Molecular analysis of lacI mutations in Rat2(TM) cells exposed to 7,12-dimethylbenz[a]anthracene: Evidence for DNA sequence and DNA strand biases for mutation

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 372, Issue 1, 1996, Pages 53-64

  Manjanatha, M G ^a   Chen, J B ^a   Shaddock Jr , J G ^a   Harris, A J ^a   Shelton, S D ^a   Casciano, D A ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

LacI; Mutant frequency; Rat2(TM) cell; Strand bias

Indexed keywords

DIMETHYLBENZ[A]ANTHRACENE;

ANIMAL CELL; ARTICLE; CELL MUTANT; DNA SEQUENCE; DNA STRAND; MUTAGEN TESTING; MUTATION; NONHUMAN; PRIORITY JOURNAL; RAT; SHUTTLE VECTOR;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BACTERIAL PROTEINS; BACTERIOPHAGE LAMBDA; CARCINOGENS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; ESCHERICHIA COLI PROTEINS; MUTAGENICITY TESTS; MUTATION; RATS; REPRESSOR PROTEINS; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, DNA; TRANSGENES;

EID: 0030580231     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00162-5     Document Type: Article

References (54)

1. [1] McCann, J.E., E. Choi, E. Yamasaki and B.N. Ames (1975) Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals, Proc. Natl. Acad. Sci. USA, 72, 5135-5139.
2. [2] Seino, Y., M. Nagao, T. Yahagi, A. Hoshi, T. Kawachi and T. Sigimura (1978) Mutagenicity of several classes of antitumor agents to Salmonella typhimurium TA98, TA100, and TA92, Cancer Res., 38, 2148-2156.
3. [3] Maron, D.M. and B.N. Ames (1983) Revised methods for the Salmonella mutagenicity test, Mutation Res., 113, 173-215.
4. [4] Pueyo, C. (1978) Forward mutations to arabinose resistance in Salmonella typhimurium strains: A sensitive assay for mutagenicity testing, Mutation Res., 54, 311-321.
5. [5] Skopek, T.R., H.L. Liber, J.J. Krolewski and W.G. Thilly (1978) Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker, Proc. Natl. Acad. Sci. USA, 75, 410-414.
6. [6] Hsie, A.W., P.A. Brimer, T.J. Mitchell and D.G. Gosslee 1975) The dose-response relationship for ethylmethane-sulfonate-induced mutations at the hprt locus in Chinese hamster ovary cells, Somatic Cell Genet., 1, 247-261.
7. +/- mouse lymphoma mutagen assay system, Mutation Res., 59, 61-108.
8. [8] Bradley, M.O., B. Bhuyan, M.C. Francis, R. Langenbach, A. Peterson and E. Huberman (1981) Mutagenesis by chemical agents in V79 Chinese hamster cells: A review and analysis of the literature, Mutation Res., 87, 81-142.
9. [9] Liber, H.L. and W.G. Thilly (1982) Mutation assay at the thymidine kinase locus in diploid human lymphoblasts, Mutation Res., 94, 467-485.
10. [10] Wyborski, D.L., S. Malkhosyan, J. Moores, M.J. Dycaico and J.M. Short (1995) Development of a rat cell line containing stably integrated copies of a lambda/ lacI shuttle vector, Mutation Res., 334, 161-165.
11. [11] Kohler, S.W., G.S. Provost, A. Fieck, P.L., Kretz, W.O. Bullock, J.A. Sorge, D.L. Putman and J.M. Short (1991) Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice, Proc. Natl. Acad. Sci. USA, 88, 7958-7962.
12. [12] Dycaico, M.J., G.S. Provost, P.L. Kretz, S.L. Ransom, J.C. Moores and J.M. Short (1994) The use of shuttle vectors for mutation analysis in transgenic mice and rats. Mutation Res., 307, 461-478.
13. [13] Huggins, C., L.C. Grand and F.P. Brillantes (1961) Mammary cancer induced by a single feeding of polynuclear hydrocarbons, and its suppression, Nature, 189, 204-207.
14. [14] Sinha, D. and T.L. Dao (1974) A direct mechanism of mammary carcinogenesis induced by DMBA, J. Natl. Cancer Inst., 53, 841-846.
15. [15] Jabara, A.G. and P.S. Anderson (1982) Effects of proges terone on mammary carcinogenesis when various doses of DMBA were applied directly to rat mammae, Pathology, 14, 313-316.
16. [16] Holtzman, S., M. Meade, J.P. Stone and C.J. Shellabarger (1985) Carcinogenic responses to chemical applied directly to rat mammary glands in situ, Carcinogenesis, 6, 769-772.
