Anti-epileptogenic and anticonvulsant activity of L-2-amino-4-phosphonobutyrate, a presynaptic glutamate receptor agonist

Brain Research

Volumn 755, Issue 2, 1997, Pages 202-212

  Abdul Ghani, Abdul Salam ^a   Attwell, Philip J E ^b   Kent, Natasha Singh ^b   Bradford, Henry F ^b   Croucher, Martin J ^c   Jane, David E ^d  

^a BIRZEIT UNIVERSITY   (Palestine)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

electrical kindling; epileptogenesis; in vitro 45Ca2+ uptake; in vitro 3H D aspartate release; L AP4; MPPG; presynaptic glutamate receptor; seizure

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; ALPHA METHYL 4 PHOSPHONOPHENYLGLYCINE; ANTICONVULSIVE AGENT; ASPARTIC ACID; GLUTAMATE RECEPTOR; PRESYNAPTIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM TRANSPORT; CONTROLLED STUDY; EPILEPSY; HISTOLOGY; INTRACEREBRAL DRUG ADMINISTRATION; KINDLING; MALE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; SEIZURE;

ALANINE; AMINOBUTYRIC ACIDS; AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; CALCIUM RADIOISOTOPES; CEREBRAL CORTEX; DRUG EVALUATION, PRECLINICAL; EPILEPSY; EXCITATORY AMINO ACID AGONISTS; KINDLING, NEUROLOGIC; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPTOSOMES;

EID: 0030981404     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00098-X     Document Type: Article

References (54)

