메뉴 건너뛰기




Volumn 77, Issue 1, 1999, Pages 1-10

The role of CTLA-4 in the regulation of T cell immune responses

Author keywords

CD28; Costimulation; CTLA 4; Immune regulation; T lymphocyte

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; T LYMPHOCYTE RECEPTOR;

EID: 0033029507     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.1999.00795.x     Document Type: Review
Times cited : (199)

References (92)
  • 1
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination
    • 1 Bretscher P, Cohn M. A theory of self-nonself discrimination. Science 1970; 169: 1042-9.
    • (1970) Science , vol.169 , pp. 1042-1049
    • Bretscher, P.1    Cohn, M.2
  • 2
    • 0025339511 scopus 로고
    • A cell culture model for T lymphocyte clonal anergy
    • 2 Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990; 248: 1349-56.
    • (1990) Science , vol.248 , pp. 1349-1356
    • Schwartz, R.H.1
  • 3
    • 0026541544 scopus 로고
    • The two-signal model of lymphocyte activation twenty-one years later
    • 3 Bretscher P. The two-signal model of lymphocyte activation twenty-one years later. Immunol. Today 1992; 13: 74-6.
    • (1992) Immunol. Today , vol.13 , pp. 74-76
    • Bretscher, P.1
  • 5
    • 0021840708 scopus 로고
    • Human T cell activation II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)
    • 5 Hara T, Fu SM, Hansen JA. Human T cell activation II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen). J. Exp. Med. 1985; 161: 1513-24.
    • (1985) J. Exp. Med. , vol.161 , pp. 1513-1524
    • Hara, T.1    Fu, S.M.2    Hansen, J.A.3
  • 6
    • 0022632220 scopus 로고
    • A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes
    • 6 Martin PJ, Ledbetter JA, Morishita Y, June CH, Beatty CH, Hansen JA. A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J. Immunol. 1986; 136: 3282-7.
    • (1986) J. Immunol. , vol.136 , pp. 3282-3287
    • Martin, P.J.1    Ledbetter, J.A.2    Morishita, Y.3    June, C.H.4    Beatty, C.H.5    Hansen, J.A.6
  • 7
    • 0023929216 scopus 로고
    • Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes
    • 7 Damle NK, Doyle LV, Grosmaire LS, Ledbetter JA. Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes. J. Immunol. 1988; 140: 1753-61.
    • (1988) J. Immunol. , vol.140 , pp. 1753-1761
    • Damle, N.K.1    Doyle, L.V.2    Grosmaire, L.S.3    Ledbetter, J.A.4
  • 8
    • 0024506159 scopus 로고
    • Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway
    • 8 Lindsten T, June CM, Ledbetter JA, Stella G, Thompson CB. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 1989; 244: 339-43.
    • (1989) Science , vol.244 , pp. 339-343
    • Lindsten, T.1    June, C.M.2    Ledbetter, J.A.3    Stella, G.4    Thompson, C.B.5
  • 9
    • 0025234426 scopus 로고
    • CD28 ligation in T-cell activation: Evidence for two signal transduction pathways
    • 9 Ledbetter JA, Imboden JB, Schieven GL et al. CD28 ligation in T-cell activation: Evidence for two signal transduction pathways. Blood 1990; 75: 1531-9.
    • (1990) Blood , vol.75 , pp. 1531-1539
    • Ledbetter, J.A.1    Imboden, J.B.2    Schieven, G.L.3
  • 12
    • 0025947895 scopus 로고
    • CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
    • 12 Jenkins MK, Taylor PS, Norton SD, Urdahl KB. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J. Immunol. 1991; 147: 2461-6.