17. [17] Moore, C.J., A.J. Bachhuber and M.N. Gould (1983) Relationship of mammary tumor susceptibility, mammary cell-mediated mutagenesis, and metabolism of polycyclic aromatic hydrocarbons in four types of rats, J. Natl. Cancer Inst., 70, 777-784.
18. [18] Cavalieri, E.L., S. Higginbotham, N.V.S. Ramakrishna, P.D. Devanesan, R. Todorovic, E.G. Rogan and S. Salmasi (1991) Comparative dose-response tumorigenicity studies of dibenzo[a,l]pyrene versus 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene and two dibenzo[a,l]pyrene dihydrodiols in mouse skin and rat mammary gland, Carcinogenesis, 12, 1939-1944.
19. [19] Manjanatha, M.G., L.E. Lyn-Cook, S.A. Gulp, R.K. Newton, F.A. Beland, R.H. Heflich and A. Aidoo (1996) Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of the mammary gland carcinogen DMBA, Mutation Res., in press,
20. [20] Oldham, J.W., D.A. Casciano and J.A. Farr (1979) The isolation and primary culture of viable, nonproliferating rat hepatocytes, TCA Mannual, 5, 1047-1050.
21. [21] Shaddock, J.G., B.Y. Robinson and D.A. Casciano (1990) Effect of pretreatment with hepatic mixed-function oxidase inducers on the genotoxicity of four rat carcinogens in the hepatocyte/DNA repair assay, Mutagenesis, 5, 387-391.
22. [22] Short, J.M., J.M. Fernandez, J.A. Sorge and W.D. Huse (1988) Lambda Zap, a bacteriophage lambda expression vector with in vivo excision properties. Nucleic Acids Res., 16, 7583-7600.
23. [23] Stiegler, G.L. and L.C. Stillwell (1993) Big Blue transgenic mouse lacI mutation analysis, Environ. Mol. Mutagen., 22, 127-129.
24. [24] Adler, K., K. Beyeuther, E. Fanning, N. Ceisler, B. Gronenborn, A. Klemm, B. Muller-Hill and A. Schmitz (1972) How the lac repressor binds to DNA, Nature, 237, 322-327.
25. [25] Adams, W.T. and T.R. Skopek (1987) Statistical test for the comparison of samples from mutational spectra, J. Mol. Biol., 194, 391-396.
26. [26] Cariello, N.F., W.W. Piegorsch, W.T. Adams, and T.R. Skopek (1994) Computer program for the analysis of mutational spectra: application to p53 mutations, Carcinogenesis, 15, 2281-2285.
27. [27] Schaaper, R.M., B.N. Danforth and B.W. Glickman (1986) Mechanisms of spontaneous mutagenesis: an analysis of the spectrum of spontaneous mutation in the E. coli lacI gene, J. Mol. Biol., 189, 273-284.
28. [28] Sisk, S.C., L.J. Pluta, J.A. Bond and L. Recio (1994) Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following exposure to 1,3 butadiene, Carcinogenesis, 15, 471-477.
29. [29] Gorelick, N.J., J.L. Andrews, M. Gu and B.W. Glickman (1995) Mutational spectra in the lacI gene in skin from DMBA-treated and untreated transgenic mice, Mol. Carcinogen., 14, 53-62.
30. [30] Kohler, S.W., G.S. Provost, A. Fieck, P.L., Kretz, W.O. Bullock, J.A. Sorge, D.L. Putman and J.M. Short (1991) Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/ lacI shuttle vector, Environ. Mol. Mutagen., 18, 316-321.
31. [31] Provost, G.S. and J.M. Short (1994) Characterization of mutations induced by ENU in seminiferous tubule germ cells of transgenic B6C3F1 mice, Proc. Natl. Acad. Sci. USA. 91, 6564-6568.
32. [32] Hart, R.W. and R.B. Setlow (1974) Correlation between DNA excision-repair and life-span in a number of mammalian species, Proc. Natl. Acad. Sci. USA, 71, 2169-2173.
33. [33] Calabrese, E.J. (1991) Principles of animal extrapolation. Lewis, Chelsea, MI, pp. 471-475.
34. [34] Dipple, A. and J.A. Nebzydoski (1978) Evidence for the involvement of a diolepoxide in the binding of DMBA to DNA in cells in culture. Chem. Biol. Interact., 20, 17-26.
35. [35] Dipple, A., M. Pigott, R.C. Moschel and N. Costantino (1983) Evidence that binding of DMBA to DNA in mouse embryo cell cultures results in extensive substitution of both adenine and guanine residues, Cancer Res., 43, 4132-4135.
