 0028937329 scopus 로고
    • Productive infection and subsequent interaction of CD4-gp120 at the cellular membrane is required for HIV-induced apoptosis of CD4+ T cells
    • Corbeil J, Richman DD. Productive infection and subsequent interaction of CD4-gp120 at the cellular membrane is required for HIV-induced apoptosis of CD4+ T cells. J Gen Virol 1995, 76:681-690.
    • (1995) J Gen Virol , vol.76 , pp. 681-690
    • Corbeil, J.1    Richman, D.D.2
  • 11
    • 0031298339 scopus 로고    scopus 로고
    • Apoptotic cell death upon contact of CD4+ lymphocytes with HIV glycoprotein-expressing cells is mediated by caspases but bypasses CD95 (Fas/Apo-1) and TNF receptor 1
    • Ohnimus H, Heinkelein M, Jassoy C. Apoptotic cell death upon contact of CD4+ lymphocytes with HIV glycoprotein-expressing cells is mediated by caspases but bypasses CD95 (Fas/Apo-1) and TNF receptor 1. J Immunol 1997, 159:5246-5252.
    • (1997) J Immunol , vol.159 , pp. 5246-5252
    • Ohnimus, H.1    Heinkelein, M.2    Jassoy, C.3
  • 13
    • 0030026848 scopus 로고    scopus 로고
    • HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck
    • Corbeil I, Tremblay M, Richman DD. HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck. J Exp Med 1996, 183:39-48.
    • (1996) J Exp Med , vol.183 , pp. 39-48
    • Corbeil, I.1    Tremblay, M.2    Richman, D.D.3
  • 14
    • 0031932876 scopus 로고    scopus 로고
    • Delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of CD4
    • Guillerm C, Coudronniere N, Robert-Hebmann V, Devaux C. Delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of CD4. J Virol 1998, 72:1754-1761.
    • (1998) J Virol , vol.72 , pp. 1754-1761
    • Guillerm, C.1    Coudronniere, N.2    Robert-Hebmann, V.3    Devaux, C.4
  • 16
    • 0031660274 scopus 로고    scopus 로고
    • Molecular and cellular analysis of human imunodeficiency vrus-induced apoptosis in lymphoblastoid T-cell-line expressing wild-type and mutated CD4 receptors
    • Moulouh L, Estaquier J, Richman DD, Corbeil, J. Molecular and cellular analysis of human imunodeficiency vrus-induced apoptosis in lymphoblastoid T-cell-line expressing wild-type and mutated CD4 receptors. J Virol 1998, 72:8061-8072.
    • (1998) J Virol , vol.72 , pp. 8061-8072
    • Moulouh, L.1    Estaquier, J.2    Richman, D.D.3    Corbeil, J.4
  • 17
    • 0030586630 scopus 로고    scopus 로고
    • β-chemokine inhibition of monocytotropic HIV-1 infection
    • Oravecz T, Pall M, Norcross MA. β-chemokine inhibition of monocytotropic HIV-1 infection. J Immunol 1996, 157:1329-1332.
    • (1996) J Immunol , vol.157 , pp. 1329-1332
    • Oravecz, T.1    Pall, M.2    Norcross, M.A.3
  • 18
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    • Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996, 272:872-877.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3    Berger, E.A.4
  • 19
    • 15844419153 scopus 로고    scopus 로고
    • Identification of a major coreceptor for primary isolates of HIV-1
    • Deng H, Liu R, Ellmeier W, et al. Identification of a major coreceptor for primary isolates of HIV-1. Nature 1996, 381:661-664.
    • (1996) Nature , vol.381 , pp. 661-664
    • Deng, H.1    Liu, R.2    Ellmeier, W.3
  • 20
    • 0029775576 scopus 로고    scopus 로고
    • The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    • Bleul CC, Farzan M, Choe H, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996, 382:829-833.
