HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck

Journal of Experimental Medicine

Volumn 183, Issue 1, 1996, Pages 39-48

  Corbeil, Jacques ^a,d   Tremblay, Michel ^c   Richman, Douglas D ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c UNIVERSITÉ LAVAL   (Canada)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; ETIOLOGY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANTIGENS, CD4; APOPTOSIS; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CELL FUSION; CELL TRANSFORMATION, VIRAL; CYTOPATHOGENIC EFFECT, VIRAL; FLOW CYTOMETRY; HIV-1; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PRECIPITIN TESTS; PROTEIN BINDING; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 0030026848     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.1.39     Document Type: Article

References (52)

1. Laurent-Crawford, A.G., B. Krust, S. Muller, Y. Rivière, M.A. Rey-Cuille, J.M. Becher, L. Montagnier, and A.G. Hovanessian. 1991. The cytopathic effect of HIV is associated with apoptosis. Virology. 185:829-839.
2. Terai, C., R.S. Kornbluth, C.D. Pauza, D.D. Richman, and D.A. Carson. 1991. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J. Clin Invest. 87.1710-1715.
3. + T cells. J. Gen. Virol. 76:681-690.
4. Dalgleish, A.G., P.C. Beverley, P.R. Clapham, D.H. Crawford, M.F. Greaves, and R.A. Weiss. 1984. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature (Lond.). 312:763-767.
5. Emmrich, F., L. Kanz, and K. Eichmann. 1987. Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells. Eur. J. Immunol. 17:529-534.
6. Owens, T., B.F. Fazekas de St. Groth, and J.F. Miller. 1987. Coaggregation of the T-cell receptor with CD4 and other T-cell surface molecules enhances T-cell activation. Proc. Natl. Acad. Sci. (USA). 84:9209-9213.
7. Anderson, P., M.L. Blue, C. Morimoto, and S.F. Schlossman. 1987. Crosslinking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T lymphocytes. J. Immunol. 539:678-682.
8. lck. Cell. 55:301-308.
9. lck. Nature (Lond.). 338:257-259.
10. Sodroski, J., W.C. Goh, C. Rosen, K. Campbell, and W.A. Haseltine. 1986. Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity. Nature (Lond.) 322: 470-474.
11. + lymphocytes and cells infected by human immunodeficiency virus. Proc. Natl. Acad. Sci. (USA). 84:1429-1433.
12. Pauza, C.D., J.E. Galindo, and D.D. Richman. 1990. Reinfection results in accumulation of unintegrated viral DNA in cytopathic and persistent human immunodeficiency virus type 1 infection of CEM cells. J. Exp. Med. 172:1035-1042.
13. Lyerly, H.K., T.J. Matthews, A.J. Langlois, D.P. Bolognesi, and K.J. Weinhold. 1987. Human T-cell lymphotropic virus IIIB glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack Proc. Natl. Acad. Sci. (USA). 84: 4601-4605.
14. Boldt-Houle, D.M., C.R. Rinaldo, Jr., and G.D. Ehrlich. 1993. Random depletion of T cells that bear specific T cell receptor V beta sequences in AIDS patients. J. Leukocyte Biol. 54:486-491.
15. Steller, H. 1995. Mechanisms and genes of cellular suicide. Science (Wash. DC). 267:1445-1449.
16. Thompson, C.B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science (Wash. DC). 267:1456-1462.
17. + T cell function by the HIV envelope protein, gp120. J. Immunol. 141:3715-3717.
18. lck activation and TCR desensitization independent of TCR tyrosine phosphorylation. J. Immunol. 153:2905-2917.
19. lck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO (Eur. Mol. Biol. Organ.) J. 13:774-783.
20. Benkirane, M., K.T. Jeang, and C. Devaux. 1994. The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells. EMBO (Eur Mol Biol. Organ.) J. 13:5559-5569.
21. Koga, Y., N. Oh-Hori, H. Sato, N. Yamamoto, G. Kimura, and K. Nomoto. 1989. Absence of transcription of lck (lymphocyte specific protein tyrosine kinase) message in IL-2-independent, HTLV-I-transformed T cell lines. J. Immunol. 142:4493-4499.
22. Sleckman, B.P., A. Peterson, J.A. Foran, J.C. Gorga, C.J. Kara, J.L. Strominger, S.J Burakoff, and J.L. Greenstein. 1988. Functional analysis of a cytoplasmic domain-deleted mutant of the CD4 molecule. J. Immunol. 141:49-54.
23. Xu, H., and D.R. Littman. 1993. A kinase-independent function of Lck in potentiating antigen-specific T cell activation. Cell. 74:633-643.
