Biphenyl-derivatives of 2-amino-7-phosphonoheptanoic acid, a novel class of potent competitive N-Methyl-D-aspartate receptor antagonists - I. Pharmacological characterization in vitro

Neuropharmacology

Volumn 35, Issue 6, 1996, Pages 643-654

  Urwyler, Stephan ^a   Laurie, David ^b   Lowe, David A ^a   Meier, Christoph L ^a   Müller, Werner ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Preclinical Research   (Switzerland)

Author keywords

Antagonists; Biphenyl AP7 derivatives; In vitro profile; NMDA receptor; Receptor affinities; Structure activity relationships

Indexed keywords

2 AMINO 4 PHOSPHONOMETHYL 3 HEPTENOIC ACID; 2 AMINO 7 PHOSPHONOHEPTANOIC ACID; DIZOCILPINE; GLUTAMIC ACID; GLYCINE; HEPTANOIC ACID DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; STRYCHNINE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CONTROLLED STUDY; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

EID: 0030175267     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00049-4     Document Type: Article

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