Dopamine ligands and the stimulus effects of amphetamine: Animal models versus human laboratory data

Psychopharmacology

Volumn 130, Issue 1, 1997, Pages 2-13

  Brauer, Lisa H ^a   Goudie, Andrew J ^b   De Wit, Harriet ^c  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Amphetamine; Animal models; Cocaine; Dopamine; Drug abuse; Human subjects; Mechanisms

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; AMPHETAMINE; BROMOCRIPTINE; CLEBOPRIDE; COCAINE; DOPAMINE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE RECEPTOR AFFECTING AGENT; DOPAMINE UPTAKE INHIBITOR; ETICLOPRIDE; HALOPERIDOL; N (2,6 DIMETHYLERGOLIN 8ALPHA YL)PIVALAMIDE; PERGOLIDE; PIMOZIDE; PIRIBEDIL; PRAZOSIN; PRECLAMOL; QUINPIROLE; RACLOPRIDE; SKF 238393; SKF 39166; SKF 75760; SPIPERONE; SULPIRIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANOXERINE;

ANIMAL MODEL; DISCRIMINATIVE STIMULUS; DOPAMINERGIC SYSTEM; DRUG ANTAGONISM; DRUG MECHANISM; EXPERIMENTAL ANIMAL; HUMAN; MOOD; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPECIES DIFFERENCE; SUBSTANCE ABUSE;

AMPHETAMINE; ANIMALS; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DRUG INTERACTIONS; HUMANS;

EID: 0031027754     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050207     Document Type: Review

References (110)