1. Abdul-Ghani A.-S., Attwell, P.J.E. and Bradford, H.F., The antiepileptic effect of 3-aminopropylarsonate on electrically kindled amygdala, Brain Res., 742 (1996) 305-312.
2. Anson, J. and Collins, G.G.S., Possible presynaptic actions of 2-amino-4-phosphono-butyrate in rat olfactory cortex, Br. J. Pharmacol., 91 (1987) 753-761.
3. Attwell, P.J.E., Kaura, S., Sigala, G., Bradford, H.F., Croucher, M.J., Jane, D.E. and Watkins, J.C., Blockade of both epileptogenesis and glutamate release by (18,3S)-ACPD, a presynaptic glutamate receptor agonist, Brain Res., 698, (1995) 155-162.
4. Baskys, A., Metabotropic receptors and 'slow' excitatory actions of glutamate agonists in the hippocampus, Trends Neurosci., 15, (1992) 92-96.
5. 4) and trans-2-aminocyclopentane-1-3-dicarboxylate (ACPD), Brain Res., 649, (1994) 339-342.
6. Burke, J.P. and Hablitz, J.J., Metabotropic glutamate receptor activation decreases epileptiform activity in rat neocortex, Neurosci. Lett., 174 (1994) 29-33.
7. 3H]2-amino-4-phosphonobutyrate binding-sites in the rat striatum, Brain Res., 381 (1986) 305-313.
8. 3H]amino-4-phosphonobutyrate binding sites in the rat hippocampus-distribution and possible physiological role, Brain Res., 419 (1987) 294-302.
9. Cain, D.P., Dosborough, K.A. and McKitrick, D.J., Retardation of amygdala kindling by antagonism of NMDA and muscarinic cholinergic receptors, Exp. Neurol., 100 (1988) 179-187.
10. Cartmell, J., Curtis, A.R., Kemp, J.A., Kendall, D.A. and Alexander, S.P.H., Subtypes of metabotropic excitatory amino acid receptor distinguished by stereoisomers of the rigid glutamate analogue 1-aminocyclopentane-1,3-dicarboxylate, Neurosci. Lett., (1993) 153, 107-110.
11. Chapman, A.G., Graham, J.L., Patel, S. and Meldrum, B.S., Anti-convulsant activity of two orally active competitive NMDA antagonists, CGP 37849 and CGP 39551 against sound induced seizures in DBA/2 mice and photically induced myoclonus in Papio papio, Epilepsia, 32 (1991) 578-587.
12. Coutinho-Netto, J., Abdul-Ghani, A.-S., Collins, J.F. and Bradford, H.F., Is glutamate a trigger factor in epileptic hyperactivity? Epilepsia, 22 (1981) 289-296.
13. Cotterell, K.L., Croucher, M.J. and Bradford, H.F., CGP 37849 and CGP 39551 raise generalized seizure thresholds in the amygdala kindling model of epilepsy, Fund. Clin. Pharmacol., 5 (1991) 444.
14. Croucher, M.J., Bradford, H.F., Sunter, D.C. and Watkins, J.C., Inhibition of the development of electrical kindling of the prepyriform cortex by daily focal injections of excitatory amino acids antagonists, Eur. J. Pharmacol., 152 (1988) 29-38.
15. Croucher, M.J. and Bradford, H.F., Kindling of full limbic seizures by repeated microinjections of excitatory amino acids into the rat amygdala, Brain Res., 501 (1989) 58-65.
16. Croucher, M.J. and Bradford, H.F., NMDA receptor blockade inhibits glutamate-induced kindling of the rat amygdala, Brain Res., 506 (1990) 349-352.
17. Croucher, M.J. and Bradford, H.F., The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds, Brain Res., 543 (1991) 91-96.
18. Croucher, M.J., Cotterell, K.L. and Bradford, H.F., Competitive NMDA receptor antagonists raise electrically kindled generalized seizure thresholds, Neurochem. Res., 17 (1992) 409-413.
19. Croucher, M.J., Cotterell, K.L. and Bradford, H.F., Amygdaloid kindling by repeated focal N-methyl-D-aspartate administration: comparison with electrical kindling, Eur. J. Pharmacol., 286 (1995) 265-271.
20. De-Sarro, G. and De-Sarro, A., Anticonvulsant activity of competitive antagonists of NMDA receptors in genetically epilepsy-prone rats, Eur. J. Pharmacol., 215 (1992) 221-229.
21. Durmuller, N., Craggs, M. and Meldrum, B.S., The effect of the non-NMDA receptor antagonist GYK1 52466 and VBQX and the competitive receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures, Epilepsy Res., 17 (1994) 167-174.
22. Duvoisin, R.M., Zhange, C. and Ramonell, K., A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb, J. Neurosci., 15 (11) (1995) 3075-3083.
23. East, S.J., Hill, M.P. and Brotchie, J.M., Metabotropic glutamate receptor agonists inhibit endogenous glutamate release from rat striatal synaptosomes, Eur. J. Pharmacol., 277 (1995) 117-121.
24. Gannon, R.L., Baty, J.T. and Terrian, D.M., L(+)-2-Amino-4-phosphonobutyrate inhibits the release of both glutamate and dynorphin from guinea-pig but not rat hippocampal mossy fiber synaptosomes, Brain Res., 495 (1989) 151-155.
25. Genazzani, A.A., Casabona, G., L'Episcopo, M.R., Condorelli, D.F., Dell'Albana, P., Shinozaki, H. and Nicoletti, F., Characterization of metabotropic glutamate receptors negatively linked to adenyl-cyclase in brain slices, Brain Res., 622 (1993) 132-138.
26. Hughes, P.D., Foley, P., Bradford, H.F., Ghatei, M., Khandanian, N., Bloom, S.R. and Wu, J.Y., The differential release of amino acids and neuropeptides from purified subpopulations of mammalian GABAergic and cholinergic cerebrocortical synaptosomes, Neurochem. Res., 18 (1993) 393-400.
27. Jane, D.E., Jones, P.L., Pook, P.C., Tse, H.W. and Watkins, J.C., Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord, Br. J. Pharmacol., 112 (1994) 809-816.