    • (1991) J. Immunol. , vol.147 , pp. 2461-2466
    • Jenkins, M.K.1    Taylor, P.S.2    Norton, S.D.3    Urdahl, K.B.4
  • 13
    • 0027403299 scopus 로고
    • The role of the CD28 receptor during T cell responses to antigen
    • 13 Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 1993; 11: 191-212.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 191-212
    • Linsley, P.S.1    Ledbetter, J.A.2
  • 14
    • 0025963594 scopus 로고
    • Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
    • 14 Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 1991; 173: 721-30.
    • (1991) J. Exp. Med. , vol.173 , pp. 721-730
    • Linsley, P.S.1    Brady, W.2    Grosmaire, L.3    Aruffo, A.4    Damle, N.K.5    Ledbetter, J.A.6
  • 15
    • 0023270567 scopus 로고
    • A new member of the immunoglobulin superfamily: CTLA-4
    • 15 Brunet JF, Denizot F, Luciani MF et al. A new member of the immunoglobulin superfamily: CTLA-4. Nature 1987; 328: 267-70.
    • (1987) Nature , vol.328 , pp. 267-270
    • Brunet, J.F.1    Denizot, F.2    Luciani, M.F.3
  • 16
    • 0025735829 scopus 로고
    • CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location
    • 16 Harper K, Balzano C, Rouvier E, Mattei MG, Luciani MF, Golstein P. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J. Immunol. 1991; 147: 1037-44.
    • (1991) J. Immunol. , vol.147 , pp. 1037-1044
    • Harper, K.1    Balzano, C.2    Rouvier, E.3    Mattei, M.G.4    Luciani, M.F.5    Golstein, P.6
  • 17
    • 0025979295 scopus 로고
    • CD28 and CTLA-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome I
    • 17 Howard TA, Rochelle JM, Seldin MF. CD28 and CTLA-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome I. Immunogenetics 1991; 33: 74-6.
    • (1991) Immunogenetics , vol.33 , pp. 74-76
    • Howard, T.A.1    Rochelle, J.M.2    Seldin, M.F.3
  • 18
    • 0025217670 scopus 로고
    • Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34
    • 18 Lafage-Pochitaloff M, Costello R, Couez D et al. Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34. Immunogenetics 1990; 31: 198-201.
    • (1990) Immunogenetics , vol.31 , pp. 198-201
    • Lafage-Pochitaloff, M.1    Costello, R.2    Couez, D.3
  • 20
    • 0029097387 scopus 로고
    • Activated T cells can induce high levels of CTLA-4 expression on B cells
    • 20 Kuiper HM, Brouwer M, Linsley PS, van Lier RA. Activated T cells can induce high levels of CTLA-4 expression on B cells. J. Immunol. 1995; 155: 1776-83.
    • (1995) J. Immunol. , vol.155 , pp. 1776-1783
    • Kuiper, H.M.1    Brouwer, M.2    Linsley, P.S.3    Van Lier, R.A.4
  • 21
    • 10544242196 scopus 로고    scopus 로고
    • Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2
    • 21 Wagner DH, Hagman J, Linsley PS, Hodsdon W, Freed JH, Newell MK. Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2. J. Exp. Med. 1996; 184: 1631-8.
    • (1996) J. Exp. Med. , vol.184 , pp. 1631-1638
    • Wagner, D.H.1    Hagman, J.2    Linsley, P.S.3    Hodsdon, W.4    Freed, J.H.5    Newell, M.K.6
  • 22
    • 0026486220 scopus 로고
    • Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes
    • 22 Linsley PS, Greene JL, Tan P et al. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J. Exp. Med. 1992; 176: 1595-604.
    • (1992) J. Exp. Med. , vol.176 , pp. 1595-1604
    • Linsley, P.S.1    Greene, J.L.2    Tan, P.3
  • 23
    • 0027282960 scopus 로고
    • Characterization of CTLA-4 structure and expression on human T cells
    • 23 Lindsten T, Lee KP, Harris ES et al. Characterization of CTLA-4 structure and expression on human T cells. J. Immunol. 1993; 151: 3489-99.