    • (1996) Nature , vol.382 , pp. 829-833
    • Bleul, C.C.1    Farzan, M.2    Choe, H.3
  • 21
    • 0030773515 scopus 로고    scopus 로고
    • A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor
    • Doranz BJ, Grovit-Ferbas K, Sharron MP, et al. A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor. J Exp Med 1997, 186:1395-1400.
    • (1997) J Exp Med , vol.186 , pp. 1395-1400
    • Doranz, B.J.1    Grovit-Ferbas, K.2    Sharron, M.P.3
  • 22
    • 0030780377 scopus 로고    scopus 로고
    • A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection
    • Murakami T, Nakajima T, Koyanagi Y, et al. A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection. J Exp Med 1997, 186:1389-1393.
    • (1997) J Exp Med , vol.186 , pp. 1389-1393
    • Murakami, T.1    Nakajima, T.2    Koyanagi, Y.3
  • 23
    • 0030830661 scopus 로고    scopus 로고
    • Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4
    • Schols D, Struyf S, Van Damme J, Este JA, Henson G, De Clercq E. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J Exp Med 1997, 186:1383-1388.
    • (1997) J Exp Med , vol.186 , pp. 1383-1388
    • Schols, D.1    Struyf, S.2    Van Damme, J.3    Este, J.A.4    Henson, G.5    De Clercq, E.6
  • 24
    • 0030695342 scopus 로고    scopus 로고
    • Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5
    • Davis CB, Dikic I, Unutmaz D, et al. Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J Exp Med 1997, 186:1793-1798.
    • (1997) J Exp Med , vol.186 , pp. 1793-1798
    • Davis, C.B.1    Dikic, I.2    Unutmaz, D.3
  • 25
    • 0030724356 scopus 로고    scopus 로고
    • Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
    • Weissman D, Rabin RL, Arthos J, et al. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 1997, 389:981-985.
    • (1997) Nature , vol.389 , pp. 981-985
    • Weissman, D.1    Rabin, R.L.2    Arthos, J.3
  • 26
    • 0032505065 scopus 로고    scopus 로고
    • Apoptosis of CD8+ T cells is mediated by macrophages through interation of gp120 with chemokine receptor CXCR4
    • Herbein G, Mahlknecht U, Batliwalla F, et al. Apoptosis of CD8+ T cells is mediated by macrophages through interation of gp120 with chemokine receptor CXCR4. Nature 1998, 395:189-194.
    • (1998) Nature , vol.395 , pp. 189-194
    • Herbein, G.1    Mahlknecht, U.2    Batliwalla, F.3
  • 27
    • 0032493283 scopus 로고    scopus 로고
    • gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5
    • Madani N, Kozak SL, Kavanaugh MP, Kabat D. gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5. Proc Natl Acad Sci USA 1998, 95:8005-8010.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8005-8010
    • Madani, N.1    Kozak, S.L.2    Kavanaugh, M.P.3    Kabat, D.4
  • 28
    • 0032568918 scopus 로고    scopus 로고
    • Spontaneous and ligand induced trafficking of CXC-chemokine receptor 4
    • Tarasova NI, Stauber RH, Michejda CJ. Spontaneous and ligand induced trafficking of CXC-chemokine receptor 4. J Biol Chem 1998, 273:15883-15886.
    • (1998) J Biol Chem , vol.273 , pp. 15883-15886
    • Tarasova, N.I.1    Stauber, R.H.2    Michejda, C.J.3
  • 29
    • 0032492918 scopus 로고    scopus 로고
    • Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
    • Hesselgesser J, Taub D, Baskar P, et al. Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4. Curr Biol 1998, 8:595-598.
    • (1998) Curr Biol , vol.8 , pp. 595-598
    • Hesselgesser, J.1    Taub, D.2    Baskar, P.3
  • 31
    • 0030587385 scopus 로고    scopus 로고
    • HIV envelope glycoprotein-induced cell killing by apoptosis is enhanced with increased expression of CD26 in CD4+ T cells
    • Jacotot E, Callebaut C, Blanco J, Riviere Y, Krust B, Hovanessian AG. HIV envelope glycoprotein-induced cell killing by apoptosis is enhanced with increased expression of CD26 in CD4+ T cells. Virology 1996, 223:318-330.
