Effects of haloperidol in a response-reinstatement model of heroin relapse

Psychopharmacology

Volumn 124, Issue 3, 1996, Pages 205-210

  Ettenberg, Aaron ^a   MacConell, Leigh A ^a   Geist, Timothy D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Dopamine; Drug relapse; Naloxone; Opiates; Response reinstatement; Self administration

Indexed keywords

DIAMORPHINE; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; HALOPERIDOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG SELF ADMINISTRATION; INSTRUMENTAL CONDITIONING; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEARNING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; RELAPSE;

ANIMALS; DOPAMINE ANTAGONISTS; EXTINCTION, PSYCHOLOGICAL; HALOPERIDOL; HEROIN; MALE; NARCOTICS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE-RELATED DISORDERS;

EID: 0029969255     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02246658     Document Type: Article

References (53)

1. Ahlenius S, Engel J, Zoller M (1977) Effects of apomorphine and haloperidol on exploratory behavior and latent learning in mice. Physiol Behav 5: 290-294
2. Bartus RT (1978) Short-term memory in the rhesus monkey: effects of dopamine blockade via acute haloperidol administration. Pharmacol Biochem Behav 9: 353-357
3. Bechara A, Martin GM, Pridgar A, Van der Kooy D (1993) The parabrachial nucleus: a brain stem substrate critical for mediating the aversive motivational effects of morphine. Behav Neurosci 107: 147-160
4. Bechara A, Nader K, van der Kooy D (1995) Neurobiology of withdrawal motivation: evidence for two separate aversive effects produced in morphine-naive versus morphine-dependent rats by both naloxone and spontaneous withdrawal. Behav Neurosci 109: 91-105
5. Beninger RJ, MacLennan AJ, Pinel JPL (1980a) The use of conditioned defensive burying to test the effects of pimozide on associative learning. Pharmacol Biochem Behav 12: 445-448
6. Beninger RJ, Mason ST, Phillips AG, Fibiger HC (1980b) The use of conditioned suppression to evaluate the nature of neuroleptic-induced avoidance deficits. J Pharmacol Exp Ther 213: 623-627
7. Bozarth MA (1987) Methods of assessing the reinforcing properties of abused drugs. Springer, Berlin, Heidelberg, New York
8. Bozarth MA, Wise RA (1981) Intracranial self-administration of morphine into the ventral tegmental area of rats. Life Sci 28: 551-555
9. Brady JV (1991) Animal models for assessing drugs of abuse. Neurosci Biobehav Rev 15: 35-53
10. Crowley TJ (1972) The reinforcers for drug abuse: why people take drugs. Compr Psychiatry 13: 51-62
11. de Wit H, Stewart J (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75: 134-143
12. de Wit H, Stewart J (1983) Drug reinstatement of heroin-reinforced responding in the rat. Psychopharmacology 79: 29-31
13. Duvauchelle CL, Ettenberg A (1990) Haloperidol prevents the establishment of brain stimulation induced conditioned place preferences but not aversions. Soc Neurosci Abstr 16: 591
14. Engel J, Oreland L (1987) Brain reward systems and abuse. Raven, New York
15. Ettenberg A (1990) Haloperidol prevents the reinstatement of amphetamine-rewarded runway responding in rats. Pharmacol Biochem Behav 36: 635-638
16. Ettenberg A, Geist TD (1992) Qualitative and quantitative differences in the operant runway behavior of cocaine and heroin reinforced rats. Pharmacol Biochem Behav 44: 191-198
17. Ettenberg A, Horvitz JC (1990) Pimozide prevents the response-reinstating effects of water reinforcement in rats. Pharmacol Biochem Behav 37: 465-469
18. Ettenberg A, Pettit HO, Bloom FE, Koob GF (1982) Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems. Psychopharmacology 78: 204-209
19. Geist TD, Ettenberg A (1990) A simple method for studying intravenous drug reinforcement in a runway. Pharmacol Biochem Behav 36: 703-706
20. Gerber GJ, Stretch R (1975) Drug-induced reinstatement of extinguished self-administration behavior in monkeys. Pharmacol Biochem Behav 3: 1055-1061
21. Hall SM, Wasserman DA, Havassy BE (1991) Relapse prevention. NIDA Res Monogr 106: 279-292
22. Harrington F, Van der Kooy D (1992) Deprivation state determines the motivational effects of neuroleptics in rats. Psychobiology 20: 294-299
23. Himmelsbach CK (1943) Morphine, with reference to physical dependence. Fed Proc 2: 201-203
24. Hodgson R, Rankin H, Stockwell T (1979) Alcohol dependence and the priming effect. Behav Res Ther 27: 379-387