1. Ando K, Miyata H, Yanagita T (1994) Effects of methamphetamine, dopamine and noradrenaline administered into the nucleus accumbens of rats discriminating subcutaneous methamphetamine. Jpn J Pharmacol 64:35-40
2. 2 agonist (-)-NPA are mediated by separate mechanisms. Life Sci 42:565-574
3. Arnt J (1996) Inhibitory effects on the discriminative stimulus properties of d-amphetamine by classical and newer antipsychotics do not correlate with antipsychotic activity. Relation to effects on the reward system. Psychopharmacology 124:117-125
4. Baldessarini R (1990) Drugs and the treatment of psychiatric disorders. In: Gilman A, Ralls T, Nies A, Taylor P (eds) The pharmacological basis of therapeutics, 8th edn. Pergamon Press, New York, pp 383-435
5. Balster R (1991) Drug abuse potential evaluation in animals. Br J Addict 86:1549-1558
6. Brauer L, de Wit H (1995) Role of dopamine in d-amphetamine-induced euphoria. Exp Clin Psychopharmacol 3:371-381
7. Brauer L, de Wit H (1996a) High dose pimozide does not block amphetamine-induced euphoria in normal volunteers. Pharmacol Biochem Behav (in press)
8. Brauer L, de Wit H (1996b) Subjective responses to d-amphetamine alone and after pimozide pretreatment in normal, healthy volunteers. Biol Psychiatry 39:26-32
9. Brauer L, Johanson C, Schuster C, Rothman R, de Wit H (1996) Evaluation of phentermine and fenfluramine, alone and in combination, in normal, healthy volunteers. Neuropsychopharmacology 14:233-241
10. 1 receptors in the nucleus accumbens. Psychopharmacology 115: 110-114
11. 2 mediation of the discriminative stimulus properties of d-amphetamine and cocaine. Psychopharmacology 103:50-55
12. 1 receptor blockade in the amygdala. Pharmacol Biochem Behav 51:759-766
13. Chait L, Uhlenhuth E, Johanson C (1985) The discriminative stimulus and subjective effects of d-amphetamine in humans. Psychopharmacology 86:307-312
14. Chait L, Uhlenhuth E, Johanson C (1986a) The discriminative stimulus and subjective effects of d-amphetamine, phenmetrazine, and fenfluramine in humans. Psychopharmacology 86:301-306
15. Chait L, Uhlenhuth E, Johanson C (1986b) The discriminative stimulus and subjective effects of phenylpropanolamine, mazindol, and d-amphetamine in humans. Pharmacol Biochem Behav 24:1665-1672
16. Chait L, Johanson C (1988) Discriminative stimulus effects of caffeine and benzphetamine in amphetamine-trained volunteers. Psychopharmacology 96:302-308
17. Clark D, White F (1987) D1 receptor function, the search for a function. Synapse 23:347-388
18. Colpaert F, Kuyps J, Niemegeers C, Janssen P (1976) Discriminative stimulus properties of a low dl-amphetamine dose. Arch Int Pharmacodyn Ther 223:34-43
19. Colpaert F, Niemegeers C, Janssen P (1978) Discriminative stimulus properties of cocaine and d-amphetamine, and antagonism by haloperidol: a comparative study. Neuropharmacology 17:937-942
20. Cunningham K, Callahan P (1991) Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat. Psychopharmacology 104:177-180
21. de la Garza R, Johanson C (1987) Discriminative stimulus properties of intragastrically administered d-amphetamine and pentobarbital in rhesus monkeys. J Pharmacol Exp Ther 243: 955-962
22. de Wit H, Griffiths R (1991) Testing the abuse liability of anxiolytic and hypnotic drugs in humans. Drug Alcohol Depend 28:83-111
23. de Wit H, Uhlenhuth E, Johanson C (1985) Drug preference in normal volunteers: effects of age and time of day. Psychopharmacology 87:186-193
24. de Wit H, Uhlenhuth E, Johanson C (1986) Individual differences in the reinforcing and subjective effects of amphetamine and diazepam. Drug Alcohol Depend 16:341-360
25. de Wit H, Uhlenhuth E, Pierri J, Johanson C (1987) Individual differences in behavioral and subjective responses to alcohol. Alcohol Clin Exp Res 11:52-59
26. Druhan J, Fibiger H, Phillips A (1991) Influence of some drugs of abuse on the discriminative stimulus properties of amphetamine. Behav Pharmacol 2:391-403
27. Druhan J, Deschamps S, Stewart J (1993) d-Amphetamine like stimulus properties are produced by morphine injections into the ventral tegmental area but not into the nucleus accumbens. Behav Brain Res 59:41-51