    • (1993) J. Immunol. , vol.151 , pp. 3489-3499
    • Lindsten, T.1    Lee, K.P.2    Harris, E.S.3
  • 24
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • 24 Walunas TL, Lenschow DJ, Bakker CY et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994; 1: 405-13.
    • (1994) Immunity , vol.1 , pp. 405-413
    • Walunas, T.L.1    Lenschow, D.J.2    Bakker, C.Y.3
  • 25
    • 0024205313 scopus 로고
    • Human Ig superfamily CTLA-4 gene: Chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains
    • 25 Dariavach P, Mattei MG, Golstein P, Lefranc MP. Human Ig superfamily CTLA-4 gene: Chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur. J. Immunol. 1988; 18: 1901-5.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 1901-1905
    • Dariavach, P.1    Mattei, M.G.2    Golstein, P.3    Lefranc, M.P.4
  • 26
    • 0027057908 scopus 로고
    • CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production
    • 26 Freeman GJ, Lombard DB, Gimmi CD et al. CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J. Immunol. 1992; 149: 3795-801.
    • (1992) J. Immunol. , vol.149 , pp. 3795-3801
    • Freeman, G.J.1    Lombard, D.B.2    Gimmi, C.D.3
  • 27
    • 0030176371 scopus 로고    scopus 로고
    • Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
    • 27 Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 1996; 4: 535-43.
    • (1996) Immunity , vol.4 , pp. 535-543
    • Linsley, P.S.1    Bradshaw, J.2    Greene, J.3    Peach, R.4    Bennett, K.L.5    Mittler, R.S.6
  • 28
    • 0031181647 scopus 로고    scopus 로고
    • Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    • 28 Chuang E., Alegre M-L, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J. Immunol. 1997; 159: 144-51.
    • (1997) J. Immunol. , vol.159 , pp. 144-151
    • Chuang, E.1    Alegre, M.-L.2    Duckett, C.S.3    Noel, P.J.4    Vander Heiden, M.G.5    Thompson, C.B.6
  • 29
    • 0030917081 scopus 로고    scopus 로고
    • Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
    • 29 Shiratori T, Miyatake S, Ohno H et al. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 1997; 6: 583-9.
    • (1997) Immunity , vol.6 , pp. 583-589
    • Shiratori, T.1    Miyatake, S.2    Ohno, H.3
  • 31
    • 0027729845 scopus 로고
    • Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice
    • 31 Freeman GJ, Borriello F, Hodes RJ et al. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 1993; 262: 907-9.
    • (1993) Science , vol.262 , pp. 907-909
    • Freeman, G.J.1    Borriello, F.2    Hodes, R.J.3
  • 32
    • 0027362823 scopus 로고
    • B70 antigen is a second ligand for CTLA-4 and CD28
    • 32 Azuma M, Ito D, Yagita H et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 1993; 366: 76-9.
    • (1993) Nature , vol.366 , pp. 76-79
    • Azuma, M.1    Ito, D.2    Yagita, H.3
  • 33
    • 0027937702 scopus 로고
    • Complementarity determining region 1 (CDR1)-and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
    • 33 Peach RJ, Bajorath J, Brady W et al. Complementarity determining region 1 (CDR1)-and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J. Exp. Med. 1994; 180: 2049-58.
    • (1994) J. Exp. Med. , vol.180 , pp. 2049-2058
    • Peach, R.J.1    Bajorath, J.2    Brady, W.3
  • 34
    • 0028215960 scopus 로고
    • Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7
    • 34 Damle NK, Klussman K, Leytze G et al. Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7. J. Immunol. 1994; 152: 2686-97.
    • (1994) J. Immunol. , vol.152 , pp. 2686-2697
    • Damle, N.K.1    Klussman, K.2    Leytze, G.3
  • 35
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • 35 Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 1995; 182: 459-65.
    • (1995) J. Exp. Med. , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 36
    • 0029117327 scopus 로고
    • Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation
    • 36 Linsley PS. Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation. J. Exp. Med. 1995; 182: 289-92.
