Evidence for the HIV-1 phenotype switch as a causal factor in acquired immunodeficiency

Nature Medicine

Volumn 4, Issue 3, 1998, Pages 346-349

  Glushakova, Svetlana ^a   Grivel, Jean Charles ^a   Fitzgerald, Wendy ^a   Sylwester, Andrew ^a   Zimmerberg, Joshua ^a   Margolis, Leonid B ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; B-LYMPHOCYTES; CULTURE TECHNIQUES; HIV-1; HUMANS; MACROPHAGES; MODELS, IMMUNOLOGICAL; PHENOTYPE; T-LYMPHOCYTES; TONSIL;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031953133     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0398-346     Document Type: Article

References (22)

1. Fauci, A.S, Host factors and the pathogenesis of HIV-induced disease. Nature 384, 529-534 (1996).
2. Zhu, T. et al. Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 261, 1179-1181 (1993).
3. Cornelissen, M. et al. Syncytium-inducing (SI) phenotype suppression at seroconversion after intramuscular inoculation of a non-syncytium-inducing/SI phenotypically mixed human immunodeficiency virus population. J. Virol. 69, 1810-1818 (1995).
4. Muro-Cacho, CA., Pantaleo, G. & Fauci, A.S. Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J. Immunol. 154, 5555-5566 (1995).
5. Ott, M. et al. Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science 275, 1481-1485 (1997).
6. Pantaleo, G. & Fauci, A.S. New concepts in the immunopathogenesis of HIV infection. Annu. Rev. Immunol. 13, 487-512 (1995).
7. Tersmette, M. Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality. Lancet 1, 983-985 (1989).
8. Schuitemaker, H. et al. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J. Virol. 66, 1354-1360 (1992).
9. + T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals. J. Virol. 67, 1772-1777 (1993).
10. Glushakova, S., Baibakov, B., Margolis, L.B. & Zimmerberg, J. Infection of human tonsil histocultures: A model for HIV pathogenesis. Nature Med. 1, 1320-1322 (1995).
11. + T cell depletion and virus syncytium-inducing/non-syncytium-inducing phenotype in histoculture inoculated with laboratory strains and patient isolates of HIV type 1. AIDS Res. Hum. Retrovir. 13, 461-471 (1997).
12. Barbi, M. et al. Immunization in children with HIVseropositivity at birth: Antibody response to polio vaccine and tetanus toxoid. AIDS 6, 1465-1469 (1992).
13. Combadiere, C., Ahuja, S.K., Tiffany, H.L. & Murphy, P.M. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1β, and RANTES. J. Leukoc. Biol. 60, 147-152 (1996).
14. Oberlin, E. et al. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382, 833-5 (1996).
15. Clark, E.A. & Ledbetter, J.A. How B and T cells talk to each other. Nature 367, 425-428 (1994).
16. Snapper, C.M., Kehry, M.R., Castle, B.E. & Mond, J.J. Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells: A redefinition of the Tl-2 vs. T celldependent antigen dichotomy. J. Immunol. 154, 11 77-1187 (1995).
17. Mishell, R.I. & Dutton, R.W. Immunization of normal mouse spleen cell suspensions in vitro. Science 153, 1004-1006 (1966).
18. Hoffman, M.K., Schmidt, D. & Oettgen, H.F. Production of antibody to sheep red blood cells by human tonsil cells in vitro. Nature 243, 408-410 (1973).
19. Lane, H.C., Volkman, D.J., Whalen, G. & Fauci, A.S. in vitro antigen-induced, antigen-specific antibody production in man: Specific and polyclonal components, kinetics, and cellular requirements. J. Exp. Med. 154, 1043-1057 (1981).
20. Roos, M.T. et al. Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection. J. Infect. Dis. 165, 427-432 (1992).
21. + lymphocytes. AIDS 8, 469-476 (1994).
22. Lane, H.C. et al. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 309, 453-458 (1983).