메뉴 건너뛰기




Volumn 309, Issue 1, 1996, Pages 71-78

Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors

Author keywords

cAMP; Cerebellar granule cell; Cortex; Metabotropic glutamate receptor; Phenylglycine; Phosphoinositide hydrolysis

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 (CARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; ADENYLATE CYCLASE; ALPHA METHYL 3 CARBOXYMETHYL 4 HYDROXYPHENYLGLYCINE; ALPHA METHYL 4 HYDROXY 3 PHOSPHONOMETHYLPHENYLGLYCINE; ALPHA METHYL 4 HYDROXYPHENYLGLYCINE; ALPHA METHYL 4 PHOSPHONOPHENYLGLYCINE; ALPHA METHYL 4 SULFONOPHENYLGLYCINE; CYCLIC AMP; FORSKOLIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR; NEW DRUG; PHENYLGLYCINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0030221979     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00313-5     Document Type: Article
Times cited : (22)

References (35)
  • 2
    • 0011945006 scopus 로고
    • Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids
    • Allan, R.D., J.R. Hanrahan, T.W. Hambley, G.A. Johnston, K.N. Mewett and A.D. Mitrovic, 1990, Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids, J. Med. Chem. 182, 397.
    • (1990) J. Med. Chem. , vol.182 , pp. 397
    • Allan, R.D.1    Hanrahan, J.R.2    Hambley, T.W.3    Johnston, G.A.4    Mewett, K.N.5    Mitrovic, A.D.6
  • 4
    • 0026344031 scopus 로고
    • Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus
    • Baskys, A. and R.C. Malenka, 1991. Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus, J. Physiol. 444, 687.
    • (1991) J. Physiol. , vol.444 , pp. 687
    • Baskys, A.1    Malenka, R.C.2
  • 5
    • 0029561572 scopus 로고
    • Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs)
    • Bedingfield, J.S., M.C. Kemp, D.E. Jane, H.-W. Tse, P.J. Roberts and J.C. Watkins, 1995, Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs), Br. J. Pharmacol. 116, 3323.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 3323
    • Bedingfield, J.S.1    Kemp, M.C.2    Jane, D.E.3    Tse, H.-W.4    Roberts, P.J.5    Watkins, J.C.6
  • 6
    • 0029133818 scopus 로고
    • Phenylglycine derivatives discriminate between mGluR1 and mGluR5-mediated responses
    • Brabet, I., S. Mary, J. Bockaert and J.-P. Pin, 1995, Phenylglycine derivatives discriminate between mGluR1 and mGluR5-mediated responses, Neuropharmacology 34, 895.
    • (1995) Neuropharmacology , vol.34 , pp. 895
    • Brabet, I.1    Mary, S.2    Bockaert, J.3    Pin, J.-P.4
  • 10
    • 0011981709 scopus 로고
    • Developmental switch in the expression of mGluR5 and mGluR1a receptors in cultured cerebellar neurons
    • Copani, A., G. Casabona, V. Bruno, T. Knopfel, R. Kuhn and F. Nicoletti, 1995, Developmental switch in the expression of mGluR5 and mGluR1a receptors in cultured cerebellar neurons, Soc. Neurosci. Abstr. 21, 338.19.
    • (1995) Soc. Neurosci. Abstr. , vol.21 , pp. 33819
    • Copani, A.1    Casabona, G.2    Bruno, V.3    Knopfel, T.4    Kuhn, R.5    Nicoletti, F.6
  • 11
    • 0028968702 scopus 로고
    • A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb
    • Duvoisin, R.M., C. Zhang and K. Ramonell, 1995, A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb, J. Neurosci. 15, 3075.
    • (1995) J. Neurosci. , vol.15 , pp. 3075
    • Duvoisin, R.M.1    Zhang, C.2    Ramonell, K.3
  • 12
    • 0025037111 scopus 로고
    • Presynaptic glutamate receptors depress excitatory monosynaptic transmission between mouse hippocampal neurones
    • Forsythe, I.D. and J.D. Clements, 1990, Presynaptic glutamate receptors depress excitatory monosynaptic transmission between mouse hippocampal neurones, J. Physiol. 429, 1.
    • (1990) J. Physiol. , vol.429 , pp. 1
    • Forsythe, I.D.1    Clements, J.D.2
  • 13
    • 0028168149 scopus 로고
    • R-2-(2,3-dicarboxycyclopropyl)glycine positively modulates metabotropic glutamate receptors coupled to polyphosphoinositide hydrolysis in rat hippocampal slices
    • R)-2-(2,3-dicarboxycyclopropyl)glycine positively modulates metabotropic glutamate receptors coupled to polyphosphoinositide hydrolysis in rat hippocampal slices, Brain Res. 659, 10.