    • (1995) J. Exp. Med. , vol.182 , pp. 289-292
    • Linsley, P.S.1
  • 37
    • 0030902622 scopus 로고    scopus 로고
    • CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion
    • 37 Wu Y, Guo Y, Huang A, Zheng P, Liu Y. CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion. J. Exp. Med. 1997; 185: 1327-35.
    • (1997) J. Exp. Med. , vol.185 , pp. 1327-1335
    • Wu, Y.1    Guo, Y.2    Huang, A.3    Zheng, P.4    Liu, Y.5
  • 38
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • 38 Linsley PS, Greene JL, Brady W, Bajorath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994; 1: 793-801.
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3    Bajorath, J.4    Ledbetter, J.A.5    Peach, R.6
  • 39
    • 0345368071 scopus 로고    scopus 로고
    • Is CTLA-4 a negative regulator for T-cell activation?
    • 39 Liu Y. Is CTLA-4 a negative regulator for T-cell activation? Immunol. Today 1997; 18: 569-72.
    • (1997) Immunol. Today , vol.18 , pp. 569-572
    • Liu, Y.1
  • 41
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • 41 Walunas TL, Bakker CY, Bluestone JA. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 1996; 183: 2541-50.
    • (1996) J. Exp. Med. , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 42
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • 42 Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 1996; 183: 2533-40.
    • (1996) J. Exp. Med. , vol.183 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 43
    • 0028841784 scopus 로고
    • The yin and yang of T cell costimulation
    • 43 Allison JP, Krummel MF. The yin and yang of T cell costimulation. Science 1995; 270: 932-3.
    • (1995) Science , vol.270 , pp. 932-933
    • Allison, J.P.1    Krummel, M.F.2
  • 44
    • 0029100024 scopus 로고
    • Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4
    • 44 Kearney ER, Walunas TL, Karr RW et al. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 1995; 155: 1032-6.
    • (1995) J. Immunol. , vol.155 , pp. 1032-1036
    • Kearney, E.R.1    Walunas, T.L.2    Karr, R.W.3
  • 45
    • 0029960141 scopus 로고    scopus 로고
    • Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo
    • 45 Krummel MF, Sullivan TJ, Allison JP. Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int. Immunol. 1996; 8: 519-23.
    • (1996) Int. Immunol. , vol.8 , pp. 519-523
    • Krummel, M.F.1    Sullivan, T.J.2    Allison, J.P.3
  • 46
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • 46 Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996; 271: 1734-6.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 47
    • 0030872154 scopus 로고    scopus 로고
    • Protective immunity to nematode infection is induced by CTLA-4 blockade
    • 47 McCoy KD, Camberis M, Le Gros G. Protective immunity to nematode infection is induced by CTLA-4 blockade. J. Exp. Med. 1997; 186: 183-7.
    • (1997) J. Exp. Med. , vol.186 , pp. 183-187
    • McCoy, K.D.1    Camberis, M.2    Le Gros, G.3
  • 48
    • 0032490620 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen 4 (CTLA-4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA-4 can function independently of CD28
    • 48 Lin H, Rathmell JC, Gray GS, Thompson CB, Leiden JM, Alegre ML. Cytotoxic T lymphocyte antigen 4 (CTLA-4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA-4 can function independently of CD28. J. Exp. Med. 1998; 188: 199-204.
    • (1998) J. Exp. Med. , vol.188 , pp. 199-204
    • Lin, H.1    Rathmell, J.C.2    Gray, G.S.3    Thompson, C.B.4    Leiden, J.M.5    Alegre, M.L.6
  • 49
    • 0032490629 scopus 로고    scopus 로고
    • B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28
    • 49 Fallarino F, Fields PE, Gajewski TF. B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28. J. Exp. Med. 1998; 188: 205-10.