    • (1996) Virology , vol.223 , pp. 318-330
    • Jacotot, E.1    Callebaut, C.2    Blanco, J.3    Riviere, Y.4    Krust, B.5    Hovanessian, A.G.6
  • 32
    • 0024639093 scopus 로고
    • Optical imaging of the spatial distribution of β-particles emerging from surfaces
    • Charpak G, Dominick W, Zaganidis N. Optical imaging of the spatial distribution of β-particles emerging from surfaces. Proc Natl Acad Sci USA 1989, 86:1741-1745.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1741-1745
    • Charpak, G.1    Dominick, W.2    Zaganidis, N.3
  • 33
    • 0032794745 scopus 로고    scopus 로고
    • Combined use of radioimagers and radioactive 3′OH DNA nick end labeling to quantify apoptosis in cell lines and tissue sections; Applications to virus induced apoptosis
    • in press
    • Jacotot E, Cardona A, Rebouillat D, et al. Combined use of radioimagers and radioactive 3′OH DNA nick end labeling to quantify apoptosis in cell lines and tissue sections; applications to virus induced apoptosis. Apoptosis 1999 (in press).
    • (1999) Apoptosis
    • Jacotot, E.1    Cardona, A.2    Rebouillat, D.3
  • 34
    • 0030745286 scopus 로고    scopus 로고
    • HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication
    • Amara A, Gall SL, Schwartz O, et al. HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med 1997, 186:139-146.
    • (1997) J Exp Med , vol.186 , pp. 139-146
    • Amara, A.1    Gall, S.L.2    Schwartz, O.3
  • 35
    • 0029013742 scopus 로고
    • Programmed cell death and AIDS pathogenesis: Significance and potential mechanisms
    • Ameisen JC, Estaquier J, Idziorek T, De Bels F. Programmed cell death and AIDS pathogenesis: significance and potential mechanisms. Curr Top Microbiol Immunol 1995, 200:195-211.
    • (1995) Curr Top Microbiol Immunol , vol.200 , pp. 195-211
    • Ameisen, J.C.1    Estaquier, J.2    Idziorek, T.3    De Bels, F.4
  • 36
    • 0031954686 scopus 로고    scopus 로고
    • Effects CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1
    • Platt EJ, Wehrly K, Kuhmann SE, Chesebro B, Kabat D. Effects CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1. J Virol 1998, 72:2855-2864.
    • (1998) J Virol , vol.72 , pp. 2855-2864
    • Platt, E.J.1    Wehrly, K.2    Kuhmann, S.E.3    Chesebro, B.4    Kabat, D.5
  • 37
    • 0028209166 scopus 로고
    • Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100
    • De Clercq F, Yamamoto N, Pauwels R, et al. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrob Agents Chemother 1994, 38:668-674.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 668-674
    • De Clercq, F.1    Yamamoto, N.2    Pauwels, R.3
  • 38
    • 0028997694 scopus 로고
    • Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120
    • Dianzani U, Bragardo M, Buonfiglio D, et al. Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120. Eur J Immunol 1995, 25:1306-1310.
    • (1995) Eur J Immunol , vol.25 , pp. 1306-1310
    • Dianzani, U.1    Bragardo, M.2    Buonfiglio, D.3
  • 39
    • 0030061175 scopus 로고    scopus 로고
    • HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation
    • Tian H, Lempicki R, King L, Donoghue E, Samelson LE, Cohen DL. HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation. Int Immunol 1996, 8:65-74.
    • (1996) Int Immunol , vol.8 , pp. 65-74
    • Tian, H.1    Lempicki, R.2    King, L.3    Donoghue, E.4    Samelson, L.E.5    Cohen, D.L.6
  • 40
    • 0031010762 scopus 로고    scopus 로고
    • Differential susceptibility of naive and memory CD4+ T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI
    • Chun TW, Chadwick K, Margolick J, Siliciano RF. Differential susceptibility of naive and memory CD4+ T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI. J Virol 1997, 71:4436-4444.