    • (1994) Brain Res. , vol.659 , pp. 10
    • Genazzani, A.A.1    L'Episcopo, M.R.2    Casabona, G.3    Shinozaki, H.4    Nicoletti, F.5
  • 14
    • 0028350739 scopus 로고
    • Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types
    • Hayashi, Y., N. Sekiyama, S. Nakanishi, D.E. Jane, D.C. Sunter, E.F. Birse, P.M. Udvarhelyi and J.C. Watkins, 1994, Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types, J. Neurosci. 14, 3370.
    • (1994) J. Neurosci. , vol.14 , pp. 3370
    • Hayashi, Y.1    Sekiyama, N.2    Nakanishi, S.3    Jane, D.E.4    Sunter, D.C.5    Birse, E.F.6    Udvarhelyi, P.M.7    Watkins, J.C.8
  • 16
    • 0027209890 scopus 로고
    • A novel metabotropic glutamate receptor agonist: Marked depression of monosynaptic excitation in the newborn rat isolated spinal cord
    • Ishida, M., T. Saitoh, K. Shimamoto, Y. Ohfune and H. Shinozaki, 1993, A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord, Br. J. Pharmacol. 109, 1169.
    • (1993) Br. J. Pharmacol. , vol.109 , pp. 1169
    • Ishida, M.1    Saitoh, T.2    Shimamoto, K.3    Ohfune, Y.4    Shinozaki, H.5
  • 17
    • 0027174866 scopus 로고
    • Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones
    • Jane, D.E., P.L.S.J. Jones, P.C.K. Pook, T.E. Salt, D.C. Sunter and J.C. Watkins, 1993, Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones, Neuropharmacology 32, 725.
    • (1993) Neuropharmacology , vol.32 , pp. 725
    • Jane, D.E.1    Jones, P.L.S.J.2    Pook, P.C.K.3    Salt, T.E.4    Sunter, D.C.5    Watkins, J.C.6
  • 18
    • 0029131705 scopus 로고
    • New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord
    • Jane, D.E., K. Pittaway, D.C. Sunter, N.K. Thomas and J.C. Watkins, 1995, New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord, Neuropharmacology 34, 851.
    • (1995) Neuropharmacology , vol.34 , pp. 851
    • Jane, D.E.1    Pittaway, K.2    Sunter, D.C.3    Thomas, N.K.4    Watkins, J.C.5
  • 21
    • 0027232329 scopus 로고
    • Molecular characterisation of a novel retinal metabotropic glutamate mGluR6 with a high agonist selectivity for L-2-amino-4-phosphobutyrate
    • Nakajima, Y., H. Iwakabe, C. Akazawa, H. Nawa, R. Shigemoto, N. Mizuno and S. Nakanishi, 1993, Molecular characterisation of a novel retinal metabotropic glutamate mGluR6 with a high agonist selectivity for L-2-amino-4-phosphobutyrate, J. Biol. Chem. 268, 11868.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11868
    • Nakajima, Y.1    Iwakabe, H.2    Akazawa, C.3    Nawa, H.4    Shigemoto, R.5    Mizuno, N.6    Nakanishi, S.7
  • 22
    • 0027378595 scopus 로고
    • Immunohistochemical localisation of a metabotropic glutamate receptor, mGluR5, in the rat brain
    • Nomura, H. Ohishi, H. Sugihara, S. Nakanishi and N. Mizuno, 1993, Immunohistochemical localisation of a metabotropic glutamate receptor, mGluR5, in the rat brain, Neurosci. Lett. 163, 53.
    • (1993) Neurosci. Lett. , vol.163 , pp. 53
    • Nomura1    Ohishi, H.2    Sugihara, H.3    Nakanishi, S.4    Mizuno, N.5
  • 23
    • 0027955170 scopus 로고
    • Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction
    • Okamoto, N., S. Hori, C. Akazawa, Y. Hayashi., R. Shigemoto., N. Mizuno and S. Nakanishi, 1994, Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction, J. Biol. Chem. 269, 1231.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1231
    • Okamoto, N.1    Hori, S.2    Akazawa, C.3    Hayashi, Y.4    Shigemoto, R.5    Mizuno, N.6    Nakanishi, S.7
  • 24
    • 0027190384 scopus 로고
    • Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat
    • Ohishi, H., R. Shigemoto, S. Nakanishi and N. Mizuno, 1993, Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat, Neuroscience 53, 1009.
    • (1993) Neuroscience , vol.53 , pp. 1009
    • Ohishi, H.1    Shigemoto, R.2    Nakanishi, S.3    Mizuno, N.4
  • 25