36. [36] Cheng, S.C., A.S. Prakash, M.A. Pigott, B.D. Hilton, J.M. Roman, H.M. Lee, R.G. Harvey and A. Dipple (1988) A metabolite of the carcinogen DMBA that reacts predominantly with adenine residues in DNA, Carcinogenesis, 9, 1721-1723.
37. [37] Newton, R.K., R.A. Mittelstaedt, M.G. Manjanatha and R.H. Heflich (1992) DNA sequence analysis of 1-nitrosopyrene-induced mutations in the hprt gene of CHO cells, Carcinogenesis, 13, 819-825.
38. [38] Manjanatha, M.G., R.K. Newton, R.A. Mittelstaedt, G.R.D. Villani, K.B. Delclos and R.H. Heflich (1993) Molecular analysis of DNA adducts and hprt mutations produced by 6-nitrosochrysene in CHO cells, Carcinogenesis, 14, 1863-1870.
39. [39] Li, E.E., R.H. Heflich and K.B. Delclos (1993) Trans-1,2-dihydrodiol-1,2-dihydroxy-6-aminochrysene is metabolized to form a major adduct with dG and produces mutations in the hprt gene of CHO cells at G:C basepairs, Carcinogenesis, 14, 2109-2114.
40. [40] Menichini, P., H. Vrieling and A.A. van Zeeland (1991) Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells, Mutation Res., 251, 143-155.
41. [41] Dorado, G., H. Steingrimsdottir, C.F. Arlett and A.R. Lehmann (1990) Molecular analysis of UV-induced mutations in a xeroderma pigmentosum cell line, J. Mol. Biol., 217, 217-222.
42. [42] McGregor, W.G., R.H. Chen, L. Lukash, V.M. Maher and J.J. McCormick (1991) Cell cycle-dependent strand biases tor UV-induced mutations in the transcribed strand of excision repair-proficient human fibroblasts but not in repair-deficient cells, Mol. Cell. Biol., 11, 1927-1934.
43. [43] Vrieling, H., M.L. Rooijen, N.A. Groen, M.Z. Zdzienicka, J.W.I.M. Simons, P.H.M. Lohman and A.A. van Zeeland (1989) DNA strand-specificity for UV-induced mutations in mammalian cells, Mol. Cell. Biol., 9, 1277-1283.
44. [44] Chen, R.-H., V.M. Maher and J.J. McCormick (1990) Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by benzo[a]pyrene in the coding region of the hprt gene, Proc. Natl. Acad. Sci. USA, 87, 8680-8684.
45. [45] Heflich, R.H., R.A. Mittelstaedt, M.G. Manjanatha, L.E. Lyn-Cook and A. Aidoo (1996) Types of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene, Environ. Mol. Mutagen., in press.
46. [46] Prelich, G. and B. Stillman (1988) Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA, Cell, 53, 117-126.
47. [47] Mellon, I., G. Spivak and P.C. Hanawalt (1987) Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian dhfr gene, Cell, 51, 241-249.
48. [48] Zarbl, H., S. Sukumar, A.V. Arthur, D. Martin-Zanca and M. Barbacid (1985) Direct mutagenesis of Ha-ras-1 oncogenes by NMU during initiation of mammary carcinogenesis in rats, Nature, 315, 382-385.
49. [49] Balmain, A. and K. Brown (1988) Oncogene activation in chemical carcinogenesis, Adv. Cancer Res., 51, 147-182.
50. [50] Loktinov, A., M. Hollstein, N. Martel, D. Galendo, J.R.P. Cabral, L. Tomatis and H. Yamasaki (1990) Tissue-specific activating mutations of Ha-and Ki-ras oncogenes in skin, lung, and liver tumors induced in mice following transplacental exposure to DMBA, Mol. Carcinogenesis 3, 134-140.
51. [51] Manam, S., R.D. Storer, S. Prahalada, K.R. Leander, A.R. Kraynak, B.J. Ledwith, M.J. van Zwieten, M.O. Bradley and W.W. Nichols (1992) Activation of the Ha-, Ki, and N-ras genes in chemically induced liver tumors from CD-1 mice. Cancer Res., 52, 3347-3352.
52. [52] Pelling, J.C., R. Neads and J. Strawhecker (1988) Epidermal papillomas and carcinomas induced in uninitiated mouse skin by tumor promoters alone contain a point mutation in the 61st codon of the H-ras oncogene, Carci nogenesis, 9, 665-667.
53. [53] Manjanatha, M.G., Li, E.E., Fu, P.P. and R.H., Heflich (1996) H-and K-ras mutational profiles in chemically induced liver tumors from B6C3F1 and CD-1 mice, J. Toxicol, Environ. Health, 47, 195-207.
54. [54] Farabaugh, P.J. (1978) Sequence of the lacI gene. Nature, 274, 765-769.