Spontaneous mutation spectrum at the lambda cll locus in liver, lung, and spleen tissue of big blue® transgenic mice

Environmental and Molecular Mutagenesis

Volumn 33, Issue 2, 1999, Pages 132-143

  Harbach, P R ^a   Zimmer, D M ^a   Filipunas, A L ^a   Mattes, W B ^a   Aaron, C S ^a  

^a Pharmacia and Upjohn   (United States)

Author keywords

Big Blue mice; Cll gene; DNA sequencing; Mutation spectra; Spontaneous mutation

Indexed keywords

ARTICLE; BACTERIOPHAGE LAMBDA; DNA FLANKING REGION; DNA SEQUENCE; FRAMESHIFT MUTATION; GENE DELETION; GENE LOCUS; IN VIVO STUDY; MALE; MOUSE; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; SPONTANEOUS MUTATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL PROTEINS; BACTERIOPHAGE LAMBDA; BASE SEQUENCE; DNA PRIMERS; ESCHERICHIA COLI PROTEINS; LIVER; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; SPLEEN; TRANSCRIPTION FACTORS; VIRAL PROTEINS;

BACTERIA (MICROORGANISMS); BACTERIOPHAGE LAMBDA; MUS MUSCULUS;

EID: 0032937876     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1999)33:2<132::AID-EM5>3.0.CO;2-2     Document Type: Article

References (26)

1. Adams WT, Skopek TR. 1987. Statistical test for the comparison of samples from mutational spectra. J Mol Biol 194:391-396.
2. Banuett F, Hoyt MA, McFarlane L, Echols H, Herskowitz I. 1986. hflB, a new Escherichia coli locus regulating lysogeny and the level of bacteriophage lambda cII protein. J Mol Biol 187:213-224.
3. Beard WA, Osheroff WP, Prasad R, Sawaya MR, Jaju M, Wood TG, Kraut J, Kunkel TA, Wilson SH. 1996. Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta. J Biol Chem 271:12141-12144.
4. Cooper DN, Youssoufian H. 1988. The CpG dinucleotide and human genetic disease. Hum Genet 78:151-155.
5. de Boer JG, Glickman BW. 1998. The lacI gene as a target for mutation in transgenic rodents and Escherichia coli. Genetics 148:1441-1451.
6. de Boer JG, Erfle H, Walsh D, Holcroft J, Provost JS, Rogers B, Tindall KR, Glickman BW. 1997. Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice. Environ Mol Mutagen 30:273-286.
7. de Boer JG, Provost S, Gorelick N, Tindall K, Glickman BW. 1998. Spontaneous mutation in lacI transgenic mice: a comparison of tissues. Mutagenesis 13:109-114.
8. Douglas GR, Gingerich JD, Gossen JA, Bartlett SA. 1994. Sequence spectra of spontaneous lacZ gene mutations in transgenic mouse somatic and germline tissues. Mutagenesis 9:451-458.
9. Gossen JA, de Leeuw WJF, Bakker AQ, Vijg J. 1993. DNA sequence analysis of spontaneous mutations at a LacZ transgene integrated on the mouse X chromosome. Mutagenesis 8:243-247.
10. Herskowitz I, Hagen D. 1980. The lysis-lysogeny decision of phage λ: explicit programming and responsiveness. Annu Rev Genet 14: 399-445.
11. Ho YS, Mahoney ME, Wulff DL, Rosenberg M. 1988. Identification of the DNA binding domain of the phage λ cII transcriptional activator and the direct correlation of cII protein stability with its oligomeric forms. Genes Dev 2:184-195.
12. Huang X, Miller W. 1991. A time-efficient, linear-space local similarity algorithm. Adv Appl Math 12:337-357.
13. Jakubczak JL, Merlino G, French JE, Muller WJ, Paul B, Adhya S, Garges S. 1996. Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage λ transgene target. Proc Natl Acad Sci USA 93:9073-9078.
14. Kohler SW, Provost GS, Kretz PL, Fieck A, Sorge JA, Short JM. 1990a. Development of a short-term, in vivo mutagenesis assay: the effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice. Nucleic Acids Res 18:3007-3013.
15. Kohler SW, Provost GS, Kretz PL, Fieck A, Sorge JA, Short JM. 1990b. The use of transgenic mice for short-term, in vivo mutagenicity testing. Genet Anal Tech Appl 7:212-218.
16. Manjanatha MG, Chen JB, Shaddock JG Jr, Harris AJ, Shelton SD, Casciano DA. 1996. Molecular analysis of lacI mutations in rat2 cells exposed to 7,12-dimethylbenz-[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation. Mutat Res 372:53-64.
17. Monroe JJ, Kort KL, Miller JE, Marino DR, Skopek TR. 1998. A comparative study of in vivo mutation assays: analysis of hprt, lacI, and cII/cI as mutational targets for N-nitroso-N-methylurea and benzo-[a]pyrene in Big Blue mice. Mutat Res 421:121-136.
18. Nishino H, Buettner VL, Haavik J, Schaid DJ, Sommer SS. 1996. Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type. Environ Mol Mutagen 28:299-312.
19. Rideout WM, Coetzee GA, Olumi AF, Jones PA. 1990. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 249:1288-1290.
20. Schmeissner U, Court D, Shimatake H, Rosenberg M. 1980. Promoter for the establishment of repressor synthesis in bacteriophage λ. Proc Natl Acad Sci USA 77:3191-3195.
21. Watson DE, Cunningham ML, Tindall KR. 1998. Spontaneous and ENU-induced mutation spectra at the cII locus in Big Blue Rat2 embryonic fibroblasts. Mutagenesis 13:487-497.
22. Wulff DL, Rosenberg M. 1983. Establishment of repressor synthesis. In: Hendrix RW, Roberts JW, Stahl FW, Weisberg RA, editors. Lambda II. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory. p 53-73.
23. Wulff DL, Mahoney M, Shatzman A, Rosenberg M. 1984. Mutational analysis of a regulatory region in bacteriophage λ that has overlapping signals for the initiation of transcription and translation. Proc Natl Acad Sci USA 81:555-559.
24. Zimmer DM, Zhang XB, Harbach PR, Mayo JK, Aaron CS. 1996. Spontaneous and ethylnitrosourea-induced mutation fixation and molecular spectra at the lacI transgene in the Big Blue Rate-2 embryo cell line. Environ Mol Mutagen 28:325-333.
25. Zimmer DM, Harbach PR, Mattes WB, Aaron CS. 1998. Effect of plating medium and phage storage on mutant frequency and titer in the lambda cII transgenic mutation assay. Environ Mol Mutagen 32: 325-330.
26. Zimmer DM, Harbach PR, Mattes WB, Aaron CS. 1999. Comparison of mutant frequencies at the transgenic lambda lacI and cII/cI loci in control and ENU-treated Big Blue mice. Environ Mol Mutagen 33: 206-213.