    • (1998) J. Exp. Med. , vol.188 , pp. 205-210
    • Fallarino, F.1    Fields, P.E.2    Gajewski, T.F.3
  • 50
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • 50 Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995; 3: 541-7.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 51
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
    • 51 Waterhouse P, Penninger JM, Timms E et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995; 270: 985-8.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 52
    • 0031154577 scopus 로고    scopus 로고
    • CTLA-4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice
    • 52 Tivol EA, Boyd SD, McKeon S et al. CTLA-4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J. Immunol. 1997; 158: 5091-4.
    • (1997) J. Immunol. , vol.158 , pp. 5091-5094
    • Tivol, E.A.1    Boyd, S.D.2    McKeon, S.3
  • 53
    • 0031405867 scopus 로고    scopus 로고
    • Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
    • 53 Chambers CA, Sullivan TJ, Allison JP. Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity 1997; 7: 885-95.
    • (1997) Immunity , vol.7 , pp. 885-895
    • Chambers, C.A.1    Sullivan, T.J.2    Allison, J.P.3
  • 54
    • 0028927607 scopus 로고
    • The Fas death factor
    • 54 Nagata S, Golstein P. The Fas death factor. Science 1995; 267: 1449-56.
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 55
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • 55 Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456-62.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 56
    • 0030113898 scopus 로고    scopus 로고
    • Lymphocyte activation: T-cell regulation by CTLA-4
    • 56 Linsley PS, Golstein P. Lymphocyte activation: T-cell regulation by CTLA-4. Curr. Biol. 1996; 6: 398-400.
    • (1996) Curr. Biol. , vol.6 , pp. 398-400
    • Linsley, P.S.1    Golstein, P.2
  • 57
    • 0030740572 scopus 로고    scopus 로고
    • Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice
    • 57 Waterhouse P, Bachmann MF, Penninger JM, Ohashi PS, Mak TW. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur. J. Immunol. 1997; 27: 1887-92.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1887-1892
    • Waterhouse, P.1    Bachmann, M.F.2    Penninger, J.M.3    Ohashi, P.S.4    Mak, T.W.5
  • 61
    • 0028211126 scopus 로고
    • The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3′-kinase
    • 61 Stein PH, Fraser JD, Weiss A. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3′-kinase. Mol. Cell. Biol. 1994; 14: 3392-402.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3392-3402
    • Stein, P.H.1    Fraser, J.D.2    Weiss, A.3
  • 62
    • 0028910221 scopus 로고
    • CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
    • 62 Schneider H, Prasad KV, Shoelson SE, Rudd CE. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 1995; 181: 351-5.
    • (1995) J. Exp. Med. , vol.181 , pp. 351-355
    • Schneider, H.1    Prasad, K.V.2    Shoelson, S.E.3    Rudd, C.E.4
  • 63
    • 0030707866 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70
    • 63 Calvo CR, Amsen D, Kruisbeek AM. Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. J. Exp. Med. 1997; 186: 1645-53.
    • (1997) J. Exp. Med. , vol.186 , pp. 1645-1653
    • Calvo, C.R.1    Amsen, D.2    Kruisbeek, A.M.3
  • 65
    • 0030001318 scopus 로고    scopus 로고
    • Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
    • 65 Marengere LE, Waterhouse P, Duncan GS, Mittrucker HW, Feng GS, Mak TW. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 1996; 272: 1170-3.
    • (1996) Science , vol.272 , pp. 1170-1173
    • Marengere, L.E.1    Waterhouse, P.2    Duncan, G.S.3    Mittrucker, H.W.4    Feng, G.S.5    Mak, T.W.6
  • 66
    • 0028852073 scopus 로고
    • Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail
    • 66 Leung HT, Bradshaw J, Cleaveland JS, Linsley PS. Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail. J. Biol. Chem. 1995; 270: 25 107-14.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25107-25114
    • Leung, H.T.1    Bradshaw, J.2    Cleaveland, J.S.3    Linsley, P.S.4
  • 67
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
    • 67 Kuchroo VK, Das MP, Brown JA et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell 1995; 80: 707-18.