    • (1997) J Virol , vol.71 , pp. 4436-4444
    • Chun, T.W.1    Chadwick, K.2    Margolick, J.3    Siliciano, R.F.4
  • 41
    • 0026073086 scopus 로고
    • Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-1-mediated cell fusion but not for viral transmission
    • Pantaleo G, Butini L., Graziosi C, et al. Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-1-mediated cell fusion but not for viral transmission. J Exp Med 1991, 173:511-514.
    • (1991) J Exp Med , vol.173 , pp. 511-514
    • Pantaleo, G.1    Butini, L.2    Graziosi, C.3
  • 42
    • 10544251446 scopus 로고    scopus 로고
    • Regulation of human immunodeficiency virus gp160-mediated cell fusion by antibodies against fusion regulatory protein 1
    • Ohgimoto S, Tabata N, Suga S, et al. Regulation of human immunodeficiency virus gp160-mediated cell fusion by antibodies against fusion regulatory protein 1. J Gen Virol 1996, 77:2747-2756.
    • (1996) J Gen Virol , vol.77 , pp. 2747-2756
    • Ohgimoto, S.1    Tabata, N.2    Suga, S.3
  • 43
    • 0028333662 scopus 로고
    • Identification of CD7 glycoprotein as an accesory molecule in HIV-1-mediated syncitium formation and cell free infection
    • Sato AI, Balamuth FB, Ugen KE, Williams WV, Weiner DB. Identification of CD7 glycoprotein as an accesory molecule in HIV-1-mediated syncitium formation and cell free infection. J Immunol 1994, 152:5142-5152.
    • (1994) J Immunol , vol.152 , pp. 5142-5152
    • Sato, A.I.1    Balamuth, F.B.2    Ugen, K.E.3    Williams, W.V.4    Weiner, D.B.5
  • 44
    • 0029665761 scopus 로고    scopus 로고
    • Bcl-2 expression facilitates human immunodeficiency virus type-1 mediated cytopathic effects during acute spreading infections
    • Sandstrom PA, Pardi D, Goldsmith CS, Chengying D, Diamond AM, Folks TM. Bcl-2 expression facilitates human immunodeficiency virus type-1 mediated cytopathic effects during acute spreading infections. J Virol 1996, 70:4617-4622.
    • (1996) J Virol , vol.70 , pp. 4617-4622
    • Sandstrom, P.A.1    Pardi, D.2    Goldsmith, C.S.3    Chengying, D.4    Diamond, A.M.5    Folks, T.M.6
  • 46
    • 0033582332 scopus 로고    scopus 로고
    • CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1 infected human lymphoid tissue
    • Penn ML, Grivel JC, Schramm B, Goldsmith MA, Margolis L. CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1 infected human lymphoid tissue. Proc Natl Acad Sci USA 1999, 96:663-668.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 663-668
    • Penn, M.L.1    Grivel, J.C.2    Schramm, B.3    Goldsmith, M.A.4    Margolis, L.5
  • 47
    • 0029882175 scopus 로고    scopus 로고
    • Progrmmed cell death in peripheral lymphocytes from HIV-infected persons: Increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression
    • Gougeon ML, Lecoeur H, Dulioust A, et al. Progrmmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J Immunol 1996, 156:3509-3520.
    • (1996) J Immunol , vol.156 , pp. 3509-3520
    • Gougeon, M.L.1    Lecoeur, H.2    Dulioust, A.3
  • 48
    • 0028198108 scopus 로고
    • Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease
    • Meyaard L, Otto SA, Keet IPM, Roos MTL, Miedema F. Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease. J Clin Invest 1994, 93:982-988.
    • (1994) J Clin Invest , vol.93 , pp. 982-988
    • Meyaard, L.1    Otto, S.A.2    Keet, I.P.M.3    Roos, M.T.L.4    Miedema, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.