Lymphocyte activation: T-cell regulation by CTLA-4

Current Biology

Volumn 6, Issue 4, 1996, Pages 398-400

  Linsley, Peter S ^a   Golstein, Pierre ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY;

ANIMAL; ARTICLE; GENETICS; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; MOUSE MUTANT; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; IMMUNOCONJUGATES; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; T-LYMPHOCYTES;

EID: 0030113898     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00506-7     Document Type: Article

References (10)

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2. Allison JP, Krummel MF: The yin and yang of T-cell costimulation. Science 1995, 270:932-933.
3. Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG, Golstein P: A new member of the immunoglobulin superfamily-CTLA-4. Nature 1987, 328:267-270.
4. Leung HT, Bradshaw J, Cleaveland JS, Linsley PS: Cytotoxic T lymphocyte-associated molecule-4, a high avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail. J Biol Chem 1995, 270:25107-25114.
5. Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA: CTLA-4 can function as a negative regulator of T-cell activation. Immunity 1994, 1:405-413.
6. + T cells in vivo is dependent upon CD28 costimulation and inhibited by CTLA-4. J Immunol 1995, 155:1032-1036.
7. Leach DR, Krummel MF, Allison JP: Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996, in press.
8. Waterhouse P, Penninger JM, Timms E, Wakeham A., Shahinian A., Lee KP, Thompson CB, Griesser H., Mak TW: Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995, 270:985-988.
9. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone J, Sharpe AH: Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995, 3:541-547.
10. Buzzetti R, Nistico L, Pozzili P, Serrano-Rios M, Larraz MT, Tosi R, Giovannini C,: The CTLA4 microsatellite identifies a new region on chromosome 2 linked to IDDM. Diabetologica 1995, 35 (Suppl 1):105.