    • 0029187946 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin, J.-P. and R. Duvoisin, 1995, The metabotropic glutamate receptors: structure and functions, Neuropharmacology 34, 1.
    • (1995) Neuropharmacology , vol.34 , pp. 1
    • Pin, J.-P.1    Duvoisin, R.2
  • 26
    • 0026860884 scopus 로고
    • Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)-and (1S,3R)-ACPD
    • Pook, P.C.K., D.C. Sunter, P.M. Udvarhelyi and J.C. Watkins, 1992, Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)-and (1S,3R)-ACPD, Exp. Physiol. 77, 529.
    • (1992) Exp. Physiol. , vol.77 , pp. 529
    • Pook, P.C.K.1    Sunter, D.C.2    Udvarhelyi, P.M.3    Watkins, J.C.4
  • 27
    • 0028331717 scopus 로고
    • Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures
    • Prézeau, L., J. Carrette, B. Helpap, K. Curry, J.-P. Pin and J. Bockaert, 1994, Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures, Mol. Pharmacol. 45, 570.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 570
    • Prézeau, L.1    Carrette, J.2    Helpap, B.3    Curry, K.4    Pin, J.-P.5    Bockaert, J.6
  • 28
    • 0029151828 scopus 로고
    • Pharmacological tools for the investigation of metabotropic glutamate receptors (mGluRs); phenylglycine derivatives and other selective antagonists - An update
    • Roberts, P.J., 1995, Pharmacological tools for the investigation of metabotropic glutamate receptors (mGluRs); phenylglycine derivatives and other selective antagonists - an update, Neuropharmacology 34, 813.
    • (1995) Neuropharmacology , vol.34 , pp. 813
    • Roberts, P.J.1
  • 29
    • 0027938407 scopus 로고
    • Temporal and depolarization-induced changes in the absolute amounts of mRNA's encoding metabotropic glutamate receptors in cerebellar granule neurones in vitro
    • Santi, M.R., S. Ikonomovic, J.T. Wroblewski and D.R. Grayson, 1994, Temporal and depolarization-induced changes in the absolute amounts of mRNA's encoding metabotropic glutamate receptors in cerebellar granule neurones in vitro, J. Neurochem. 6, 1207.
    • (1994) J. Neurochem. , vol.6 , pp. 1207
    • Santi, M.R.1    Ikonomovic, S.2    Wroblewski, J.T.3    Grayson, D.R.4
  • 30
    • 0028207306 scopus 로고
    • Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors
    • Saugstad, J.A., J.M. Kinzie, E.R. Mulvihill, T.P. Segerson and G.L. Westbrook, 1994, Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors, Mol. Pharmacol. 45, 367.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 367
    • Saugstad, J.A.1    Kinzie, J.M.2    Mulvihill, E.R.3    Segerson, T.P.4    Westbrook, G.L.5
  • 32
    • 0027410488 scopus 로고
    • Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate, mGluR3 and mGluR4
    • Tanabe, Y., A. Nomura, M. Masu, R. Shigemoto, N. Mizuno and S. Nakanishi, 1993, Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate, mGluR3 and mGluR4, J. Neurosci. 13, 1372.
    • (1993) J. Neurosci. , vol.13 , pp. 1372
    • Tanabe, Y.1    Nomura, A.2    Masu, M.3    Shigemoto, R.4    Mizuno, N.5    Nakanishi, S.6
  • 33
    • 0028805210 scopus 로고
    • Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells
    • Toms N.J., D.E. Jane, H.-W. Tse and P.J. Roberts, 1995, Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells, Br. J. Pharmacol. 116, 2824.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2824
    • Toms, N.J.1    Jane, D.E.2    Tse, H.-W.3    Roberts, P.J.4
  • 34
    • 0026487038 scopus 로고
    • An easy cAMP extraction method facilitating adenylyl cyclase assays
    • Voss, T. and E. Wallner, 1992, An easy cAMP extraction method facilitating adenylyl cyclase assays, Anal. Biochem. 207, 40.
    • (1992) Anal. Biochem. , vol.207 , pp. 40
    • Voss, T.1    Wallner, E.2
  • 35
    • 0027992583 scopus 로고
    • Phenylglycine derivatives as antagonists of glutamate receptors
    • Watkins, J. and G. Collingridge, 1994, Phenylglycine derivatives as antagonists of glutamate receptors, Trends Pharmacol. Sci. 15, 333.
    • (1994) Trends Pharmacol. Sci. , vol.15 , pp. 333
    • Watkins, J.1    Collingridge, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.