28. Dworkin S, Bimle C (1989) 6-Hydroxydopamine lesions of the nucleus accumbens attenuate the discriminative stimulus effects of amphetamine. Drug Dev Res 166:435-451
29. Evans S, Johanson C (1987) Amphetamine-like effects of anorectics and related compounds in pigeons. J Pharmacol Exp Ther 241:817-825
30. 2 dopamine receptor agonists in rats discriminating d-amphetamine from saline. Behav Pharmacol 3:609-619
31. 2 dopamine agonists on the d-amphetamine discriminative stimulus. Behav Pharmacol 1:101-111
32. 2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Arch Gen Psychiatry 49:538-544
33. Fibiger H, Phillips A, Brown E (1992) The neurobiology of cocaine-induced reinforcement. In: Bock G, Whelan J (eds) Cocaine: scientific and social dimensions. Wiley, Chichester, UK, pp 96-124
34. Fischman M (1989) Relationship between self-reported drug effects and their reinforcing effects: studies with stimulant drugs. In: Fischman M, Mello N (eds) Testing for abuse liability of drugs in humans. NIDA Res Monogr No. 92, US Government Printing Office, Rockville Md, pp 211-230
35. Fischman M, Foltin R (1991) Utility of subjective-effects measurements in assessing abuse liability of drugs in humans. Br J Addict 86:1563-1570
36. Foltin R, Fischman M (1991) Assessment of abuse liability of stimulant drugs in humans: a methodological survey. Drug Alcohol Depend 28:3-48
37. Garcha H, Stolerman I (1989) Discrimination of a drug mixture in rats: role of training dose and specificity. Behav Pharmacol 1:25-31
38. Gawin F (1986) Neuroleptic reduction of cocaine-induced paranoia but not euphoria? Psychopharmacology 90:142-143
39. Gawin F, Allen D, Humblestone B (1989) Outpatient treatment of "crack" cocaine smoking with flupenthixol decanoate: a preliminary report. Arch Gen Psychiatry 46:322-325
40. George F, Ritz M (1993) A psychopharmacology of motivation and reward related to substance abuse treatment. Exp Clin Psychopharmacol 1:7-26
41. Goodall E, Trenchard E, Silverstone T (1987) Receptor blocking drugs and amphetamine anorexia in human subjects. Psychopharmacology 92:484-490
42. Goudie A (1977) Discriminative stimulus properties of fenfluramine in an operant task in rats. Psychopharmacology 53:97-104
43. Goudie A (1991) Discriminative stimulus properties of amphetamine, cathinone, and related agents. In: Glennon R, Jarbe T, Frankenheim J (eds) Drug discrimination: applications to drug abuse research. NIDA Res Monogr No. 116, US Government Printing Office, Rockville Md, pp 45-60
44. Goudie A, Reid D (1988) Qualitative discrimination between amphetamine and cocaine in rats. Eur J Pharmacol 151:471-474
45. Goudie A, Atkinson J, West C (1986) Discriminative stimulus properties of the psychostimulant dl-cathinone in a two lever operant task. Neuropharmacology 25:85-94
46. Goudie A, Dubicki W, Leathley M (1988) Paroxetine, a selective 5-hydroxytryptamine uptake inhibitor with antidepressant properties, lacks amphetamine-like stimulus properties in an operant drug discrimination bioassay in rats. J Pharm Pharmacol 40:192-216
47. Grant K, Colombo G (1993) Pharmacological analysis of the mixed discriminative stimulus effects of ethanol. Alcohol Alcohol Suppl 2:445-449
48. Gunne L, Anggard E, Jonsson L (1972) Clinical trials with amphetamine-blocking drugs. Psychiatr Neurol Neurochir 75: 225-226
49. Heishman S, Henningfield J (1991) Discriminative stimulus effects of d-amphetamine, methylphenidate, and diazepam in humans. Psychopharmacology 103:436-442
50. Ho B, Huang J (1975) Role of dopamine in d-amphetamine-induced discriminative responding. Pharmacol Biochem Behav 3:1085-1092
51. Hoffman B, Lefkowitz R (1990) Catecholamines and sympathomimetic drugs. In: Gilman A, Rall T, Nies A, Taylor P (eds) The pharmacological basis of therapeutics, 8th edn. Pergamon Press, New York, pp 187-220
52. Hyttel J, Larsen J, Christensen A, Arnt J (1985) Receptor-binding profiles of neuroleptics. Psychopharmacology Suppl 2:9-18
53. Jacobs D (1986) Noradrenergic mechanisms in the response to dextroamphetamine in humans. Int Clin Psychopharmacol 1:199-209
54. Jacobs D, Silverstone T (1986) Dextroamphetamine-induced arousal in human subjects as a model for mania. Psychol Med 16:323-329
