Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: Role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism

Cancer Research

Volumn 58, Issue 11, 1998, Pages 2366-2374

  Larsen, Michele Campaigne ^a   Angus, William G R ^a   Brake, Paul B ^a   Eltom, Sakina E ^a   Sukow, Kristine A ^a   Jefcoate, Colin R ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; DIMETHYLBENZ[A]ANTHRACENE; MESSENGER RNA; POLYCYCLIC AROMATIC HYDROCARBON;

ARTICLE; BREAST EPITHELIUM; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; METABOLISM; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ARYL HYDROCARBON HYDROXYLASES; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BREAST; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DNA-BINDING PROTEINS; ENZYME INDUCTION; EPITHELIAL CELLS; FEMALE; HELIX-LOOP-HELIX MOTIFS; HUMANS; POLYCYCLIC HYDROCARBONS, AROMATIC; POLYMERASE CHAIN REACTION; RECEPTORS, ARYL HYDROCARBON; RNA; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTORS;

EID: 0032100577     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Cancer Facts and Figures: 1995. Atlanta, GA: American Cancer Society, Inc., 1995.
2. Dao, T. L. Studies on mechanism of carcinogenesis in the mammary gland. Prog. Exp. Tumor Res., 11: 235-261, 1969.
3. Huggins, C. B. Induction of mammary cancer in rat. In: Experimental Leukemia and Mammary Cancer, pp. 73-79. Chicago: University of Chicago Press, 1979.
4. Gould, M. N., Cathers, L. E., and Moore, C. J. Human breast cell-mediated mutagenesis of mammalian cells by polycyclic aromatic hydrocarbons. Cancer Res., 42: 4619-4624, 1982.
5. Eldridge, S., Gould, M. N., and Butterworth, B. E. Genotoxicity of environmental agents in human mammary epithelial cells. Cancer Res., 52: 5617-5621, 1992.
6. Li, D., Wang, M., Dhingra, K., and Hittelman, W. N. Aromatic DNA adducts in adjacent tissues of breast cancer patients: clues to breast cancer etiology. Cancer Res., 56: 287-293, 1996.
7. Obana, H., Hori, S., Kahimoto, L., and Kunita, N. Polycyclic aromatic hydrocarbons in human fat and liver. Bull. Environ. Contam. Toxicol., 27: 23-27, 1981.
8. Martin, F. L., Carmichael, P. L., Crofton-Sleigh, C., Venitt, S., Phillips, D. H., and Grover, P. L. Genotoxicity of human mammary lipid. Cancer Res., 56: 5342-5346, 1996.
9. Baron, J., Hildebrandt, A. G., Peterson, J. A., and Estabrook, R. W. The role of oxygenated cytochrome P-450 and of cytochrome b5 in hepatic microsomal drug oxidations. Drug Metab. Dispos., 1: 129-138, 1973.
10. Conney, A. H. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res., 42: 4875-4917, 1982.
11. Jefcoate, C. R. Integration of xenobiotic metabolism in carcinogen activation and detoxication. In: J. Caldwell and W. Jakoby (eds.), Biological Basis of Detoxication, pp. 31-76. New York: Academic Press, 1983.
12. Guengerich, F. P. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res., 48: 2946-2954, 1988.
13. Shimada, T., Martin, M. V., Pruess-Schwartz, D., Marnett, L. J., and Guengerich, F. P. Roles of individual cytochrome P-450 enzymes in the bioactivation of benzo-(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Cancer Res., 49: 6304-6312, 1989.
14. Cavalieri, E., and Rogan, E. Mechanisms of tumor initiation by polycyclic aromatic hydrocarbons in mammals. In: A. H. Nelson (ed.), Handbook of Environmental chemistry: PAHs and Related Compounds, Vol. 3, pp. 10.1-10.11. Heidelberg, Germany: Springer-Verlag, 1997.
15. Moore, C. J., Tricomi, W. A., and Gould, M. N. Interspecies comparison of polycyclic aromatic hydrocarbon metabolism in human and rat mammary epithelial cells. Cancer Res., 46: 4946-4952, 1986.
16. Balmain, A., and Brown, K. Oncogene activation in chemical carcinogenesis. In: O. Klein and S. Weinhouse (eds.), Advances in Cancer Research. Vol. 51, pp. 147-182. New York: Academic Press, 1988.
17. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. p53 mutations in human cancers. Science (Washington DC), 251: 49-53, 1991.
18. Sukumur, S., Notario, V., Martin-Zancu, D., and Barbacid, M. Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature (Lond.), 306: 658-661, 1983.
19. Dandekar, S., Sukumar, S., Zarbl, H., Young, L. J. T., and Cardiff, R. D. Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors. Mol. Cell Biol., 6: 4104-4108, 1986.
20. Lehman, T. A., Modali, R., Boukamp, P., Stanek, J., Bennett, W. P., Welsh, J. A., Metcalf, R. A., Stampfer, M. R., Fusenig, N., Rogan, E. M., and Harris, C. C. p53 mutations in human immortalized epithelial cell lines. Carcinogenesis (Lond.), 14: 833-839, 1993.
21. Stampfer, M. R., and Bartley, J. C. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo(a)pyrene. Proc. Natl. Acad. Sci. USA, 82: 2394-2398, 1985.
22. Russo, J., Calaf, G., and Russo, I. H. A critical approach to the malignant transformation of human breast epithelial cells with chemical carcinogens. Crit. Rev. Oncog., 4: 403-417, 1993.
23. Russo, J., Calaf, G., Sohi, N., Tahin, Q., Zhang, P. L., Alvarado, M. E., Estrada, S., and Russo, I. H. Critical steps in breast carcinogenesis. Ann. N. Y. Acad. Sci., 698: 1-20, 1993.
24. Whitlock, J. P. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu. Rev. Pharmacol. Toxicol, 30: 251-277, 1990.
25. Whitlock, J. P., Okino, S. T., Dong, L., Ko, H. P., Clarke-Katzenberg, R., Ma, Q., and Li, H. Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription. FASEB J., 10: 809-818, 1996.
26. Gonzalez, F. J. The molecular biology of cytochrome P450s. Pharmacol. Rev., 40: 243-288, 1989.
27. Harris, M., Piskorska-Pliszczynska, J., Zacharewski, T., Romkes, M., and Safe, S. Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor. Cancer Res., 49: 4531-4535, 1989.
28. Thomsen, J. S., Nissen, L., Stacey, S. N., Hines, R. N., and Autrup, H. Differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans-acting factors. Eur. J. Biochem., 197: 577-582, 1991.
29. Savas, U., Bhattacharayya, K. K., Christou, M., Alexander, D. L., and Jefeoate, C. R. Mouse cytochrome P-450-EF, representative of a new 1B subfamily of cytochrome P450s: cloning, sequence determination, and tissue expression. J. Biol. Chem., 269: 14905-14911, 1994.
30. Bhattacharayya, K. K., Brake, P. B., Eltom, S. E., Otto, S. A., and Jefcoate, C. R. Identification of a rat adrenal cytochrome P450 active in polycyclic aromatic hydrocarbon metabolism as rat CYP1B1: demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. J. Biol. Chem., 270: 11595-11602, 1995.
31. Sutter, T., Tang, Y. M., Hayes, C. L., Wo, Y. P., Jabs, E. W., Li, X., Yin, H., Cody, C. W., and Greenlee, W. F. Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. J. Biol. Chem., 269: 13092-13099, 1994.
32. Tang, Y. M., Wo, Y. P., Stewart, J., Hawkins, A. L., Griffin, C. A., Sutter, T. R., and Greenlee, W. F. Isolation and characterization of the human cytochrome P450 CYP1B1 gene. J. Biol. Chem., 271: 28324-28330, 1996.
33. Shimada, T., Hayes, C. L., Yamazaki, H., Amin, S., Hecht, S. S., Guengerich, F. P., and Sutter, T. R. Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Res., 56: 2979-2984, 1996.
34. Stoilov, I., Akarsu, A. N., and Sarfarazi, M. Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Hum. Mol. Genet., 6: 641-647, 1997.
35. Christou, M., Savas, U., Spink, D. C., Gierthy, J. F., and Jefcoale, C. R. Coexpression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinomaderived MCF-7 cells. Carcinogenesis (Lond.), 15: 725-732, 1994.
36. Spink, D. C., Hayes, C. L., Young, N. R., Christou, M., Sutter, T. R., Jefcoate, C. R., and Gierthy, J. F. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17β-estradiol 4-hydroxylase. J. Steroid Biochem. Mol. Biol., 51: 251-258, 1994.
