Inhibition of 7,12-dimethylbenz(a)anthracene-and n-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin

Cancer Research

Volumn 48, Issue 20, 1988, Pages 5754-5758

  Verma, Ajit K ^a   Johnson, Jeffrey A ^a   Gould, Michael N ^a   Tanner, Martin A ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; METHYLNITROSOUREA; QUERCETIN;

ANIMAL EXPERIMENT; BREAST CARCINOGENESIS; CANCER INHIBITION; DIET; HISTOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMAL; DIET; FEMALE; FLAVONES; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; QUERCETIN; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; WEIGHT GAIN;

EID: 0023681264     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Singleton, V. L. Naturally occurring food toxicants: Phenolic substances of plant origin common in risk foods. Adv. Food Res., 27:149-242, 1981.
2. International Agency for Research on Cancer. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: Some food additives and naturally occurring substances. 11: 33-35, 1983.
3. MacGregor, J. T. Genetic toxicology of dietary flavonoids. Prog. Clin. Biol. Res., 213: 33-43, 1986.
4. MacGregor, J. T. Genetic and carcinogenic effects of plant flavonoids: An overview. Nutritional and toxicology aspects of food safety. Adv. Exp. Med. Biol., 177:497-526, 1900.
5. Stavric, B. Mutagenic food flavonoids. Fed. Proc., 43: 2454-2458, 1984.
6. Hatcher, J. F., and Bryan, G. T. Factors affecting the mutagenic activity of quercetin for Salmonella typhimurium TA98: Metal ions, antioxidants, and pH. Mutat.Res., 148: 13-23, 1985.
7. Bjeldanes, L. F., and Chang, G. W. Mutagenic activity of quercetin and related compounds. Science (Wash. DC), 197: 577-578, 1977.
8. MacGregor, J. T., and Jurd, L. Mutagenicity of plant flavonoids: Structural requirements for mutagenic activity in Salmonella typhimurium. Mutat. Res., 54: 297-309, 1978.
9. Eilinger, C. A., Henika, P. R., and MacGregor, J. T. Mutagenicity of flavones, chromones, and acetophenones in Salmonella typhimurium. New structureactivity relationships. Mutat. Res., 135:77-86, 1984.
10. Carver, J. H., Carrano, A. V., and MacGregor, J. T. Genetic effects of the flavonols quercetin, kaempferol, and galangin on Chinese hamster ovary cells in vitro. Mutat.Res., 113:45-60, 1983.
11. van der Hoeven, J. C. M., Bruggeman, I. M. and Debets, F. M. H. Genotoxicity of quercetin in cultured mammalian cells. Mutat. Res., 136:9-21, 1984.
12. Pamukcu, A. M., Yalciner, S., Hatcher, J. F., and Bryan, G. T. Quercetin, arat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum). Cancer Res., 40: 3468-3472, 1980.
13. Erturk, E., Hatcher, J. F., Nunoya, T., Pamukcu, A. M., and Bryan, G. T. Hepatic tumors in Sprague-Dawley (SD) and Fischer 344 (F) female rats chronically exposed to quercetin (Q) or its glycoside rutin (R). Proc. Am. Assoc. Cancer Res., 25: 95, 1984.
14. William, G. M. Food-borne carcinogens. Prog. Clin. Biol. Res., 206: 73-81, 1986.
15. Saito, F., Shirai, A., Malsushima, T., Sugimura. T., and Hirono, I. Test of carcinogenicity of quercetin, widely distributed mutagen in food. Teratog. Carcinog. Mutagen., 1: 213-221, 1980.
16. Hosaka, S., and Hirono, I. Carcinogenicity test of quercetin by pulmonaryadenoma bioassay in strain A mice. Gann, 72: 327-328, 1981.
17. Hirono, I., Ueno, I., Hosaka, S., Takanashi, H., Matsushima, T., Sugimura, T., and Natori, S. Carcinogenicity examination of quercetin and rutin in AC1 rats. Cancer Lett., 13: 15-21, 1981.
18. Takanashi, H., Aiso, S., Hirono, I., Matsushima, T., and Sugimura, T. Carcinogenicity test of quercetin and kaempferol in rats by oral administration. J. Food Saf., 5: 55-60, 1983.
19. Aeschbacher, H.-U., Meier, H., and Ruch, E. Nonmutagenicity in vivo of the food flavonol quercetin. Nutr. Cancer, 4:90-98, 1982.
20. Habs, M., Habs, H., Berger, M. R., and Schmahl, D. Negative dose-response study for carcinogenicity of orally administered rutin sulfate in SpragueDawley rats. Cancer Lett., 23: 103-108, 1984.