55. Jarbe T (1982) Discriminative stimulus properties of d-amphetamine in pigeons. Pharmacol Biochem Behav 17:671-675
56. Johanson C, Barrett J (1993) The discriminative stimulus properties of cocaine in pigeons. J Pharmacol Exp Ther 267:1-8
57. Johanson C, Kilgore K, Uhlenhuth E (1983) Assessment of dependence potential of drugs using multiple indices. Psychopharmacology 81:144-149
58. Jonsson L (1972) Pharmacological blockade of amphetamine effects in amphetamine dependent subjects. Eur J Clin Pharmacol 4:206-211
59. Kamien J, Woolverton W (1989) A pharmacological analysis of the discriminative stimulus properties of d-amphetamine in rhesus monkeys. J Pharmacol Exp Ther 248:938-946
60. Kamien J, Bickel W, Hughes J, Higgins S, Smith B (1993) Drug discrimination by humans compared to nonhumans: current status and future directions. Psychopharmacology 111:259-270
61. Koob G (1992) Dopamine, addiction and reward. Sem Neurosci 4:139-148
62. Kumor K, Sherer M, Jaffe J (1989) Effects of bromocriptine pretreatment on subjective and physiological responses to IV cocaine. Pharmacol Biochem Behav 33:829-837
63. Lamb R, Henningfield J (1994) Human d-amphetamine drug discrimination: methamphetamine and hydromorphone. J Exp Anal Behav 61:169-180
64. Lamb R, Preston K, Schindler C, Meisch R, Davis F, Katz J, Henningfield J, Goldberg S (1991) The reinforcing and subjective effects of morphine in post-addicts: a dose-response study. J Pharmacol Exp Ther 259:1165-1173
65. Melia K, Spealman R (1991) Pharmacological characterization of the discriminative stimulus effects of GBR 12909. J Pharmacol Exp Ther 258:626-632
66. 1A agonists. Behav Pharmacol 5:591-598
67. Nencini P, Woolverton W (1988) Effects of nimodipine on the discriminative stimulus properties of amphetamine in rats. Psychopharmacology 96:40-44
68. Nielsen E, Jepsen S (1985) Antagonism of the amphetamine cue by both classical and atypical antipsychotic drugs. Eur J Pharmacol 11:167-176
69. Nielsen E, Scheel-Kruger J (1986) Cueing effects of d-amphetamine and LSD: elicitation by direct microinjection into the nucleus accumbens. Eur J Pharmacol 125:85-92
70. Nielsen E, Randrup K, Anderson P (1989) Amphetamine discrimination: effects of dopamine receptor agonists. Eur J Pharmacol 160:253-262
71. Nurnberger J, Simmons-Alling S, Kessler L, Jimerson S, Schreiber J, Hollander E, Tamminga C, Nadi N, Goldstein D, Gershon E (1984) Separate mechanisms for behavioral, cardiovascular, and hormonal responses to dextroamphetamine in man. Psychopharmacology 84:200-204
72. Preston K, Bigelow G (1991) Subjective and discriminative effects of drugs. Behav Pharmacol 2:293-313
73. Preston K, Jasinski D (1991) Abuse liability studies of opioid agonist-antagonists in humans. Drug Alcohol Depend 28:49-82
74. Preston K, Sullivan J, Strain E, Bigelow G (1992) Effects of cocaine alone and in combination with bromocriptine in human cocaine abusers. J Pharmacol Exp Ther 262:279-291
75. Preston K, Sullivan J, Berger P, Bigelow G (1993) Effects of cocaine alone and in combination with mazindol in human cocaine abusers. J Pharmacol Exp Ther 267:296-307
76. 1 agonist SKF 81297. Behav Pharmacol 4:135-146
77. Risner M, Jones B (1976) Role of noradrenergic and dopaminergic processes in amphetamine self-administration. Pharmacol Biochem Behav 5:477-482
78. Ritz M, Kuhar M (1989) Relationship between self-administration of amphetamine and monoamine receptors n the brain - comparison with cocaine. J Pharmacol Exp Ther 248:1010-1018
79. Ritz M, Lamb R, Goldberg S, Kuhar M (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237:1219-1223
80. Robinson T, Berridge K (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 18:247-291
81. Sasaki J, Tatham T, Barrett J (1995) The discriminative stimulus properties of amphetamine in pigeons. Psychopharmacology 120:303-310
82. Schechter M, Schlechter J, Calcagnetti D (1992) Direct microinjection of cathinone into the rat brain produces discriminative stimuli. Pharmacol Biochem Behav 42:619-623
83. Schuster C, Johanson C (1988) Relationship between the discriminative stimulus properties and subjective effects of drugs. In: Colpaert F, Balster R (eds) Transduction mechanisms of drug stimuli. Springer, Berlin Heidelberg New York, pp 161-175