24. Karber, G. 1931. Beiträge zur kollektiven behandlung pharmakologisher reihenversuche. Arch. Exp. Pathol. Pharmakol. 162:480-483.
25. Darzynkiewicz, Z., X. Li, and J. Gong. 1994. Assays of cell viability: discrimination of cells dying by apoptosis. Methods Cell Biol. 41:15-38.
26. Telford, W.G., L.E. King, and P.J. Fraker. 1992. Comparative evaluation of several DNA binding dyes in the detection of apoptosis-associated chromatin degradation by flow cytometry. Cytometry. 13:137-142.
27. Ho, S.N., H.D. Hunt, R.M. Horton, J.K. Pullen, and L.R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene. 77:51-59.
28. Garcia, J.V., J. Alfano, and A.D. Miller. 1993. The negative effect of human immunodeficiency virus type I Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4. J. Virol. 67:1511-1516.
29. lck. J. Biol. Chem. 268:17547-17553.
30. Wright, D.D., B.M. Sefton, and M.P. Kamps. 1994. Oncogenic activation of the Lck protein accompanies translocation of the lck gene in the human HSB-2 T-cell leukemia. Mol. Cell. Biol. 14:2429-2437.
31. Aiken, C., J. Konner, N.R. Landau, M.E. Lenburg, and D. Trono. 1994. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell. 76:853-864.
32. Lenburg, M.E , and N.R. Landau. 1993. Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4. J. Virol. 67:7238-7245.
33. Willey, R.L., F. Maldarelli, M.A. Martin, and K. Strebel. 1992. Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes. J. Virol. 66:226-234.
34. Koga, Y., M. Sasaki, H. Yoshida, H. Wigzell, G. Kimura, and K Nomoto. 1990. Cytopathic effect determined by the amount of CD4 molecules in human cell lines expressing envelope glycoprotein of HIV. J. Immunol. 144:94-102.
35. Shaw, A S., K.E. Amrein, C. Hammond, D.F. Stern, B.M. Sefton, and J.K. Rose. 1989. The Lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain. Cell. 59:627-636.
36. Pawson, T. 1995. Protein modules and signalling networks. Nature (Lond.). 372:573-580.
37. lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits. J. Cell Biol. 117:279-290.
38. lck interacts via its src homology 2 domain with the ZAP-70 kinase. J. Exp. Med. 179:1163-1172.
39. lck T cell receptor complexes. Science (Wash. DC). 254:439-441.
40. lck complex in T cells. Mol. Cell. Biol. 12:5260-5267.
41. lck protein tyrosine kinase in human T-cells. Cell Growth & Differ. 2:609-617.
42. lck in CD4 T cells from HIV-1 infected patients. Int. Immunol. 6:611-621.
43. lck protein tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc. Natl. Acad. Sci. (USA). 92:349-353.
44. Ho, D.D., A.U. Neumann, A.S. Perelson, W. Chen, J.M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (Lond.). 373:123-126.
45. Wei, X., S.K. Ghosh, M.E. Taylor, V.A Johnson, E.A. Emini, P. Deutsch, J.D. Lifson, S. Bonhoeffer, M.A. Nowak, B.H. Hahn, et al. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature (Lond.). 373:117-122.
46. Adleman, L.M., and D. Wofsy. 1993. T-cell homeostasis: implications in HIV infection. J. Acquired Immune Defic. Syndr. 6:144-152.
47. Embretson, J., M. Zupancic, J.L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, and A.T. Haase. 1993. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature (Lond.). 362: 359-362.
48. Pantaleo, G., C. Graziosi, J.F. Demarest, L. Butini, M. Montroni, C.H. Fox, J.M. Orenstein, D.P. Kotler, and A.S. Fauci. 1993. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature (Lond.). 362:355-358.
49. Piatak, M., Jr., M.S. Saag, L.C. Yang, S.J. Clark, J.C. Kappes, K.C. Luk, B.H. Hahn, G.M. Shaw, and J.D. Lifson. 1993. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science (Wash. DC). 259: 1749-1754.
50. Muro-Cacho, C.A., G. Pantaleo, and A.S. Fauci. 1995. Analysis of apoptosis in lymph nodes of HIV-infected persons. J. Immunol. 154:5555-5566.
51. Antoni, B.A., P. Sabbatini, A.B. Rabson, and E. White. 1995. Inhibition of apoptosis in human immunodeficiency virus-infected cell enhances virus production and facilitates persistent infection. J. Virol. 69:2384-2392.
52. Estaquier, J., T. Idziorek, F. de Bels, F. Barre-Sinoussi, B. Hurtrel, A.M. Aubertin, A. Venet, M. Mehtali, E. Muchmore, P. Michel, et al. 1994. Programmed cell death and AIDS: significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections. Proc. Natl. Acad. Sci. (USA). 91:9431-9435.