21. Nakadate, T., Yamamoto, S., Aizu, E., and Kato, R. Effects of flavonoids and antioxidants on 12-O-tetradecanoylphorbol-13-acetate caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds. Gann, 75: 214-222, 1984.
22. Kalo, R., Nakadate, T., Yamamoto, S., and Sugimura, T. Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate induced tumor promotion and ornithine decarboxylase activity by quercetin: Possible involvement of lipoxygenase inhibition. Carcinogenesis (Lond.), 4: 1301-1305, 1985.
23. Chang, R. L., Huang, M. T., Wood, A. W., Wong, C. Q., Newmark, H. L., Yagi, H., Sayer, J. M., Jerina, D. M., and Conney, A. H. Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo(a)pyrene and (±)7β,8α,-dihydroxy-9α, 1α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene on mouse skin and in the newborn mouse. Carcinogenesis (Lond.), 6:1127-1133, 1985.
24. Bresnick, E., and Bin, D. Inhibitory effects of the flavonoid, apigenin, on epidermal ornithine decarboxylase and mouse skin tumorigenesis. Proc. Am. Assoc. Cancer Res., 29: 136, 1988.
25. 2+ calmodulin complex: Possible mechanism for anti-tumor-promoting action of the flavonoid. Gann, 74:311-316, 1984.
26. Huang, M. T., Johnson, E. F., Eberhard, U. M., Koop, D. R., Coon, M. J., and Conney, A. H. Specificity in the activation and inhibition of flavonoids of benzo(a)pyrene hydroxylation by cytochrome P-450 enzyme from rabbit liver microsomes. J. Biol. Chem., 256: 10897-10901, 1981.
27. Buening, M. K., Chang, R. L., Huang, M. T., Chang, R. L., Fortner, J. G., Wood, A. W., and Conney, A. H. Activation and inhibition ofbenzo(o)pyrene and aflatoxin H, metabolism in human liver microsomes by naturally occurring flavonoids. Cancer Res., 41:67-71, 1981.
28. Lasker, J. M., Huang, M. T., and Conney, A. H. In vitro and in vivoactivation of oxidative drug metabolism by flavonoids. J. Pharm. Exp. Ther., 229:162-170, 1984.
29. Wargovich, M. J., Eng, V. W. S., and Newmark, H. L. Inhibition by plantphenols of benzo(a)pyrene-induced nuclear aberrations in mammalian intestinal cells: A rapid in vivo assessment method. Food Chem. Toxicol., 23:47-49, 1985.
30. Huang, M.-T., Wood, A. W., Newmark, H. L., Sayer, J., Yagi, H., Jerina, D. M., and Conney, A. H. Inhibition of the mutagenicity of bay-region diolepoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids. Carcinogenesis (Lond.), 4:1631-1637, 1983.
31. Huggins, C. B. Experimental Leukemia and Mammary Cancer. Chicago: University of Chicago Press, 1979.
32. Cullino, P. M., Pettigrew, H. M., and Granthram, F. H. N-Nitrosomethylurea as mammary gland carcinogen in rats. J. Natl. Cancer Inst., 54: 401-414, 1975.
33. Bhatacharyya, G. K., and Johnson, R. A. Statistical Concepts and Methods. New York: Wiley, 1977.
34. Pariza, M. W., and Boutwell, R. K. Historical perspective and energy expenditure in Carcinogenesis. Am. J. Clin. Nutr., 45: 151-156, 1987.
35. Das, M., Mukhtar, H., Bik, D. P., and Bichers, D. R. Inhibition of epidermal xenobiotic metabolism in SENCAR mice by naturally occurring plant phenols. Cancer Res., 47:760-766, 1987.
36. Das, M., Khan, W. A., Asokan, O., Bichers, D. R., and Mukhtar, H. Inhibition of polycyclic aromatic hydrocarbon-DNA adduct formation in epidermis and lungs of SENCAR mice by naturally occurring plant phenols. Cancer Res., 47: 767-773, 1987.
37. Gottardis, M. M., and Jordan, V. C. Animal models to study the therapy of hormone-dependent breast cancer. In: V. C. Jordan (ed.), Estrogen/Antiestrogen Action and Breast Cancer Therapy, pp. 283-300. Madison, WI: The University of Wisconsin Press, 1986.
38. Martin, P. M., Horwitz, K. B., Ryan, D. S., and McGuire, W. L. Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endo crinology, 103:1860-1867, 1978.
39. Levy, J., Teuerstein, I., Marbach, M., Radian, S., and Sharoni, Y. Tyrosine kinase activity in the DMBA-induced rat mammary tumor: Inhibition by quercetin. Biochem. Biophys. Res. Commun., 123:1227-1233, 1984.
40. Sharoni, Y., Teuerstein, I., and Levy, J. Phosphoinositide phosphorylation precedes growth in rat mammary tumors. Biochem. Biophys. Res. Commun., 134: 876-882, 1986.