28. Jane, D.E., Pittaway, K., Sunter, D.C., Thomas, N.K. and Watkins, J.C., New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptor in neonatal rat spinal cord, Neuropharmacology, 34 (1995) 851-856.
29. Kaura, S., Bradford, H.F., Young, A.M.J., Croucher, M.J. and Hughes, P.D., The effect of amygdaloid kindling on the content and release of amino acids from the amygdaloid complex: In vivo and In vitro studies, J. Neurochem., 65 (1995) 1240-1249.
30. Kemp, M., Robert, P.J., Pook, P.C.-K., Jane, D.E., Jones, A.W., Jones, P.L. St. J., Sunter, D.C., Udvarhelyi, P.M. and Watkins, J.C., Antagonism of pre-synaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors, Eur. J. Pharmacol., 266 (1994) 187-192.
31. Minamoto, Y., Itano, T., Tokuda, M., Matsui, H., Janjua, N.A., Hosokawa, K., Okada, Y., Murakami, T.H., Negi, T. and Hatase, O., In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat, Brain Res., 573 (1992) 345-348.
32. Monoghan, D.T., Bridges, R.J. and Cotman, C.W., The excitatory amino acid receptors: Their classes, pharmacology and distinct properties in the function of the CNS, Annu. Rev. Pharmac. Toxicol., 29 (1989) 365-402.
33. Mori, N. and Wada, J.A., Bidirectional transfer between kindling induced by excitatory amino acids and electrical stimulation, Brain Res., 425 (1987) 45-48.
34. Musgrave, M.A., Madigan, M.A., Bennett, B.M. and Goh, J.W., Stimulation of postsynaptic and inhibition of presynaptic adenyl cyclase activity by metabotropic glutamate receptor activation, J. Neurochem., 62 (1994) 2316-2324.
35. Nakajima, Y., Iwakabe, H., Akawaza, C., Nawa, H., Shigemoto, R., Mizuno, N. and Nakanishi, S., Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate, J. Biol. Chem., 268 (1993) 11868-11873.
36. Okamoto, N., Hori, S., Akazawa, C., Hayashi, Y., Shigemoto, R., Mizuno, N. and Nakanishi, S., Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction, J. Biol. Chem., 269 (1994) 1231-1236.
37. Peterson, D.W., Collins, J.F. and Bradforod, H.F., Anticonvulsant action of amino acid antagonists against kindled hippocampal seizures, Brain Res., 311 (1984) 176-180.
38. Pin, J.P. and Duvoisin, R., The neurotransmitter receptors: 1., The metabotropic glutamate receptors: Structure and functions, Neuropharmacology, 34 (1995) 1-26.
39. Pook, P.C.K., Sunter, D.C., Udvarhelyi, P.M. and Watkins, J.C., Evidence for pre- synaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S.3S)- and (1S.3R)-ACPD, Expl. Physiol., 77 (1992) 529-532.
40. Racine, R.J., Modification of seizure activity by electrical stimulation II., Motor seizure, Electroencephalogr. Clin. Neurophysiol., 32 (1972) 281-294.
41. Schoepp, D.D. and Conn, P.J., Metabotropic glutamate receptors in brain function and pathology, Trends Pharmacol. Sci., 141 (1993) 13-20.
42. Schoepp, D.D., Johnson, B.G., True, R.A. and Monn, J.A., Comparison of (1S,3R)-1-aminocyclopentane-l,3-dicarboxylic acid (1S,3R-ACPD) and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis, Eur. J. Pharmacol., 207 (1991) 351-353.
43. Schoepp, D.D., Johnson, B.G. and Monn, J.A. (1S,3R)-1-Amino-cyclopentane-1,3-dicarboxylic acid-induced increases in cyclic AMP formation in the neonatal rat hippocampus are mediated by a synergistic interaction between phosphoinositide and inhibitory cyclic AMP-coupled mGLuRs, J. Neurochem., 66 (1966) 1981-1985.
44. Slater, N.T., Stelzer, A. and Galvan, M., Kindling-like stimulus patterns induce epileptiform discharges in the guinea-pig in vitro hippocampus, Neurosci. Lett., 60 (1985) 25-31.
45. Stasheff, S.F., Anderson, W.W., Clark, S. and Wilson, W.A., NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model, Science, 245 (1989) 648-651.
46. Stelzer, A., Slater, N.T. and ten Bruggencate, G., Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy, Nature, 326 (1987) 698-701.
47. Sunter, D.C., Edgar, G.E., Pook, P.C.K., Howard, J.A.K., Udvarhelyi, P.M. and Watkins, J.C., Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected isolated spinal cord of the neonatal rat, Br. J. Pharmacol., 104 (1991) 377P.
48. Swartz, K.J. and Bean, B.P., Inhibition of calcium channels in rat CA3 pyramidal neurons by metabotropic glutamate receptor, J. Neurosci., 12 (1992) 4358-4371.
49. Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R. and Nakanishi, S., A family of metabotropic glutamate receptors, Neuron, 8 (1992) 169-179.
50. Tanabe, Y., Nomura, A., Masu, M., Shigemoto, R., Mizuno, N. and Nakanishi, S., Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4, J. Neurosci., 13 (1993) 1372-1378.
51. Tizzano, J.P., Griffey, K.I. and Schoepp, D.D., Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice: Neuroprotective Agents, Annu. NY Acad. Sci., 765 (1995) 230-235.
52. Watkins, J.C. and Collingridge, G., Phenylglycine derivatives as antagonists of metabotropic glutamate receptors, Trends Pharmacol. Sci., 15 (1994) 333-342.
53. 2+ channel blockers, Eur. J. Pharmacol., 130 (1986) 243-248.
54. Wright, R.A. and Schoepp, D.D., Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus, Eur. J. Pharmacol., 297 (1996) 275-282.