    • (1995) Cell , vol.80 , pp. 707-718
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3
  • 68
    • 0029553431 scopus 로고
    • Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
    • 68 Miller SD, Vanderlugt CL, Lenschow DJ et al. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 1995; 3: 739-45.
    • (1995) Immunity , vol.3 , pp. 739-745
    • Miller, S.D.1    Vanderlugt, C.L.2    Lenschow, D.J.3
  • 69
  • 71
    • 0030586626 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis
    • 71 Perrin PJ, Maldonado JH, Davis TA, June CH, Racke MK. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J. Immunol. 1996; 157: 1333-6.
    • (1996) J. Immunol. , vol.157 , pp. 1333-1336
    • Perrin, P.J.1    Maldonado, J.H.2    Davis, T.A.3    June, C.H.4    Racke, M.K.5
  • 72
    • 2642655282 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
    • 72 Lühder F, Höglund P, Allison JP, Benoist C, Mathis D. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 1998; 187: 427-32.
    • (1998) J. Exp. Med. , vol.187 , pp. 427-432
    • Lühder, F.1    Höglund, P.2    Allison, J.P.3    Benoist, C.4    Mathis, D.5
  • 73
    • 0027299866 scopus 로고
    • Homing of naive, memory and effector lymphocytes
    • 73 MacKay CR. Homing of naive, memory and effector lymphocytes. Curr: Opin. Immunol. 1993; 5: 423-7.
    • (1993) Curr: Opin. Immunol. , vol.5 , pp. 423-427
    • MacKay, C.R.1
  • 74
    • 8944259914 scopus 로고    scopus 로고
    • The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes
    • 74 Nistico L, Buzzetti R, Pritchard LE et al. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Hum. Mol. Genet. 1996; 5: 1075-80.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1075-1080
    • Nistico, L.1    Buzzetti, R.2    Pritchard, L.E.3
  • 75
    • 0029837733 scopus 로고    scopus 로고
    • Panning for gold: Genome-wide scanning for linkage in type 1 diabetes
    • 75 Todd JA, Farrall M. Panning for gold: Genome-wide scanning for linkage in type 1 diabetes. Hum. Mol. Genet. 1996; 5: 1443-8.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1443-1448
    • Todd, J.A.1    Farrall, M.2
  • 76
    • 0031975367 scopus 로고    scopus 로고
    • Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population
    • 76 Awata T, Kurihara S, Iitaka M et al. Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population. Diabetes 1998; 47: 128-9.
    • (1998) Diabetes , vol.47 , pp. 128-129
    • Awata, T.1    Kurihara, S.2    Iitaka, M.3
  • 77
    • 8544274482 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
    • 77 Marron MP, Raffel LJ, Garchon HJ et al. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum. Mol. Genet. 1997; 6: 1275-82.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1275-1282
    • Marron, M.P.1    Raffel, L.J.2    Garchon, H.J.3
  • 78
    • 0031810837 scopus 로고    scopus 로고
    • CTLA-4 gene polymorphism is associated with predisposition to IDDM in a population from central Poland
    • 78 Krokowski M, Bodalski J, Bratek A, Machejko P, Caillat-Zucman S. CTLA-4 gene polymorphism is associated with predisposition to IDDM in a population from central Poland. Diabete Metab. 1998; 24: 241-3.
    • (1998) Diabete Metab. , vol.24 , pp. 241-243
    • Krokowski, M.1    Bodalski, J.2    Bratek, A.3    Machejko, P.4    Caillat-Zucman, S.5
  • 79
    • 9844263372 scopus 로고    scopus 로고
    • CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers
    • 79 Van der Auwera BJ, Vandewalle CL, Schuit FC et al. CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. Clin. Exp. Immunol. 1997; 110: 98-103.