37. Hayes, C. L., Spink, D. C., Spink, B. C., Cao, J. Q., and Walker, N. J. 17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc. Natl. Acad. Sci. USA, 93: 9776-9781, 1996.
38. Liehr, J. G., Ricci, M. J., Jefcoate, C. R., Hannigan, E. V., Hokanson, J. A., and Zhu, B. T. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc. Natl. Acad. Sci. USA, 92: 9220-9224, 1995.
39. Abul-Hajj, Y. J., Thijssen, J. H. H., and Blakenstein, M. A. Metabolism of estradiol by human breast carcinoma. Eur J. Cancer Clin. Oncol., 24: 1171-1178, 1988.
40. Liehr, J. G., and Ricci, M. J. 4-Hydroxylation of estrogens as marker of human mammary tumors. Proc. Natl. Acad. Sci. USA, 93: 3294-3296, 1996.
41. Bartley, J. C., and Stampfer, M. R. Factors influencing benzo(a)pyrene metabolism in human mammary epithelial cells in culture. Carcinogenesis (Lond.), 6: 1017-1022, 1985.
42. Grover, P. L., MacNicoll, A. D., Sims, P., Easty, G. C., and Nelville, A. M. Polycyclic hydrocarbon activation and metabolism in epithelial cell aggregates prepared from human mammary tissue. Int. J. Cancer, 26: 467-475, 1980.
43. Christou, M., Savas, U., Schroeder, S., Shen, X., Thompson, T., Gould, M. N., and Jefcoate, C. R. Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland: cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones. Mol. Cell. Endocrinol., 115: 41-50, 1995.
44. Hushka, L., and Greenlee, W. F. Ah receptor activation impairs mammary gland development. Proc. Am. Assoc. Cancer Res., 38: 555, 1997.
45. Taylor-Papadimitriou, J., Stampfer, M., Bartek, J., Lewis, A., Boshell, M., Lane, E. B., and Leigh, I. M. Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium. J. Cell Sci., 94: 403-413, 1989.
46. Pottenger, L. H., and Jefcoate, C. R. Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2. Carcinogenesis (Lond.), 11: 321-327, 1990.
47. McKay, J. A., Melvin, W. T., Ah-See, A. K., Ewen, S. W. B., Greenlee, W. F., Marcus, C. B., Burke, M. D., and Murray, G. I. Expression of cytochrome P450 CYP1B1 in breast cancer. FEES Lett., 374: 270-272, 1995.
48. Pollenz, R. S., Sattler, C. A., and Poland, A. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa1c1c7 cells by immunofluorescence microscopy. Mol. Pharmacol., 45: 428-438, 1993.
49. Pottenger, L. H., Christou, M., and Jefcoate, C. R. Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. Arch. Biochem. Biophys., 286: 488-497, 1991.
50. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
51. Towbin, H., Staehlin, T., and Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA, 76: 4350-4354, 1979.
52. + RNA. Bio Techniques, 6: 114-116, 1988.
53. Fritsch, E. F., and Sambrook, J. In: T. Maniatis (ed.), Molecular Cloning: A Laboratory Manual, pp. 7.19-7.22. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1982.
54. Piskorska-Pliszczynaska, J., Keys, B., Safe, S., and Newman, M. S. The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons. Toxicol. Lett., 34: 67-74, 1986.
55. Pollenz, R. S. The aryl hydrocarbon receptor, but not the aryl hydrocarbon receptor nuclear transporter protein, is rapidly depleted in hepatic and non-hepatic cultured cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol. Pharmacol., 49: 391-398, 1996.
56. Murray, G. I., Taylor, M. C., McFayden, M. C. E., McKay, J. A., Greenlee, W. F., Burke, M. D., and Melvin, W. T. Tumor-specific expression of cytochrome P450 CYP1B1. Cancer Res., 57: 3026-3031, 1997.
57. Huang, Z., Fasco, M. J., Figge, H. L., Keyomarsi, K., and Kaminsky, L. S. Expression of cytochromes P450 in human breast tissue and tumors. Drug Metab. Dispos., 24: 899-905, 1996.
58. Einolf, H. J., Story, W. T., Marcus, C. B., Larsen, M. C., Jefcoate, C. R., Greenlee, W. F., Yagi, H., Jerina, D. M., Amin, S., Park, S. S., Gelboin, H. V., and Baird, W. M. Role of cytochrome P450 enzyme induction in the metabolic activation of benzo [c]phenanthrene in human cell lines and mouse epidermis. Chem. Res. Toxicol., 10: 609-617, 1997.