84. Schuster C, Fischman M, Johanson C (1981) Internal stimulus control and subjective effects of drugs. In: Thompson T, Johanson C (eds) Behavioral pharmacology of human drug dependence. NIDA Res Monogr No. 37, US Government Printing Office, Rockville, Md, pp 116-129
85. Schwartz J-C, Giros B, Martres M-P, Sokoloff P (1992) The dopamine receptor family: molecular biology and pharmacology. Semin Neurosci 4:99-108
86. Seiden L, Sabol K, Ricuarte G (1993) Amphetamine: effects on catecholamine systems and behavior. Annu Rev Pharmacol Toxicol 32:639-377
87. Sherer M, Kumor K, Jaffe J (1989) Effects of intravenous cocaine are partially attenuated by haloperidol. Psychiatry Res 27: 117-125
88. Silverstone T, Fincham J, Wells B, Kyriakides M (1980) The effect of the dopamine receptor blocking drug pimozide on the stimulant and anorectic actions of dextroamphetamine in man. Neuropharmacology 19:1235-1237
89. Smith F, St. John C, Yang T, Lyness W (1989) Role of specific dopamine receptor subtypes in amphetamine discrimination. Psychopharmacology 97:501-506
90. Snoddy A, Tessel R (1983) Nisoxetine and amphetamine share discriminative stimulus properties in mice. Pharmacol Biochem Behav 19:205-210
91. Snoddy A, Tessel R (1985) Prazosin: effect on psychomotor stimulant cues and locomotor activity in mice. Eur J Pharmacol 116:221-228
92. Stolerman I, D'Mello G (1981) Role of training conditions in discrimination of central nervous stimulants by rats. Psychopharmacology 73:295-303
93. Stone A, Greenstein R, Gamble G, McLellan A (1993) Cocaine use by schizophrenic outpatients who receive depot neuroleptic medication. Hosp Commun Psychiatry 44:176-177
94. Tella S (1994) Differential blockade of chronic versus acute effects of intravenous cocaine by dopamine receptor antagonists. Pharmacol Biochem Behav 48:151-159
95. Tessel R (1990) Noradrenergic processes in the behavioral actions of psychomotor stimulants. Drug Dev Res 20:359-368
96. Thabit M, Goudie AJ (1992) Evidence for dopaminergic involvement in the cocaine discriminative stimulus. Br J Pharmacol 106S:133
97. Vangroll B, Appel J (1992) Stimulus effects of d-amphetamine I-DA mechanisms. Pharmacol Biochem Behav 43:967-973
98. West W, Vangroll B, Appel J (1995) Stimulus effects of amphetamine II - DA, NE and 5-HT mechanisms. Pharmacol Biochem Behav 51:69-76
99. Wise R (1984) Neural mechanisms of the reinforcing action of cocaine. In: Grabowski J (ed) Cocaine: pharmacology, effects and treatment of abuse. NIDA Res Monogr No. 50. US Government Printing Office, Rockville, Md., pp 15-33
100. Wise R, Rompre P (1989) Brain dopamine and reward. Annu Rev Psychol 40: 191-225
101. Wood D, Emmett-Oglesby M (1988) Substitution and cross-tolerance profiles of anorectic drugs in rats trained to detect the discriminative stimulus properties of cocaine. Psychopharmacology 95:364-368
102. Wood D, Emmett-Oglesby M (1989) Mediation in the nucleus accumbens of the discriminative stimulus produced by cocaine. Pharmacol Biochem Behav 33:453-457
103. Woolverton W (1984) Pharmacological analysis of the discriminative stimulus effects of d-amphetamine in rhesus monkeys. Pharmacologist 26:161
104. 2 dopamine antagonist on the self-administration of cocaine and piribedil by rhesus monkeys. Pharmacol Biochem Behav 24:531-535
105. Woolverton W (1987) Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys. Pharmacol Biochem Behav 26:853-859
106. Woolverton W, Johnson K (1992) Neurobiology of cocaine abuse. Trends Pharmacol Sci 13:193-201
107. Woolverton W, Kleven M (1988) Multiple dopamine receptors and the behavioral effects of cocaine. In: Clouet D, Asghar K, Brown R (eds) Mechanism of cocaine abuse and toxicity. NIDA Res Monogr No. 88. US Government Printing Office, Rockville, Md, pp 160-184
108. Woolverton W, Massey B, Winger G, Patrick G, Harris L (1995) Evaluation of the abuse liability of aminorex. Pharmacol Biochem Behav 36:187-192
109. Yokel R, Wise R (1975) Increased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward. Science 187:547-549
110. Yokel R, Wise R (1976) Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats. Psychopharmacology 48:311-318