    • (1997) Clin. Exp. Immunol. , vol.110 , pp. 98-103
    • Van Der Auwera, B.J.1    Vandewalle, C.L.2    Schuit, F.C.3
  • 80
    • 0031014716 scopus 로고    scopus 로고
    • CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type I diabetes mellitus
    • 80 Donner H, Rau H, Walfish PG et al. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type I diabetes mellitus. J. Clin. Endocrinol. Metab. 1997; 82: 143-6.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 143-146
    • Donner, H.1    Rau, H.2    Walfish, P.G.3
  • 81
    • 0031434409 scopus 로고    scopus 로고
    • CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese
    • 81 Yanagawa T, Taniyama M, Enomoto S et al. CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. Thyroid 1997; 7: 843-6.
    • (1997) Thyroid , vol.7 , pp. 843-846
    • Yanagawa, T.1    Taniyama, M.2    Enomoto, S.3
  • 82
    • 0030816688 scopus 로고    scopus 로고
    • A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism
    • 82 Kotsa K, Watson PF, Weetman AP. A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism. Clin. Endocrinol. 1997; 46: 551-4.
    • (1997) Clin. Endocrinol. , vol.46 , pp. 551-554
    • Kotsa, K.1    Watson, P.F.2    Weetman, A.P.3
  • 85
    • 0030927323 scopus 로고    scopus 로고
    • Making the T cell receptor go the distance: A topological view of T cell activation
    • 85 Shaw AS, Dustin ML. Making the T cell receptor go the distance: A topological view of T cell activation. Immunity 1997; 6: 361-9.
    • (1997) Immunity , vol.6 , pp. 361-369
    • Shaw, A.S.1    Dustin, M.L.2
  • 86
    • 0028178873 scopus 로고
    • Signals and signs for lymphocyte responses
    • 86 Janeway Jr CA, Bottomly K. Signals and signs for lymphocyte responses. Cell 1994; 76: 275-85.
    • (1994) Cell , vol.76 , pp. 275-285
    • Janeway C.A., Jr.1    Bottomly, K.2
  • 88
    • 0030300139 scopus 로고    scopus 로고
    • The role of CTLA-4 in the regulation and initiation of T-cell responses
    • 88 Chambers CA, Krummel MF, Boitel B et al. The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol. Rev. 1996; 153: 27-46.
    • (1996) Immunol. Rev. , vol.153 , pp. 27-46
    • Chambers, C.A.1    Krummel, M.F.2    Boitel, B.3
  • 89
    • 0031091743 scopus 로고    scopus 로고
    • Is CTLA-4 a master switch for peripheral T cell tolerance?
    • 89 Bluestone JA. Is CTLA-4 a master switch for peripheral T cell tolerance? J. Immunol. 1997; 158: 1989-93.
    • (1997) J. Immunol. , vol.158 , pp. 1989-1993
    • Bluestone, J.A.1
  • 90
    • 0030694234 scopus 로고    scopus 로고
    • The emerging role of CTLA-4 as an immune attenuator
    • 90 Thompson CB, Allison JP. The emerging role of CTLA-4 as an immune attenuator. Immunity 1997; 7: 445-50.
    • (1997) Immunity , vol.7 , pp. 445-450
    • Thompson, C.B.1    Allison, J.P.2
  • 91
    • 0030873556 scopus 로고    scopus 로고
    • Differential requirements for survival and proliferation of CD8 naive or memory T cells
    • 91 Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 1997; 276: 2057-62.
    • (1997) Science , vol.276 , pp. 2057-2062
    • Tanchot, C.1    Lemonnier, F.A.2    Perarnau, B.3    Freitas, A.A.4    Rocha, B.5
  • 92
    • 0028500255 scopus 로고
    • Absence of B7-dependent responses in CD28-deficient mice
    • 92 Green JM, Noel PJ, Sperling Al et al. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1994; 1: 501-8.
    • (1994) Immunity , vol.1 , pp. 501-508
    • Green, J.M.1    Noel, P.J.2    Sperling, Al.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.