25. Hoffmann NG, Miller NS (1993) Perspectives of effective treatment for alcohol and drug disorders. Psychiatr Clin N Am 16: 127-140
26. Horvitz JC, Ettenberg A (1988) Haloperidol blocks the response reinstating effects of food reward: a methodology for separating neuroleptic effects on reinforcement and motor processes. Pharmacol Biochem Behav 31: 861-865
27. Jaffe JH, Cascella NG, Kumor KM, Sherer MA (1989) Cocaine-induced cocaine craving. Psychopharmacology 97: 59-64
28. Koob GF (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 13: 177-184
29. Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Science 242: 715-723
30. Koob GF, Stinus L, LeMoal M, Bloom FE (1989) Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence. Neurosci Biobehav Rev 13: 135-140
31. Ludwig AM, Wikler A, Stark LH (1974) The first drink: psychobiological aspects of craving. Arch Gen Psychiatry 30: 539-574
32. McFarland K, Ettenberg A (1995) Haloperidol differentially affects reinforcement and motivational processess in rats running an alley for intravenous heroin. Psychopharmacology 122:346-350
33. Mackey WB, Van der Kooy, D (1985) Neuroleptics block the positive reinforcing effects of amphetamine but not of morphine as measured by place conditioning. Pharmacol Biochem Behav 22: 101-105
34. Marlatt A, Gordon J (1985) Relapse prevention. Guilford, New York
35. Nader K, Bechara A, Roberts DCS, van der Kooy D (1994) Neuroleptics block high- but not low-dose heroin place preferences: further evidence for a two-system model of motivation. Behav Neurosci 108: 1128-1138
36. O'Brien CP, Childress AR, McLellan AT (1991) Conditioning factors may help to understand and prevent relapse in patients who are recovering from dependence. NIDA Res Monogr 106: 293-312
37. Pettit HO, Ettenberg A, Bloom FE, Koob GF (1984) Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology 84: 167-173
38. Roberts DCS, Corcoran ME, Fibiger HC (1977) On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine. Pharmacol Biochem Behav 6: 615-620
39. Roberts DCS, Koob GF, Klonoff P, Fibiger HC (1980) Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacol Biochem Behav 12:781-787
40. Satel SL, Kosten TR, Schuckit MA, Fischman MW (1993) Should protracted withdrawal from drugs be included in the DSM-IV? Am J Psychiatry 150: 695-704
41. Schuster CR, Thompson T (1969) Self-administration of and behavioral dependence on drugs. Annu Rev Pharmacol 9: 483-502
42. Shoaib M, Spanagel R (1994) Mesolimbic sites mediate the discriminativge stimulus effects of morphine. Eur J Pharmacol 252: 69-75
43. Slikker W, Brocco MJ, Killam KF (1984) Reinstatement of responding maintained by cocaine or thiamylal. J Pharmacol Exp Ther 228: 43-52
44. Smith SG, Davis WM (1973) Haloperidol effects on morphine self-administration: testing for pharmacological modification of the primary reinforcement mechanism. Psychol Rec 23: 215-221
45. Solomon RL, Corbit JD (1974) An opponent-process theory of motivation. I. Temporal dynamics of affect. Psychol Rev 81: 119-145
46. Spyraki C, Fibiger HC, Phillips AG (1983) Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system. Psychopharmacology 79: 278-283
47. Stewart J (1984) Reinstatement of heroin and cocaine self-administration behavior in the rat by intracerebral application of morphine in the ventral tegmental area. Pharmacol Biochem Behav 20: 917-923
48. Stewart J, Wise RA (1992) Reinstatement of heroin self-administration habits: morphine prompts and naltrexone discourages renewed responding after extinction. Psychopharmacology 108: 79-84
49. Stewart J, de Wit H, Eikelboom R (1984) Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol Rev 91: 251-268
50. Stretch R, Gerber GJ (1973) Drug-induced reinstatement of amphetamine self-administration in monkeys. Can J Psychol 27: 168-177
51. Tobena A, Fernandez-Teruel A, Escorihuela RM, Nunez JF, Zapata A, Ferre P, Sanchez R (1993) Limits of habituation and extinction: implications for relapse prevention programs in addictions. Drug Alcohol Depend 32: 209-217
52. Wise RA (1987) Intravenous drug self-administration: a special case of positive reinforcement. In: Bozarth MA (ed) Methods of assessing the reinforcing properties of abused drugs. Springer, Berlin, Heidelberg, New York, pp 117-141
53. Wise RA, Murray A, Bozarth MA (1990) Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever-pressing in rats. Psychopharmacology 100: 355-360